University Hospital, Bordeaux

This study looks at two different blood thinner plans after a procedure to close a small heart pouch in people with atrial fibrillation. About 60 adults will get either aspirin alone or aspirin plus clopidogrel for 3 months. The goal is to see which plan better prevents small bra…

This study tests a combined approach to make emergency breathing tube placement safer for adults in life-threatening situations outside hospitals. The strategy includes using a specific muscle relaxant, mask ventilation before the tube, and a special guide. Researchers will track…

This study compares two treatments for men with intermediate-risk prostate cancer: focal HIFU (a targeted ultrasound that destroys cancer cells) and radical prostatectomy (surgery to remove the entire prostate). The goal is to see which approach offers better value for money and …

This study looks at whether giving a drug called oxybutynin early to boys (ages 3-6 months) with posterior urethral valves can improve bladder function. The trial involves 50 participants and compares the drug to no treatment over 9 months. The goal is to see if the drug helps th…

This study looks at two less invasive options—radiofrequency ablation (RFA) and uterine artery embolization (UAE)—for women with heavy bleeding due to adenomyosis who are eligible for hysterectomy. The goal is to see if these treatments can reduce bleeding and pain as well as hys…

This study aims to validate a heart ultrasound test that helps doctors decide if a critically ill child on a low-volume breathing machine needs more fluids. Giving unnecessary fluids can be harmful, so this test could prevent fluid overload. The study will include 60 children in …

This study is testing whether measuring a specific protein, called P2X4, on blood cells can help doctors diagnose ALS (Lou Gehrig's disease) more accurately. Researchers will compare P2X4 levels in 50 people with ALS to those in healthy volunteers. If successful, this could lead …

This study looks at a new, noninvasive test to quickly tell if a critically ill child needs more IV fluids. The test uses a gentle belly press and a simple heart monitor to measure blood flow. It aims to help doctors avoid giving unnecessary fluids, which can be harmful. The stud…

This study is developing a blood test that can determine the father of a fetus without any risk to the pregnancy. It is designed for victims of sexual assault who become pregnant and need to know paternity for legal reasons. The test analyzes fetal DNA found naturally in the moth…

This study aims to see if a protein test on bile fluid can accurately diagnose cholangiocarcinoma (bile duct cancer). Researchers will collect bile samples from 200 adults with bile duct narrowing during a routine scope procedure. They will compare the protein test results with s…

This study is testing whether a special PET/CT scan using gallium-68 citrate can better diagnose infections in artificial heart valves. About 40 adults with suspected valve infections will receive the scan, and results will be compared to standard diagnostic criteria after 3 mont…

This study aims to create a new diagnostic tool that uses a panel of 19 blood steroid hormones plus body mass index, blood sugar, and blood pressure to better identify adrenal adenomas that produce moderate amounts of cortisol. Researchers will enroll 291 patients with adrenal no…

This study is testing whether a new type of PET scan (68Ga-FAPI-46) can better detect the spread of pancreatic and bile duct cancers compared to standard CT and MRI scans. About 120 adults with newly diagnosed, potentially curable cancer will receive the new scan. If it proves mo…

This study tests whether a computer-aided detection (CAD) system helps doctors find more polyps during screening colonoscopy, aiming to reduce the chance of advanced adenomas (precancerous growths) three years later. About 592 adults undergoing routine colonoscopy will be randoml…

This study looks at how hormone replacement therapy (HRT) changes sexual quality of life in women with premature ovarian failure (early menopause). About 135 women will fill out a questionnaire before and 6 months after starting HRT. The goal is to see if HRT helps with desire, a…

This study tests whether a shared decision-making tool can help pharmacists and patients decide together when antibiotics are truly needed for uncomplicated bladder infections (cystitis). About 500 women with symptoms will take part. The goal is to reduce unnecessary antibiotic u…

This study looks at whether a short hypnosis session before a cardiac MRI can improve the quality of the images in patients who feel anxious. Researchers will compare scans from 90 anxious and non-anxious adults. The goal is to see if hypnosis reduces movement or stress, leading …

