Mortality

This trial tests whether changing from acid-blocking drugs to a stomach-lining protector called teprenone after a stem cell transplant can reduce the risk of acute graft-versus-host disease (aGVHD), a serious complication where donor immune cells attack the recipient's body. Abou…

This trial compares two ways of feeding very preterm infants (born before 32 weeks and under 1500 grams). One group receives a short period of small 'trophic' feeds for one day before advancing to full feeds, while the other receives trophic feeds for three days. The goal is to s…

This trial investigates whether giving a single dose of azithromycin to children in rural Niger can lower death rates under age five. Over 3 million children are involved, with monitoring of both mortality and antimicrobial resistance. The study adapts every two years to refine t…

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This study tests whether adding the antibiotic minocycline to standard stroke care can improve survival and reduce disability in adults who have had a moderate stroke. About 1,164 participants will be randomly assigned to receive either minocycline pills for five days plus usual …

This study compares two types of drainage after surgery for chronic subdural hematoma (a blood collection on the brain). 354 adults in Denmark will receive either active drainage under the scalp or passive drainage under the brain's outer layer for 24 hours. The goal is to see wh…

Researchers are building AI models that score standard physical and cognitive screening tests from video and audio, and that predict results a person did not obtain. The study enrolls adults 18 and older and follows them for life, linking records to a long-term aging study to che…

This study watches how different ICUs around the world help patients on breathing machines get better. It will look at what kinds of exercises and therapies are used, and how they affect recovery and quality of life. The goal is to find the best ways to help these patients recove…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at whether providing acute medical care at home for people aged 75 and older is as effective as sending them to the emergency department. Researchers will compare health outcomes, including hospital stays and death rates, between those who received home-based car…

This study will track 1,000 adults admitted to the intensive care unit (ICU) in Colombia's Orinoco region to understand why some patients die. Researchers will look at factors like disease type and use a scoring tool called APACHE II to see how well it predicts death. The goal is…

This study is observing 2,500 children in France to understand how pneumococcal vaccines have changed the severity and types of pneumococcal infections. Researchers will look at which bacterial strains cause disease, how severe the infections are, and whether children were vaccin…