COGNITIVE DYSFUNCTION

This study is testing a new, easy-to-use screening tool called ToolBoxDetect that helps doctors find early signs of memory loss or dementia during regular checkups. Over 41,000 adults aged 65 and older from diverse primary care clinics will take a quick computer-based test, and r…

This study tests a type of talk therapy called Metacognitive Interpersonal Therapy for Eating Disorders (MIT-ED) in 64 adults with various eating disorders, including those who are underweight. Participants will attend up to 40 therapy sessions over about 10 months. Researchers w…

This small pilot study tests whether a telehealth program called HOBSCOTCH, originally designed for epilepsy, can help people with long COVID who have memory and thinking problems. Ten participants will attend nine virtual coaching sessions and complete surveys about their qualit…

This small pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease who have memory or thinking problems. Ten participants will attend nine virtual coaching sessions and complete question…

This small pilot study is testing whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted to help people with multiple sclerosis (MS) who have memory and thinking difficulties. Eleven participants will work one-on-one with a coach in nine v…

This study looks at blood tests that may help predict Alzheimer's disease and related dementias. Researchers will track changes in these blood markers over time in over 13,000 older adults to see if the patterns differ between men and women. The goal is to create a personalized r…

This study aims to find brain-based markers that predict whether depression will return in older adults. Researchers will measure stress reactions and brain network activity in 210 people aged 60 and older, some currently depressed and some in remission. The goal is to understand…

This study compares two approaches to help adults who had a stroke and still have mild to moderate thinking problems. Both groups use a computer game to train how fast they process information. One group also gets in-person training on everyday tasks, while the other learns about…

This study looks at how well older adults and rehab patients understand their own walking abilities and whether that affects their risk of falling. About 100 people aged 60-85 will take cognitive tests, fill out questionnaires, and walk with sensors—sometimes while doing a second…

This study tests whether training nursing home staff to lead a gentle mind-body exercise program can help older Veterans with dementia maintain their physical function and independence. About 288 Veterans and staff from VA Community Living Centers will take part. The goal is to s…

This study follows 1,800 adults with chronic kidney disease (not on dialysis) to see how nutrition and lifestyle affect their health over time. Researchers will track heart health, bone health, thinking skills, and daily function using hospital records and a mobile app. The goal …

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that may lead to thinking problems in CKD patients. Participan…

This study observes 260 Chinese adults with memory problems, Parkinson's disease, or healthy brains to learn how the immune system and nervous system interact as we age. Participants get free memory tests, brain scans, and lab work. The goal is to find better ways to diagnose and…