PROSTATE CANCER

This study is testing different doses of an experimental drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The main goal is to find the highest dose that can be given safely without causing severe s…

This study tested whether adding the drug sunitinib to standard hormone therapy could better shrink or control prostate tumors before surgical removal. It involved 64 men with high-risk prostate cancer who were scheduled for prostate surgery. Researchers gave participants both tr…

This study is testing a new, shorter radiation schedule for men with intermediate-risk prostate cancer. The goal is to see if delivering a lower overall dose to the healthy prostate, while focusing a higher dose on the tumor, can reduce treatment side effects like urinary and bow…

This study aimed to test two experimental radioactive drugs (AAA602 and AAA802) in men with high-risk prostate cancer that hasn't spread far. The drugs were designed to target and deliver radiation directly to prostate cancer cells before surgery to remove the prostate. The goal …

This study is testing whether a common surgery for prostate cancer, which is normally followed by a hospital stay, can be safely performed as an outpatient procedure. It will involve 20 men with localized prostate cancer who are scheduled for robot-assisted surgery. The main goal…

This study is testing a new drug called ST101 for people with advanced solid tumors that have not responded to other treatments. The main goals are to find a safe dose and see if the drug can help control cancers like glioblastoma, melanoma, breast cancer, and prostate cancer. Th…

This study is testing whether two drugs, abemaciclib and atezolizumab, can help control advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. The trial will see if using the drugs alone or together is safe and can shrink tumors or st…

This study is testing a new radioactive drug designed to find and deliver radiation directly to prostate cancer cells. It is being given to a small group of men with high-risk prostate cancer before they have surgery to remove the prostate. The main goals are to see if the drug d…

This study is testing whether adding a drug called talazoparib to a standard prostate cancer drug (enzalutamide) works better than the standard drug alone. It is for men whose prostate cancer has spread and has specific DNA repair gene mutations. The main goal is to see if the co…

This study is testing whether giving two cancer drugs together before prostate removal surgery works better than giving either drug alone. Researchers want to see if the combination leaves less cancer behind after surgery. The trial involves 144 men with intermediate or high-risk…

This early-stage study tests whether modified immune cells can safely fight advanced prostate cancer. Doctors take a patient's own T-cells, genetically alter them in a lab to better recognize cancer, then return them to the body. The goal is to see if these reprogrammed cells can…

This study is testing whether a shorter course of hormone-blocking drugs, combined with two types of targeted radiation, is a safe and effective way to control high-risk prostate cancer. It aims to prevent the cancer from returning or spreading to other parts of the body. The tre…

This study is testing if removing the prostate (surgery) along with the best available drug therapy helps men live longer than using drug therapy alone. It focuses on men whose prostate cancer has spread to only a few bones. Researchers will track survival, cancer progression, an…

This small, early-stage study is testing a personalized approach to hormone therapy for men with advanced prostate cancer that still responds to hormone treatment. Instead of giving medication continuously, doctors will adjust the timing and dose based on each patient's PSA level…

This study is testing if a new oral drug, darolutamide, can control prostate cancer as effectively as standard hormone therapy (ADT) over 24 weeks. It will compare how well the drug lowers PSA levels and will closely track side effects and quality of life. The goal is to see if t…

This study is testing whether a special coffee made from the sweet wormwood plant (Artemisia annua) can help control prostate cancer that has started to return. It is for men whose PSA blood levels are rising again after initial surgery or radiation, but who show no signs of canc…

This study compares two shorter radiation schedules for prostate cancer that has returned after prostate removal surgery. Researchers want to see if a very short 2-week schedule causes similar or fewer urinary and bowel side effects compared to a standard 4-week schedule. The tri…

This study is testing if using advanced MRI scans can help doctors give more precise radiation treatment for prostate cancer. The goal is to see if this approach can control the cancer effectively in a shorter treatment time, while trying to reduce side effects. Men with localize…

This program offered an investigational cancer drug called NanoPac to patients with advanced pancreatic, prostate, or lung cancer who could not join the main clinical trials. It was a way for people who did not meet the strict trial requirements to potentially try the treatment. …

This study is testing whether a combination of two drugs, olaparib and AZD6738, can help control advanced prostate cancer that has spread and no longer responds to standard hormone treatments. It will involve about 49 men to see how well the drugs work together and how safe they …

This study is for men whose prostate cancer shows signs of returning after surgery. It compares two treatment plans: radiation plus standard hormone therapy versus radiation plus a stronger, two-drug hormone therapy. The goal is to see if the more intensive approach keeps the can…

This study is monitoring the safety and side effects of the drug Talzenna in men with a specific, advanced form of prostate cancer. It involves men whose cancer has spread and continues to grow despite low hormone levels, and who have a specific genetic change (BRCA mutation). Th…

This study is testing whether adding an immunotherapy drug called nivolumab to the standard treatment of radiation and hormone therapy is safe and more effective for men with a high-risk form of prostate cancer. The goal is to see if this combination can better control the cancer…

