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Can a sound wave boost aging brains? a new trial tests 40 hz tones

NCT ID NCT07087951

Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This study tests whether listening to a specific 40 Hz sound for one hour a day, five days a week over 12 weeks, can improve memory, brain activity, sleep, and quality of life in older adults with mild cognitive impairment or mild dementia. Half of the participants will receive the active sound stimulation, while the other half will receive a sham (inactive) version, and neither they nor the researchers will know which they got. The goal is to see if this simple, non-invasive approach can help support brain function in people experiencing cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Gamma auditory stimulation device (active setting)
What this could lead to
If it works, this could offer a non-invasive, drug-free way to help preserve memory and brain function in older adults with mild cognitive decline.
What could go wrong
This is an early-stage trial with a small number of participants, and results may not be conclusive or apply to everyone. The device is not a proven treatment, and its long-term benefits are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age over 60 years old. 2. MMSE≤ 24 3. CDR scores of 0.5 and 1 4. Voluntary to sign the Informed Consent Form. Exclusion Criteria: 1. Diagnosis of other psychiatric or neurological disorders 2. Drug or alcohol addictions. 3. Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests. 4. History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease cognitive disorder Cognitive Dysfunction dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer's disease (AD) and related disorders Cognitive dysfunction Eeg brain oscillations

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chang Gung University

    RECRUITING

    Taoyuan, Guishan, 33302, Taiwan

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