Depressive disorder

This trial tests whether transcranial magnetic stimulation (TMS) aimed at a brain circuit linked to the subgenual anterior cingulate cortex can reduce depression symptoms. Adults with major depressive disorder or persistent depressive disorder will receive either active or sham T…

This study investigates whether Shugan Jieyu Capsules, a traditional Chinese herbal medicine, can effectively treat depression of varying severity in everyday clinical practice. Researchers will follow 400 patients aged 13-65 with depression, giving them the capsules alone or alo…

This trial tests a personalized approach to maintaining improvement in people with treatment-resistant depression. Participants who previously responded to a type of brain stimulation called iTBS will receive maintenance stimulation scheduled by a symptom-based algorithm, along w…

This phase 3 trial tests whether adding an experimental drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms in adults with major depressive disorder. Participants receive either brenipatide or a placebo by injection, alongsid…

This trial is testing whether a personalized form of brain stimulation, called accelerated intermittent theta-burst stimulation (iTBS), can improve symptoms of depression and anxiety in people with treatment-resistant depression. The approach uses brain imaging to target specific…

This trial tests whether the schedule of maintenance transcranial magnetic stimulation (rTMS) affects the risk of depression relapse. Adults who responded to an initial course of theta burst stimulation are randomly assigned to receive 20 maintenance sessions either clustered tog…

This study compares dapagliflozin and metformin for managing weight gain caused by antipsychotic medications. About 110 adults aged 16 and older will take one of the drugs plus lifestyle advice for 26 weeks. The goal is to see which drug works better and is safer for weight contr…

This study tests a program that combines group counseling, financial literacy training, and savings accounts to help Ugandan teens with HIV manage depression and stick to their medication. About 588 adolescents aged 15-19 will take part. The goal is to see if this approach can re…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study tests a new, intensive form of brain stimulation for elderly people (65 and older) who have depression that hasn't improved with medication and also have memory or thinking problems. The treatment uses magnetic pulses targeted to a specific brain area, guided by brain …

This study explores whether routine blood vessel tests can help identify depression in people with chronic atrophic gastritis, a stomach condition. Many patients with this disease have undiagnosed depression due to stigma. Researchers will use ultrasound and other vascular measur…

This study will check if an artificial intelligence (AI) system can diagnose depression as accurately as a psychiatrist. About 100 adults with depression will take part. Their AI-based diagnosis will be compared to the diagnosis made by a mental health specialist.

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

Researchers are testing a 10-session bilingual therapy program called PrEPared Minds/Mentes PrEParadas. The program uses cognitive behavioral therapy to reduce anxiety and depression in men who have sex with men. The goal is to see if improving mental health helps these men learn…

This trial tests a school-based program that uses an AI chatbot to teach high school students about depression, reduce stigma, and encourage them to seek professional help when needed. About 720 students aged 15 to 19 in Taiwan will take part in four weekly sessions, with some re…

This trial tests whether a collaborative psychological model—combining daily music listening, a smartphone app with AI chatbot support and mindfulness exercises, telephone check-ins, and wearable monitoring—can reduce the risk of postnatal depression and persistent pain after chi…

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study tests whether trained youth mentors can deliver a brief therapy to reduce suicide risk in Hispanic adolescents aged 12-17. Participants will either receive 6 therapy sessions with a mentor or usual care. The goal is to see if this approach is feasible and helps reduce …

This study tests a community-based program to help Black and Hispanic teens aged 15-20 cope with chronic stress and prevent depression. Participants will join peer groups to learn skills and will be tracked for 2 years. The goal is to reduce depressive symptoms and improve physic…

This study tests whether a 4-hour resilience workshop can prevent PTSD and depression in 800 first responders in New York and Texas. Participants will be randomly assigned to the workshop or a control group and followed for one year. The goal is to see if the training helps them …

This study tests whether an AI-informed peer-mentoring program can help healthy teens and young adults (ages 12-25) manage stress and build social skills, lowering their risk of developing anxiety or depression. Researchers will compare this program to standard mentoring and heal…

