Baking soda in epidural may reduce need for general anesthesia in urgent C-Sections
NCT ID NCT05313256
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This study tested whether adding sodium bicarbonate (baking soda) to the standard epidural painkiller (lidocaine with epinephrine) could provide better pain relief for women needing an extremely urgent C-section during labor. 65 women were randomly assigned to receive either the buffered or standard version. The main goal was to see if fewer women would need general anesthesia due to inadequate pain control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lidocaine with epinephrine, with or without sodium bicarbonate (baking soda)
- What this could lead to
- If it works, this could offer faster, more reliable pain relief for emergency C-sections, lowering the need for general anesthesia.
- What could go wrong
- This is a small, completed Phase 2/3 trial with only 65 participants, so results may not apply widely. The intervention only targets pain during a specific procedure, not the underlying condition.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CH de la Côte Basque
Bayonne, France
-
CHU de Bordeaux
Bordeaux, France
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