Alcohol-related disorders

This study investigates whether a daily probiotic supplement containing Lactobacillus bacteria can help reduce alcohol cravings, withdrawal symptoms, and the severity of alcohol use disorder in adult men. Participants take either the probiotic or a placebo for 12 weeks, and resea…

This study tests whether adding a smartphone-based incentive program to standard counseling helps veterans with alcohol use disorder reduce heavy drinking. Participants use a mobile app to submit breath alcohol readings and earn rewards for abstinence. The trial compares this com…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This study tests a 5-week community-based program that teaches protective behavioral strategies to reduce alcohol use in men aged 35–44 with hazardous drinking habits in rural Vietnam. Participants learn to set safe drinking limits, choose nonalcoholic drinks, and plan ahead, wit…

This study compares a fully automated digital screening and brief intervention (e-SBI) to the traditional in-person approach for reducing harmful alcohol consumption. Researchers will enroll over 500 adults from Brazilian public health clinics to see which method works better at …

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This study tests whether virtual reality exposure therapy (VRET) can help men with alcohol use disorder reduce their psychological dependence on alcohol and prevent relapse. Eighty men who have completed detox will be randomly assigned to either VRET or standard treatment. VRET u…

This small pilot study tested whether giving spironolactone, a drug normally used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on wheth…

This study tested whether a paced breathing app could help women with substance use disorder resist triggers in real time. 77 women used the app whenever they felt a craving or faced a trigger. Researchers tracked substance use and feedback to see if the app helped reduce drinkin…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested a program that combines personalized feedback with text messages to help young adults (ages 18-25) who drink to cope with anxiety or depression. Participants were in a psychiatric partial hospitalization program and drank heavily. The program aimed to reduce dri…

This phase 2 trial tested whether the drug sunobinop (V117957) can reduce heavy drinking in adults with moderate to severe alcohol use disorder who want treatment. 209 participants took either sunobinop or a placebo daily for several weeks. The study measured changes in heavy dri…

This study tested an experimental drug called ADX-629 in 4 adults with moderate alcohol-related hepatitis. The goal was to see if the drug is safe and can help control liver inflammation. Participants had to stop drinking alcohol during the trial. The study is now complete, and r…

This study tested a non-invasive brain stimulation technique called TMS to see if it could help people with alcohol use disorder drink less. 147 adults who wanted to cut back on drinking received TMS and were tracked for 4 months. The goal was to measure changes in drinking days,…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested a behavioral activation program given as part of a freshman orientation course at the University of Kansas. The program helps students set personal goals and engage in rewarding activities to indirectly reduce alcohol misuse, stress, binge eating, and depression…

This early-phase pilot study tested whether combining topiramate (a seizure medication) with N-acetyl cysteine (a supplement) is safe and tolerable for people with alcohol use disorder. Seventeen adults who were heavy drinkers and seeking treatment took either the combination or …

This early-phase study tested a single nasal spray dose of BPL-003, a psychedelic drug, combined with psychological support in 13 adults with moderate to severe alcohol use disorder. The main goals were to check safety and tolerability, and to explore effects on drinking behavior…

This completed trial tested whether a combination of nutraceutical supplements and psychological support could lower GGT, a liver enzyme, in 197 adults with alcohol use disorder. Participants received liver-supporting supplements and counseling to reduce drinking. The goal was to…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This early study tested a smartphone app that rewards people for staying sober. Participants submitted breath samples three times a day to prove they hadn't been drinking. The goal was to see if this approach is practical and helps people with alcohol use disorder. Only 12 people…

This study tested whether tolcapone, a drug used for Parkinson's disease, could change how people with both alcohol use disorder and ADHD respond to alcohol and make decisions. 23 adults completed the trial, which involved taking tolcapone or a placebo and then undergoing alcohol…

This study tested whether kudzu, an herbal supplement, can help people who binge drink reduce their alcohol use and related risky sexual behaviors. Researchers enrolled 120 sexually active adults who binge drink and are at high risk for HIV. Participants received either kudzu or …

This study tested whether a broccoli sprout extract supplement could improve gut health in older adults (50+) who drink at least 8 alcoholic drinks per week and have a low-quality diet. Over 28 days, 40 participants took either the supplement or a placebo. The goal was to see if …

