University Hospital, Bordeaux

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested whether adding the drug methotrexate to standard UVB light therapy helps adults with active, spreading vitiligo. 32 participants received either the combination or light therapy alone. The main goal was to measure changes in skin repigmentation using a standard …

This study tested whether giving early treatment to adults with COVID-19 who have risk factors (like age over 60 or high blood pressure) could prevent them from needing oxygen, hospitalization, or dying. About 412 people took part. The goal was to see if these treatments are safe…

This study tested a special stent called MEMOKATH 051 in 13 adults with long-term ureter blockages who usually need a standard double J stent. The goal was to see how long the new stent lasts and how well it is tolerated over 3 years. Participants had the new stent placed during …

This study looked at 60 adults with a slipped vertebra in the lower back (degenerative spondylolisthesis) who needed surgery. It compared two types of spine fusion: one that only fuses the back of the spine (GPLI) and one that also fuses the front (TLIF). The goal was to see whic…

This study tested whether using sevoflurane (a gas for anesthesia) during kidney transplant surgery helps the new kidney start working faster compared to the standard drug propofol. About 120 adults receiving a kidney transplant took part. The goal was to see if sevoflurane could…

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This study tested whether a hormone called DHEA can improve exercise ability in adults with COPD who also have high blood pressure in their lungs. About 60 participants took either DHEA or a placebo daily for a year. The main goal was to see if they could walk farther in six minu…

This study looked at 238 adults having heart surgery (bypass or valve replacement). It compared using half the usual dose of the blood thinner heparin during surgery versus the full dose, both with a special mini heart-lung machine. The goal was to see if the lower dose reduces b…

This study tested whether adding a stronger chemotherapy combination (Folfirinox) before standard radiation and chemo could help more people with early-stage rectal cancer avoid surgery and keep their rectum. About 218 adults with small, low-lying rectal tumors took part. The goa…

This study looked at 31 adults with chronic myeloid leukemia (CML) whose cancer came back after they stopped taking imatinib. They were given nilotinib, a more powerful targeted therapy, to see if it could make their cancer undetectable again and allow them to stop treatment once…

This study tested the drug lenalidomide in 19 people with a rare type of skin lymphoma (leg-type) that returned or did not respond to initial chemotherapy plus rituximab. The goal was to see if lenalidomide could shrink tumors and control the disease. Results will help decide if …

This study tested whether the drug sodium valproate could improve memory and motor skills in children with Rubinstein-Taybi syndrome, a rare genetic condition that affects learning and development. Forty-one children aged 6 to 21 received either valproate or a placebo for one yea…

This study tested the drug imatinib (Glivec) against a placebo in 28 adults with severe scleroderma, a disease that causes skin to harden and tighten. The goal was to see if imatinib could reduce skin thickness and improve quality of life. Participants took the drug or placebo fo…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study tested whether exenatide, a diabetes drug, plus lifestyle changes helps adults with severe weight gain after treatment for a rare brain tumor (craniopharyngioma). 42 adults aged 18-75 took either exenatide or a placebo for 6 months. The main goal was to see if they los…

This study looked at whether a common antibiotic (piperacillin-tazobactam) could effectively treat ventilator-associated pneumonia in ICU patients who carry resistant bacteria in their gut. The goal was to see if this approach could reduce the need for stronger, last-resort antib…

This study looked at whether giving a dose of oxytocin (a drug that helps the uterus contract) after a second-trimester pregnancy termination could lower the chance of retained placenta. 27 women took part, and half received oxytocin while the other half did not. The main goal wa…

This lab study tested a new drug called concizumab in blood samples from 20 people with Glanzmann thrombasthenia, a rare genetic bleeding disorder. The drug works by blocking a natural protein that stops clotting, potentially offering a longer-lasting and easier-to-use treatment …

This study tested the drug sunitinib (Sutent) in 71 people with advanced thyroid cancer that had spread or could not be removed by surgery. The goal was to see if the drug could shrink tumors when standard treatments like radioactive iodine no longer work. Participants took sunit…

This early-phase study tested a combination of two drugs, axitinib and everolimus, in 19 adults with advanced solid tumors, especially kidney cancer. The main goal was to find the safest dose by monitoring side effects. Participants had either failed standard treatments or had no…

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for chan…

This study looked at 460 women with both vaginal and anal chlamydia infections. It compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—to see which one clears the anal infection better. The goal was to find the best treatment to prevent the i…

This study tested whether giving tranexamic acid (TXA) during a C-section can prevent severe bleeding (postpartum hemorrhage). Over 4,500 women having a planned or emergency C-section after 34 weeks of pregnancy took part. The drug was given right after birth and compared to a pl…

This study tested a new way to treat ventricular tachycardia, a fast and dangerous heart rhythm, in 119 people who had a prior heart attack. Instead of the standard method that maps the heart during the procedure, doctors used a CT scan taken beforehand to plan the treatment. The…

This study looked at 222 adults with Hodgkin lymphoma that returned or didn't respond to initial treatment. They received a combination of two drugs, brentuximab vedotin and bendamustine. The goal was to see how well the treatment worked and what side effects occurred in real-wor…

This study tested whether adding the drug baricitinib to light therapy helps adults with active, spreading vitiligo regain skin color. About 49 participants received either the combination or light therapy alone for 12 weeks. The main goal was to measure changes in the amount of …

