Alcohol-related disorders

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will receive either a high or low dose of psilocybin du…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a natural molecule called oleoylethanolamide (OEA) can reduce inflammation, improve thinking, and lower alcohol use in young adults aged 18–25 with alcohol use disorder. Participants will take OEA or a placebo daily for 6 weeks and provide blood, saliva, …

This trial tests whether simple reminders—sent to patients' phones and to their care teams—can increase the use of alcohol screening and brief counseling (SBIRT) during cancer care. About 315 adults with cancer across four clinics will take part, with some clinics using the remin…

This trial tests a program called ROOTS that places substance use counselors and peer recovery specialists directly in rural schools. The goal is to see if this approach helps teens who are referred or seek help on their own to engage in treatment and reduce their substance use. …

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This trial tests whether adding a relational health enhanced parenting support (RHEP) program to standard family-focused peer recovery services helps parents with substance use disorders. The study compares outcomes like parenting satisfaction, treatment retention, and substance …

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This trial tests whether pregnenolone, a natural hormone, can help adults with both alcohol use disorder and major depression. Participants take either pregnenolone or a placebo for 12 weeks, while researchers track drinking, cravings, and mood. Brain scans will also look at how …

This study looks at whether adding a recovery coach and an online sober community can help people who have had a liver transplant stay away from alcohol. About 40 adults who received a liver transplant in the last 5 years and have a history of alcohol use disorder will take part.…

This trial tests whether a six-week body-focused mindfulness program can help people with alcohol use disorder feel more connected to their bodies, manage emotions better, and reduce alcohol cravings. Participants in inpatient treatment will either take part in mindfulness sessio…

This study tests whether a program called CourtConnect, where peer recovery specialists meet with people in courthouses, can increase substance use disorder treatment and reduce overdose and incarceration. The program provides information, referrals, and up to three months of fol…

This trial tests whether the sleep medication daridorexant can help people with alcohol use disorder and insomnia drink less. Participants take either daridorexant or a placebo nightly for 12 weeks, along with brief counseling. The study tracks alcohol use through self-reports an…

This pilot study investigates whether adding Dialectical Behavior Therapy (DBT)-informed principles to standard short-term inpatient substance abuse treatment helps patients better manage emotions and reduce symptoms. About 70 adults in a 12-week program will either receive usual…

This Phase 2 trial at Johns Hopkins will test whether combining semaglutide (a GLP-1 drug used for diabetes) with naltrexone (a medication for alcohol dependence) is safe and helps reduce alcohol use. About 45 adults with alcohol use disorder will take the combination or a placeb…

This study tests a new eight-session group therapy program for adults hospitalized with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and behavioral activation to help participants manage cravings and develop alternati…

This trial investigates whether cognitive cycling—a series of structured mental exercises—can help prevent relapse in adults with alcohol use disorder after they complete alcohol withdrawal. Participants are randomly assigned to receive either 12 cognitive cycling sessions over f…

This study tests whether nimodipine, a blood pressure medication, can reduce alcohol consumption and craving in adults with Alcohol Use Disorder who are heavy drinkers. Participants receive nimodipine or a placebo over 18 hours, then take part in a controlled drinking session whe…

This study tests whether peer support specialists—people who have been through liver transplant for alcohol-related disease themselves—can help others in the same situation stay sober and attend medical appointments. About 95 participants will meet regularly with a peer supporter…

This trial tests a culturally adapted program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) for trauma patients who drink alcohol. Emergency department staff in Cameroon will screen patients for risky drinking, offer a short motivational counseling sessi…

This phase 2 trial tests whether a high-protein diet (30% protein, 40% carbs, 30% fat) can reduce liver fat and improve liver function in 72 adults with alcoholic fatty liver disease. Participants will be randomly assigned to either the high-protein diet or a standard diet for 6 …

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This trial tests whether an AI chatbot called MICA, combined with weekly text reminders, can help emergency department patients reduce risky alcohol use. About 750 adults who report heavy drinking will be randomly assigned to use MICA or receive usual care. The study tracks how m…