This study will test whether a personalized smartphone app can help prevent anxiety and depression in adults who do not currently have these conditions. About 2,595 people in Spain and Chile will use either a highly interactive app (Pandora-1), a simpler educational app (Pandora-…

This study tests whether a personalized smartphone app can prevent depression and anxiety in adults who do not currently have these conditions. Over 9,000 participants in Spain will use the app, which creates a custom plan with activities like exercise, sleep improvement, and pro…

People hospitalized after a traumatic injury often face post-traumatic stress, depression, and substance use problems. This study tests a program called Trauma Resilience and Recovery Program Portal 2.0, which adds bedside screening, education, text-message check-ins, and follow-…

Researchers at the University of Bergen are testing whether a two-week, self-guided smartphone screen time reduction program can reduce depression symptoms in young adults. The trial enrolls 200 students in Oslo who have sought help at the student mental health service. Participa…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

Researchers at the Medical University of South Carolina are testing a program that adds community health workers to standard trauma recovery services. The study enrolls 100 adult trauma patients who screen positive for PTSD or depression risk and report at least one unmet social …

This study looks at whether combining group cardiovascular exercise with group therapy can help reduce symptoms of anxiety and depression in adults living in rural areas. Twenty participants with generalized anxiety or depressive disorders will take part in a structured program. …

Researchers at Peking University are studying a 49-day digital mindfulness program for adults with emotional distress, depression, or anxiety. About 100 participants use a mobile app that delivers daily guided meditations, short lessons on emotions, and practical exercises. The t…

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This study tests a self-help program for 200 post-9/11 veterans who have depression or PTSD symptoms but are not in therapy. The program teaches healthy coping skills and how to find support services. Researchers will compare the self-help group to those receiving standard resour…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This trial tests whether an online therapy program, supported by peer sessions, can reduce depression symptoms in veterans receiving primary care through the VA. About 400 veterans with moderate depression will either get enhanced usual care or the peer-supported online program. …

This trial tests whether a 10-session online group cognitive-behavioral skills training program can reduce symptoms of depression and anxiety in university students. About 400 students who screen positive for these symptoms will be randomly assigned to either the online CBT progr…

This pilot study tests a culturally adapted empowerment self-defense program for Indigenous women (including American Indian, Alaska Native, and Two Spirit individuals) who have experienced sexual violence and currently have moderate to severe depression or PTSD. The program teac…

This trial tests whether a daily probiotic supplement containing Lactobacillus plantarum can improve cognitive function and reduce depressive symptoms in women aged 50-64 with mild depression. Over 12 weeks, participants will take either the probiotic or a placebo capsule, and re…

This study tests a brain stimulation treatment called TMS to help female athletes with both depression and concussion symptoms. About 35 women aged 18-65 who have had a concussion and have moderate to severe depression will receive the treatment. The goal is to see if TMS can imp…

This trial tests whether light therapy glasses can reduce depression in people with end-stage kidney disease who undergo hemodialysis three times a week. Participants wear either active glasses (1000 lux) or a sham device (50 lux) for 30 minutes each session over five weeks. The …

This trial investigates whether the Healthy Minds Program, a mobile meditation training app, can reduce symptoms of depression in adults. About 1,500 participants with elevated depressive symptoms will complete a 4-week well-being program using the app. Researchers will measure c…

This trial is testing whether a specially adapted form of cognitive behavioral therapy, called CBT-DAY, can reduce depressive symptoms in autistic youth aged 11 to 17. Participants will be randomly assigned to receive either CBT-DAY or standard care, and researchers will compare …

This trial tests whether a 12-week Latin dance program—featuring Rumba, Cha-cha, and Jive—can improve psychological health in primary school children aged 6 to 12. Participants are randomly assigned to either the dance program or regular physical education classes. Researchers wi…