This study looked at whether taking non-steroidal anti-inflammatory drugs (NSAIDs) every day, along with anti-TNF therapy, can prevent new bone growth in the spine of people with ankylosing spondylitis. Researchers compared two groups of 188 adults to see if continuous NSAID use …

This study looked at 222 people whose leg artery stents had become blocked again. It compared three treatments: standard balloon angioplasty, a drug-coated balloon, and using a laser plus a drug-coated balloon. The goal was to see which option is most cost-effective and improves …

This study tested whether a single blood thinner (ticagrelor) is safer than the standard two-drug combination after a minimally invasive heart valve replacement (TAVI) for aortic stenosis. About 50 older adults participated, and researchers tracked complications like bleeding, st…

This study tested a combination of two drugs, peginterferon alfa2a and ribavirin, in 17 adults with both HIV and chronic hepatitis C who had not responded to a previous hepatitis C treatment. The goal was to see if this second-line treatment could clear the hepatitis C virus from…

This study tested a new way to perform deep brain stimulation (DBS) for Parkinson's disease. Instead of the standard awake surgery with micro-electrode recordings, the new method uses MRI-based targeting under general anesthesia. 128 patients were enrolled to see if the asleep te…

This study compared two surgical techniques for covering traumatic skin loss on the lower leg: a newer method using Integra (a dermal substitute) and the standard flap surgery. 72 patients with leg, ankle, or foot wounds were enrolled. The main goal was to see which approach led …

This study tested a man-made bone material (HAP/TCP) to repair the nasal septum in 26 adults with severe nose injuries from trauma. The goal was to see if it is safe and works as well as using the patient's own bone, avoiding the need for a separate graft surgery. The material is…

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study looked at whether people with mechanical heart valves can safely and cost-effectively monitor their own blood thinning medication at home instead of going to a clinic. About 919 adults who recently had valve surgery took part. The goal was to see if self-monitoring red…

This study tested whether giving personalized physical activity advice to older cancer patients (70+) could help them stay independent during treatment. 302 patients with various cancers receiving curative care were randomly assigned to general health advice or a tailored exercis…

This small pilot study tested whether beta-blockers, a type of heart medication, could shrink or stabilize kidney tumors (angiomyolipomas) in people with tuberous sclerosis. Only 2 participants were enrolled. The goal was to see if this drug could be a gentler alternative to surg…

This study tested a mouthrinse made with red grape seed extract and fluoride to see if it can reduce dental plaque. Fifty healthy volunteers used the rinse for 4 days without brushing or flossing. The results were compared to a placebo rinse to measure how well it worked.

This study looked at whether people with chronic myeloid leukemia (CML) who had been in complete remission for at least two years could stop taking imatinib without the cancer coming back. Researchers followed 220 adults to see how many stayed in remission and what factors predic…

This study looked at whether pravastatin, a cholesterol-lowering drug, is safe and effective for people with HIV who have high cholesterol from their HIV medications. 21 adults with well-controlled HIV took pravastatin or a placebo for 12 weeks. Researchers checked cholesterol le…

This study tested a stem cell transplant approach for adults with relapsed follicular lymphoma, a type of blood cancer. The treatment included a drug called rituximab to help control the disease and reduce side effects. The goal was to see if this strategy could improve survival …

This study tested a new way to treat paroxysmal atrial fibrillation (a type of irregular heartbeat) using pulsed field energy instead of standard radiofrequency. The goal was to see if the new method is faster, safer, and works better. About 292 adults with drug-resistant AF took…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study looked at whether a detailed MRI scan can accurately tell the difference between harmless and cancerous small kidney tumors. About 387 adults with small kidney masses (1.5-4 cm) were scanned before surgery or biopsy. The goal is to help doctors decide who truly needs s…

This study tested a new way to measure temperature inside the prostate using MRI. The goal was to help doctors better find and treat prostate cancer with laser therapy. Researchers studied 70 adults who were already getting a prostate MRI for diagnosis. The approach is still in e…

This study tested a new genetic screening approach to find cases of a rare inherited nerve disease called TTR-FAP in 130 patients with chronic neuropathy of unknown cause. The goal was to see how many of these patients actually have TTR-FAP, which is often missed due to varied sy…

This study tested whether a newer PET scan tracer, 18F-choline, can find more bone lesions than the standard 18F-FDG PET scan in people newly diagnosed with multiple myeloma. Twenty patients received both types of PET scans plus an MRI to compare how many lesions each method dete…

This study tested whether a special MRI scan can accurately measure kidney function in people who have received a kidney transplant. 71 patients with suspected kidney problems were scanned and compared to the standard radioactive tracer test. The goal was to see if the MRI method…

This study tested a virtual reality (VR) application to help diagnose ADHD in children aged 8 to 12. Researchers measured things like mistakes, reaction time, and head movements during VR tasks to see which signs best identify ADHD in real-life-like situations. The goal is to mak…

This study looked at whether a special lung MRI can diagnose bronchiolitis obliterans syndrome (BOS), a serious lung complication after stem cell transplant, as well as the standard CT scan. Sixteen adults who had a stem cell transplant and showed signs of lung problems took part…

This study looked at whether a portable sleep monitor used during a short hospital stay can accurately diagnose sleep apnea in people with multiple system atrophy (MSA), compared to the standard overnight lab test. Thirty adults with probable MSA took part. The goal was to see if…

This early-phase study tested a new radioactive tracer called 68Ga-DOTATOC for PET-CT scans in 20 adults suspected of having neuroendocrine tumors. The goal was to see if this new method could find tumors more accurately than the current standard scan (OctreoScan). Researchers al…

