Alcohol-related disorders

This phase 2 trial tested whether cannabidiol (CBD), a non-psychoactive compound from cannabis, could help people with alcohol use disorder reduce their drinking. The study also looked at whether CBD could protect the brain and liver from alcohol's harmful effects. Only 10 people…

This study tested a drug called INT-787 in 67 people with severe alcohol-associated hepatitis, a serious liver condition. The trial was a phase 2a proof-of-concept study, but it was terminated early. Researchers were looking at safety, how well the drug works, and how the body pr…

This study tested whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) could help people with alcohol use disorder reduce cravings and risky behavior during inpatient treatment. Only 2 people were enrolled before the trial was stopped early. The …

This phase 2 study tested a drug called TMP-301 in 110 adults with alcohol use disorder to see if it is safe and helps reduce drinking. Participants took TMP-301 or a placebo daily for 14 weeks. The trial was terminated early, so we don't have clear results on whether the drug wo…

This study tested a drug called acamprosate in adults with alcohol dependence who were part of a DUI court program. The goal was to see if the medication could help them stay sober and reduce cravings. Only 4 people enrolled before the study was stopped, so results are very limit…

This small, early-phase study tested whether the heart medication digoxin could reduce inflammation in people with severe alcohol-associated hepatitis. 23 participants were randomly assigned to receive intravenous digoxin or no digoxin for up to 28 days. The trial was terminated …

This study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This study tested a small device worn on the ear that uses mild electrical pulses to help control pain after a liver transplant. The goal was to see if it could reduce the need for strong painkillers like opioids. The study was stopped early and included 27 adults waiting for a l…

This study tested whether a specially designed video game could reduce alcohol-related problems like hangovers, blackouts, and risky sex in LGBTQ+ teens aged 14-18. The game was meant to teach safer drinking habits. The study was stopped early and only 28 people took part, so res…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…

This study looked at how being exposed to alcohol before birth might affect adults' ability to read emotions and make decisions. Researchers planned to compare adults with prenatal alcohol exposure to those without, using computer tasks. The study was terminated early and only en…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study tracked 239 adults in France taking baclofen for alcohol use disorder. Researchers called participants monthly for a year to see how many stopped the drug due to side effects. The goal was to better understand which side effects are caused by baclofen versus other fact…