This trial tests whether a structured, culturally adapted home-based exercise program helps Afghan women with mild to moderate depression stay active compared to routine exercise advice. About 60 women aged 18-50 will be randomly assigned to either the exercise program or usual c…

This trial tests whether a culturally tailored mobile health program, called Self-Compassion, Health, and Empowerment (SHE), can improve mental health in Chinese immigrant women who have experienced intimate partner violence. Participants receive six weekly sessions covering safe…

This trial tests whether systemic couple therapy (SCT) can reduce depression and improve relationship quality in married couples where at least one partner has mild to moderate depression. Participants will either receive 8 weekly SCT sessions or standard care. Researchers will m…

This trial tests whether self-guided digital programs can reduce both insomnia and depression in breast cancer survivors. Participants use an online insomnia program or a mental health program, either alone or in sequence, to see which approach works best. The goal is to find a s…

This pilot study tests whether a nurse-led digital cognitive behavioral therapy for insomnia (dCBT-I), delivered through a chatbot on WhatsApp, can help university students with mild to moderate anxiety or depression. Participants will complete a two-week daily sleep diary via th…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

Many Asian Americans with depression also suffer from physical symptoms like pain or fatigue, but no proven treatment addresses both together. This study will test whether combining a stress management program with Qigong/Tai Chi movements is practical and acceptable for 70 adult…

This trial tests whether a brief email program that helps young adults focus on positive experiences can reduce symptoms of depression and anxiety. One hundred participants aged 18-25 in Zimbabwe will either receive the email program or general mental health information. The stud…

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This study tests whether taking a probiotic supplement called Ecologic® Barrier for 16 weeks can reduce depressive symptoms and change brain activity in adults aged 25-40 with mild-to-moderate depression. Participants will be randomly assigned to receive the probiotic or a placeb…

This study tests whether a digital mental health platform called NAVO:J can help teens feel better. About 250 students will use the app in weekly group sessions at school for 17 weeks. Researchers will measure changes in depression, anxiety, stress, and resilience to see if the p…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests a 12-week telehealth program called PARTNER-MH, where trained peer specialists help minoritized veterans navigate mental health care, address social needs, and improve communication with clinicians. The trial will enroll 268 veterans with depression, anxiety, or …

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This pilot study will test whether a 6-week app-based mental fitness program can improve wellbeing and self-compassion in anesthesiology residents. Sixty residents will be randomly assigned to either the mental fitness app or a control program. The main goal is to see if such a p…

This study tests whether virtual reality (VR) can help improve thinking and daily functioning in people aged 70 and older who have depression. Participants will do 12 VR sessions over 6 weeks, doing tasks like sorting groceries or following recipes. The main goal is to see if sen…

This study tests three types of support—individual counseling, group stress and budget workshops, or a mix—for health students aged 18-30 who face financial hardship. About 110 students from the University of Rouen will try these programs, and researchers will track changes in an…

This study tests a program called Natural Psychotherapy to see if it can reduce anxiety and depression symptoms in 3,000 Chinese students aged 7 to 18. Participants will be randomly assigned to the program or a control group, and their progress will be tracked for 6 months. The g…

This study tests whether a tailored online support group (VOCALE LBD) can reduce depression in family caregivers of people with Lewy body dementia (LBD). LBD caregivers often face high stress and depression rates. The 8-week program brings small groups together online to discuss …

This study tests whether reading specific self-help books can lower anxiety, depression, and rumination in university students aged 18-25. 110 students from health science programs will be randomly assigned to read one of two books or join a waiting list. Over 8 weeks, they will …

This study will test two smartphone apps, Tankevirus and Grubl, designed to help people with mild to moderate anxiety and depression. About 1000 Norwegian adults will use one of the apps or a placebo app for two weeks. Researchers will measure changes in symptoms and quality of l…

This study will test a behavioral activation therapy program delivered via telehealth for Spanish-speaking adults with depression living in rural areas of Montana and New Mexico. The goal is to see if the program improves depressive symptoms and keeps people engaged in mental hea…

