Alcohol-related disorders

This phase 2 trial tests whether zonisamide, a drug currently used for seizures, can help adults with alcohol use disorder drink less. About 205 treatment-seeking participants will receive either zonisamide or a placebo, along with standard support. The study measures alcohol con…

This study tests a telehealth program called the Ria Treatment Platform for people with alcohol use disorder. Participants receive medication, coaching, educational videos, and a Bluetooth breathalyzer through their phone. The goal is to see if this approach helps reduce heavy dr…

This study tests whether a lifestyle physical activity program, supported by a Fitbit and phone counseling, can help women with depression who are in alcohol treatment reduce their risk of relapse. Participants are randomly assigned to either receive the full program or just a Fi…

This phase 2 trial tests whether mazdutide, a drug given as a shot, can help people with alcohol use disorder drink less. About 308 participants will receive either mazdutide or a placebo for up to 36 weeks. The study measures changes in drinking behaviors using a standard questi…

This study aimed to see if asking people to put down a deposit (between $30 and $100) that they could earn back by meeting their drinking goals would help them drink less. Participants would wear a remote alcohol monitor to track their drinking. The study was withdrawn before any…

This study tests whether a personalized addiction monitoring program helps liver transplant patients avoid serious alcohol relapse one year after surgery. Researchers will follow 64 adults who are being evaluated for a liver transplant at a French hospital. The program includes m…

This study tests whether citicoline, an over-the-counter supplement, can help young people ages 16 to 22 with alcohol use disorder. Over 4 weeks, participants receive either citicoline or a placebo. Researchers measure changes in immune markers, brain chemistry, and thinking skil…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This small pilot study tested whether propranolol, a beta blocker usually used for high blood pressure, can reduce alcohol drinking triggered by stress. Twenty adults with alcohol use disorder were randomly assigned to take propranolol or a placebo for about two weeks, then compl…

This study tests a program called Just Care for Families, designed to help parents in rural Oregon who are involved with child welfare services and struggle with opioid or methamphetamine use. The program combines substance use treatment, mental health support, parenting training…

This study tests whether ibudilast, an anti-inflammatory drug used in Japan, can help people with alcohol use disorder drink less. Fifty adults will take either ibudilast or a placebo for 6 weeks, plus counseling. The main goal is to see if it reduces the number of heavy drinking…

This study tests whether starting alcohol use disorder treatment while still in the hospital helps people stay in treatment and drink less after they go home. 450 adults with moderate to severe alcohol problems will receive either a brief counseling session alone, or that session…

This study is testing a specially adapted form of talk therapy for transgender and nonbinary people who have alcohol use disorder. The therapy, based on interpersonal psychotherapy, is designed to address unique life experiences that may affect drinking. The study will enroll 30 …

This study tests if a mobile app called Stand Down, with or without extra support from a peer specialist over the phone, can help Veterans who drink heavily cut back. About 234 Veterans who screened positive for hazardous drinking and own a smartphone are taking part. The goal is…

This study was designed to see if hyperbaric oxygen therapy or computerized cognitive training could help adults with Fetal Alcohol Spectrum Disorder (FASD) think and function better. It planned to enroll 0 participants and was withdrawn before starting, so no results are availab…

This study tests a guided internet-based treatment program called eBA for people with harmful alcohol use. Participants complete 9 online modules over 8-12 weeks, with therapist support. The goal is to see if the program reduces drinking and improves mental health and quality of …

This study tests a program called Khanya, where trained peers (people with lived substance use experience) help HIV patients stick to their medication and reduce drug or alcohol use. The program is offered in steps: a basic version first, then a more intensive one if needed. Rese…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people with HIV reduce unhealthy alcohol use and improve their overall health. About 308 participants in Alabama will receive either the combined program or b…

This study tests whether a collaborative care model—where a nurse care manager works with your primary care doctor and an addiction specialist—can help adults reduce their use of opioids, stimulants (like cocaine or meth), and heavy drinking. About 300 patients from primary care …

