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Two common drugs put to the test for safer brain surgery intubation

NCT ID NCT07820540

Symptom relief Sponsor: Benha University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Placing a breathing tube during general anesthesia can briefly raise heart rate, blood pressure, and pressure inside the head. This matters most for people having brain surgery. Researchers are testing whether intravenous dexmedetomidine or lidocaine, compared with a saline placebo, can blunt those changes. They will measure the optic nerve sheath with ultrasound as an indirect sign of brain pressure in 90 adults scheduled for elective brain surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine, lidocaine, or saline given intravenously before anesthesia
What this could lead to
If dexmedetomidine or lidocaine works, doctors could use it to keep brain pressure steadier when placing a breathing tube in people having brain surgery.
What could go wrong
This is a small, single-center study in one type of brain surgery. The eye measurement is an indirect sign of brain pressure, so the results may not apply to other patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 65 years * Male or female participants * American Society of Anesthesiologists physical status I to III * Scheduled for elective supratentorial craniotomy under general anesthesia Exclusion Criteria: * Raised intraocular pressure * Pre-existing eye disease or ocular injury * Severe cardiac or pulmonary disease * Hepatic or renal impairment * Coagulopathy * Pregnancy * Known allergy to any of the study drugs * Difficult airway * Emergency craniotomy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endotracheal intubation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Benha University Hospitals

    Banhā, Qalyubia Governorate, 13511, Egypt

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