This study tests whether using a personalized medicine clinic to tailor antidepressant doses can improve depressive symptoms. Researchers will enroll 200 adults with depression and track changes using a standard depression survey. The goal is to see if customizing medication base…

This study will test an internet-based therapy program for 366 adults with anxiety or depression. The program starts with self-guided modules, and based on early progress, some participants will also get live sessions with a therapist. The goal is to see if personalizing the trea…

This study tests whether Xiaochaihu Granules, a traditional Chinese herbal medicine, can help with depression in people who have had a stem cell transplant. About 46 patients will receive either a low or high dose of the granules for 100 days, alongside standard care. Researchers…

This study will test whether psilocybin, the active ingredient in magic mushrooms, can help treat depression. Fifty adults with depression will receive a 25 mg capsule of synthetic psilocybin along with therapy. Researchers will use MRI brain scans and other tests to see how psil…

This study tests whether a mobile app called SocialRx, which recommends personalized arts and cultural activities, can improve depression, anxiety, and loneliness in teens aged 15-18. About 230 teens with depression or anxiety will either use the app for a year or continue their …

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare different combinations of activ…

This study tests whether a probiotic called Bifidobacterium PB-18 can improve symptoms of mild to moderate depression in adults aged 18 to 65 who are not taking antidepressants. Participants will take either the probiotic or a placebo daily for 8 weeks. Researchers will measure d…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study tests a 6-week program for adults 55 and older that combines group book discussions with simple mouth exercises. The goal is to see if it can reduce depression, improve physical and oral health, and boost mental toughness. Half of the 60 participants will do the progra…

This study tests an 8-week mindfulness program designed to help nursing students reduce stress, anxiety, and depression while improving their emotional control. About 93 students will learn meditation, breathing exercises, and mindful movement. The goal is to see if these techniq…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests whether an interactive virtual reality (VR) program can help reduce pain, anxiety, and fatigue in 20 hospitalized palliative care patients. Participants use a VR headset with sensors to interact with a calming natural environment for 10 minutes daily over 14 days…

This study tests a computerized cognitive behavioral therapy (cCBT) program designed to help caregivers of veterans who have mild to moderate depression. Twenty caregivers will use the online course over several weeks. Researchers will measure how satisfied participants are and w…

This study tests a guided self-help program for veterans with moderate depression. Participants follow a workbook and get coaching sessions from their VA primary care team. The goal is to see if this approach is practical and helps reduce depression symptoms, potentially making m…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens aged 13-24 who use Chicago Park District programs. About 268 participants will either get access to this program or a digital CBT workbook. The goal is to see if the program help…

This study tests a type of brain stimulation called theta burst stimulation (TBS) for people with depression that hasn't improved with medication. About 120 adults and teens will either get real TBS or a fake version first, then real TBS later. Researchers will measure changes in…

This study tests a program designed to help low-wage hospital workers manage depression and become more active. The program includes counseling, work coaching, and text message support. About 60 workers will take part to see if the program is practical and improves mood, stress, …

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests an experimental tablet called JS1-1-01 in 180 adults with moderate to severe depression. Participants will take either a low dose, high dose, or placebo for 8 weeks. The goal is to see if the drug safely reduces depression symptoms better than a placebo.

This study tests whether a smartphone app called SOLOMIYA is helpful and easy to use for people living under the stress of war in Ukraine. About 80 adults with mild to moderate depression or sleep problems will use the app for a few weeks. The app provides relaxation exercises, m…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study will test whether adding a mental health app called TREE-Connect to remote therapy sessions helps reduce depression in adults aged 50 to 80. Sixty participants with mild-to-moderate depression will use the app and attend therapy remotely. The main goal is to see if peo…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study will test an internet-based therapy program for people with emotional disorders like depression and anxiety. The program teaches skills to manage emotions and is designed to be used at home. Researchers want to see if it works well in primary care settings, if it is co…

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This study tests whether playing a virtual reality music-movement game can improve mood and social connection in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be split into three groups: one playing a social VR game with others, one playin…