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This pilot study tests a web-based program called Let's Do Addiction Recovery Together! (LDART) for adults with alcohol use disorder. Participants use the website to set daily goals, watch motivational messages from people in recovery, and find local support groups. The study wil…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This study tests whether combining online sessions with in-person therapy helps people with alcohol use disorder stay in treatment longer and drink less. About 1800 adults seeking public alcohol treatment in Denmark will take part. The goal is to see if this blended approach work…

This study tests a behavioral program called contingency management for people who have had a liver transplant due to alcohol-related liver disease and have started drinking again. Participants get rewards like gift cards for staying alcohol-free, measured by urine and blood test…

This pilot study tests whether giving the smoking-cessation drug varenicline to people with HIV who also have alcohol use disorder is practical and safe. Thirty participants will receive the medication along with support from a pharmacist and psychiatrist. The goal is to see if t…

This study tests new technology-driven programs to help people with alcohol use disorder manage their drinking and well-being. The programs focus on personal goals and healthy behaviors. Researchers will see if these virtual tools help people start and stick with treatment and re…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve daily functioning in 100 veterans who have both alcohol use disorder and a history of mild traumatic brain injury. Researchers will identify a specific brain target and then stimulate it w…

This study tests whether giving small monetary rewards for sober breathalyzer readings, collected remotely via a smartphone app, helps people with alcohol use disorder stay abstinent after completing detox. About 91 participants will use the app and breathalyzer at home, and rese…

This study tests whether giving people with alcohol use disorder monetary rewards for submitting breathalyzer tests that show no alcohol can help them stay abstinent. Participants use a smartphone app and a breathalyzer at home. The goal is to see if this remote approach works as…

This early-phase study tests whether a type of brain stimulation called rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Participants receive 50 sessions of stimulation over one week. Researchers will measure changes in thi…

This study tests whether a brain stimulation technique called deep rTMS can help people with alcohol use disorder drink less. Participants receive either real or sham rTMS over 3 weeks while staying in the hospital. Researchers measure changes in alcohol self-administration and c…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with both major depression and alcohol use disorder. Researchers at Johns Hopkins will give 90 adults either psilocybin or a placebo and track changes in mood and drinking habits. The g…

This study tests whether a personalized program—including patient navigation, individual health benefits, and financial help—can reduce deaths from preventable causes like heart attacks, strokes, heavy drinking, and HIV in low-income adults aged 35–64. Researchers will track chan…

This study compares two ways to treat alcohol use disorder in Black adults: a computer-based therapy offered in a Black church versus traditional care at a specialty clinic. Researchers want to see which setting gets more people to start and stay in treatment, and leads to more d…

This early-stage study tests whether a drug called apremilast can help people with Alcohol Use Disorder drink less alcohol. Ten adults will take the medicine and then have their drinking measured in a lab setting. The goal is to see if the drug reduces alcohol consumption, especi…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests a program for couples to help adolescent girls and young women (ages 15-24) living with HIV in Uganda stay engaged in their HIV care. The approach works with male partners to reduce heavy drinking and intimate partner violence, which often interfere with women ta…

This study tests whether online mindfulness-based relapse prevention (MBRP) helps people with alcohol use disorder maintain long-term recovery. About 470 adults who recently sought treatment or tried to cut back on drinking will either join MBRP video groups or be referred to onl…

This pilot study tests whether a single dose of psilocybin or ketamine, combined with psychotherapy, can help men with moderate to severe alcohol use disorder drink less. Twenty men aged 25-65 will receive one of the two drugs and be followed for changes in drinking habits and br…

This study tests a weekly injection called pemvidutide to see if it can reduce heavy drinking in adults with alcohol use disorder who are also overweight or obese. About 100 participants will receive either the drug or a placebo for 24 weeks. The main goal is to measure the chang…

This study tests a single 75-minute counseling session called CAMI, which is a motivational interview adapted for Latino/a immigrants who drink heavily. Researchers will train community health workers to deliver CAMI at a primary care clinic and follow 220 participants for 12 mon…