This study tests a modified surgery that aims to preserve ejaculation in men over 40 with an enlarged prostate, compared to the standard complete removal of prostate tissue. The goal is to see if the new method can relieve urinary symptoms just as well while avoiding the common s…

This study looks at how small vessel disease in the brain affects thinking skills. Researchers will measure brain waves in 80 older adults to find new markers of cognitive decline. They will also test if personalized brain training or gentle electrical stimulation can improve thi…

This study follows 1,000 adults with diabetic foot ulcers for up to 5 years to learn why they face higher death rates. Researchers will track health events like infections, amputations, and deaths to build a risk score. No new treatments are tested—the goal is to better understan…

This study looks at how the brain processes internal body signals in people with Restless Legs Syndrome (RLS). Researchers will use MRI scans and daily symptom tracking via a smartphone app and activity monitor to compare 30 adults with RLS to healthy volunteers. The goal is to u…

This study looks at how cortisol and other steroid hormones are produced over 24 hours in people with small adrenal tumors. Researchers will use a special device to take fluid samples every 20 minutes for one to two days. The goal is to better understand the differences between t…

This study looks at how well different imaging methods can measure the stiffness of kidney tumors. Researchers will compare these methods to see if they can help create more realistic 3D models for surgeons. About 50 adults scheduled for kidney tumor removal will take part. The g…

This study looks at two new ways to predict gestational diabetes and large babies (macrosomia) in pregnant women. Researchers will compare skin autofluorescence and glycated albumin to the standard HbA1c test. About 800 pregnant women will join to see if these markers can catch p…

This study aims to translate and validate a French version of the Sleep Regularity Questionnaire, a tool that measures how consistent a person's sleep patterns are. Researchers will enroll 50 adults with chronic insomnia or circadian rhythm disorders to test the questionnaire's a…

This study looks at women who had a stem cell transplant for leukemia as adults. It aims to find out how common gynecological problems and infertility are after the transplant. Researchers will review medical records to track issues like early menopause and graft-versus-host dise…

This study surveys 500 transgender adults in France to find out how much they know about gynecological care and cancer screening. The goal is to better understand the health needs of this group and improve medical recommendations. Participants complete a questionnaire about their…

This study looks at whether adding a simple microscope test of the tiny blood vessels at the base of your fingernails (capillaroscopy) can help doctors diagnose a type of lung disease called interstitial lung disease (PID) that is linked to connective tissue diseases (like lupus …

This study is creating and testing a new tool to assess the mouth condition of intensive care patients who have a breathing tube. Currently, there is no specific tool for these patients, and mouth problems can affect recovery. The tool will be tested on 500 adults in the ICU to s…

This study involves 20 adults with severe lung failure (ARDS) who are on a breathing machine. Researchers will use a special belt (electrical impedance tomography) to monitor lung overinflation and collapse while adjusting ventilator pressure, both lying on the back and stomach. …

This study looks at whether multiple sclerosis (MS) affects a woman's egg supply (ovarian reserve). Researchers will compare blood hormone levels and ultrasound results between 160 women with MS and healthy women aged 25 to 35. The goal is to understand if MS itself impacts ferti…

This study looks at how a type of cell death called ferroptosis, which is triggered by iron, may play a part in lupus. Researchers will measure certain markers in immune cells from 120 people with lupus and compare them to people with other inflammatory diseases. The goal is to b…

This study aims to develop and test new MRI sequences to make scans faster, sharper, and more detailed. Researchers will enroll 200 healthy adults to compare new imaging methods against standard ones. The goal is to improve diagnosis and treatment monitoring without any direct be…

This study is looking for better ways to predict blood clots in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will measure specific markers in the blood of 300 participants to see if they can tell who is at higher risk for clots. The goal …