This study tests whether using a virtual reality headset for 30 minutes each week can reduce depression in teenage girls aged 13-18. Half the participants will use VR, while the other half take standard antidepressant pills. Researchers will measure changes in depression scores a…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study tests a structured psycho-social program (PSP) for adults aged 30-40 with type 2 diabetes who have mild-to-moderate mental health issues. Over 6-8 sessions, participants learn to manage stress, challenge negative thoughts, and improve daily habits. The goal is to reduc…

This study looks at whether craniosacral therapy, a gentle manual therapy, can reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers aged 18-55 will either receive the therapy or be i…

This study tests whether a Mediterranean diet, adapted for Hong Kong, can reduce depression symptoms in 90 adults with moderate to severe depression. Participants will receive meal deliveries and track their mood and diet via phone surveys. The study also looks at how gut bacteri…

This study tests an enhanced version of depression treatment (COMBEX) for youth aged 15-24 with HIV. It combines therapy, medication management, and extra support strategies to improve mood and HIV care. Researchers will compare it to standard combination therapy over 72 weeks in…

This study tests a program called REWIRE for teens aged 12-17 who feel anxious or depressed and use social media over 3 hours daily. The program aims to cut social media use by about half and replace it with positive offline activities like hobbies or time with friends. Researche…

This pilot study will test a 'blended' therapy approach for adults with emotional disorders like anxiety and depression. Participants will either receive standard face-to-face therapy, a mix of face-to-face sessions and a smartphone app, or be placed on a waitlist. The goal is to…

This study tests whether a dietary supplement called GynMDD, taken alongside weekly supportive therapy, can improve symptoms of mild to moderate depression more than therapy plus a placebo. 168 adults aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks, c…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. Sixty students will attend weekly sessions for a semester and fill out questionnaires to measure changes. The goal is to see if t…

This study tests whether a community-based programme can improve well-being and reduce loneliness in adults aged 55 and older who have mild depression symptoms. 300 participants will be randomly assigned to either an 8-week programme of well-being sessions and follow-up support, …

This study tests a new approach where general practitioners and pharmacists work together to help adults who have been taking antidepressants for a long time but are feeling stable. The goal is to see if this teamwork helps more people safely stop their medication without their d…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study will test two types of exercise—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in 68 healthy young adults aged 18 to 21. Over 8 weeks, researchers will measure changes in cardiorespiratory fitness, testosterone and cortisol le…

This study looks at whether community health workers (CHWs) can effectively provide a mental health program to Spanish-speaking Latine parents who have symptoms of depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month…

This study tests whether a gentle hand-application method called Jin Shin Jyutsu can help perimenopausal women feel better emotionally and physically. Sixty women aged 40-54 will practice the technique daily for two weeks. Researchers will measure changes in quality of life, stre…

This study tests whether internet-based group cognitive behavioral therapy (CBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students in Malaysia. About 128 students with moderate to severe symptoms will be randomly assigned to either the th…

This study tests whether EMDR group therapy can help adults who experienced the April 2025 Silivri earthquake in Turkey. Forty participants will be randomly assigned to either the therapy group or a waitlist. Researchers will measure changes in PTSD, depression, anxiety, sleep qu…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 women having breast cancer surgery will be randomly assigned to receive either esketamine or a placebo during anesthes…

This study looks at whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked after sur…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have completed treatment for breast, prostate, or colorectal cancer. Researchers will enroll 76 participants with mild to moderate depression to see if the program is feasibl…

This study tests whether a special type of acupressure—timed to the body's natural daily rhythms—can improve sleep in nursing home residents aged 60 and older. Eighty participants will receive either real or fake acupressure twice a day for four weeks. Researchers will measure sl…

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study tests a new visual safety plan designed for autistic teenagers who have had suicidal thoughts or self-harm. About 90 teens aged 13-18 will be randomly assigned to either get the visual plan plus usual care, or just usual care. The goal is to see if the plan is easy to …