This study is testing whether a combination of targeted radiation and a specific set of drugs can better control prostate cancer that has spread to only a few other places in the body. It involves 21 men who have already had initial treatment for their prostate cancer. The goal i…

This study follows prostate cancer patients who previously received a temporary balloon implant to protect healthy tissue during radiation treatment. Researchers are tracking these patients long-term to see if the protective balloon helps reduce lasting bowel and urinary side eff…

This study is testing if adding a radioactive drug called Radium-223 to standard targeted radiation (SBRT) works better than radiation alone for men whose prostate cancer has spread to just a few spots in their bones. The goal is to see if the combination can keep the cancer from…

This study aimed to see if a standard drug combination for advanced prostate cancer works differently for men of different racial and ethnic backgrounds. It planned to enroll men who identified as Black, Hispanic, White, or Native American. The trial was withdrawn before any part…

This clinical trial is testing a new targeted radiation treatment called [Ac-225]-PSMA-62 for men with advanced prostate cancer that has spread. The treatment uses a radioactive drug designed to find and deliver radiation directly to prostate cancer cells throughout the body. The…

This study compares three different radiation treatment approaches for prostate cancer to determine which provides the best balance of cancer control and manageable side effects. Researchers are testing whether shorter, more intense radiation courses work as well as or better tha…

This study is testing a new radioactive drug called [225Ac]Ac-PSMA-R2 in men with advanced prostate cancer that has spread. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for men whose cancer has progressed despite previous hormone therapy and…

This study is testing a new radioactive drug called 225Ac-J591 for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The first phase aims to find the safest dose and schedule, while the second phase checks how well it lowers …

This study is testing whether a home-delivered, whole-food, plant-based diet can help men with prostate cancer manage their weight while they are on hormone therapy. Researchers are comparing this special meal plan with standard nutritional advice in 76 overweight or obese men. T…

This early-stage study aims to find the safest and most effective dose of a new drug, ADI-PEG20, when combined with two existing chemotherapy drugs (carboplatin and cabazitaxel). It is for men with a fast-growing, hard-to-treat form of advanced prostate cancer. The goal is to con…

This study is testing whether a much shorter radiation schedule works as well as the standard longer one for low-risk prostate cancer. Men in the study are randomly assigned to receive either 44 treatments over about 9 weeks or just 5 treatments over 1-2 weeks. Researchers will c…

This study is looking at how well surgery works to remove prostate cancer while trying to preserve normal body functions. Researchers will track 20 men with prostate cancer that hasn't spread beyond the prostate area. They'll measure how often the cancer comes back after surgery …

This study is testing whether a much shorter radiation treatment for prostate cancer—just 5 sessions instead of the usual 7-8 weeks—is safe and effective. It uses MRI guidance to precisely target the tumor while aiming to protect surrounding healthy tissue. The main goal is to se…

This study is testing whether a phone-based coaching program can help men on hormone therapy for prostate cancer. Participants work with a coach to gradually extend their overnight fasting period, aiming for 16 hours each night, and report their progress via text messages. The go…

This study is testing whether a new targeted radiation drug called 177Lu-PSMA-617 can slow the growth of advanced prostate cancer better than the standard chemotherapy drug, docetaxel. It is for men whose cancer has spread and is no longer responding to standard hormone-blocking …

This study follows patients who previously received AvenCell's CAR-T cell therapy in earlier clinical trials. Researchers want to understand the long-term safety and effectiveness of these cancer treatments over time. The study will track 178 patients with various blood cancers a…

This study compares two ways to deliver radiation for prostate cancer. One method gives an extra high dose to visible tumor areas using MRI guidance, while the other uses daily radiation treatments. Researchers want to see which approach better controls cancer while reducing side…

This study is testing whether combining two existing cancer drugs can help control advanced cancers that usually don't respond to standard immunotherapy. The trial is for adults with specific advanced cancers, like certain types of pancreatic, breast, and prostate cancer, who hav…

This study is testing whether daily high-dose fish oil supplements can slow the progression of prostate cancer in men whose cancer is returning after initial treatment. Forty men with rising PSA levels but no visible spread of cancer will take either the fish oil supplement or a …

This early-stage study is testing a new type of cell therapy for men with advanced prostate cancer that has stopped responding to standard hormone treatments. Doctors take a patient's own immune cells, genetically modify them in a lab to better target prostate cancer cells and re…

This study is testing if a much shorter course of radiation therapy is as good as the standard, longer course for controlling prostate cancer. Men with low or intermediate-risk prostate cancer received either 5 treatments or 26 treatments. The main goal is to see if the shorter c…

This study is testing a new, highly focused radiation technique for men with high-risk prostate cancer. The goal is to see if delivering a strong, precise dose of radiation directly to the main tumor and surrounding areas is safe and can be done effectively. Researchers will clos…

This study is testing a new gel called SpaceIT that is placed between the prostate and rectum before radiation therapy for prostate cancer. The goal is to see if this gel safely creates space to protect the rectum from radiation damage, potentially reducing side effects. It is be…

This study is testing whether giving an extra-high dose of radiation directly to the main prostate tumor, while treating the rest of the prostate with a standard dose, can better control intermediate-risk prostate cancer. Researchers want to see if this 'boost' approach can cut t…

