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C-Section bleeding breakthrough: tranexamic acid tested on 4,500 women

NCT ID NCT03431805

Completed Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large study tested whether giving tranexamic acid right after a cesarean delivery can prevent postpartum hemorrhage, or dangerous heavy bleeding. Over 4,500 women participated across multiple hospitals. The drug was given as a single injection after the umbilical cord was clamped, alongside standard care. The main goal was to see if it reduced the number of women who lost more than 1 liter of blood or needed a blood transfusion.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tranexamic acid
What this could lead to
If effective, this could become a standard preventive treatment to reduce dangerous bleeding after cesarean delivery.
What could go wrong
The trial is completed but results may not apply to all women, and there is a small risk of blood clots or seizures with tranexamic acid.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Postpartum Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTPARTUM HEMORRHAGE

Contacts and locations

Locations

  • CH de Pau

    Pau, France

  • CHRU Côte de Nacre

    Caen, 14033, France

  • CHRU de Nancy

    Nancy, 54000, France

  • CHU Angers

    Angers, 49033, France

  • CHU Bordeaux

    Bordeaux, 33076, France

  • CHU Charles Nicolle

    Rouen, 76000, France

  • CHU Estain

    Clermont-Ferrand, 63001, France

  • CHU Jean Minjoz

    Besançon, 25000, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU Nîmes

    Nîmes, 30900, France

  • CHU Rennes

    Rennes, 35033, France

  • CHU Saint Etienne

    Saint-Etienne, 42270, France

  • CHU Strasbourg

    Strasbourg, 67098, France

  • CHU Tours

    Tours, 37044, France

  • CHU de Montpellier

    Montpellier, 34295, France

  • Centre Hospitalier Intercommunal Poissy-Saint Germain

    Poissy, 78303, France

  • Centre Hospitalier Intercommunal de Créteil

    Créteil, France

  • Hopital Nord

    Marseille, 13915, France

  • Hôpital Paule de Viguier CHU Toulouse

    Toulouse, 31059, France

  • Hôpital Saint Joseph Marseille

    Marseille, 13008, France

  • Hôpital Saint Joseph Paris

    Paris, 75014, France

  • Hôpital Trousseau

    Paris, 75012, France

  • Hôpital universitaire Kremlin-Bicètre

    Paris, 94270, France

  • Hôpital universitaire Necker-Enfants malades

    Paris, 75015, France

  • Hôpital universitaire Robert Debré

    Paris, 75019, France

  • Maternité de Port-Royal Paris

    Paris, 75014, France

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