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This study looks at whether therapeutic gardening can help teenagers with depression who harm themselves. 66 teens will take part in gardening activities like planting and caring for plants. The goal is to see if this reduces self-harm, improves mood, and helps with sleep and lon…

This study tests whether mindfulness-based cognitive therapy (MBCT), adapted for Vietnamese culture, can reduce depression symptoms and improve quality of life. One hundred sixty adults with mild-to-moderate depression will be recruited from eight Buddhist pagodas near Hanoi. Hal…

This study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…

This study tests whether a digital mental health platform with open peer support can improve quality of life in adults with mild anxiety or depression symptoms. 82 participants will use the platform for 31 days. The goal is to see if their overall well-being, stress, and mood imp…

This pilot study tests whether a one-day online cognitive behavioral therapy (CBT) workshop can help women with postpartum depression in Türkiye. Sixty mothers with depressive symptoms will be randomly assigned to either the workshop or usual care. The study focuses on whether th…

This study tests whether using a virtual reality headset during a breast biopsy can lower depression, anxiety, and stress. 80 women will either wear a VR headset showing calming nature scenes or receive standard care. Researchers will measure their mood before and after the proce…

This study tests a non-invasive brain stimulation technique called iTBS to help ease depression in young women aged 16 to 24. Eight female participants will receive the treatment to see if it improves mood and brain function. The goal is to find a new way to reduce depression sym…

This study tests a program that combines doctor care, digital tools, virtual reality, and school-based support to help teens and adults in Morocco with depression and anxiety. About 146 participants will be split into two groups: one gets the new program, the other gets usual car…

This study tests whether a short, intensive psychological program before lung cancer surgery can lower anxiety and depression. About 138 adults scheduled for lung cancer surgery will be split into three groups: one receiving four weekly therapy sessions, one refusing support, and…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. The manual uses culturally adapted stories and exercises over eight weeks. Researchers will enroll 108 adults in Pakistan to see if the manual is feasible, a…

This study tests if adding exercise and education to standard talk therapy helps people with depression feel better. About 112 adults will be split into two groups: one gets therapy alone, the other adds an 8-week program of guided exercise and learning sessions. Researchers will…

This study tests whether structured group therapy, including cognitive behavioral therapy and mindfulness, can reduce symptoms of depression and anxiety in adults in Pakistan. About 108 participants will attend 12 weekly group sessions. The goal is to see if this approach improve…

This study looks at whether teaching mindfulness skills to pregnant women admitted to the hospital for risk of preterm delivery can reduce their depression, anxiety, and stress. Researchers will enroll 60 mothers and provide four weeks of mindfulness training. Participants will f…

This study will test a program called Living Well, which includes a mobile app with 21 mental health modules and personal coaching sessions, for breast cancer patients with moderate to severe anxiety. The goal is to see if the program can lower anxiety and reduce overall healthca…

This study tests whether a digital monitoring device called Dalia can improve depression symptoms when added to usual care. About 644 adults with moderate-to-severe depression will use the device for 3 months. The main goal is to see if more people feel significantly better compa…

This study is testing a virtual reality (VR) platform designed to help first-time pregnant women prepare for childbirth and improve their mental wellbeing. The VR program includes education about childbirth and exercises to build coping skills and confidence. Researchers will com…

This study compares two add-on treatments—esketamine nasal spray and aripiprazole pills—for older adults (60-74) whose depression hasn't improved with standard antidepressants. Around 220 participants will receive either esketamine once or twice weekly or daily aripiprazole, alon…

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

This study tests whether showing Black and Asian young adults (ages 18–29) the true social norms around depression and suicide can reduce stigma and increase their willingness to seek help. Participants receive personalized feedback that corrects misperceptions about what others …

Researchers at Assiut University are asking whether ADHD symptoms in medical students are linked to depression, anxiety, and lower grades. About 52 undergraduate medical students will fill out questionnaires that screen for adult ADHD, depression, and anxiety. The study also coll…

