PET scans reveal hidden brain changes in young COVID survivors
NCT ID NCT04764721
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at 25 young adults (ages 18-65) who had severe COVID-19 and now have thinking or memory problems. Researchers used a special PET-CT scan to see if there are changes in brain activity and how that relates to lung damage. The goal was to better understand the link between COVID-19 and lasting cognitive issues.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors understand why some young people have lasting thinking or memory problems after severe COVID-19.
- What could go wrong
- This is a small, completed observational study with only 25 participants. It does not test a treatment, so it cannot directly lead to new therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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25 people
The number who actually took part.
- Started
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Nov 2021
- Finished
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Nov 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged between 18 and 65 years * Patient included in the Neurocog-Covid study (i.e. presenting a cognitive disorder that has been objectified on the neuropsychological assessment and having to undergo a cerebral MRI), * Patient who has received full information about the organization of the research and has given written informed consent (or a third person, independent of the investigator and sponsor, in the case of literacy disability), * Patient affiliated to or beneficiary of a social security plan Exclusion Criteria: * Women of childbearing age who do not have effective contraception. * Pregnant woman or nursing mother. * Persons referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code. * Persons deprived of liberty by a judicial or administrative decision, persons undergoing psychiatric care pursuant to articles L. 3212-1 and L. 3213-1 * Contraindication to perform 18F-FDG PET-CT * Patients with a history of pre-Covid-19 psychiatric or chronic illness * Persons referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHRU NANCY Brabois, nuclear medicine department
Vandœuvre-lès-Nancy, 54511, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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