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Can a nasal cannula outperform a face mask in keeping patients oxygenated during emergency intubation?

NCT ID NCT07723430

Disease control Sponsor: Khyber Teaching Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether a high-flow nasal cannula (HFNC) can maintain oxygen levels better than a tight face mask during rapid sequence induction, a procedure used for emergency intubation. Adult patients needing intubation will be randomly assigned to receive preoxygenation with either HFNC or a tight face mask. The study measures the lowest oxygen saturation and other safety outcomes to see which method is more effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-flow nasal cannula delivering oxygen at 60 L/min
What this could lead to
If high-flow nasal cannula proves better, it could become the standard method for keeping patients oxygenated during emergency intubations, improving safety.
What could go wrong
This is a single-center trial with 290 participants, so results may not apply to all settings. The intervention may not show a meaningful advantage over the standard face mask.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 290 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Patients requiring rapid sequence induction (RSI) for endotracheal intubation in the operating room, emergency department, or intensive care unit. * Patients in whom both high-flow nasal cannula (HFNC) and tight face mask preoxygenation are technically feasible. * Patients (or their legally authorized representatives, when applicable) able to provide written informed consent. Exclusion Criteria: * Patients requiring immediate crash intubation without sufficient time for preoxygenation. * Patients with facial deformities, upper airway obstruction, or other conditions preventing the use of either HFNC or a tight face mask. * Known contraindications or hypersensitivity to medications used for rapid sequence induction. * Pregnant women. * Patients younger than 18 years of age. * Patients with do-not-intubate (DNI) orders. * Patients already intubated or mechanically ventilated before enrollment. * Patients who underwent endotracheal intubation within the previous 24 hours.

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Conditions

The condition(s) this trial relates to.

Hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Airway management Endotracheal intubation Hypoxemia Rapid sequence induction

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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