COGNITIVE DYSFUNCTION

This early-stage trial tests whether stem cells taken from a person's own fat can reduce brain inflammation and slow memory decline in adults aged 60-80 with early Alzheimer's or mild cognitive impairment. Participants receive four stem cell infusions over 12 weeks and are monito…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. Researchers will enroll 2,400 adults aged 60 and older who are having bypass or valve surgery. Participants will receive either dexm…

This study tests whether a program of nutrition education, physical activity, and at-home cognitive training can help prevent memory decline in adults aged 55 to 85 who are at higher risk for dementia. Over 120 participants will follow a Mediterranean diet-focused plan and attend…

This study tests a natural omega-3 supplement (ALA) in 20 older adults with mild memory problems and a genetic risk for Alzheimer's (APOE4). The goal is to see if ALA can protect the brain's blood vessels and barrier, potentially slowing or preventing further memory decline. Part…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study tests whether playing video games or tossing a ball can help improve eye-hand coordination in people aged 60 and older with mild cognitive impairment (MCI). Poor coordination can make daily tasks like dressing or eating harder. The study will compare the two activities…

This study tests whether a daily broccoli sprout extract can improve memory and thinking in 100 adults aged 55-85 who have mild cognitive impairment (some memory loss but not dementia). Participants will take the extract or a placebo for 12 weeks, and researchers will measure cha…

This study tests whether a remotely supervised online cognitive stimulation program can reduce memory and thinking complaints in breast cancer patients who have finished chemotherapy. About 300 participants will either get the supervised program or do unsupervised brain exercises…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study tests two different remote brain injury rehab programs for Veterans who have had a mild to moderate traumatic brain injury (TBI) and struggle with attention, memory, or staying on track. About 120 Veterans will take part from home using digital apps and video sessions.…

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory and thinking skills in overweight young adults (ages 18-40) who have prediabetes (mildly high blood sugar). Researchers will also check if the probiotic helps with blood sugar control, chole…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet virtually with a coach for 8 weekly sessions to learn problem-solving and relaxation techniques. The goal is to see if the program …

This study tests whether a 6-week home-based virtual reality program, guided remotely by a therapist, can improve memory, attention, and social skills in adults aged 40-80 with early memory concerns. Participants will be randomly assigned to either the VR program or traditional p…

This study is testing whether a non-invasive nerve stimulation on the wrist can help improve thinking and memory in people who have had a traumatic brain injury. The researchers will enroll 30 adults aged 18-64 who have thinking problems after their injury. Participants will rece…

This study tests a treatment that combines gentle, non-invasive brain stimulation with computer-based thinking exercises for people with mild cognitive impairment (MCI), a condition that can lead to memory and thinking problems. About 50 older adults (ages 60-85) will receive the…

This study tests if using a small device that gently stimulates a nerve in the ear, combined with computer-based brain training, can improve thinking skills and mood. Twenty adults aged 45-80 who have noticed changes in their memory or thinking will do the treatments at home for …

This study compares two 30-hour cognitive rehab programs for 30 adults with long COVID who have mild to moderate brain fog. Both programs use computer games, in-person training, and a mild nerve stimulation device. One program focuses on thinking skills and work tasks, while the …

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults (60+) who have had lasting cognitive symptoms after COVID-19. 75 participants will either use the brain-training program or do other computer activities for about 6 week…

This study looks at how fibromyalgia-related pain sensitivity (central sensitization) is linked to thinking and memory problems, often called 'fibro fog.' Researchers will assess 100 adults with fibromyalgia using questionnaires and cognitive tests. The goal is to better understa…

This study looks at how 3-4 cycles of chemotherapy before surgery affects frailty in adults over 55 with advanced ovarian or endometrial cancer. Researchers will use an electronic frailty index to measure changes in fitness and cognitive function. The goal is to understand whethe…

This study looks at whether cognitive remediation (brain exercises with coaching) can improve thinking skills and reduce problem behaviors in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take part. Th…

This study looks at how common sexual problems are in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. Researchers will survey 140 women with relapsing-remitting MS who have a regular partner and are s…

This study tests whether a virtual reality (VR) tool called bWell is practical and acceptable for people with major depression who have trouble with thinking and memory. Forty adults aged 19-55 will try the VR assessments and either cognitive training or VR scenes twice a week fo…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study looks at why some people who have had a stem cell transplant continue to feel extremely tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand t…

This study tests if a wearable headband that uses sound waves and light can safely monitor blood flow in the brains of people who have had a stroke, as well as those with dementia, depression, or delirium. Researchers will also use artificial intelligence to analyze the data. Abo…

This study aims to create a large, diverse group of 1,000 older adults (age 60+) to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will have yearly check-ups including memory tests, brain s…

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to find out what factors predict falls. Participants will be tracked through diaries and monthly calls. The goal is to develop better fall prevention strategies for this vulnerable group.

This study follows 10,000 adults aged 18 and older over many years to see if a set of health measurements can predict how long people live and what diseases they may get. Participants undergo health screenings and are followed until death. The goal is to better understand aging a…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking performance in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants complete sho…

This study follows 1,000 adults with primary aldosteronism (a hormone disorder that causes high blood pressure) to see how often they develop memory or thinking problems. Participants take regular cognitive tests and health check-ups for up to 5 years. The goal is to understand t…

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…

This study looks at how natural plant compounds (flavonoids) from a Mediterranean-style diet are broken down by gut bacteria and whether these byproducts help protect memory and thinking in older adults. Researchers will measure changes in blood, stool, and cognitive test scores …

This study tests whether a special program can reduce confusion (delirium) after surgery in older adults. Researchers will screen patients aged 60 and older before their operation to find those at highest risk. Those identified will receive extra care recommendations and educatio…