This study is testing a two-step treatment plan for men with high-risk prostate cancer that has spread. First, patients receive strong hormone-blocking drugs. Then, they receive chemotherapy combined with hormone therapy. The goal is to see if this sequence can better control the…

This study aimed to test a precise, high-dose radiation treatment for prostate cancer that returns only in the prostate after initial radiation therapy. It planned to treat only the visible tumor spots, not the whole prostate, to see if this controlled the cancer and was safe. Th…

This study compares two ways to deliver radiation for early-stage prostate cancer. It tests a shorter treatment schedule (SBRT) against the standard longer schedule (IMRT) in Asian patients. The main goal is to see which approach better preserves patients' quality of life while c…

This study is testing a new technology to make prostate cancer radiation therapy more precise. It tracks the prostate in real-time during treatment and automatically pauses the radiation beam if the prostate moves more than 3mm. The goal is to see if this 'gating' technique is pr…

This small, early study is testing a new way to take the prostate cancer drug abiraterone. It aims to see if stopping the drug when PSA levels drop, and restarting only when they rise again, can help control the cancer longer while keeping patients feeling well enough for daily a…

This study compares two ways to deliver an extra dose of radiation (called a 'boost') to men with intermediate or high-risk prostate cancer. Researchers want to see if a high-dose-rate method works as well as a low-dose-rate method at keeping cancer from returning, while causing …

This study is testing whether a drug called palbociclib can help control advanced prostate cancer that has spread and stopped responding to standard hormone treatments. It involves 19 men whose cancer has progressed despite previous therapies. Researchers will monitor how the can…

This study is testing whether adding two oral drugs, darolutamide and abemaciclib, to standard hormone therapy is safe and effective for men with high-risk prostate cancer. The first part aims to find the best dose, and the second part would have compared the full combination to …

This study is testing whether regular treadmill walking at home affects markers that indicate how aggressive prostate cancer might become. It involves 36 men with low-risk prostate cancer who are being monitored rather than immediately treated. Participants are assigned to either…

This study is testing a new targeted radiation drug called 177Lu-PSMA-617 for men in Japan with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. The drug is designed to find and deliver radiation directly to prostate cancer cells…

This large, late-stage trial is testing if combining a standard hormone-blocking pill (enzalutamide) with a bone-targeted radiation treatment (Ra223) works better than the pill alone for men whose prostate cancer has spread to their bones and is no longer responding to standard h…

This large, late-stage study tested whether adding a new drug called apalutamide to standard hormone therapy works better for men whose prostate cancer has spread. Over 1,000 participants were randomly assigned to receive either the new combination or standard therapy plus a plac…

This study aims to improve health and quality of life for Black breast and prostate cancer survivors in Washington, D.C. by addressing social and economic barriers. It will test whether connecting survivors with community health workers and providing anti-racism training for clin…

This early-stage study is testing the safety and initial effectiveness of an experimental drug called xaluritamig. It involves about 50 men whose prostate cancer has started to return (shown by rising PSA levels) but hasn't spread to other body parts. The main goal is to see if t…

This early-phase study is testing an experimental oral medication called MRT-2359 in people with advanced cancers that have run out of standard treatment options. The trial focuses on several types of solid tumors and lymphoma, particularly those driven by specific genes called L…

This study is testing a new drug, PF-07220060, to see if it is safe and can help control advanced cancers. It will be given alone and in combination with other standard hormone therapies. The trial is for people with certain advanced solid tumors, including breast, prostate, and …

This study observes men with prostate cancer that hasn't spread but has stopped responding to standard hormone therapy. It tracks their experience after their doctor has already decided to treat them with the drug darolutamide. The main goal is to understand the drug's real-world…

This study is testing a new way to treat prostate cancer by using a laser to destroy tumors. The laser is guided by ultrasound imaging, which researchers hope will be more comfortable for patients than the standard MRI-guided method. The goal is to see if this approach is practic…

This study is testing whether a new, shorter course of highly targeted radiation is a safe and practical way to treat intermediate-risk prostate cancer. It will involve 35 men and uses advanced MRI scans to aim the radiation very precisely at the main tumor and the entire prostat…

This study is testing whether a two-step treatment approach is safe and practical for men with intermediate-risk prostate cancer. First, doctors use a targeted electrical pulse treatment (IRE) to destroy the main tumor area, followed by a short course of precise, image-guided rad…

This study aimed to find out if adding a chemotherapy drug (docetaxel) to a standard two-drug hormone therapy regimen works better for controlling prostate cancer that has spread but is still limited in volume. Men with this specific type of cancer would have been randomly assign…

This study is testing a new, more specific plan for monitoring men with low-risk prostate cancer. It compares a standard set of rules for when to do more tests or start treatment against the usual way doctors monitor patients. The goal is to safely reduce unnecessary treatments a…

This study is testing a two-step treatment for men with aggressive prostate cancer. First, patients receive a short, intense course of targeted radiation (SBRT). Then, they undergo surgery to remove the prostate. The main goal is to find out if this combined approach is safe and …