This study looked at whether a detailed heart ultrasound can find early signs of heart damage in people with leukemia who are receiving a type of chemotherapy called anthracycline. About 100 adults aged 18 to 65 took part. The goal was to catch heart problems sooner, so doctors c…

This study tested whether a noninvasive device that measures oxygen levels in the brain can detect dangerous blood vessel spasms after a severe brain bleed. Current methods like ultrasound and CT scans are helpful but not perfect. The study involved 50 adults with severe aneurysm…

This study looked at whether analyzing proteins in kidney biopsy samples can better detect early signs of rejection after a transplant. Researchers studied 141 kidney transplant recipients to see if a protein signature could identify microvascular inflammation, a key sign of anti…

This study looked at whether a special scan called PET-CT can help doctors diagnose infections on the heart's natural valves. 31 adults with suspected endocarditis received the scan. The goal was to see how well the scan detects the infection and finds any spread to other parts o…

This study tested whether MRI can be used instead of CT scans to see lung damage from allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by fungus. Researchers compared MRI and CT images from 25 adults with ABPA or severe asthma. The goal was to see if MRI co…

This study tested a new rapid test for bacteremia (bacteria in the blood) in 110 intensive care patients with suspected infections. The goal was to see if the test could identify the bacteria in a few hours instead of the usual 48-72 hours needed for standard blood cultures. Fast…

This study tested whether a special light (autofluorescence) can help find precancerous spots and mouth cancers earlier than a regular exam. It included 180 people who smoked and drank heavily, since they are at high risk. The goal was to see if the light method is reliable and c…

This study tested a new MRI method to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method does not require a contrast injection, unlike the standard approach. Researchers compared the new scan to the standard contrast-enh…

This study tested an artificial intelligence (AI) system called CAD EYE to see if it could accurately predict whether colon polyps are cancerous during a colonoscopy. Researchers compared the AI's predictions to those of doctors and the final lab results. The goal was to improve …

This study looked at how changes in two brain chemical systems—acetylcholine and dopamine—relate to symptoms in people with Dementia with Lewy Bodies (DLB). Researchers used special scans (SPECT imaging) to measure these chemicals in 34 participants, including healthy volunteers.…

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safe…

This study tested whether giving breathing support early (non-invasive ventilation and high-flow nasal oxygen) to people with chest injuries and low oxygen levels could prevent them from needing a breathing tube. 144 patients in the ICU took part. The goal was to see if this earl…

This study tested a new way to position the weak arm in stroke patients to prevent shoulder pain, a common problem that can slow recovery. 76 people who had a stroke within the last 48 hours took part. The program used special supports and slings, along with training for patients…

This study tested whether a continuous drip of numbing medicine into the surgical wound for two days after back fusion surgery could reduce pain and speed recovery better than a placebo. Fifty adults having lumbar fusion for degenerative spine disease took part. The goal was to i…

This study compared taking an oral steroid (prednisolone) for three days to getting a partial root canal for emergency pain relief from severe tooth nerve inflammation (pulpitis). The goal was to see if the pill could work as well as the dental procedure. Only 5 people were enrol…

This study looked at whether a structured mindfulness program (MBSR) is practical for people with Parkinson's disease. 31 participants were asked to complete meditation sessions and daily exercises. The goal was to see if they could stick with the program, not to measure health o…

This study tested whether a high-flow oxygen system (Optiflow) works better than a standard oxygen mask for patients with breathing failure. About 100 adults in intensive care who needed non-invasive ventilation (NIV) took part. The goal was to see if Optiflow keeps oxygen levels…

This study tested a special diet (low-FODMAP) in 31 adults with GERD (chronic heartburn) that didn't improve with standard acid-reducing medication. The goal was to see if changing what they eat could ease their symptoms. Results focused on symptom scores and quality of life.

This study tested whether plasma exchange (a blood-filtering treatment) helps people with multiple sclerosis who have severe flare-ups that don't get better with steroids. Thirty-eight adults took part, and researchers compared real plasma exchange to a sham procedure. The main g…

This study tested whether a brain-training technique called neurofeedback can help healthy young adults stay awake and think clearly after a full night of sleep deprivation. Twenty-two participants completed eight neurofeedback sessions designed to change specific brain wave patt…

This study tested whether a drug called Polaramine can prevent dangerous drops in blood pressure when patients come off a heart-lung machine during aortic valve replacement. 18 adults took part. The goal was to see if the drug helps the body keep a stable blood pressure after sur…

This study tested three ways to help children with ADHD: a computer-based attention training program using a virtual classroom, the medication methylphenidate, and supportive talk therapy. Fifty-one children aged 7 to 11 took part. The goal was to see if the virtual classroom tra…

This study looked at whether giving a special therapy called EMDR to people in the emergency room right after a traumatic event could help prevent post-traumatic stress disorder (PTSD). About 110 adults who were at high risk for PTSD took part. The therapy uses eye movements to h…

This study tested whether a botulinum toxin injection could reduce pain in people with tennis elbow that didn't get better after six months of usual care. Sixty-one adults received either the injection or a placebo, and pain levels were checked three months later. The goal was to…

This study tested whether a newer breathing machine method (NAVA) helps patients with respiratory failure come off the ventilator faster than the usual method (PSV). The study included 47 adults who had trouble weaning from the ventilator. Researchers measured how long it took to…

This study tested whether a simple online program could help people with long-term insomnia stop using sleeping pills like benzodiazepines or Z-drugs. 62 adults who wanted to quit their medication were randomly assigned to either taper off the pills on their own or use the online…

This study looked at whether a single hypnosis session before a hysterectomy (surgery to remove the uterus) could lower anxiety in women with pelvic gynecological cancer. 29 women participated. The goal was to see if hypnosis helps them feel calmer before and after the operation.