This study tested a blended collaborative care model that uses telemedicine to integrate mental health treatment into primary care at smaller VA clinics serving rural veterans. Researchers enrolled 318 veterans who screened positive for depression, alcohol use disorder, or PTSD. …

This study tested a short, motivational counseling session for injured patients who drink alcohol, delivered in the emergency department in Tanzania. Over 600 adults took part, and the goal was to see if the intervention could reduce binge drinking and related harms. The approach…

This study tested whether giving people with alcohol dependence a one-month course of diazepam (40 mg per day) after detoxification could reduce the chance of relapsing into drinking within the next three months. The standard detoxification treatment is usually about one week. Th…

This study tested whether N-acetylcysteine (NAC), a widely available supplement, could help people with both alcohol use disorder and PTSD. 182 adults took either NAC or a placebo daily for 12 weeks, along with weekly therapy. Researchers measured changes in drinking habits, crav…

This study tested a therapy called Multisystemic Therapy-Emerging Adults (MST-EA) for young people aged 16-26 with substance use issues and recent arrests. The therapy works with the young adult and their social network at home and in the community to reduce criminal behavior and…

This phase 3 trial tested whether a single injection of radioactive lipiodol (Lipiocis) into the liver artery could prevent hepatocellular carcinoma from coming back after surgery or ablation. The study enrolled 73 adults with cirrhosis and one or two liver tumors that had been s…

This study tested a program for 160 HIV-positive fisherfolk in Uganda who were heavy drinkers and struggling to stick with their HIV medication. The program combined individual and group counseling with help opening savings accounts and building social support. The goal was to re…

This study tested whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with psychological support could help people with alcohol use disorder drink less. 60 adults in Denmark who were heavy drinkers took part. The main goal was to see if th…

This study tested whether adding the sleep medication lemborexant (Dayvigo) to the standard alcohol craving drug naltrexone helps people with alcohol use disorder and insomnia. Eight adults took either the combination or naltrexone plus a placebo. Researchers measured alcohol cra…

This pilot study tested a 4-week virtual intensive outpatient program for 63 people with moderate to severe alcohol use disorder. The program included group therapy, individual therapy, medication management, and multiple daily breathalyzer checks using facial recognition. The go…

This study tested whether a gentle brain stimulation technique called tDCS, combined with cognitive training, could improve thinking skills and reduce relapse in veterans with alcohol use disorder. 45 veterans received either real or sham tDCS during cognitive exercises. The goal…

This study tested whether certain drugs (NNC0194-0499, semaglutide, and cagrilintide) can reduce liver damage and alcohol use in people with alcohol-related liver disease. About 270 adults with a history of heavy drinking took part. Participants received different drug combinatio…

This early-stage trial tested a device called miroliverELAP, which uses a bioengineered liver graft to filter blood outside the body, in 10 adults with acute liver failure. The goal was to check safety and see if it can support the liver for up to 48 hours, giving time for recove…

This study tested two smartphone apps designed to reduce risky drinking and its effects during the COVID-19 pandemic. One app focused on the drinker, the other on their family partner. About 400 pairs (a drinker and a family member) joined the 12-month study. The goal was to see …

This study tested whether giving small rewards for attending treatment and providing negative alcohol tests helps people with alcohol use disorder stay sober. 74 adults in outpatient treatment were randomly assigned to standard care or standard care plus rewards. The goal was to …

This study tested a drug called GET73 in 79 people with moderate-to-severe alcohol use disorder who were not seeking treatment. Participants took GET73 or a placebo for 8 days and had MRI scans to see how their brains reacted to alcohol cues. The goal was to see if GET73 could re…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could help veterans with alcohol use disorder stay sober for six months. Forty-nine veterans who were already in treatment received either real or sham …

This study tested whether a technique called Episodic Future Thinking (EFT) — where people vividly imagine positive events in their future — could help reduce drinking in 154 adults with alcohol use disorder. Participants either practiced EFT or recalled past events (control), th…

This early-stage trial tested a new drug called DCR-AUD in 16 healthy adults who are social drinkers. The drug is designed to reduce the effects of alcohol by targeting the liver. The main goal was to check safety and how the body processes the drug, not to treat alcohol use diso…