This study is testing a new approach called 'extreme bipolar androgen therapy' for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. It alternates high doses of testosterone with a drug that blocks testosterone's effects, aim…

This large study aims to see if a shorter, more intense 2-week radiation schedule for the pelvic area is just as effective and safe as the standard 4-5 week schedule for men with prostate cancer that may have spread to nearby lymph nodes. Both groups will also receive a targeted …

This study is testing a new, highly targeted radiation technique for men with early-stage prostate cancer. The goal is to deliver a strong dose of radiation to the cancer while carefully avoiding nearby healthy areas like the urethra, rectum, and blood vessels. Researchers want t…

This study is testing whether a Mediterranean diet is a practical and helpful option for medically underserved men with prostate cancer. It will enroll 25 Hispanic and Black/African American men from a specific Houston hospital. The main goal is to see if participants can stick w…

This study is testing whether taking a daily fish oil supplement (rich in EPA, an omega-3) can help men with high-risk prostate cancer. It aims to see if the supplement reduces inflammation, slows cancer cell growth, and improves mood and quality of life. About 130 men scheduled …

This study aims to find the highest, safest dose of targeted radiation for men with high-risk prostate cancer. It tests a precise, high-dose radiation technique on the prostate and surrounding pelvic area in 60 participants. The main goal is to see how much radiation the body can…

This study is testing if using a bedside lung ultrasound during surgery can help doctors better adjust a breathing machine's pressure settings. The goal is to see if this personalized approach helps keep the lungs open and healthy in patients having robotic surgery for prostate o…

This study is testing whether a device that uses water vapor (steam) can safely and effectively treat intermediate-risk prostate cancer. It will involve 400 men with early-stage cancer to see if the treatment can control the disease while preserving urinary control and sexual fun…

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This study is testing whether a newer, more precise radiation tracking system causes fewer long-term side effects in the pelvic area compared to standard radiation for prostate cancer. Men with low- or intermediate-risk prostate cancer will be randomly assigned to receive radiati…

This study is testing if giving men with high-risk or early-spreading prostate cancer a combination of hormone-blocking drugs for several months before surgery can shrink the cancer as much as possible. The goal is to control the disease better and lower the chance of it coming b…

This early-stage study is testing a new injection for men with high-risk prostate cancer. The injection uses alcohol and numbing medicine to block the nerves that feed the prostate, aiming to slow or stop the cancer's growth. Researchers will give the injection during a standard …

This study is testing whether adding a second DNA vaccine to an immunotherapy drug helps control advanced prostate cancer better than using one vaccine with the drug. It involves men whose cancer has spread and stopped responding to standard hormone-blocking treatments. The goal …

This study is for men with advanced prostate cancer that has spread and stopped responding to standard hormone-blocking treatments. Researchers are testing if adding a new, targeted radiation drug (225Ac-J591) to a standard immunotherapy (pembrolizumab) and hormone therapy works …

This study is testing whether a 16-week home exercise program can slow the progression of prostate cancer in Black men who are on active surveillance (monitoring without immediate treatment). Researchers want to see if high-intensity interval training (HIIT) can help control canc…

This large, late-stage trial is testing if adding a radioactive drug called Radium-223 to standard chemotherapy (docetaxel) helps men with advanced prostate cancer that has spread to the bones live longer. The study enrolled 732 men to directly compare the combination treatment a…

This study is testing a shorter, more intense form of radiation therapy for prostate cancer. Instead of the standard 40-45 daily treatments, this approach delivers the radiation in just 5 sessions. The main goals are to see how well it controls the cancer long-term and to measure…

This study is testing the safety and performance of Medtronic's new Hugo robotic surgery system for urologic procedures, primarily for cancers of the bladder, prostate, and kidney. It will enroll 144 adult patients needing specific cancer surgeries to see if the robot can complet…

This early-stage trial is testing the safety and finding the right dose of a two-drug combination (naptumomab estafenatox and durvalumab) for people with advanced or metastatic solid tumors. It will enroll about 120 adults with one of many eligible cancer types, including breast,…

This study is testing whether adding a medication called darolutamide to standard prostate cancer surgery works better than surgery alone for men with high-risk or locally advanced prostate cancer. About 240 participants will be randomly assigned to receive either just surgery or…

This study aims to determine if combining two targeted radiation treatments is safe for men with intermediate-risk prostate cancer. The approach involves a brief internal radiation treatment followed by a shorter, more precise external radiation course over three weeks. Researche…

This study is testing whether using MRI scans to guide radiation treatment can more precisely target prostate tumors while sparing healthy tissue. It involves 40 men with localized prostate cancer who will receive standard radiation plus an extra focused dose to visible tumors. R…

This study is testing whether permanently implanting tiny radioactive seeds into the prostate can effectively control intermediate-risk prostate cancer. Researchers will track 300 patients to see if their PSA levels remain stable and monitor side effects. The goal is to determine…

