COGNITIVE IMPAIRMENT, MILD

This study tests whether siponimod, a drug already used for multiple sclerosis, can safely slow brain shrinkage in people with mild Alzheimer's disease. About 105 participants will receive either the drug or a placebo for 12 months, then be monitored for another 6 months. The mai…

This study tests whether taking atorvastatin (a statin) can help healthy adults aged 75 and older avoid dementia, disability, and heart problems. About 20,000 participants will be randomly assigned to take either the drug or a placebo pill for several years. The goal is to see if…

This study tests whether using a digital app that shares personalized memories can improve symptoms like apathy and depression in older adults with mild neurocognitive disorders. Eighty participants over age 60 will use the app for 10-15 minutes daily over 25 days. Researchers wi…

This study looks at whether a fun, music-based dance program can help older adults with mild memory or thinking problems improve their mental focus and physical abilities. About 50 people aged 55 and older with early signs of cognitive decline will take part. The dance routine is…

This study tests whether playing soft sounds during deep sleep can improve memory and slow cognitive decline in older adults. Sixty people aged 60-85 with mild memory problems will use a home device for 4 weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests a 12-week program that combines hearing exercises with memory training for people with mild cognitive impairment and hearing loss. The goal is to see if this integrated approach can improve thinking skills, hearing, and quality of life. Researchers will compare t…

This study tests a 16-week exercise program where people with mild dementia and their family caregivers work out together as a team. The goal is to improve thinking skills, mood, and the quality of their relationship. About 236 pairs will join from community centers in Hong Kong.

This study aims to understand how common depression and mild memory problems are in adults hospitalized for chronic heart failure, and whether these issues lead to worse health outcomes. Researchers will follow 300 participants for 12 months, tracking serious events like death, h…

This study looks at how a drug called scopolamine changes brain activity related to memory. Researchers will test 60 adults with epilepsy who are already having brain surgery for seizure monitoring. Participants will do memory tasks after receiving either the drug or a saltwater …