Scientists track T-Cell activity in COVID-19 patients to unlock immunity secrets
NCT ID NCT04707820
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how T-cells, a key part of the immune system, respond to the COVID-19 virus in 51 people—hospitalized patients and healthy hospital staff. Researchers measured T-cell activity at several time points using a blood test called ELISPOT. The goal was to better understand how the body builds immunity against the virus.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help develop better tests to measure T-cell immunity against COVID-19, which may improve understanding of how the body fights the virus.
- What could go wrong
- This is a small, observational study with only 51 participants, so results may not apply to everyone. It does not test any treatment or vaccine.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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51 people
The number who actually took part.
- Started
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Apr 2020
- Finished
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Apr 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with an acute SARS-CoV-2 infection, confirmed by PCR or typical CT images, requiring hospitalization in a COVID unit at the Rouen University Hospital (pneumonic form requiring oxygen therapy \< 4 L/min.) * Rouen University Hospital staff free of any symptomatology compatible with an SARS-CoV-2 infection (fever, cough, fatigue, loss of taste, loss of smell) since February 1, 2020 * Age ≥ 18 years old * Adult patient who has read and understood the information letter and signed the consent form * Affiliation to a social security scheme Exclusion Criteria: * Patient with PCR-confirmed SARS-CoV-2 infection and hospitalized in intensive care units (acute respiratory distress and/or organ failure, whose pathogenesis may differ from the more frequently described forms with secondary aggravation (5)). * Patient with PCR-confirmed but non-hospitalized SARS-CoV-2 infection (non-acute form, managed by confinement) * A person participating in a therapeutic trial that may interfere with the procedures being investigated, including lymphocyte response prior to D+56±14 days. * Known Pregnancy * Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection / subtutorship or guardianship * Staff at the Rouen University Hospital with SARS-CoV-2 infection confirmed by PCR and/or typical scan images during the epidemic period. * Hospital staff who were exposed to the virus (working in a Covid unit)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rouen University Hospital
Rouen, France
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Other studies related to the condition(s) this trial covers.
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