This study is testing if adding an experimental drug called LY2157299 to the standard drug enzalutamide can help men with advanced prostate cancer that has stopped responding to hormone therapy. It will compare how long the cancer stays under control with the combination versus e…

This study is testing a two-drug combination (relugolix and darolutamide) for men with hormone-sensitive prostate cancer. The main goal is to see if men's testosterone levels return to normal within 18 months after finishing the two-year treatment. Researchers will also closely m…

This study is testing whether a daily green tea extract pill can help control early-stage prostate cancer in men who are being monitored instead of immediately treated. 115 men will take either the green tea extract or a placebo pill for two years to see if it slows the cancer's …

This large study is testing whether adding radiation to the entire pelvic area, along with standard hormone-blocking drugs and prostate radiation, helps men with aggressive prostate cancer live longer. It compares this more extensive treatment to the standard approach of targetin…

This study compares two ways of delivering radiation directly to the prostate to treat early-stage cancer. Researchers want to see which method—a one-time implant or two separate treatments—causes fewer urinary problems and side effects while still controlling the cancer. The stu…

This study is testing a new surgical method for prostate cancer that aims to improve patients' quality of life. It compares a new technique called NeuroSAFE, which checks for leftover cancer during surgery, against the standard surgical approach. The goal is to see if the new met…

This study is testing if a new hormone drug called darolutamide, when given with radiation therapy, works as well as standard hormone therapy for men with intermediate-risk prostate cancer. A key goal is to see if this new combination can control the cancer while causing fewer si…

This large study compares two standard radiation treatments for prostate cancer: proton therapy and photon therapy. It aims to see which one leads to better quality of life, fewer side effects, and effective disease control for 3,000 men. The study is observational, meaning patie…

This study is testing a 4-month lifestyle program designed specifically for African American men who have completed treatment for prostate cancer. The program involves twice-weekly sessions focused on healthy eating and physical activity, following American Cancer Society guideli…

This study is testing whether adding a newer drug called enzalutamide to the standard two-drug treatment (androgen deprivation therapy plus docetaxel chemotherapy) works better for men with prostate cancer that has spread. The goal is to see if this three-drug combination is safe…

This early-stage study is testing the safety of a personalized vaccine designed to teach the immune system to attack a man's specific prostate cancer. It is for men with aggressive prostate cancer who have had their prostate removed but still have a high risk of the cancer coming…

This study compares two methods for detecting significant prostate cancer: MRI-guided biopsies and a newer micro-ultrasound technology called ExactVu. Researchers want to see which method better finds cancer that needs treatment, particularly in underserved communities with limit…

This study is testing whether a special imaging test called a PYLARIFY PET scan can safely and accurately find prostate cancer that may have spread outside the prostate gland. Men with a specific, newly diagnosed type of prostate cancer will receive one scan. If the scan suggests…

This study aims to find out which of two urine collection methods is better at predicting whether a prostate biopsy will show cancer. Researchers are comparing samples collected after a prostate massage with regular urine samples. The goal is to develop less invasive tests that c…

This study is testing a more personalized screening method for men at high genetic risk of prostate cancer. Researchers want to see if using a specific blood test (PHI) and an advanced MRI scan can find aggressive cancers earlier than the current standard tests. The goal is to he…

This study is testing whether a PSMA PET scan can help doctors better find serious prostate cancer in men whose MRI results are unclear. It will compare two groups: one gets the new scan and may avoid a biopsy if it's negative, while the other gets the standard biopsy procedure. …

This study is testing a new type of PET scan that uses a special tracer to look for a protein called PARP-1 in prostate cancer tumors. It involves 30 men with prostate cancer who are already scheduled for surgery. The goal is to see if this scan can better identify and locate can…

This study is testing whether a new computer analysis method (called radiomics) applied to prostate ultrasound images can help doctors perform more accurate biopsies. Researchers will compare this AI-guided approach to standard biopsy methods in 464 men who need a prostate check.…

This study is testing a new blood test that looks at RNA from tiny particles called exosomes to diagnose prostate cancer. Researchers want to see if this test can accurately identify prostate cancer and distinguish between aggressive and less serious forms. The study involves 1,6…

This study is testing a new type of imaging scan to see if it can better locate prostate cancer in the body. It is for men who have been newly diagnosed with high-risk cancer or whose cancer has returned after initial treatment. Participants receive an injection of a radioactive …

This study is testing a new screening approach for prostate cancer that uses MRI scans alongside traditional PSA blood tests. It aims to better distinguish between aggressive cancers that need immediate treatment and slow-growing ones that may not, potentially reducing unnecessar…

This study is testing whether a new type of imaging scan, called a PSMA PET scan, is more accurate than standard scans at showing how prostate cancer responds to treatment. Researchers will follow 58 men with progressive prostate cancer. The goal is to see if changes on these spe…

This study is testing whether a new type of PET scan (called 18F-DCFPyL-PSMA PET/CT) can better detect the spread of prostate cancer in men who are starting a specific treatment (enzalutamide). It compares this new scan to standard imaging methods like bone scans and CT scans. Th…

