COGNITIVE DYSFUNCTION

This early-stage trial is testing whether stem cells taken from a patient's own body fat can reduce harmful inflammation in the brain and slow the progression of Alzheimer's disease. Researchers will give 12 adults with early memory problems four infusions of their processed stem…

This study is testing whether a daily broccoli sprout extract can help improve memory and thinking skills in older adults with mild cognitive impairment. One hundred participants, aged 55-85, will take either the extract or a placebo pill for 12 weeks. Researchers will measure ch…

This study is testing whether a special computer-based 'brain training' program can help improve memory and thinking skills in older adults who have persistent cognitive problems after a viral infection like COVID-19. Researchers will compare the brain training program to other c…

This study is testing whether taking a daily probiotic supplement for 12 weeks can improve memory, thinking skills, and blood sugar control in overweight adults aged 18-35 who have early signs of blood sugar regulation problems. Seventy participants will be randomly assigned to r…

This study is testing whether a computer-based brain training program can help people in forensic mental health care. The training aims to improve thinking skills like planning and problem-solving, which are often impaired. Researchers hope better thinking skills will lead to few…

This study is testing whether a daily supplement made from flaxseed oil (a source of alpha-linolenic acid, or ALA) can help protect brain health and slow memory decline. It is for adults aged 60+ who have mild memory problems and carry a specific gene (APOE4) linked to higher Alz…

This study is testing whether a 6-month program focused on nutrition education, healthy cooking classes, and at-home brain exercises can help prevent cognitive decline in adults at higher risk for dementia. Researchers will enroll 120 adults aged 55-85 and randomly assign them to…

This study is testing a program designed to prevent delirium, a common and serious state of confusion after surgery in older adults. Researchers will first test patients' memory before surgery to identify those at highest risk. Those patients and their care teams will then receiv…

This study is testing whether a sedative drug called dexmedetomidine can prevent long-term memory and thinking problems that sometimes occur after heart surgery. It will involve 2,400 patients aged 60 and older who are having planned heart surgery. Researchers will compare the dr…

This study is testing whether a virtual reality app used at home can help improve memory, attention, and social skills in people with early memory concerns. Researchers will compare the app-based training to traditional paper-and-pencil exercises over six weeks. The goal is to se…

This study is testing two different remote training programs to help Veterans who have had a traumatic brain injury (TBI). The programs, delivered via video calls and smartphone apps, aim to improve skills like memory, focus, and emotional control to help Veterans reach their per…

This study is testing a special exercise program designed to help people with diabetic nerve damage. The program combines balance training with mental tasks to see if it improves stability, reduces fall risk, and helps with mild memory problems. Researchers will compare this new …

This study is testing a home-based program called HOBSCOTCH-CA, designed to help brain cancer survivors manage memory and thinking problems that often follow their illness. Participants will work one-on-one with a coach over video calls to learn problem-solving and relaxation tec…

This study is testing a home-based video coaching program called HOBSCOTCH-MS. It aims to help people with multiple sclerosis (MS) who are struggling with memory and thinking problems. Participants will work one-on-one with a coach to learn problem-solving and relaxation techniqu…

This study is testing whether playing video games or doing ball tossing exercises can improve hand-eye coordination in older adults with mild cognitive impairment (MCI). Better coordination can help with everyday tasks like dressing, eating, and pouring drinks. Researchers will c…

This small pilot study is testing whether gently stimulating a nerve in the wrist can help improve thinking skills like memory and attention in people who have recently suffered a traumatic brain injury. Researchers will enroll 30 patients to see if this non-invasive technique is…

This study is testing if an online brain exercise program works better when a trained coach supervises it remotely. It's for people with breast cancer who have finished chemotherapy and are struggling with memory and thinking problems, often called 'chemo fog.' Researchers want t…

This study aims to build a detailed database of information to help scientists understand Alzheimer's disease and related memory problems. It will enroll 1,000 adults aged 60 and older, including those with and without memory concerns. Participants will undergo annual check-ups, …

This study aims to understand how a condition called 'central sensitization'—where the nervous system becomes overly sensitive to pain—might be connected to memory and thinking problems (often called 'brain fog') in people with fibromyalgia. Researchers will enroll 100 adults wit…

This study aims to understand if people with a hormone condition called primary aldosteronism are more likely to develop memory problems or dementia. Researchers will follow 1,000 patients for up to 5 years, giving them regular memory tests and health check-ups. The goal is to le…

This study aims to understand if giving chemotherapy before surgery changes how fit or frail older adults with advanced ovarian or endometrial cancer feel. Researchers will measure frailty and thinking skills in about 35 participants before and after 3-4 rounds of pre-surgery che…

This study aims to test a simple method for understanding the daily lives of breast cancer survivors. Researchers want to see if a 14-day mobile phone diary is a practical way to track daily stress and thinking patterns. They will recruit 30 diverse survivors who are at least fiv…

This study aims to understand how common sexual dysfunction is in women living with multiple sclerosis (MS). Researchers will enroll 140 women with MS to complete surveys about their sexual health, fatigue, mood, and other symptoms. The goal is to identify connections between sex…

This study aims to find out what factors best predict the risk of falling in older adults who have mild cognitive impairment (MCI), a condition involving early memory changes. Researchers will follow 417 participants in France for one year, collecting detailed information on thei…

This study aims to understand how certain foods, like those in a Mediterranean diet, might help maintain brain health as we age. Researchers will enroll 100 adults over 50 who are at risk for Alzheimer's disease to see how plant compounds affect gut bacteria and, in turn, cogniti…

This study aims to understand why some people experience severe fatigue and thinking problems after stem cell transplants. Researchers will examine 30 transplant survivors to see if brain inflammation might be causing these symptoms. They'll use brain scans and spinal fluid tests…

This study aims to see if a small, contactless device placed in the bedroom can detect subtle changes in sleep patterns, walking speed, and daily activity in people with mild memory problems or early Alzheimer's disease. About 40 participants will have the device monitor them at …

This study aims to create and test a new questionnaire called LiCCoS, designed to help spot thinking and memory problems in adults with liver cirrhosis. Researchers will ask 230 participants with liver disease to complete the questionnaire and some standard memory tests to see if…

This study is testing whether a new wearable device and computer software can safely and effectively monitor brain blood flow in people at home. It will involve 140 people, including healthy older adults and those who have had a stroke, dementia, depression, or delirium. The main…