This study uses a virtual reality task to measure how people with depression make decisions involving physical effort and reward. Participants will walk on a treadmill in a VR environment while researchers track brain activity, heart rate, and energy use. The goal is to better un…

This study investigates whether certain chemicals in the blood, called kynurenine metabolites, are linked to depressive disorders. Researchers will compare 45 people with depression to 45 healthy individuals, all aged 18 to 60. Participants will undergo psychological assessments …

This study explores how financial insecurity—such as trouble paying for housing, food, or healthcare—affects the mental health of university students and whether it keeps them from seeking help. Researchers will conduct in-depth interviews with 30 students from two French univers…

This study investigates how often older adults in China experience anxiety and depression before undergoing major non-cardiac surgery. Researchers will use standard questionnaires to screen 8,000 patients aged 65 and older across multiple hospitals. The goal is to better understa…

This study looks at how depression changes a person's sense of control over events in their life, and whether antidepressant medication can help restore it. Researchers will track 124 adults with depression over 8 weeks of standard SSRI or SNRI treatment, using computer tasks to …

This study measures how often depression occurs in adults with alopecia areata, a condition that causes patchy hair loss. Researchers will use a questionnaire to assess depressive symptoms in 100 patients at a dermatology clinic. No treatments or interventions are involved — the …

This study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the …

This study aims to adapt a digital mental health app called Wysa for adolescent girls aged 13-18 in rural Uttar Pradesh, India, who have anxiety or depression. Researchers will work with the girls, their families, and community members to identify what helps or hinders app use an…

This study will enroll 500 adults with high levels of repetitive negative thinking (like worry or rumination) to understand why cognitive-behavioral therapy helps. Participants will receive one of two digital therapy programs: one focusing on concrete thinking, the other on self-…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…

This study looks at how physical activity levels are linked to posture, sleep quality, depression, and muscle or joint pain in health science professors and researchers at Istanbul Aydin University. About 73 academics aged 23 to 65 will fill out questionnaires. The goal is to und…

This study is creating a decision-support tool called CRAFTT to help therapists tailor mental health treatments to the cultural values and experiences of Latine youth (ages 5-15). The goal is to improve how well these treatments work and reduce mental health disparities. Research…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study will analyze data from 500 adults to see if depression and asthma are connected, and if one might cause the other. Researchers will use medical records and genetic information to identify factors like age, smoking, or weight that could influence the link. No new treatm…

This study tests whether a smartphone app, co-created with teens, plus trained peer navigators can help more young people ages 13-22 get mental health care in schools and clinics. Over 8,000 youth will take part across multiple sites. The goal is to see if this approach increases…

This observational study looks at whether some teenage girls with depression are especially sensitive to natural changes in estrogen and progesterone. About 94 participants will track their hormone levels daily at home and answer mental health surveys for 90 days. The goal is to …

This study aims to develop a brain wave (EEG) test that can measure how ketamine affects depression symptoms. Researchers will give ketamine infusions to 20 adults with treatment-resistant depression and track changes in their mood and brain signals. The goal is to find a reliabl…

This study checks if an AI software can accurately measure depression and anxiety symptoms in 650 adults. Participants will have their symptoms rated by both the AI and human experts to see if the AI works well across different groups. The study does not provide any treatment—it …

This study will test a digital tool called AI-COA® to see how well it measures the severity of depression and anxiety compared to standard clinician ratings. About 150 adults in the U.S. who are starting a new treatment for depression or anxiety will use the tool over 12 weeks. T…

This pilot study tests a 3-5 minute recorded message called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and feasible. The goa…

This study looks at whether low magnesium levels are linked to sleep problems in people with major depressive disorder. Researchers will measure magnesium in the blood of 90 adults and compare it to their sleep quality. The goal is to better understand this possible connection, n…

This study will survey about 289 medical students and interns at Assiut University to find out how common anxiety and depression are among them. Researchers will use standard questionnaires to measure symptoms and look for links to academic performance and other risk factors. The…