This Phase 2 trial tested whether a naltrexone implant, placed under the skin, can help people with alcohol use disorder drink less heavily. 210 adults received either a low-dose, high-dose, or placebo implant, plus counseling. Researchers tracked heavy drinking days over 24 week…

This study tested a structured emotional regulation program for adults in residential rehab for substance use. The program combined techniques from behavior therapy, dialectical behavior therapy, and acceptance and commitment therapy over 11 weekly sessions. Researchers compared …

This study tested whether combining virtual reality mindfulness sessions with cognitive bike exercises could reduce the risk of relapse in people hospitalized for alcohol addiction. 135 patients were split into two groups: one received standard care, the other added six VR mindfu…

This study tested whether a gentle brain stimulation technique called tDCS could help people with alcohol disorder stay sober. 90 participants who had already stopped drinking received either real or fake tDCS sessions. Researchers then checked if the real stimulation helped them…

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This early-stage trial tested whether a one-time infusion of donor stem cells is safe for people with both alcohol use disorder and major depression. Thirty-one participants received either the stem cells or a placebo. The main goal was to check for serious side effects, like sui…

This study tested whether a non-invasive brain stimulation technique called deep TMS can help veterans with alcohol use disorder drink less or stay sober. Eight veterans in treatment received the therapy, and researchers checked their drinking habits 6 months later. The goal was …

This study tested whether semaglutide (Rybelsus), a drug used for diabetes, can help people with alcohol use disorder drink less. Fifty adults who wanted to cut down took either the drug or a placebo for 8 weeks. Researchers measured changes in alcohol cravings and daily drinking…

This study tested whether trained community health workers visiting pregnant women at home could improve health for both mothers and children in a rural area of South Africa. The program focused on supporting women with HIV, depression, or alcohol use, and on improving child grow…

This study looked at whether early liver transplantation can help people with severe alcoholic hepatitis who did not get better with medical treatment. Researchers compared alcohol relapse rates in 284 patients who received early transplants to those transplanted after a 6-month …

This study tested whether adding an antibiotic (amoxicillin-clavulanic acid) to the usual steroid treatment could improve survival in people with severe alcoholic hepatitis. About 300 adults at high risk of death within two months took part. The goal was to see if the antibiotic,…

This study tested whether semaglutide, a drug used for diabetes and weight loss, can safely reduce alcohol drinking in people with alcohol use disorder. 80 adults took either semaglutide or a placebo, and researchers tracked how much they drank over several weeks. The goal was to…

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This completed trial tested a digital health app (QG-A) that combines cognitive-behavioral therapy with the medication naltrexone to help adults with moderate to severe alcohol use disorder reduce their drinking. 242 participants were randomly assigned to either the app-based pro…

This study tested a stepped care system to help Congolese refugees and local community members in Zambia reduce unhealthy alcohol and drug use. The program started with a quick screening and brief advice, then offered more support if needed. 400 adults took part, and the main goa…

This early-phase study tested whether suvorexant (Belsomra), a sleep medication, can reduce stress sensitivity and heavy drinking in 81 adults with moderate to severe alcohol use disorder. Participants took either suvorexant or a placebo for 4 weeks, and researchers measured thei…

This study tested whether topiramate, a seizure medication, can help people who are dependent on both alcohol and nicotine. 236 adults received either a low or high dose of topiramate or a placebo, plus behavioral therapy. The goal was to see if the drug could reduce heavy drinki…

This study tested a phone-based program called MommyCheckup to see if it helps pregnant women who drink alcohol cut back or stop. The program includes a short motivational video and tailored text messages. Researchers enrolled 384 pregnant women across three states to see if the …

This study tested a smartphone-based program that uses rewards, coaching, and breathalyzer tests to help 236 adults with alcohol use disorder reduce drinking. Participants earned money for staying sober, tracked via breath tests and self-reports. The goal was to see if this digit…

This study tested a mindfulness program for 392 women in prison who have alcohol use disorder. The goal was to see if mindfulness training could reduce alcohol cravings, drinking, and criminal behavior after release. The program targets mental habits that often lead to relapse an…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This study tested whether the drug baclofen, typically used for muscle spasms, can help people with alcoholism reduce their drinking. Over 300 adults who wanted to cut back or quit took either baclofen or a placebo for a year. The main goal was to see if more people on baclofen a…