This study tested a freezing technique called cryoablation to treat painful venous malformations (abnormal blood vessels) that had returned after surgery or sclerotherapy. Fourteen adults with recurring symptoms like pain or swelling received the freezing treatment. The main goal…

This study tested whether a single educational phone call from a nurse, before a doctor's appointment, could help people with medication overuse headaches. 88 adults with frequent migraines (over 15 headache days per month) took part. The goal was to see if the call reduced the n…

This study tested whether using computer navigation with pre-operative EOS imaging helps surgeons place hip implants more accurately. 78 adults with hip osteoarthritis who needed a total hip replacement took part. The goal was to see if this technology reduces complications like …

This study looked at whether special physiotherapy, which includes both breathing exercises and early movement, could lower the chance of serious breathing problems in the week after a breathing tube is removed. The study involved 245 ICU patients at high risk of breathing failur…

This study tested whether a numbing injection (TAP block) given before a tummy tuck reduces pain and the need for strong painkillers after surgery. Fifty-two adults took part, receiving either the real injection or a placebo. The main goal was to see how much opioid pain medicine…

This study looked at two ways to do bunion (hallux valgus) surgery. In one method, a small screw is used to hold the bone in place; in the other, no screw is used. The goal was to see which approach leads to better toe movement one year after surgery. 58 adults who needed bunion …

This study looked at two different breathing machines used to help newborn babies with breathing trouble. The goal was to see if a newer device called nasal high frequency percussive ventilation (nHFPV) is as well-tolerated as the standard nasal CPAP machine. The study included 4…

This study tested whether adding a personalized therapy scale to standard treatment helps people with substance use or behavioral addictions. 151 adults seeking outpatient care participated. The approach aimed to reduce craving intensity by tailoring treatment to each person's un…

This study tested a special counseling and support program for people with multiple system atrophy (MSA) and their caregivers. MSA is a rare, serious brain disease that makes daily activities very hard. The goal was to see if this program could improve the emotional and social we…

This study tested whether L-carnitine, a natural supplement, can help reduce fatigue in people with multiple sclerosis (MS). 59 adults with MS and significant fatigue took either L-carnitine or a placebo, then switched treatments. The goal was to see if L-carnitine improves fatig…

This study tested whether botulinum toxin type A (like Botox) can ease symptoms of restless legs syndrome (RLS) in 27 adults who did not get enough relief from standard treatments. Participants received one injection, and researchers checked if leg discomfort and urge to move imp…

This study looked at whether hypnosis sessions led by a nurse over video calls are possible for people with chronic nerve pain. Thirty adults with nerve pain lasting over a year took part. The main goal was to see if they could complete five sessions, either in person or by video…

This study tested a new way to target brain areas for deep brain stimulation (DBS) in 22 people with severe essential tremor. The new method uses a computer model to guide surgery while the patient is asleep, instead of the usual awake surgery. The goal was to see if it works as …

This study tested a drug called BX1514M in 38 people with hypertrophic cardiomyopathy, a condition where the heart muscle is too thick and blocks blood flow. The drug works by tightening veins to reduce the blockage. The main goal was to see if patients could walk farther after 1…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This study tested whether adding sodium bicarbonate (baking soda) to a standard numbing medicine (lidocaine with epinephrine) could provide better pain relief for women needing an extremely urgent C-section during labor. Researchers compared the two mixtures in 65 women to see if…

This study tested whether a virtual reality shopping simulation (VAP-S) helps stroke survivors improve their ability to perform everyday tasks. 29 adults who had a stroke 1 to 18 months earlier and had thinking difficulties were split into two groups: one received standard rehab,…

This study looked at whether propranolol, a beta-blocker usually used for heart conditions, can help people with hereditary hemorrhagic telangiectasia (HHT) who have frequent nosebleeds. Fifteen adults with HHT took propranolol for three months. The main goal was to see if the to…

This study tested a new MRI method that measures temperature inside the heart in real time. Researchers want to see if it works well in people, including those with irregular heartbeats or larger body sizes. 61 patients had special MRI scans, and the data will help improve future…

This study looked at the brain activity of 14 people with Tourette syndrome to find out which parts of the brain cause tics. Participants wore a portable EEG device for 24 hours to record brain waves while going about their daily lives. The goal was to identify new brain targets …

This study looked at how blood sugar levels change during the day in frail or disabled people aged 75 and older with diabetes who use basal insulin. Researchers used a continuous glucose monitor to compare two types of insulin. The goal was to gather information, not to test a ne…

This study compared two devices that help patients breathe during surgery: the LMA ProSeal and the I-Gel. Researchers looked at how often each device was placed successfully, how well it sealed the airway, and any side effects. 700 adults having surgery that allowed the use of a …

This study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or lupus). Researchers measured stress, depression, and anxiety levels over 6 months. The goal was to unde…

This study tested a way to make a lung exam (bronchoscopy) safer and more comfortable for people with severe breathing failure. Doctors used a breathing mask and special sedation to keep oxygen levels stable during the procedure. The goal was to see if this approach works better …