This early study tests whether brexanolone, a drug already approved for postpartum depression, can safely reduce stress-induced alcohol use in 25 adults with both PTSD and alcohol use disorder. Participants receive a continuous 20-hour IV infusion under medical supervision. The m…

This pilot study follows 20 adults in Oregon who are using psilocybin (the active ingredient in magic mushrooms) to help with alcohol use disorder. Researchers are observing how often participants have heavy drinking days before and after psilocybin sessions. The study does not p…

This study tests whether a stepped alcohol treatment delivered via video or phone calls can help people with advanced liver disease cut back on unhealthy drinking. About 180 participants will be randomly assigned to either the treatment program or usual care. The goal is to see i…

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study aims to eliminate hepatitis C among people who use drugs in Paris, Marseille, Lyon, and Fort-de-France. Researchers will screen participants, provide immediate treatment, and use a peer-referral system to reach more people. The goal is to see if this community-based ap…

This study tests whether an AI system can help doctors identify patients with fatty liver disease who need specialist care. About 8,000 adults getting routine CT scans will have their images analyzed by AI to flag those at risk. The goal is to see if AI can improve detection and …

This study is testing whether a new blood test score, called GAAD, can detect liver cancer earlier in people with chronic liver disease. The GAAD score combines a person's gender, age, and two blood markers (AFP and PIVKA-II). Researchers will compare the GAAD score to standard u…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This study looks at how to best help HIV clinics in Vietnam offer a short alcohol counseling program to patients who drink heavily. The goal is to reduce risky drinking and lower the chance of spreading HIV. Over 3,200 people living with HIV and clinic staff are taking part to se…

This study tests whether a brief alcohol intervention (a few counseling sessions) helps people who are starting or restarting PrEP (HIV prevention pills) to drink less and stick with their PrEP routine. About 562 participants in Hanoi will be randomly assigned to receive the inte…

This study tests whether training store staff and increasing enforcement can reduce marijuana sales to obviously-intoxicated customers. Researchers will send actors pretending to be drunk to buy marijuana and see if stores refuse the sale. The goal is to prevent impaired driving …

This study tests whether a mobile app for PTSD, along with brief weekly support sessions, can help people who are already in treatment for alcohol problems. About 300 adults with both PTSD and alcohol use disorder will use the app or receive standard care. Researchers will track …

This study tests whether a self-help handbook called the 5-Step Method can help family members cope with the stress of a relative's drug or alcohol misuse. 24 adults in the US will be split into two groups: one gets the handbook, the other does not. The goal is to see if the prog…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This pilot study is testing whether giving people non-alcoholic beer or sparkling water can help them reduce their alcohol intake. 60 adults with alcohol use disorder who are already in treatment will receive one of the two drinks for 6 weeks. The main goal is to see if people fi…

This study tests a cognitive behavioral therapy (CBT) group designed specifically for women Veterans who have alcohol use disorder. About 162 women will take part, and the therapy focuses on changing drinking habits and related behaviors. The goal is to see if this female-only ap…

This study tests a phone-based sleep therapy for people who have insomnia and drink alcohol in ways that could harm their health. The therapy adapts standard insomnia treatment to also address alcohol-related thoughts and behaviors. Researchers will first refine the approach with…

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both alcohol use disorder and PTSD. About 175 veterans will get either oxytocin or a placebo along with therapy. The goal is to see if oxytocin helps the…

This study tests whether a ketone supplement called Kenetik can reduce withdrawal symptoms in people undergoing alcohol detox. Fifty adults with alcohol use disorder will receive either the supplement or a placebo drink during their 5-day inpatient treatment. The goal is to see i…

