COGNITIVE IMPAIRMENT, MILD

This study is testing whether siponimod, an oral medication already approved for multiple sclerosis, can slow brain shrinkage in people with mild Alzheimer's disease. Over 18 months, 105 participants will take either siponimod or a placebo pill to see if the drug is safe and if i…

This large study aims to see if taking a daily cholesterol-lowering drug (atorvastatin) can help prevent dementia, disability, and death in healthy adults aged 75 and older. It will enroll 20,000 participants who do not have heart disease or dementia. Half will take the drug, and…

This study is testing a 12-week training program designed to help older adults who have both mild memory loss and hearing difficulty. The program combines hearing exercises, memory games, and family support to see if it can improve communication and thinking skills. Researchers w…

This study is testing whether a daily digital app that helps people reminisce about personal memories can improve symptoms like low mood, lack of motivation, and poor sleep in older adults with mild cognitive impairment or early-stage dementia. Participants will use the app for a…

This study aims to understand how common depression and memory problems are in people hospitalized for chronic heart failure, and whether these conditions lead to worse health outcomes. Researchers will survey 300 hospitalized patients about their mood and thinking skills, then t…

This study aims to understand how a drug called scopolamine affects brain activity during memory tasks. Researchers will work with 60 adults who have epilepsy and already have electrodes implanted in their brains for medical monitoring. Participants will complete memory games on …