This study tested whether a special ultrasound technique (dynamic contrast-enhanced ultrasound) can predict how well rectal cancer responds to chemotherapy and radiation. Only 2 participants were enrolled. The goal was to see if this imaging method could help doctors decide which…

This study looked at whether a special type of MRI (called SWI-MRI) can find endometriosis spots more accurately before surgery. Endometriosis lesions contain old blood, and SWI-MRI is very good at detecting blood byproducts. Researchers compared the MRI results with what surgeon…

This study looked at 47 older adults without major memory problems to see if changes in their sleep/wake cycles are linked to early brain changes that might increase Alzheimer's risk. Researchers used wrist-worn activity monitors and brain scans to measure sleep patterns and brai…

This study looked at how repeatedly heading a soccer ball affects the brain and whether wearing a mouthguard with clenched jaws can reduce harm. Twenty-one male soccer players performed 10 headers in two sessions—once with a mouthguard and once without. Researchers measured head …

This study looked at whether a special PET scan called FMISO can help predict how well head and neck cancer patients respond to treatment. Sixteen adults with this cancer received the scan before starting radiation therapy. The goal was to see if the scan's results matched their …

This study tested a 4-hour head ultrasound (transcranial-holter) to detect tiny blood clots in people who recently had a stroke. The goal was to see if this test could help doctors find the exact cause of the stroke, which is important for choosing the right treatment to prevent …

This study looked at whether placing a drain in the pelvis after rectal cancer surgery reduces the risk of serious infections. About 494 adults with rectal cancer were randomly assigned to get a drain or not. The main goal was to see how many people developed pelvic infections wi…

This study looked at how a specific brain chemical system (cholinergic) might be involved in dystonia, a condition causing muscle spasms and abnormal postures. Researchers used PET scans to measure chemical activity in the brains of 40 adults with a genetic form of dystonia (DYT1…

This study looked at what psychoactive substances people were using at music festivals in Aquitaine, France. Researchers tested 25 patients who came to medical tents with symptoms like confusion or agitation after taking drugs. The goal was to find out which drugs were being used…

This study looked at a program to make sure patients at Bordeaux University Hospital get the right care for their needs. Researchers checked if the program helped improve how well care matched what patients actually needed. The study involved 63 hospital services and their staff,…

This study looked at 28 people with Glanzmann thrombasthenia, a rare bleeding disorder, to find out why some develop antibodies after blood transfusions or pregnancy. Researchers checked for antibodies and linked them to genetic, treatment, and lifestyle factors. The goal was to …

This study looked back at 46 cases of periventricular pseudocysts (small fluid-filled sacs in the brain) found during pregnancy ultrasounds at a French hospital over 5 years. Researchers wanted to see how these children developed after birth, tracking milestones like sitting, wal…

This study tested whether a special type of brain MRI (called arterial spin labeling) can predict how well newborns with brain injury from oxygen deprivation will do at 3 months old. Researchers scanned 31 full-term babies in their first week of life. The goal was to see if this …

This study tested whether a special type of CT scan (dual energy CT) can help doctors better understand and predict the severity of pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers looked at lung images from 60 adults already diagnosed with the…

This study tested whether routinely checking oxygen levels in healthy newborns (pulse oximetry) can help find hidden critical heart defects early. Over 44,000 babies took part. The goal was to see if this screening reduces serious complications and deaths, and if it is worth the …

This study looked at how getting only 4 hours of sleep for 5 days or staying awake all night affects driving ability and mental performance. 40 healthy young and mature adults, including some who snore, took part. They used a driving simulator and took tests to measure sleepiness…

This study looked at whether a special type of scan called 4D PET-CT can help doctors plan radiation therapy better for people with non-small cell lung cancer. Seven patients had both a standard CT scan and a 4D PET-CT scan, and researchers compared the radiation target areas fro…

This study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…

This study looked at how quickly paramedics can start an IV or IO line in adults having a cardiac arrest outside the hospital. Researchers tracked 200 patients to find out what causes delays or failures in getting that access. The goal is to improve emergency procedures and save …

This study looked at 50 people with and without COPD to understand how fibrocytes—a type of cell—might be involved in airway damage. Researchers measured fibrocytes in the blood and around the airways of patients at different COPD stages and compared them to healthy controls. The…

This study looked at whether saliva can be used to measure endocannabinoids—natural chemicals linked to appetite and weight—instead of taking blood. Researchers compared 12 obese and 12 normal-weight adults after fasting. The goal was to see if saliva levels differ between the gr…

This study looked at how to best set a breathing machine during lung surgery when only one lung is being used. The goal was to see if using smaller breaths with higher pressure could keep oxygen levels stable. 88 adults having lung surgery took part. The study measured oxygen in …

This study tested whether a detailed eye scan called SD-OCT can tell the difference between people with glaucoma and healthy individuals. Glaucoma is a leading cause of blindness, and current tests often miss early damage. Researchers used new scan measurements on 109 participant…

This study tested whether very low doses of fentanyl, an opioid painkiller, can change how healthy volunteers feel pain. The goal was to see if this response could help predict who might develop severe pain after surgery. 48 men aged 18-40 took part, some with a history of past s…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the focus…

This study aimed to find very early signs of Alzheimer's disease using brain imaging in older adults who had no memory problems. Researchers scanned the brains of 304 retired farmers in rural France and measured changes in key areas like the hippocampus. The goal was to see if th…

