Needle-Free COVID-19 vaccine shows promise in early trial
NCT ID NCT06851611
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 trial tested a nasal COVID-19 vaccine called COV2 in 40 healthy adults aged 18-75. The study compared two dose levels (low and high) and two administration methods (nasal drops vs. spray) to see which is safest and best at boosting immunity. Participants included both people who had prior COVID-19 vaccines and those who had never been vaccinated.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- COV2 nasal COVID-19 vaccine
- What this could lead to
- If successful, this could lead to a needle-free COVID-19 booster that is easier to administer and may better protect against variants.
- What could go wrong
- This is a small, early-phase trial focused on safety and immune response, not on preventing infection. The vaccine may not work as hoped in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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40 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Jun 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria 1. Has voluntarily signed the written informed consent 2. 18-75 years old 3. Good general health 4. a) Prior vaccination with at least two doses of any COVID-19 vaccine, OR b) No prior COVID-19 vaccination Exclusion Criteria 1. Pregnant, planning to become pregnant or breastfeeding women 2. COVID-19 infection within the last nine (9) months 3. Any other vaccination within the last two (2) months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kuopio University Hospital
Kuopio, Northern Savonia, 70210, Finland