This pilot study tests a program called Kisoboka Amaka for men living with HIV who drink heavily and have pregnant partners. The program combines counseling, financial training, and mobile savings to help men drink less and take their HIV medication consistently. Researchers will…

This study will test a Spanish-language program called Healthy Choices for 45 young adults (ages 18-29) living with HIV in the Dominican Republic who also struggle with alcohol use and stigma. The program is designed to help them better manage their health and reduce the impact o…

This study tests whether giving hospitalized heavy drinkers a liver stiffness scan and personalized alcohol counseling can reduce future emergency hospital visits. 500 adults at risk of alcohol-related liver disease will be randomly assigned to get this extra support or usual car…

This study looks at whether adding a mobile app to a nurse-led counseling program helps men with alcohol use disorder stay sober longer. About 74 men aged 18-59 who own an Android phone will take part. The goal is to see if the app reduces relapse rates over three months compared…

This study tests a digital pill system that tracks when people with alcohol-related liver disease take their medication (acamprosate) and provides personalized support to help them stay on track. The system includes a sensor in the pill, a wearable patch, and a smartphone app wit…

This phase II trial tests whether a palm-derived form of vitamin E (tocotrienol) can improve liver health in adults with alcoholic fatty liver disease. 26 participants will take either the supplement or a placebo for six months, with regular blood tests and liver scans to track c…

This trial tests a coordinated care program called CCAP for men with alcohol problems in primary care centers in Goa, India. The program includes mobile messages for mild cases, counseling for moderate cases, and home detoxification for severe cases. Over 1,000 participants will …

This study tests whether daridorexant, a drug used for insomnia, can reduce alcohol cravings and drinking while improving sleep in people with alcohol use disorder and sleep problems. About 150 adults will receive either daridorexant or a placebo for several weeks. The goal is to…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) aimed at the amygdala, a brain region linked to cravings. Researchers will enroll 60 adults with alcohol use disorder to see if tTIS can reduce alcohol craving…

This study tests whether giving financial rewards based on a blood test can help people with alcohol-related liver disease stop or reduce drinking. The blood test detects alcohol use over the past month. 90 adults will be randomly assigned to either a rewards group that gets esca…

This study tests whether repeated sessions of a gentle brain stimulation technique called tDCS can help people with alcohol use disorder drink less. Over 12 weeks, 312 participants will receive either real or sham tDCS in 5-day clusters each month. The goal is to see if this appr…

This Phase 3 trial tests a naltrexone implant placed under the skin to help people with moderate to severe alcohol use disorder drink less. About 240 adults will receive either the implant or a placebo, plus counseling. Researchers will track heavy drinking days over 24 weeks to …

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce liver fat in people with alcohol-related fatty liver disease (MetALD). 105 participants will receive either personalized rTMS, standard rTMS, or a sham (placebo) treatment over 20 sessions.…

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days, alongside standard care, can improve alcohol withdrawal in adults aged 19-65 with alcohol use disorder. The goal is to reduce gut permeability and support recovery. Participants will provide b…

This study tests whether a weekly injection of tirzepatide (a diabetes drug) plus cognitive-behavioral therapy can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking days. 46 participants will receive either the drug or a placebo shot for 8 week…

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

This pilot study will test whether a high-intensity brain stimulation device can help people with alcohol use disorder reduce their cravings and drinking. Eighteen adults will receive 20 sessions of stimulation over 10 days. Researchers will measure changes in cravings, drinking …

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study looks at whether measuring a protein called TREM-1 in liver tissue can help doctors better predict how patients with severe alcoholic hepatitis will do. Researchers will compare TREM-1 levels in 300 people—half with alcoholic hepatitis and half with other liver disease…

This trial tests whether giving students accurate information about their peers' actual behavior can reduce heavy drinking and risky sexual activity. About 1,350 adolescents in three Ugandan schools will complete surveys and receive personalized feedback comparing their own estim…

This trial tests a digital app that coaches parents of 5th and 6th graders on how to discourage underage alcohol use. Many parents allow sips, which raises the risk of serious problems later. The study involves 4,000 parent-child pairs and measures teen drinking over time.

