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Can math training rewire Kids' brains? stanford launches new study

NCT ID NCT05201534

Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-one coaching. Researchers will use brain scans and tests to see if the training improves number skills and alters brain patterns. The goal is to understand why some children struggle with math and how best to help them.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tablet-based math and cognitive training with weekly one-to-one coaching
What this could lead to
If successful, this study could reveal how the brain changes with math training, pointing toward more effective interventions for children with math learning disabilities.
What could go wrong
This is an early-stage, observational study focused on understanding brain mechanisms, not testing a treatment. Results may not directly lead to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 12 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Elementary school aged children starting from first grade (6-12 years old) 2. IQ: Participants with a Full Scale IQ \> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II). 3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests 4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests 5. Normal or corrected-to-normal vision and no hearing impairments 6. Inclusion in MRI scan session: Right-handed Exclusion Criteria: 1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.) 2. History of trauma involving head injury 3. Consistent psychiatric medications 4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)

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Conditions

The condition(s) this trial relates to.

Behavior Child Behavior Cognition Disorders cognitive disorder Cognitive Dysfunction developmental disability dyscalculia follicular lymphoma learning disability Orientation, Spatial specific learning disability

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Behavior Behavior and behavior mechanisms Behavior, child Child development Cognition Cognition disorder Cognitive abnormality Cognitive change Cognitive deficits, mild Cognitive delay, mild Cognitive developmental delay Cognitive dysfunction Cognitive impairment, mild Cognitive orientation Decision making Developmental disability Dyscalculia Dyscalculia, acquired Dyscalculia, primary Individuality Learning curve Learning disabilities Learning disabled Math learning disability Mathematics disorder Neuronal plasticity Neuroscience Specific learning disorder, with impairment in mathematics

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Stanford Cognitive and Systems Neuroscience Laboratory

    RECRUITING

    Palo Alto, California, 94304, United States

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