This study is testing if a different type of imaging scan (Fluciclovine PET) can find recurring prostate cancer in men whose standard PSMA PET scan was negative. It involves 50 men whose blood tests suggest the cancer has returned. The main goal is to see if this second scan can …

This study is exploring whether substances found in tears and blood can help doctors distinguish between aggressive and less aggressive forms of prostate cancer. Researchers are collecting samples from 75 men who are already being evaluated for possible prostate issues. The goal …

This study is testing whether combining two types of medical scans (PET and MRI) with artificial intelligence (AI) can more accurately determine how aggressive a solid tumor is. It involves about 135 adults with prostate cancer or other solid tumors like liver or brain cancer. Th…

This study aims to improve how doctors predict the aggressiveness of prostate cancer and the risk of it returning after surgery. Researchers will analyze detailed MRI scans from 125 patients to find patterns that help distinguish between slow-growing and fast-growing cancers. The…

This study is following 7,500 men for many years to compare different ways of screening for prostate cancer. It aims to find out which combination of blood tests, special biomarker tests, and MRI scans is most effective at finding serious cancers early and reducing deaths. The re…

This study is testing a new type of PET scan to see if it can better predict whether prostate cancer will come back after surgery. Men with high-risk prostate cancer planning to have their prostate removed will get this new scan before their operation. Researchers will then follo…

This study is testing if a new type of imaging scan can better detect prostate cancer that has spread to other parts of the body, like bones. Men with metastatic prostate cancer will get two different scans to compare their accuracy. The goal is to see if the new scan, which uses…

This study is testing whether a genetic score from a saliva test can help doctors decide which men should be screened for prostate cancer. It enrolled 329 men aged 55-69 to see if those with the highest genetic risk scores are more likely to have cancer found on a biopsy. The goa…

This study is testing a new tracking system that works like a mini-GPS inside a needle. It aims to help doctors more accurately guide needles to hard-to-find tumors during biopsy or ablation procedures, using a weak magnetic field. The research will see if this 'smart needle' can…

This study aimed to test a shorter, less expensive type of MRI scan for detecting prostate cancer. The goal was to see if this new scan, which doesn't use contrast dye, could find cancer as accurately as the standard, longer MRI. The study was designed for men with confirmed pros…

This study aims to determine if the Decipher® prostate cancer test predicts aggressive disease with the same accuracy in African-American men as in non-African-American men. The test was developed mainly using samples from men of European descent, and researchers want to validate…

This study is testing new software that combines MRI scans with live ultrasound images during prostate biopsies. The goal is to help doctors more accurately find and diagnose aggressive prostate cancer early. Researchers will enroll 100 men who are already scheduled for a standar…

This study is testing whether MRI scans can help detect prostate cancer earlier in men with BRCA gene mutations, who have a higher risk of aggressive prostate cancer. Researchers are comparing MRI screening to standard blood tests and physical exams to see if it finds cancer at m…

This early-stage study is testing a new imaging agent for PET scans in men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The goal is to see if this new tracer can better detect and locate cancer tumors by targeting a specific protein (CD…

This study is testing a new smartphone app designed to help African American men learn about prostate cancer and complete PSA screening tests at home. Researchers will compare the new app to an existing government health app to see if it's more effective at increasing knowledge a…

This study is testing whether regular aerobic exercise can prevent cancer from returning in people who have already been treated. Researchers are working with 33 people who have had breast, prostate, or colorectal cancer to find the right amount of weekly exercise that safely low…

This study is testing whether giving one of two drugs, mannitol or nitroglycerin, during robotic surgery for prostate or bladder cancer can help prevent a sudden drop in kidney function afterward. It will involve 90 patients with generally healthy or mildly reduced kidney functio…

This study compares two radiation treatments for prostate cancer to see which causes fewer side effects. Men with low or intermediate risk prostate cancer receive either IMRT (using X-rays) or proton beam therapy. Researchers track bowel, urinary, and erectile problems over five …

This study is testing whether acupuncture can help reduce nighttime urination (nocturia) in men who have survived prostate cancer. Researchers want to see if acupuncture is a practical treatment option that can also improve related symptoms like poor sleep, hot flashes, fatigue, …

This study compares two approaches to managing pain after robotic prostate cancer surgery. One group receives standard opioid pain medication, while the other receives a combination of non-opioid drugs like ketamine, ketorolac, and acetaminophen. Researchers want to see if the op…

This study is testing whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer stay more active and protect their heart health while they undergo chemotherapy. About 135 participants are randomly assigned to try eith…

This study is testing whether a 12-week support program can be successfully added to regular follow-up care for men living with advanced cancers of the prostate, kidney, bladder, testicles, or penis. The program includes nutrition advice, physical therapy, and other support servi…

This study aims to find the best combination of treatments to reduce severe fatigue in men with prostate cancer who are receiving radiation and hormone therapy. Researchers are testing different mixes of guided exercise, supportive counseling, and a stimulant medication (or a pla…

This study is testing whether a temporary gel called SpaceOAR Vue can protect the bowel from damage during a precise type of radiation therapy for prostate cancer. The goal is to see if the gel reduces serious bowel side effects like pain, bleeding, or diarrhea that can occur mon…