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This study tested a smartphone app designed to help people recovering from alcohol dependence avoid relapse. The app uses a training game to change unconscious habits that make people reach for alcohol. 600 participants used either the active training or a placebo version. The go…

This study tested a school-based program called Preventure in 3,900 Canadian teens. The program targets four personality traits linked to substance misuse, aiming to delay or prevent alcohol and drug use. Researchers also measured whether delaying substance use helps protect cogn…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

This study tested a culturally adapted mobile health program called Mobile CHOICES to help urban American Indian and Alaska Native young women (ages 16-20) avoid drinking alcohol during pregnancy. The goal was to reduce the risk of Fetal Alcohol Spectrum Disorders, which cause li…

This study tested a mobile program called Comunică to help Romanian gay and bisexual men reduce HIV risk and heavy drinking. 300 participants used their phones or laptops to complete surveys and eight one-hour sessions with a counselor or by reading health information. The progra…

This study tests a group program that combines mindfulness and art therapy for adolescents with a history of abuse. The program aims to improve how teens see their bodies and reduce feelings of shame. Participants attend sessions that include meditation, creative art activities, …

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This study tested a type of talk therapy called Behavioral Activation (BA) in 10 U.S. veterans who have both alcohol use disorder and PTSD. BA helps people change their daily activities and thinking to reduce drinking and PTSD symptoms. The study compared BA to another therapy ca…

This completed Phase 2 trial tested whether a drug called sunobinop can reduce alcohol cravings in people with moderate to severe alcohol use disorder who want treatment. Forty participants took either sunobinop or a placebo pill daily. Researchers measured cravings using questio…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested two brief, video-based therapies for women who experienced sexual assault and now struggle with PTSD and heavy drinking. One therapy focused on facing trauma memories, the other on building healthier drinking habits. The goal was to see if these short treatments…

This small pilot study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve cognitive flexibility in people recently detoxified from alcohol. Fourteen adults with alcohol use disorder received either re…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether a curcumin supplement (NatureU Cheers Friends Curcumin) could reduce hangover symptoms in 12 healthy adult men. Participants took either the curcumin or a standard hangover product before drinking alcohol, then reported their hangover severity the next m…

This pilot study tested whether people experiencing alcohol withdrawal can be safely treated at home using telemedicine. Thirty adults who wanted to quit drinking received remote monitoring and symptom-triggered medication over three days. The goal was to see if this approach kep…

This study tested two types of therapy for insomnia in 134 people also being treated for alcohol use disorder. The goal was to see if improving sleep could help them stay sober and feel better during the day. Participants received either a standard insomnia treatment or a tailore…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested whether a type of brainwave training called neurofeedback could help people with alcohol use disorder feel more confident about staying sober and improve mindfulness. Seventeen adults took part: some received 24 sessions of neurofeedback over 8 weeks, while othe…

This study tested a combination of a smartphone breathalyzer, a blood alcohol estimator app, and a brief counseling session to help young adults ages 18-25 drink more moderately. Twenty-four participants used the tools for two weeks while drinking. The goal was to see if the tech…

This study tested a 5-week behavioral therapy for women who experienced sexual assault and use alcohol. The therapy combines writing about the trauma with skills to manage alcohol cravings. Researchers measured changes in drinking habits and PTSD symptoms. The goal is to see if e…

This study tested an enhanced version of internet-delivered cognitive behaviour therapy (ICBT) for people who misuse alcohol. Researchers added real patient stories and optional resources for common issues like anxiety and depression. 205 adults from Saskatchewan took part, eithe…

This pilot study tested whether taking naltrexone only when needed can help people who want to reduce or stop drinking during Dry January. Nineteen adults who did not have severe alcohol problems took a 50mg pill before drinking or daily as a precaution. The study checked if this…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This study tested whether tailored online writing exercises could help sexual minority women, transgender, and nonbinary people who have experienced trauma. The goal was to reduce PTSD symptoms and heavy drinking. 131 participants completed the writing program and were followed f…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took part. The main goal was to see if the drug was well-tolerated and if partici…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study tested a behavioral program called IMPROVE to help college students who drink heavily and feel anxious. The program teaches skills to handle anxiety and uncertainty without turning to alcohol. Forty students took part, and researchers checked if the program was easy to…