This study tests whether taking a probiotic supplement for four weeks can reduce alcohol cravings and improve thinking, mood, and gut health in people with alcohol use disorder. 38 participants are randomly assigned to receive either the probiotic or a placebo, and neither they n…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This pilot study tests whether a 6-week telephone-based therapy called Acceptance and Commitment Therapy (ACT) can help Hong Kong Chinese young adults (ages 18-25) with alcohol use disorder drink less. Sixty participants will be randomly assigned to receive either ACT or social s…

This study tests whether a home-based physical activity program, using a Fitbit and coaching sessions, can help people with HIV who drink heavily increase their daily steps and reduce their alcohol intake. The trial involves 222 participants in the U.S. who are low-active and dri…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests whether a non-invasive ultrasound treatment on the brain can lower cravings and help prevent relapse in people with alcohol use disorder. About 40 adults will be randomly assigned to receive either the real ultrasound or a fake (sham) treatment, and neither they …

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in two weeks. The goal is to see…

This study tests a behavioral program for 18- to 29-year-olds who are not in college and drink heavily. The program combines a brief counseling session with wellness activities to reduce stress and offer alternatives to alcohol. Researchers will track changes in drinking and rela…

This study aims to test a new assessment tool called the ANA, which uses surveys and computer tasks to measure three key brain functions related to addiction. Researchers will study 1,400 adults with alcohol use disorder to see how these brain functions relate to drinking behavio…

This study looks at whether two blood markers, zonulin and LBP, can help detect liver damage in people with both ulcerative colitis (UC) and fatty liver disease. Researchers will measure these markers and use a special ultrasound to check liver stiffness in 100 adults with UC who…

This study looks at 300 patients with advanced liver scarring (cirrhosis) caused by hepatitis B or alcohol who have shown signs of getting better. Researchers want to understand what predicts this improvement and how long it lasts. The goal is to create clearer guidelines for whe…

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study follows 100 adults who drink alcohol at least weekly and have some interest in cutting back. Researchers want to see how alcohol use, suicidal thoughts, and decision-making are linked. Participants get access to a self-guided online cognitive behavioral therapy program…

This study aimed to see how well a blood test (phosphatidylethanol) detects heavy alcohol use. Researchers planned to compare test results in heavy drinkers and check how stable the samples are over time. However, the study was withdrawn before enrolling anyone, so no results are…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study uses smartphone data to understand what triggers anxiety and alcohol use in each person, then tailors therapy to those specific triggers. 81 adults with anxiety and alcohol problems will receive 11 sessions of cognitive behavioral therapy (CBT) either personalized to t…

This study tests whether telehealth programs can help people manage their alcohol use and improve well-being. About 300 adults with alcohol use disorder will join remotely via video or phone. They will be split into two groups: one gets a telehealth program, the other gets usual …

This study follows 70 Romanian adults with alcohol use disorder who have been sober for at least a year. Researchers use personality tests and spiritual well-being surveys to see what predicts a calm, fulfilling sobriety versus a difficult one. The goal is to better understand re…

This study looks at how alcohol changes brain activity when people interact with each other. Researchers will use special brain scans (EEG) on pairs of people while they drink and do tasks. The goal is to understand the brain processes behind alcohol's social effects. 240 adults …

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study looks at whether a method called the 15-Method can help doctors in general practice better identify and treat patients with alcohol problems. The method combines screening with treatment options already available in primary care. Researchers will track how many patient…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study examines how young adults who regularly binge drink respond to alcohol, caffeine, and Benadryl. Researchers want to see if these responses can predict future drinking patterns. About 800 participants will complete lab sessions and be followed for at least two years.