This study is testing if a simple, non-invasive device can make prostate biopsies more comfortable. The device, called AcuTENS, delivers mild electrical stimulation through the skin. Researchers are comparing it to a fake device to see if it helps reduce pain and anxiety for men …

This study aims to find out which of two common prostate cancer medications—enzalutamide or darolutamide—has less impact on memory, concentration, and other thinking skills. About 111 men with advanced prostate cancer will take one of the drugs and complete regular computer-based…

This study aimed to compare two physical therapy programs for men experiencing urine leakage after prostate cancer surgery. Researchers wanted to see if exercises focusing on posture and whole-body stability work better than traditional pelvic floor exercises alone. The trial was…

This study is testing a new, culturally adapted exercise program designed for Hispanic prostate cancer survivors and the person who helps care for them. The program involves the survivor and caregiver working out together in remote group classes for three months. The main goal is…

This study is testing whether using a deeper level of muscle relaxation during robotic prostate cancer surgery leads to less pain after the operation. Researchers are comparing this deeper relaxation to the standard moderate level in about 140 men having this surgery. The goal is…

This study is testing whether a personalized mobile app with live coaching can improve quality of life for people who have had cancer. The 18-month program focuses on exercise, meditation, and diet advice. Researchers will compare the app's coaching to standard lifestyle resource…

This study is testing if a guided pelvic floor muscle exercise program, taught by a physical therapist before and after prostate removal surgery, is practical and acceptable for patients. Researchers will see how many people join and stick with the program, and ask participants a…

This study aims to find blood markers that connect lifestyle habits like diet and physical activity to a man's risk of developing prostate cancer. Researchers are following over 2,000 men at higher risk for prostate cancer to see if specific measurable factors in their blood chan…

This study is testing whether an online interactive tool called 'Talk to Nathan' helps men make better decisions about prostate cancer screening. Researchers are comparing this tool against standard educational materials to see which approach improves knowledge and reduces decisi…

This study is looking at whether a genetic test called the Genomic Prostate Score (GPS) can work together with MRI scans to help doctors better select patients for a less-invasive prostate cancer treatment called focal therapy. Researchers will analyze past data and tissue sample…

This study is testing a program designed to help doctors follow established guidelines when ordering imaging scans for prostate cancer patients. The program provides doctors with feedback on their scan ordering patterns compared to peers and guidelines, along with education. Rese…

This study collects and analyzes information about patients who had robotic surgery to remove their prostate due to cancer. Researchers are looking at how patients do before, during, and after the surgery to understand recovery, survival, and if the cancer returns. The goal is to…

This study is creating Brazil's first national program to monitor men with low-risk prostate cancer instead of immediately treating them. Researchers will track 490 patients in the public health system who receive regular check-ups rather than surgery or radiation. The goal is to…

This study aims to see if a simple blood test can predict which prostate cancer patients will experience memory and thinking problems when they start hormone therapy (ADT). Researchers will follow 32 men to check if changes in a specific blood protein are linked to cognitive decl…

This study is testing whether a short, animated video can help men newly diagnosed with early-stage prostate cancer better understand their treatment options. Researchers want to see if clearly explaining all choices—including active monitoring, targeted therapy, or standard trea…

This study aims to learn more about how prostate cancer changes after radiation treatment by using advanced MRI scans. Researchers will scan 120 men with prostate cancer before and after their radiation therapy. The goal is to see if these detailed pictures can help doctors bette…

This study collects normal and cancerous tissue, blood, and fluid samples from men with various prostate conditions. Researchers will analyze these samples to understand why some people get prostate cancer, why some cancers are more aggressive, and why treatments work differently…

This study analyzed medical records and tissue samples from over 3,300 men diagnosed with early-stage prostate cancer between 1990 and 2006 who chose watchful waiting (no immediate treatment). Researchers looked back at these cases to identify which factors—like PSA levels, cance…

This study aims to find new, non-invasive ways to track prostate cancer by analyzing blood, urine, and tissue samples from patients. It will observe 500 men with different risk levels of prostate cancer who are receiving standard care. The goal is to discover biomarkers that coul…

This study is testing whether artificial intelligence (AI) can help doctors more quickly and accurately outline the prostate gland on ultrasound images. This outlining is a key step in planning a precise, high-dose radiation treatment called brachytherapy. The study will compare …

This study aims to understand how a person's mental outlook and coping ability affect their quality of life during and after radiation treatment for prostate cancer. Researchers will follow 250 men for one year, asking them to complete questionnaires about their health and well-b…

This is a long-term observational study designed to understand if exposures common in farming—like pesticides, fuels, and dust—increase the risk of developing cancer and other diseases. It follows nearly 90,000 licensed pesticide applicators and their families in Iowa and North C…

This study aimed to learn how a drug called ruxolitinib changes immune cells inside prostate tumors. Men scheduled for prostate cancer surgery would have taken the drug for four weeks before their operation. Researchers planned to analyze tumor and blood samples to see how the dr…