This study tested whether real-time brain scans (fMRI) could help 21 adults with alcohol use disorder learn to control their cravings. Participants practiced shifting their brain activity toward future goals instead of alcohol. The goal was to see if this mental training could re…

This study tested whether a therapy called dialectical behavior therapy (DBT) is helpful and acceptable for teens aged 14–17 with fetal alcohol spectrum disorders (FASD). Nine teens and their caregivers took part in a program that included individual therapy, group skills trainin…

This study tested whether an online program for insomnia (called SHUTi) could help heavy drinkers reduce their alcohol use. 113 adults who drank heavily and had trouble sleeping took part. The goal was to see if improving sleep would also lead to less drinking and fewer binge epi…

This study tested a mobile health app designed to help young adults aged 18-25 reduce heavy drinking. 40 participants were randomly assigned to use the app or just complete surveys. Over 4 weeks, they received text message surveys to track drinking and engagement. The goal was to…

This study tested a mindfulness-based treatment (MBRP) combined with cognitive behavioral therapy to help people reduce alcohol use and quit smoking. 67 adults who smoked and drank heavily participated. The goal was to see if the program was practical and satisfying for patients,…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tested a smartphone app called FMF Connect for parents and caregivers of children with fetal alcohol spectrum disorders (FASD). The app provides helpful information and peer support to manage children's behavior. 129 parents participated, and researchers measured chang…

This study tested an 8-week cognitive training program delivered via telehealth for veterans recovering from alcohol use disorder. The goal was to see if the program was feasible and acceptable to participants. Nineteen veterans took part, and the study focused on recruitment, re…

This study tested a program called "Choizitaconso" that teaches people with alcohol use disorder how to control their drinking and reduce harm. About 110 adults took part, learning skills to manage their alcohol use and avoid negative consequences. The goal was to see if the prog…

This study tested a new web-based tool called LDART that provides daily social support to people who drink heavily and want to cut down. Each night, users set a goal for the next day and check in the following night to see if they met it, receiving encouraging messages from the r…

This pilot study tested whether a daily dose of EGCG, a natural compound found in green tea, could improve cognitive performance in 36 children aged 7 to 14 with fetal alcohol syndrome. The children took EGCG for one year and had their thinking skills measured at the start, at 6 …

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study used brain scans to see if heavy drinking causes inflammation in the brain and how that affects memory and thinking. 74 adults aged 30-75, including heavy drinkers and healthy volunteers, had PET and MRI scans along with thinking tests. The goal was to measure brain in…

This study looked at how sleep quality and beliefs about sleep affect the risk of relapse in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home, measuring sleep with questionnaires and activity monitors. The g…

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

Sleep problems affect up to 90% of people with alcohol dependence and often lead to relapse. This study tests whether a short questionnaire called the Short Sleep Index (SSI) can reliably measure sleep quality compared to a longer, standard sleep questionnaire. Researchers will a…

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study tested a brief digital alcohol intervention for smokers who drink heavily. Participants enrolling in a smoking cessation program through an online portal were offered the intervention if they scored high on a drinking questionnaire. The main goal was to see how many pe…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This study looked at whether combining two existing drugs—duloxetine (an antidepressant) and methylphenidate (an ADHD medication)—could reduce the desire to drink alcohol in people with alcohol use disorder. Nineteen adults who were not seeking treatment participated in a lab set…

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This study combined brain imaging with real-world data from mobile devices to explore how addiction affects the brain. Researchers scanned the brains of 107 people with alcohol, cannabis, or nicotine dependence, along with healthy controls. They also tracked cravings and daily fu…

This completed study followed 1,681 people with steatotic liver disease (fatty liver) in Germany to observe how the condition progresses over time. Researchers measured liver stiffness, inflammation, and tracked whether participants developed heart problems or tumors. The goal wa…

This study looked at how Alcoholics Anonymous (AA) helps people with alcohol use disorder reduce their drinking. Researchers tracked 192 adults daily for six months to see which AA activities—like building social support or spiritual practices—led to fewer drinking days. The goal…

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This observational study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in people who regularly use both alcohol and cannabis. 77 heavy drinkers who also smoke cannabis took part, providing blood and stool samples and completing…

This study tested whether hands-on training could help people convicted of driving under the influence (DUI) better understand the risks of drinking alcohol. A total of 112 participants took part. The goal was to see if this training could reduce binge drinking and cravings.