This study used powerful 3-Tesla MRI scanners to compare the visual pathways in the brains of 114 people—some with glaucoma and some healthy. The goal was to see if glaucoma causes damage beyond the eye, similar to diseases like Alzheimer's. Researchers measured brain structure a…

This study tested a new catheter designed to measure the heart's electrical signals in people with irregular heartbeats (atrial fibrillation, ventricular fibrillation, or junctional tachycardia). Researchers enrolled 42 adults to see if the device could better identify abnormal e…

This study looked at whether specific cells from the blood, called fibrocytes, are involved in muscle wasting (sarcopenia) in people with COPD. Researchers compared thigh muscle samples from 22 COPD patients with and without muscle loss. The goal was to understand why muscle loss…

This study followed 248 adults in France who take PrEP (a daily pill to prevent HIV) to see if longer use changes risky sexual behaviors or increases sexually transmitted infections (STIs). Researchers compared people on PrEP for over a year to those on it for less than a year. T…

This study looked at whether changes in the back of the eye (the retina) can be an early sign of Alzheimer's disease. Researchers measured the thickness of the retinal nerve fiber layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye …

This study looked at how modafinil, a drug that promotes wakefulness, affects driving ability in 27 people with narcolepsy or hypersomnia. Participants took driving tests in a simulator to measure lane control and sleepiness. The goal was to understand if the treatment reduces dr…

This study looked at whether a test that measures acid and liquid movement in the throat and esophagus can better identify people with laryngopharyngeal reflux (LPR). LPR happens when stomach contents flow back into the throat, causing symptoms like hoarseness, a lump in the thro…

This study looked at whether measuring the stiffness of uterine fibroids can help predict how well they respond to a non-invasive treatment called MR-HIFU. Forty women with symptomatic fibroids were enrolled. The goal was to improve patient selection so that only those likely to …

This completed study looked at whether natural plant estrogens (phytoestrogens) in food might be a risk factor for lupus flares. Researchers measured phytoestrogen levels in blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or healthy control…

This study tested whether a CT scan before a heart procedure could help doctors better target the source of a dangerous heart rhythm called ventricular tachycardia. 23 people who had a prior heart attack and needed catheter ablation took part. The approach aimed to see if using C…

This study checked 137 people aged 6 to 65 who had chronic pain with no known cause to see if they had Fabry disease, a rare genetic disorder. Researchers used blood tests and genetic analysis to find cases. The goal was to learn how often Fabry disease appears in this group, not…

This study tested a new ultrasound technique (ARFI) to measure muscle stiffness in 65 volunteers: young adults (18-30), healthy older adults (70+), and older adults undergoing cancer treatment. The goal was to see if this method could help screen for sarcopenia (age-related muscl…

This study looked at 46 infants under 2 years old in the pediatric ICU with severe bronchiolitis. Researchers used a heart ultrasound measure called TAPSE to see if it could predict how long babies needed intensive care. The goal was to find a simple test that helps doctors plan …

This study looked at how well the nausea drug metoclopramide works when given as a shot under the skin (subcutaneous) compared to through a vein. It included 5 patients in a palliative care unit who had nausea or vomiting. The goal was to measure how much of the drug gets into th…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions like fibrosis, cirrhosis, or hepatitis. The goal was to establish normal stiffness values and see how consistent the …

This study tested two different techniques for applying alcohol-based antiseptic to healthy skin before inserting an IV. The goal was to see which method reduces more germs on the skin. 132 healthy volunteers took part, and researchers measured the number of microorganisms before…

This study looked at whether neck muscle activity during sleep affects breathing in ICU patients recovering from COVID-19-related lung injury. Researchers monitored 17 patients overnight to see if those with more neck muscle activity had worse sleep and breathing. The goal was to…

This study used a special MRI technique to create detailed maps of the Achilles tendon in 121 adults. Researchers compared healthy volunteers to people with a type of arthritis called spondyloarthropathy, both with and without tendon pain. The goal was to better understand tendon…

This study looked at how the brain chemical serotonin works in people with multiple system atrophy (MSA), a rare and serious brain disease. Researchers used special PET scans to measure serotonin receptors in 53 participants, including those with MSA and Parkinson's disease. The …

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This study looked at how natural cannabis-like chemicals in the body (endocannabinoids) interact with the stress hormone cortisol in people with Cushing's syndrome. Researchers measured these chemicals in 40 adults to see if cortisol levels affect endocannabinoid activity. The go…

This study looked at how blood clotting changes during planned C-sections and whether a drug called tranexamic acid (TXA) can help prevent heavy bleeding. Researchers measured clot breakdown times in 34 women who had a C-section. The goal was to better understand bleeding risks a…

This study looked at health records from over 36,000 people in France to create better ways to measure the quality of care for stroke and chronic heart disease. The goal was to develop tools that can be used nationwide to track and improve patient care pathways. No new treatments…

This study tested a short, computerized thinking and memory test for people with multiple sclerosis (MS). The goal was to see if it could quickly spot early cognitive problems, like slower thinking or memory trouble. Over 400 French-speaking adults with MS and healthy volunteers …

This small pilot study looked at whether clopidogrel, a drug that stops blood clots, could lower a substance called sCD40L in people with lupus. Lupus is an autoimmune disease where the body attacks itself. The study involved 18 adults with lupus and measured sCD40L levels in the…