This study aimed to learn more about prostate cancer by measuring certain chemical signals in patients' blood and urine. It was an observational study, meaning it only collected information and samples without testing a new treatment. The goal was to gather knowledge that could h…

This study aimed to collect and store prostate tissue samples from men undergoing brachytherapy (a type of radiation seed implant) for prostate cancer. The goal was to build a tissue bank for researchers to study how prostate cancer and its surrounding tissue respond to radiation…

This study aims to discover if certain genes make a person more likely to develop prostate cancer and, if they do get it, more likely to have it spread. Researchers are collecting DNA, blood, and tissue samples from nearly 2,000 men with prostate cancer to analyze their genes. Th…

This study is testing a new system designed to give doctors a more complete picture of an older patient's overall health and life circumstances when planning cancer treatment. It combines questions about aging, daily function, mental health, and social needs like housing and food…

This study aims to understand why some prostate cancer survivors experience memory and thinking problems, often called 'chemo brain' or 'cancer-related cognitive dysfunction.' Researchers are collecting information from 200 survivors to explore connections with anxiety, depressio…

This study aims to understand why some cancer treatments work for certain patients but not others. Researchers will collect tumor tissue and blood samples from 156 people with advanced prostate, kidney, or bladder cancer who are about to start a new treatment. By analyzing the ge…

This study aims to find inherited genetic changes that increase a man's risk of developing prostate cancer. Researchers are collecting blood samples and family history information from over 23,000 men, focusing on those diagnosed at a younger age or with a family history of the d…

This study aims to improve how doctors use a special total-body PET scanner to see cancer more clearly. Researchers will test three different FDA-approved imaging agents in people with prostate cancer, breast cancer, or neuroendocrine tumors. The goal is to collect better data on…

This study aimed to understand how much information people can remember about their own cancer screening and diagnosis. Researchers wanted to see if giving people time or helping them access their online medical records would help them recall more accurate details. The study was …

This study aims to find out if removing lymph nodes during prostate cancer surgery helps prevent the cancer from returning, or if skipping this step avoids unnecessary risks. Researchers are comparing two groups of men with intermediate-risk prostate cancer: one group gets standa…

This study aims to understand the unique experiences and decision-making challenges faced by Spanish-speaking Latiné men after prostate cancer treatment. Researchers will conduct focus groups with survivors to learn about their cultural perspectives and needs regarding health iss…

This small, early-stage study aims to find clues that can predict how well a patient's high-risk prostate cancer will respond to standard treatment. Researchers will look at special medical scans and a genetic test from 30 men already scheduled to receive radiation and hormone th…

This study aims to understand how often bowel control problems occur in men who have received a specific type of radiation therapy for prostate cancer. Researchers will follow 200 survivors to measure the link between the radiation dose to a key muscle and the severity of bowel i…

This study aims to understand if annual PSA blood tests can help find prostate cancer earlier in men who carry high-risk BRCA or Lynch syndrome gene mutations. It will compare about 850 men with these mutations to 850 similar men without them over five years. The goal is to learn…

This study is testing whether advanced MRI scans can detect early changes in prostate cancer and surrounding healthy tissues during radiation therapy. Researchers will scan 38 men at three points in their treatment to see if the MRI results can predict treatment effectiveness or …

This study aims to understand whether exposure to farm environments during childhood increases the risk of developing cancer and other diseases in adulthood. Researchers are following over 64,000 adults who grew up on farms, collecting health information and biological samples ov…

This study aims to understand if common hormone therapies for prostate cancer affect memory, concentration, and daily functioning in men aged 65 and older. Researchers will compare the thinking skills of men starting therapy, men already on it, and men not on it. The goal is to g…

This study is testing whether an artificial intelligence (AI) tool can help research staff find patients who are eligible for a specific prostate cancer treatment trial. The AI scans patient health records and suggests who might qualify. Researchers will compare how well and how …

This study is testing whether a special type of MRI scan can predict how well treatment will work for men with high-risk prostate cancer. One hundred men who are scheduled to receive standard radiation and hormone therapy will get this advanced scan before, during, and after trea…

This small, early study aims to understand if standard hormone therapy drugs change how prostate cancer appears on a specialized PSMA PET scan. About 15 men with recurrent prostate cancer will receive a standard hormone pill and have two scans over four weeks. The goal is to gath…

This study aims to find new ways to predict how a patient's body and their prostate tumor will respond to a short, precise course of radiotherapy. Researchers will test if analyzing a patient's breath, blood, and scan images during treatment can forecast side effects and treatmen…

This study is testing a different way to provide genetic testing to cancer patients. Instead of referring patients to a genetic counselor, doctors themselves order the tests, and counselors then give results by phone. Researchers are measuring how this change affects patient dist…

This study is testing different online tools to help people who have inherited a gene change that increases cancer risk. It aims to help them better share this important information with their family members and follow the recommended cancer screening and prevention guidelines. T…

This study aims to understand why prostate cancer sometimes comes back after radiation treatment. Researchers are testing if changes in a specific blood marker (CgA) after treatment can predict which patients are at higher risk of their cancer returning. The study involves 118 me…