This study checks how consistent the Maintenance of Wakefulness Test (MWT) is when repeated in people who feel very sleepy during the day. About 100 participants will take the test twice to see if results are stable. The goal is to decide if the MWT can be used to help determine …

This study looks at 800 adults in the ICU who have tumor lysis syndrome (a complication from cancer treatment) and sudden kidney injury. Researchers want to see if starting dialysis early or waiting helps kidney function better after 30 days. The goal is to find the best timing t…

This study looks at a blood test that may help doctors decide which children need extra fluids after heart surgery. Giving fluids when not needed can be harmful. The researchers will check if a certain blood marker can predict which children will benefit from fluids. About 110 ch…

This study will follow 150 adults with systemic granulomatosis (including sarcoidosis) for up to 10 years. Researchers will track how the disease progresses and collect blood, urine, and DNA samples. The goal is to better understand the disease and find factors that predict its c…

This study is building a large French database of 30,000 kidney cancer patients. Researchers will collect detailed medical information and biological samples to better understand the disease and improve care. The goal is to create a powerful resource for future studies, not to te…

This study aims to find unique biological markers in the blood of people with atrial fibrillation (AF), a common heart rhythm problem. Researchers will compare 400 adults with AF to people without AF to identify markers that predict whether AF will come back after treatment. The …

This study looks at how mitochondrial diseases affect the immune system. Researchers will measure immune cells and antibodies in 60 people with confirmed mitochondrial disease. The goal is to better understand these immune problems, which could lead to better diagnosis and new tr…

This study looks at how a special filter (OXIRIS membrane) used for kidney dialysis affects blood clotting and immune cells in intensive care patients with septic shock. Researchers will measure markers of clotting and immune activation before and after using the filter. The goal…

This study looks at how the immune system ages faster in people with lupus. Researchers will measure specific immune cells and telomeres in 75 adults with lupus. The goal is to understand the aging process better, not to test a new treatment.

This study follows 500 adults with systemic sclerosis (a rare autoimmune disease causing skin and organ hardening) for up to 5 years. Researchers will track how the disease naturally progresses, including complications like lung or kidney problems, and collect blood samples to be…

This study follows 15,000 people with spinal problems (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Researchers will track which treatments are used and how patients feel. No new treatment is being tested—this is a…

This study looks at two ways to fix large bone gaps in the leg: the Masquelet technique and electromagnetic transport nails. Researchers will track how long it takes for the bone to heal and how well patients recover function. About 250 adults with bone loss from tumors, infectio…

This study looks at whether giving extra nutrition through a feeding tube before surgery can lower the chance of complications in malnourished people with esophageal or stomach cancer. About 670 participants will be followed to compare those who get nutritional support with those…

This study is testing whether a blood test called MAIPA can help doctors tell if a low platelet count is caused by an autoimmune problem. Researchers will study 225 adults with low platelets who have not started treatment yet. The goal is to see if finding certain antibodies in t…

This study tracks 300 adults who develop a surgical site infection after orthopedic surgery (like hip or spine procedures). Researchers want to see how often depression and malnutrition occur after the infection. The goal is to better understand these complications so doctors can…

This study explores whether using a smartphone app to collect real-time data is a practical way to track symptom changes in people with Restless Legs Syndrome (RLS). Researchers will ask 62 adults with RLS to complete daily assessments on a study phone for two weeks. The goal is …

This study looks at specific immune cells (B cells and CD4 T cells) in the blood and spinal fluid of 150 people with multiple sclerosis or early symptoms. The goal is to identify which cell types cause damage in different forms of MS. This research does not offer treatment but ma…

This study checks if using special clean water in reusable bottles for colonoscopies is safe. It looks for any contamination from the patient's own gut bacteria. The goal is to make the procedure more eco-friendly without risking patient safety. About 40 adults having a colonosco…

About 13 in 1,000 children are born with heart disease, but current tools struggle to assess how well the heart fills with blood. This study will test a new ultrafast ultrasound technique in 300 children to measure heart stiffness and blood flow. The goal is to improve diagnosis …