This study looked at 22 ICU patients who had difficulty being taken off a breathing machine (ventilator). The goal was to measure how strong and how long-lasting their breathing muscles were during the weaning process. By understanding which muscle problem is more important, doct…

This study tested a new biosensor that measures blood sugar every 10 minutes in people with type 1 diabetes who use an insulin pump. The goal was to see if the new sensor works better than current continuous glucose monitors, especially during meals and exercise. Only one person …

This study looked at how getting older, your internal body clock, and missing sleep affect your ability to think and make decisions. Twenty-eight volunteers stayed awake for 40 hours or took short naps in a controlled setting. Researchers measured their reaction times and mental …

This pilot study tested a standardized 5-step weaning procedure to safely remove tracheostomy tubes in 30 brain-injury patients. The goal was to see if patients could be decannulated without needing the tube reinserted within 96 hours. The study aims to improve recovery and reduc…

This study looked at how blood vessel function relates to heart blockage in people with a genetic heart condition called hypertrophic cardiomyopathy. Researchers measured blood flow and vessel flexibility in 40 adults. The goal was to understand the connection, not to test a trea…

This study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…

This study looked at how blood vessel cells and immune cells talk to each other in people with systemic sclerosis, a rare autoimmune disease that causes skin hardening. Researchers collected skin samples from 350 adults aged 18 to 75 to measure a specific protein (OX40L) on blood…

This study looked at 75 people with relapsing-remitting multiple sclerosis who were taking Aubagio. Researchers used virtual reality and real-world tasks to measure thinking skills in daily life, along with advanced brain scans. The goal was to better understand how thinking prob…

This study looked at whether people with essential tremor have trouble making decisions or recognizing facial emotions. Researchers compared 39 patients with healthy volunteers using special tests. The goal was to understand how the condition might affect daily social life.

This study looked at why people with Parkinson's disease often gain weight after getting deep brain stimulation. Researchers measured how the body uses energy at rest and after eating in 20 patients. The goal was to see if weight gain is linked to changes in energy balance.

This study looked at how well people with COPD can learn to use different inhaler devices correctly. 24 participants were observed to see if they made major mistakes when using the inhalers. The goal was to find ways to improve training and reduce errors, helping patients get the…

This study looked at how multiple sclerosis (MS) changes the brain's ability to handle social situations, like understanding others' thoughts and feelings. Researchers used special MRI scans to compare brain activity and structure in 35 people with MS and healthy volunteers. The …

This study looks at how often patients and their family members develop post-traumatic stress disorder (PTSD) after surviving a sudden cardiac arrest. Researchers will interview 20 survivors and 20 relatives within one week of the event and again three months later using standard…

This study tested a non-invasive heart mapping system (Cardioinsight) to help doctors treat heart rhythm problems. 492 patients used the system during procedures like ablation or pacemaker implantation. The goal was to see if the mapping improved outcomes compared to standard car…

This study followed 40 women with cervical, uterine, or ovarian cancer to understand how their couple relationship and sexual communication changed from diagnosis to 3 months after treatment. Researchers used questionnaires to track sexual activity, pleasure, and discomfort. The …

This study aimed to collect detailed measurements of the spine and pelvis in 161 healthy adults using a special low-dose X-ray technology called EOS. By understanding what a normal, pain-free spine looks like, doctors hope to better diagnose and treat people with lower back pain.…

This study tested whether a video call between paramedics and a stroke specialist can help decide the right treatment—like clot-busting drugs or clot removal—before the patient arrives at the hospital. About 215 adults with suspected stroke took part. The goal was to see if remot…

This study looked for small missing or extra pieces of DNA in 90 children with obesity and intellectual disability. The goal was to find hidden genetic causes that might explain both conditions. By identifying these genetic changes, researchers hope to discover new genes involved…

This study looked at how stress and insomnia influence each other in women aged 20-50. Researchers measured stress reactions during a driving simulation and tracked sleep afterward using monitors. The goal was to understand why some people develop long-term sleep problems after s…

This study tested whether a special heart ultrasound (speckle tracking strain echocardiography) can detect early heart muscle changes in 61 adults with type 1 diabetes, before symptoms appear. Researchers looked for links between these changes and small blood vessel damage (micro…

This study tested whether doctors can safely check and adjust pacemakers and defibrillators from a remote location, instead of requiring patients to come into the clinic. 110 adults with these heart devices took part. The goal was to see if remote programming works as well as in-…

This study looked at the oral health of 88 people with chronic kidney disease (stages 2 to 5) to see how dental problems relate to kidney health. Researchers checked teeth, gums, saliva, and breath, and tracked nutrition and inflammation over 12 months. The goal was to understand…

This study tested a new questionnaire to better understand eye rubbing habits in people with or suspected keratoconus, a condition where the cornea thins and bulges. Researchers enrolled 292 participants to see if the questionnaire is reliable and useful. The goal is to improve h…

This study looked at 65 adults with a rare heart condition called wild-type TTR cardiac amyloidosis to see how many also have nerve damage (neuropathy). Researchers used exams and nerve tests to find out. The goal was to learn more about the condition, not to test a new treatment…

This study looked at whether lung MRI could be used instead of CT scans to diagnose idiopathic pulmonary fibrosis (IPF), a serious lung disease. Researchers compared MRI images to standard CT scans in 60 adults to see if MRI could spot the same key signs of IPF without using radi…

This study tested whether giving nursing mothers omega-3 supplements (from rapeseed oil and special margarine) changes the fat composition of their breast milk compared to standard olive oil. 82 mothers with babies born full-term took part. The goal was to measure key fatty acids…

