Gut bacteria may hold key to slowing memory loss

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 50+ years * BMI ≥ 25 kg/m2 * Enhanced risk of AD - defined as family history of AD, 1st degree family member * Habitually consume suboptimal diets such as typical Western diet (i.e., high in animal products, refined carbohydrates and processed food). * Subjects capable of and willing to comply with the protocol and to give their written informed consent. Exclusion Criteria: * Cognitive impairment at time of recruitment into the study, as measured by the Mini Mental Status Exam (MMSE, score 25-30), and Clinical Dementia Rating (CDR, score=0) or Everyday Cognition Scale-12 (ECog-12, score\<1.36 included). * Pre-existing psychosis or psychiatric conditions. * Currently receiving treatment for dementia. * History of substance abuse or cerebrovascular events. * Heavy use of tobacco (\>1/2 pack per day) * Any intolerance or allergy documented or suspected to one of the components of the study products. * Have taken probiotics or antibiotic therapy within the last 1 month * Change in medication use in the last 3 months. * Frailty, malnutrition, or food allergy/intolerance requiring special diets will also be excluded. * Following any specific diet (vegetarian, vegan, etc.) * Body weight at enrolment greater than 400lbs due to weight restrictions on the MRI table. * Pregnant, breastfeeding, postpartum for less than 6 months, or unwilling to practice birth control during participation in the study. * Unable to safely participate in the MRI (claustrophobia, presence of devices affected by MRI such as pacemakers, neurostimulators, or metallic foreign body, etc.) * Chronic pain. * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. * Having a psychological or linguistic inability to sign the informed consent; * Under legal protection (guardianship, wardship) or deprived from his rights following administrative or judicial decision; * Subject participating in another biomedical study or participation in another study within the 3 months before entry into this study.