This study tests LaunchPad, an online program designed to help high school seniors avoid drug and alcohol problems as they leave school. Researchers will randomly assign 5,000 students to different lessons and measure changes in their attitudes, confidence, and intentions around …

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests whether internet-based programs can prevent alcohol use disorders in people who are not currently seeking help. About 3,500 adults with risky drinking habits will be randomly assigned to receive online brief advice, unguided online therapy, or guided online thera…

This study tests if a phone-based therapy called Acceptance and Commitment Therapy (ACT) can help young adults aged 18-35 who drink heavily to quit or reduce alcohol use. Participants will receive weekly phone sessions for 6 weeks and track their drinking. The study compares ACT …

This trial tests whether Snoezelen therapy—a calming, multisensory experience using lights, sounds, and textures—can improve health in adults with schizophrenia (including those needing institutional care) and women with alcohol dependence. Participants will attend 30-minute sess…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This pilot study tests a short brain training program called EEG neurofeedback in adults with alcohol use disorder. Over about one week, participants complete three sessions where scalp sensors record brain activity and provide real-time feedback to help them lower alpha brain wa…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This pilot study tests a culturally adapted empowerment self-defense program for Indigenous women (including American Indian, Alaska Native, and Two Spirit individuals) who have experienced sexual violence and currently have moderate to severe depression or PTSD. The program teac…

This study tests a mindfulness program designed to help sexual assault survivors reduce alcohol misuse and tobacco use. Researchers will enroll 120 college students aged 18-24 who have experienced sexual violence and drank alcohol recently. Participants will take online surveys a…

This study tests a new 8-session group program designed to help people with substance use disorder better understand and regulate their emotions. About 20 adults receiving inpatient care at two hospitals in Korea will take part. The program combines motivational interviewing and …

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce alcohol withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study looks at whether a nutritional ketone supplement can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then u…

This study tests whether taking cannabidiol (CBD) every night for four weeks can improve sleep quality and reduce alcohol cravings and use. Fifty-eight adults with poor sleep and hazardous drinking will take either CBD or a placebo. Participants will wear activity monitors, compl…

This study looks at whether a 6-week program that combines problem-solving therapy with small rewards can help new mothers feel less depressed and drink less alcohol. About 30 mothers who gave birth in the last year will take part. Half will get the program, and the other half wi…

This study explores whether listening to music can help young adults (ages 18-35) manage stress during their first year of recovery from alcohol use disorder. Researchers will use a smartphone app and a wearable device to detect stress in real time and suggest calming music. The …

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether hypnosis and self-exercises can help people with moderate to severe alcohol addiction control their drinking. About 98 outpatients will be split into two groups to compare the hypnosis-based approach with standard care. The main goal is to see how quickly…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study tests a new tool called SIM-AiR that helps teens (ages 12-19) with alcohol use disorder visually map their social identities and networks. The goal is to support lasting recovery by addressing social risk and protective factors. Researchers will ask teens and their cli…

This study is testing a short behavioral treatment for women veterans who drink too much. The treatment involves 4 to 6 sessions with a behavioral health provider in a primary care clinic. Researchers want to see if it is practical, acceptable, and helps reduce alcohol use and im…

This study tests a 10-week cognitive remediation program for people with alcohol use disorder who are recently sober. The program includes group and individual brain exercises to improve thinking skills and self-confidence. Researchers will measure changes in general self-efficac…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The…

This early-stage study tests a brief couples therapy for 80 Veterans with PTSD and alcohol use disorder. Veterans receive individual treatment while attending 3-4 sessions with their romantic partner. The goal is to see if involving loved ones improves treatment satisfaction and …