This study tested a smartphone app called CampusGANDR that uses a game about college life to give students personalized feedback on their drinking habits. Over 1,100 first-year college students in California and Texas played the game for 12 weeks. Researchers measured changes in …

This study looks at how alcohol use disorder (AUD) might reorganize the way the brain links words and ideas. Researchers will compare 30 AUD patients and 30 healthy controls using word-association tasks and brain tests. The goal is to see if these mental patterns can help predict…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity and tested whether a technique called neurofeedback could help people control their cravings. The stu…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study tested whether a coaching program for primary care doctors at one VA clinic could improve care for veterans with unhealthy alcohol use. The program aimed to help doctors offer more counseling, medications, and referrals to specialty treatment. Researchers tracked chang…

This study looked at whether a simple slow-breathing exercise can help binge drinkers control their reactions to alcohol-related images and improve their ability to say no. One hundred binge drinkers completed tasks measuring brain activity and attention after either slow breathi…

This study tested a mobile app called WisePath designed to help adults who are thinking about suicide and may also misuse alcohol. Over 12 weeks, 127 participants either used the WisePath app or received standard self-help resources. Researchers measured changes in suicidal thoug…

This study looked at 10,000 older adults (age 60+) with fatty liver disease to find out what increases their risk for serious liver problems like scarring, cirrhosis, or liver cancer. Researchers used medical records and yearly check-ups to build a computer model that predicts th…

This study looked at how consistent FibroScan, a non-invasive device that measures liver stiffness and fat, is when used by different operators on different days. 108 adults with fatty liver or alcohol-related liver disease had multiple scans and blood tests over two visits. The …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study explores the link between gut bacteria and alcohol use disorder (AUD). Researchers compared gut microbiota in three groups: current heavy drinkers with AUD, people with AUD who have been abstinent for at least 4 weeks, and healthy moderate drinkers. Participants provid…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This study looked at 385 adults diagnosed with their first lung or head & neck cancer to see how many continued using tobacco or alcohol over the next year. Researchers tracked smoking and drinking habits, as well as how long patients lived without the cancer getting worse. The g…

This study looked at how negative emotions and stress influence alcohol use in 81 women veterans, including those with PTSD. Researchers measured cravings, heart rate, and drinking patterns, and also examined how these effects change across the menstrual cycle. The goal was to be…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This completed study in Slovakia examined how psychological factors like resilience, stress, and positive thinking relate to the body's immune system. Researchers measured immune markers in blood and compared them to mental health questionnaires in 700 adults, including people in…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …

This completed study looked at 574 hospitalized adults with end-stage liver disease to see if alcoholic patients had the same chance of getting on the national liver transplant waiting list as non-alcoholic patients. The goal was to find out if non-medical reasons limit access fo…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This study looked at whether a single dose of methylphenidate (Ritalin) changes how people with both ADHD and alcohol use disorder respond to alcohol-related cues. Thirty-one adults aged 18-25 completed brain scans, EEG, and behavioral tests after taking either the drug or a plac…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study tested a Spanish-language electronic screening tool called TAPS-ESP to identify tobacco, alcohol, prescription drug, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic participated. The goal was to see if the tool accurately de…

This study looked at 125 young adults aged 18-25 to understand what makes someone more likely to binge drink. Researchers used brain scans, genetic tests, and thinking skill assessments to find patterns. The goal is to identify risk factors and improve prevention efforts.

This study looked at over 5,000 adults in Zambia to find out how many have hepatitis B and how many need treatment. Researchers tested people in their homes and then did more tests on those who tested positive. The goal was to gather information, not to test a new treatment or cu…

This completed study looked at how thinking skills (like flexibility and self-control) and social understanding (like reading emotions) are connected to alcohol use disorder. Researchers tested 216 people using puzzles, eye-tracking, and brain scans. The goal was to find early wa…

This study looked at 188 children (ages 0-18) with Fetal Alcohol Spectrum Disorders (FASD) in Reunion Island to better describe the condition and find a unique "epigenetic signature" in their DNA. Researchers collected blood and cheek swabs from a small group of children with FAS…

