C-Section bleeding breakthrough: drug cuts hemorrhage risk

NCT ID NCT03431805

First seen May 22, 2026 · Last updated May 24, 2026 · Updated 1 time

Summary

This study tested whether giving tranexamic acid (TXA) during a C-section can prevent severe bleeding (postpartum hemorrhage). Over 4,500 women having a planned or unplanned C-section at 34 weeks or later took part. The drug was compared to a placebo to see if it reduced the need for blood transfusions and kept blood loss under 1 liter.

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Contacts and locations

Locations

  • CH de Pau

    Pau, France

  • CHRU Côte de Nacre

    Caen, 14033, France

  • CHRU de Nancy

    Nancy, 54000, France

  • CHU Angers

    Angers, 49033, France

  • CHU Bordeaux

    Bordeaux, 33076, France

  • CHU Charles Nicolle

    Rouen, 76000, France

  • CHU Estain

    Clermont-Ferrand, 63001, France

  • CHU Jean Minjoz

    Besançon, 25000, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU Nîmes

    Nîmes, 30900, France

  • CHU Rennes

    Rennes, 35033, France

  • CHU Saint Etienne

    Saint-Etienne, 42270, France

  • CHU Strasbourg

    Strasbourg, 67098, France

  • CHU Tours

    Tours, 37044, France

  • CHU de Montpellier

    Montpellier, 34295, France

  • Centre Hospitalier Intercommunal Poissy-Saint Germain

    Poissy, 78303, France

  • Centre Hospitalier Intercommunal de Créteil

    Créteil, France

  • Hopital Nord

    Marseille, 13915, France

  • Hôpital Paule de Viguier CHU Toulouse

    Toulouse, 31059, France

  • Hôpital Saint Joseph Marseille

    Marseille, 13008, France

  • Hôpital Saint Joseph Paris

    Paris, 75014, France

  • Hôpital Trousseau

    Paris, 75012, France

  • Hôpital universitaire Kremlin-Bicètre

    Paris, 94270, France

  • Hôpital universitaire Necker-Enfants malades

    Paris, 75015, France

  • Hôpital universitaire Robert Debré

    Paris, 75019, France

  • Maternité de Port-Royal Paris

    Paris, 75014, France

Conditions

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