This pilot study will test a new type of talk therapy called ACT-SHARE for veterans who have both PTSD and alcohol problems and are struggling with conflict in their romantic relationships. The therapy aims to help veterans manage difficult thoughts and feelings and take actions …

This pilot study tests whether a short, peer-led counseling session can reduce binge drinking among university students in Romania. About 120 students who drink heavily will receive either a 15-20 minute motivational interview from a trained peer or no intervention. Researchers w…

This study tests whether adding neuromuscular electrical stimulation (NMES) to resistance exercises can improve muscle strength and physical performance in hospitalized patients with alcoholic liver cirrhosis who have muscle loss (sarcopenia). About 112 participants aged 47–70 wi…

This study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study tests a web-based program for people who are worried about their romantic partner's drinking. The program teaches skills like self-care and positive communication. Researchers will first study 50 couples to understand daily patterns, then develop the program with 15 pa…

This study looks at whether adding alcohol-related smells to virtual reality scenes makes people with alcohol use disorder feel stronger cravings. Sixty participants will experience different combinations of visual scenes (neutral or alcohol-related) and smells (none or alcohol).…

This study looks at adults in Dorset who visit urgent or emergency care five or more times a year. Researchers will interview patients, carers, and healthcare workers, and analyze data to understand their needs. The goal is to work with the community to design a prevention model …

This study aims to improve a short motivational conversation to help young adults (ages 18-25) who were injured in an assault and also misuse alcohol or cannabis. Researchers will interview and survey 50 participants from a hospital violence intervention program to understand how…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study aims to validate a virtual reality version of the Multiple Errands Test for assessing executive functions in people with alcohol use disorder. Ninety participants will complete both a real-world and a virtual supermarket task, along with other cognitive tests. The goal…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study will interview clinical staff and review patient data from an NHS alcohol care service in North West England. Researchers want to understand how acceptable the psychosocial interventions are to staff and what social or economic factors affect whether patients engage wi…

This study aims to understand how inflammation in the body influences mood and alcohol cravings in people with alcohol use disorder (AUD). Researchers will give 64 participants (32 with AUD and 32 without) a single low dose of a substance that causes temporary inflammation or a p…

This study looks at whether sharing results from a blood test that shows recent alcohol use can help people with HIV drink less. Researchers will enroll 80 people in Uganda who drink heavily. Half will get standard counseling plus their blood test results, and half will get couns…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study compares 200 people with alcohol use disorder to healthy volunteers using questionnaires that measure psychological processes and emotional symptoms like depression and anxiety. The goal is to identify differences in how people think and cope. It is purely observationa…

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This pilot study will test whether it is possible to run a larger trial comparing two ways to help people with alcohol use disorder. Sixty participants will either be invited to meet a therapist at the hospital for up to 10 sessions over 6 months, or receive guidance on finding a…

This study aims to adapt a proven suicide prevention program for people with alcohol use disorder in Tanzania, where mental health resources are scarce. Researchers will enroll 30 adults who drink heavily and have had recent suicidal thoughts, then test whether the telehealth int…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the ability to adapt in people with alcohol use disorder. Thirty participants will complete a computer task and questionnaires in one 45-minute session. No medication or treatment is in…

This study tests whether a mobile app-based program called mSTARS is practical and well-liked by adults who drink heavily and have recently been hospitalized for suicidal thoughts or behaviors. Thirty-five participants will be randomly assigned to the app, standard care, or stand…

This study looks at whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can be used in hospitals to help teenagers with chronic medical conditions who may be misusing alcohol. Researchers will work with hospital staff, teens, and parents to a…

This study looks at whether a single dose of methylphenidate (Ritalin) changes how the brain responds to alcohol-related images in young adults aged 18-25 with alcohol use disorder. Participants will have brain scans and complete tasks after taking either the drug or a placebo. T…

This study will test if a smart chatbot can help young adults (ages 18-29) who drink heavily to cut back. The chatbot will have personalized conversations to encourage healthier drinking habits. The main goal is to see if young adults find the chatbot easy and helpful to use, not…