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MRI study seeks clues to COVID brain fog

NCT ID NCT05855434

Knowledge-focused Sponsor: NHS Grampian Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry that might explain these cognitive difficulties. The goal is to better understand the long-term effects of COVID-19 on the brain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help explain why some people experience 'brain fog' after COVID-19, pointing toward future ways to diagnose or treat these cognitive changes.
What could go wrong
This is a very small pilot study with only 30 participants, so results may not apply to everyone. It is observational and does not test any treatment, so it cannot directly improve symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Jan 2023

Finished

Jul 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients aged 16 and over who were hospitalised due to SARS-CoV-2 infection, having a positive PCR, and reporting cognitive change from baseline in the NHS Grampian region of Scotland.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

PARTICIPANTS: Inclusion Criteria * A patient who has been hospitalised with COVID-19 disease (with a positive Polymerase Chain Reaction (PCR) result for SARS-CoV2 infection) within NHS Grampian hospitals with subsequent subjective reporting and objective evidence of cognitive change. * Patients aged over 18. * Patient has completed neuropsychometric testing protocol as described above. * Participant who is willing and able to give informed consent for participation in the study. Exclusion Criteria * Any patient whose physical condition will preclude them from lying still for the duration of the brain scan. * Contraindication to magnetic resonance scanning such as an implantable cardiac device. * Patients who required intensive care treatment for SARS-CoV2 infection. * Patients with a pre-existing diagnosis of a Neurodegenerative disease (eg. Dementia), Intellectual Disability, previous moderate/severe brain injury or previous brain injury with noted cognitive change. * Patients with a pre-existing neuro-inflammatory disorder (eg. Multiple Sclerosis). * Patients under investigation for, or with a history of, cognitive change prior to hospitalisation with COVID-19 disease. * Patients with a dependency on alcohol or recreational drugs.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction COVID-19 long COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive change Cognitive dysfunction SARS-CoV-2 infection

Contacts and locations

Locations

  • Aberdeen Royal Infirmary

    Aberdeen, Grampian, AB25 2ZH, United Kingdom

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