This study aimed to understand how a person's socioeconomic status (like income and education) affects their recovery from substance use disorder. Researchers planned to follow adults in early recovery for up to 3 years, measuring changes in social functioning, quality of life, a…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This study looks at how a single dose of a ketone ester supplement (DeltaG) changes glucose use in the brain and heart of people with alcohol use disorder compared to healthy volunteers. Twenty participants will receive either the supplement or a placebo, then undergo PET scans. …

This study aimed to develop a digital health worker named PAHOLA to deliver brief counseling for people who drink too much but avoid traditional treatment. The goal was to see if a computer-based coach could help reduce alcohol use and improve health. The study was withdrawn befo…

This study looks at whether a single dose of diclofenac, a common pain reliever, can change a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-blind fashion.…

This study looks at how to help primary care clinics screen more adults for substance use problems. It compares different support strategies like coaching, team learning, and financial rewards. 144 clinic staff from 48 practices will take part. The goal is to find the best way to…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study tests whether offering brief counseling in barbershops can help men in rural Arkansas drink less alcohol. About 611 men will take part, and researchers will track their drinking habits and mental health. The goal is to see if barbershops are a good place to reach men w…

This study tests whether a "Care Navigator" — a personal guide — can help people with substance use problems start and stay in treatment. About 360 adults who call a mental health access center will be randomly assigned to get usual care or extra help from a navigator. The goal i…

This study looks back at 10,000 hospital patients to learn more about low sodium levels (hyponatremia). Researchers want to know how common it is, how fast doctors correct it, and whether that affects patient outcomes like brain damage or death. No new drug or treatment is being …

This study tests a new mobile app that uses an avatar guide to help young adults (ages 18-29) who struggle with binge drinking and suicidal thoughts. The goal is to see if the app is easy to use and if people will stick with it. Ten participants from the emergency department will…

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cra…

This study follows 250 adults with alcohol use disorder who receive 12 weeks of talk therapy. Researchers will track their drinking habits, negative consequences, and quality of life for a year after treatment. The goal is to better understand the different ways people recover an…

This study looks at how alcohol disrupts sleep in women versus men, and whether menstrual cycle phase plays a role. Healthy adults aged 21-45 who drink regularly will have their sleep monitored in a lab after receiving alcohol or a placebo. The goal is to understand if female sex…

This long-term study follows 733 adults with alcohol use disorder to learn what helps people recover and what leads to relapse. Participants complete surveys and tasks about their drinking, emotions, and daily life over time. The goal is to find patterns that could guide future p…

This observational study follows 1,222 adults with liver cirrhosis to understand why some develop serious complications like fluid buildup or bleeding. Participants have check-ups every six months, including questionnaires, physical exams, and imaging. The goal is to build better…

This study tests whether a brief information session can help people with risky alcohol use feel more comfortable seeking help. Many avoid help due to shame or fear of consequences, even though effective treatments exist. Researchers will measure changes in participants' willingn…

This study follows 300 patients with severe alcoholic hepatitis who receive early liver transplants, before the usual 6-month sobriety period. Researchers will track how many survive one year after transplant and how many return to drinking. The goal is to better understand the r…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This pilot study looks at whether a computer-based alcohol intervention, combined with help from a community health worker, can reduce heavy drinking and improve HIV prevention among women. About 12 women who drink heavily and are either living with HIV or at risk for it will tak…

This early-phase study is testing a new PET scan tracer called [18F]NOS to see if it can detect inflammation in the brain and body of people with alcohol use disorder (AUD). Researchers will compare up to 60 people with AUD and up to 30 healthy volunteers. Each person gets one PE…

This study is testing whether a special MRI scan can accurately measure the severity of alcoholic liver disease without needing a biopsy. Researchers will scan 20 adults with the condition to look for imaging markers that reflect liver damage. The goal is to develop a non-invasiv…

This early study is testing whether focused ultrasound, a non-invasive technique that uses sound waves to target specific brain areas, is safe and feasible for people with opioid or other substance use disorders. The study involves 20 adults aged 22-60 who are currently in treatm…

This study follows 120 people in group therapy for alcohol use disorder to see which patient factors—like mental health, drinking severity, personality, or thinking skills—predict who finishes treatment and stays sober a year later. Researchers hope to learn how to match patients…

This pilot study tested whether a 'care navigator' could help people with substance use disorders follow through on treatment plans. The navigator worked alongside usual care coordinators to address barriers like language, income, or location. The study involved 74 patients and f…