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Citrus flavonoid hesperidin put to the test as a brain booster for overweight adults

NCT ID NCT07750223

Disease control Sponsor: Min Hou Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether a natural compound from citrus fruits, hesperidin, can improve cognitive function in overweight and obese adults aged 55 to 75. Participants take either a placebo, a low dose, or a high dose of hesperidin daily for 10 weeks. The study measures changes in memory, attention, and executive function, and also looks at gut bacteria as a possible link. The goal is to see if this simple supplement could be a nutritional way to support brain health in this population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hesperidin, a natural flavonoid from citrus fruits, taken as oral capsules
What this could lead to
If it works, hesperidin could become a simple nutritional strategy to support brain health and slow cognitive decline in people at higher risk due to excess weight.
What could go wrong
This is a small, early-stage trial, and results may not apply to everyone. The supplement might not improve cognition, and any benefits could be modest or short-lived.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 105 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 55-75 years * BMI ≥ 24 kg/m² or waist circumference ≥ 90 cm (men) / ≥ 85 cm (women) * Willing to participate and sign informed consent Exclusion Criteria: * MMSE score \< 20 * History of neurological diseases (Parkinson's, Alzheimer's, stroke, etc.) * Malignant tumors, severe liver/kidney/gastrointestinal diseases * Use of weight-loss drugs or antidepressants (except statins) within recent months * Strict vegetarians, binge eating disorder, heavy alcohol consumption * Participation in other intervention studies * Other conditions judged by investigators as unsuitable

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive dysfunction Overweight and obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Community Health Centers in Shanghai

    RECRUITING

    Shanghai, Shanghai Municipality, 200030, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.