This study looked at whether a strong sense of 'presence' during virtual reality therapy could help people with alcohol dependence manage cravings and avoid relapse. Sixty abstinent patients who had recently completed withdrawal treatment took part. Researchers measured craving l…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This study tested a program called SLAC that helps Veterans who drink heavily and have mental health issues like PTSD or depression get connected to alcohol care. 140 Veterans from VA primary care took part. The goal was to see if the program is practical and liked by Veterans an…

This study looked at how a person's genes might change the way they think and act after drinking alcohol. Nine healthy adults completed tasks measuring aggression after consuming alcohol or a placebo. The goal was to better understand why some people react differently to alcohol,…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This completed study looked at whether fragments from gut bacteria (called peptidoglycans) are linked to alcohol-related liver disease. 40 participants with liver cirrhosis provided stool samples to measure these fragments. The goal was to see if these fragments could be used as …

This study looked at whether thinking about financial scarcity changes how people with alcohol use disorder value alcohol and make decisions. 124 adults who wanted to cut down on drinking listened to either a story about scarcity or a neutral story. Researchers then measured thei…

This study looked at whether adults with ADHD are more likely to relapse into drinking after completing a detox program. Researchers followed 113 people for 12 weeks, using interviews and questionnaires to assess ADHD and other mental health conditions. The goal was to see if ADH…

This study looked at how young adults with bipolar disorder respond to alcohol compared to healthy people. Sixty participants aged 21-26 completed brain scans and surveys after drinking alcohol or a placebo. The goal was to understand differences in brain activity and feelings of…

This study compared two simple questionnaires—the MoCA and the BEARNI—to see which one better detects cognitive problems in people with alcohol use disorder. Researchers tested 90 patients and compared the results against a full set of standard neuropsychological tests. The goal …

This study tested whether showing people in early recovery from alcohol use disorder personalized, high-intensity images of future events could help them think more about long-term rewards and increase their interest in treatment. Fifty-eight participants were split into two grou…

This study looked at how two brain networks—one that controls impulses and one that reacts to alcohol cues—interact in people with alcohol use disorder. Using a powerful 7 Tesla MRI scanner, researchers compared 59 participants (patients and healthy controls) to see if a stronger…

This study tested two programs—one focused on sexual communication and consent, the other on reducing alcohol misuse—among over 2,000 U.S. Air Force Academy cadets. Cadets received one or both programs, and researchers tracked self-reported sexual assault experiences and alcohol …

This study looked at whether a blood test called carbohydrate deficient transferrin (CDT) can better detect long-term alcohol abuse in people aged 60 and older compared to standard methods. Researchers enrolled 194 older adults in France and compared CDT results with a common que…

This study looked at how drinking alcohol and using high-THC cannabis concentrates together affects people. 146 heavy drinkers who also use cannabis regularly took part. Researchers measured things like blood alcohol level, heart rate, and how impaired they felt, depending on whe…

This study looked at how accurately patients with alcohol intoxication in the emergency department estimate their own blood alcohol concentration (BAC) compared to a real blood test. Researchers enrolled 34 adults aged 15-64 with a BAC of 60 mg/dL or higher. The goal was to see i…

This study tested whether using electronic health records and support staff could help more people with alcohol use disorder get the care they need. Researchers looked at how often patients started and stayed in treatment when their doctors had extra reminders and help. The goal …

This study looked at 488 adults with alcohol use disorder who had suicidal thoughts or attempts. Researchers wanted to understand why some people call the National Suicide Prevention Lifeline during a crisis and others don't. They also tested if a therapy session about the hotlin…

This study tested whether a bacterial toxin called endotoxin can increase alcohol consumption in people with alcohol use disorder. 27 participants received either endotoxin or a placebo, and their alcohol intake was measured during a 2-hour session. The goal was to gather early d…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This study looked at whether using a Fitbit activity tracker can help people receiving inpatient treatment for alcohol use disorder increase their physical activity and improve their emotional state. Ninety adults in treatment wore the tracker and completed questionnaires about t…

This completed study looked at how living in rural areas and drinking alcohol might make people more likely to use tobacco products or less likely to quit. Researchers asked 737 adults about their hypothetical choices in a simulated tobacco marketplace. The goal was to understand…

This study used brain imaging (fMRI) to see how heavy drinkers' brains respond to pictures of alcohol versus non-alcoholic drinks. 72 non-treatment-seeking heavy drinkers made hypothetical decisions about buying alcohol at different prices while in the scanner. The goal was to un…