COGNITIVE DYSFUNCTION

This study aims to understand how personalized nutrition and lifestyle management can help people with declining kidney function stay healthier and slow disease progression. Researchers will follow 1,800 adults with reduced kidney function (not on dialysis) for up to ten years, t…

This study is testing whether an investigational drug called JNJ-63733657 can slow the progression of early Alzheimer's disease. The drug is an antibody designed to target and clear tau protein, one of the key abnormal proteins that builds up in the Alzheimer's brain. About 523 p…

This study is testing a new, quick iPad-based tool called ToolboxDetect to help primary care doctors spot early signs of memory and thinking problems in older adults during their annual wellness visits. It aims to see if this 7-8 minute test is better than usual care at finding c…

This small pilot study is testing whether a home-based coaching program originally developed for epilepsy can be adapted to help people with multiple sclerosis (MS). Participants attend nine virtual coaching sessions to learn self-management strategies for memory and thinking pro…

This study is testing two different rehabilitation programs for adults who have had a stroke and are experiencing ongoing mild to moderate thinking problems. Both programs include a web-based computer game designed to improve how quickly people process information. One program ad…

This small pilot study is testing whether a home-based coaching program originally developed for epilepsy can help people with Parkinson's disease. Participants attend nine virtual sessions with a coach to learn self-management strategies for memory and thinking problems. The mai…

This study is testing whether digital brain games (on a device) or physical, hands-on puzzles and activities are better at helping older adults with mild to moderate Alzheimer's disease. It involves over 500 participants in Portugal and aims to see which type of activity best sup…

This small pilot study is testing whether a home-based coaching program, originally designed for epilepsy, can be adapted to help people with Long COVID. Ten participants with self-reported memory and thinking problems will work one-on-one with a coach over nine virtual sessions.…

This study is testing a special group exercise program called PLIÉ for Veterans with dementia living in VA long-term care centers. The program aims to help residents improve their physical function, mood, and social engagement. Researchers are also training staff to lead these cl…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for over four years, tracking their cognitive function and brain scans. The goal is to identify …

This research aims to understand how blood tests for Alzheimer's disease work differently in men and women. Researchers will analyze blood samples and health data from over 13,000 older adults to see if these tests predict dementia risk differently based on sex. The goal is to cr…

This study aims to understand why depression often returns in older adults. Researchers will observe 210 people over 60, including those currently depressed, previously depressed, and never depressed. They will use brain scans and track daily moods to find patterns that predict i…

This study aims to understand if a person's self-awareness—their ability to recognize their own strengths and limitations—is linked to their risk of falling while walking. Researchers will test about 100 adults aged 60-85, measuring their thinking skills, self-awareness, and walk…