This study looked at 33 patients who had both cancer and a bleeding disorder called immune thrombocytopenia (ITP). The goal was to see if cancer cells trick the immune system into attacking the body's own platelets. Researchers found that treating the cancer often helped the ITP …

This study looked at why some people have trouble with memory and thinking after a heart attack. Researchers used brain scans to check for hidden damage in the brain. The goal was to better understand these problems and help doctors spot them early. The study involved 49 adults a…

This study looked at tiny particles in the blood and urine of 208 people with lupus or scleroderma. Researchers measured changes in these particles over 12 months to see if they could help predict disease activity or lead to new treatments. The goal was to better understand these…

This study looked at 56 stroke patients who had successful treatment to restore blood flow to the brain. Researchers used a special MRI scan to measure tiny changes in brain tissue that standard scans might miss. The goal was to understand how much hidden damage remains and how i…

This study followed 516 elderly French people for up to 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers looked at genetic, clinical, and lifestyle factors that might increase risk. The goal is to better understand …

This study looked at 100 adults having heart surgery who needed a central line placed in the subclavian vein (under the collarbone). Doctors used either a transversal or longitudinal ultrasound view to guide the needle. The goal was to see which method was quicker and had fewer c…

This study looked at how the blood flow, water movement, and stiffness of uterine fibroids affect the success of a non-invasive treatment called MR-HIFU. The goal was to understand why some fibroids respond better than others. Forty women with symptomatic fibroids participated, a…

This study looked at whether a heart attack slows down stomach emptying, which could delay how quickly oral anti-clotting drugs work. Researchers measured stomach emptying in 23 heart attack patients and compared them to stable heart patients. The goal was to understand if using …

This study tested a computer system called PRoSIT that automatically checks hospital discharge prescriptions for dangerous drug interactions. Researchers looked at nearly 5,800 prescriptions for patients aged 65 and older from heart, internal medicine, and neurology departments. …

This study tested a new way to monitor vision during brain surgery near the optic nerve. Researchers used special goggles and anesthesia to track brain signals (visual evoked potentials) in 40 patients. The goal was to see if this method could help surgeons avoid damaging eyesigh…

This study looked at how the skeleton lines up with gravity in adults who have posture problems. Researchers used special 3D X-ray images to measure bone positions in 26 people. The goal was to better understand what causes poor balance, not to test a treatment.

This study looked at 36 adults with pulsatile tinnitus (a rhythmic noise in the ear) to see if a special ear test called multifrequency impedancemetry could detect changes related to the condition. Researchers measured how the ear responds to different sound frequencies and check…

This study tested a special PET scan to measure oxygen levels in glioblastoma brain tumors. Low oxygen (hypoxia) can make tumors resistant to treatment. The goal was to find the best way to use this scan to guide therapy. 14 adults with newly diagnosed glioblastoma took part.

This study looked for hidden brain damage in 38 adults hospitalized with COVID-19. Instead of relying only on MRI scans, researchers used electrical tests to check how well the brainstem was working. The goal was to see if COVID-19 can affect the brain even when standard imaging …

This study measured levels of a hormone called pregnenolone and related compounds in the blood of 25 men—some with obesity and some at a healthy weight. Researchers wanted to see if a breakdown in the body's natural feedback loop might lead to overactivity of the endocannabinoid …

This study checked if people with long-term pain of unknown cause might have Fabry disease, a rare genetic disorder. Researchers tested 776 patients aged 6 to 80 from pain clinics across France. The goal was to see how often Fabry disease appears in this group, not to provide tre…

This study tested a new way to monitor breathing at home in 120 adults with severe asthma. The goal was to see if a special analysis of resting breath patterns could predict when an asthma attack might occur. The approach is observational and aims to improve early warning, not to…

This study looked at whether women would be willing to collect their own urine sample instead of having a traditional cervical swab (Pap smear) for cervical cancer screening. 173 women aged 31-49 who were already coming in for a Pap smear tried the urine self-test and answered a …

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study looked at 27 people with advanced basal cell skin cancer who were taking the drug vismodegib. The goal was to see if the amount of drug in their blood was linked to side effects like muscle cramps, hair loss, and taste changes. Researchers monitored patients for 6 mont…

This study looked at whether regular physical activity can slow down memory and thinking problems in healthy older adults and people with early-stage Alzheimer's disease. Researchers measured brain function, fitness, and daily activity in 139 people aged 60-80. The goal was to se…

This study looked at whether radiation therapy for certain brain tumors (cavernous sinus meningioma or pituitary adenoma) can harm autobiographical memory—the memory of personal life events. Researchers recruited 17 patients aged 35 to 65 who were scheduled for radiotherapy. They…

This study looked at 14 men with intermediate-risk prostate cancer who were scheduled for prostate removal surgery. Each man received two different PET scans to see which one better highlighted the cancer. The goal was to gather information to improve future detection, not to tre…

This study involved 22 men with prostate cancer who were scheduled for surgery. Each participant received two different types of PET/CT scans (68Ga-RM2 and 68Ga-PSMA-617) to see which one provides clearer images of the cancer. The goal was to compare how well each scan detects tu…

This study looked at 38 people who had a first stroke in the cerebellum, a brain area involved in mood. Researchers used interviews and smartphone tracking to measure depression, anxiety, and apathy in daily life. The goal was to better understand how these mood problems develop …