PROSTATE CANCER

This study looks at whether testosterone replacement therapy is safe for men who have both low-risk prostate cancer and low testosterone, and are under active surveillance. Researchers will track if the cancer gets worse within 12 months. The goal is to see if this treatment can …

This study tests a weekly, image-guided radiation therapy for men with very high-risk prostate cancer that has not spread widely. 54 participants will receive five precise radiation doses to the prostate and pelvic lymph nodes, with higher doses to any visible tumors. The goal is…

This study tests two treatments for men with high-risk prostate cancer that hasn't spread. One group gets darolutamide alone, the other gets darolutamide plus hormone therapy. After 3-6 months, all men have surgery to remove the prostate. The goal is to see if the drugs shrink th…

This early-stage study tests a special sheet called dMD-002 that helps repair nerves damaged during prostate cancer surgery. About 30 men who are having their prostate removed will receive either the sheet or a placebo. The goal is to see if it improves erectile function and blad…

This study is testing a new drug called TRC003 in 90 men with a type of advanced prostate cancer that has spread and is no longer responding to standard hormone therapy or chemotherapy. The goal is to see if the drug is safe and can shrink tumors or lower PSA levels. Participants…

This early-phase trial tests a new way to deliver carbon-ion radiation for prostate cancer, using just 6 sessions instead of the usual 12. It includes 20 men with low- or intermediate-risk prostate cancer. The main goal is to check safety, especially any serious side effects with…

This study tests whether a vaccine (TriAdeno) plus a drug (N-803) can stop early-stage prostate cancer from getting worse. About 52 men with low- or medium-risk prostate cancer who are currently under active surveillance will receive four cycles of injections. The goal is to see …

This study tests two ways of giving radiation for prostate cancer: treating the whole prostate gland or focusing extra radiation on the main tumor seen on MRI. The goal is to see which method causes fewer bladder and bowel side effects. About 186 adults with prostate cancer will …

This study tests whether the antibiotic trimethoprim, taken daily for 3 months, can safely lower folate levels in men starting hormone therapy for advanced prostate cancer. About 50 men will participate. The goal is to see if this approach is safe and might help control the cance…

This early study tests the safety of a new treatment for prostate cancer that has come back after initial therapy. Up to 12 participants will receive tiny implants that deliver a strong form of radiation (alpha rays) directly into the tumor. The goal is to see if this approach is…

This study tests a new way to give radiation therapy for several pelvic cancers (prostate, endometrial, cervical, and rectal). The approach uses daily scans to adjust the radiation beam to the exact shape of the tumor, allowing for fewer but stronger treatments. The goal is to se…

This study tests whether using PSMA-PET scans to guide radiation therapy can improve cancer control in men with high-risk prostate cancer that hasn't spread to lymph nodes. About 250 participants will receive radiation to the prostate and nearby tissues, with or without whole pel…

This study tests whether adding a common heart medication (propranolol) to standard hormone therapy before prostate removal can improve outcomes for men with high-risk prostate cancer. About 30 participants will receive the combination treatment for several months before surgery.…

This study tests a new way to give radiotherapy for prostate cancer. Instead of many treatments, it uses just 2, with the second dose adjusted based on how the tumor responds to the first. The goal is to see if this personalized approach is safe and effective for men with interme…

This study tests whether adding the chemotherapy drug carboplatin to standard treatment can help men with a fast-growing type of prostate cancer that has spread. The cancer must have a BRCA gene mutation or show neuroendocrine features. About 330 men will receive either standard …

This early-stage study tests BPX-601, a personalized CAR-T cell therapy made from a patient's own immune cells, for advanced prostate cancer that has stopped responding to standard treatments. The main goals are to find the safest dose and understand side effects. Up to 36 partic…

This study tests a drug called pacritinib in people with advanced prostate cancer that has stopped responding to hormone therapy. The goal is to see if it can slow or stop cancer growth. Participants must have a specific protein marker (STAT5) in their tumor. The study involves 3…

This early-phase study tests a new drug called GLR2037 in 65 men with metastatic prostate cancer that has spread to bones or soft tissues. The main goal is to check the drug's safety and find the right dose. Participants must have had prior hormone therapy and still have castrate…

This study tests whether injecting stem cells from donated fat tissue can help men recover the ability to have erections after prostate cancer surgery. Forty men aged 40 to 70 with early-stage prostate cancer will receive either stem cells or a placebo. The goal is to see if the …

This study will test a new procedure called PFA (pulsed field ablation) in 50 men with early-stage prostate cancer. The goal is to see if it is safe and can control the cancer. Participants must be at least 45 years old and have low or favorable intermediate-risk prostate cancer.

This long-term registry will follow 2500 men with prostate cancer who receive Vanquish water vapor ablation therapy, a treatment that uses steam to destroy cancer cells. The study aims to see how well the therapy controls the disease and its safety over time, using real-world dat…

This early-stage trial tests a new radioactive drug, 161Tb-LNC1011, in 15 men with advanced prostate cancer that has stopped responding to hormone therapy. The drug is designed to seek out and deliver radiation directly to cancer cells. The main goals are to check safety and find…

This study looks at whether daily step counts can be used as a simple way to track how well vulnerable patients with advanced prostate cancer are doing on a combination of darolutamide and standard hormone therapy. About 80 adults who are frail or have other health issues will we…

This study tests a new radioactive drug, terbium-161 PSMA, in 60 men with advanced prostate cancer that has spread and stopped responding to standard treatments. The goal is to see if it can shrink tumors and improve quality of life. Participants will receive three doses, six wee…

This study tests whether memantine hydrochloride, a drug typically used for Alzheimer's, can help control advanced prostate cancer that has stopped responding to standard treatments. Fifteen men with metastatic castration-resistant prostate cancer will take the drug alongside the…

This early-phase study tests a new treatment for people with metastatic breast or prostate cancer that has spread and is no longer responding to standard therapies. The treatment uses the patient's own immune cells, which are collected, coated with a special antibody (HER2Bi), an…

This phase 2 trial tests whether adding dapagliflozin, a common diabetes medication, to standard hormone therapy can help control metastatic prostate cancer better than hormone therapy alone. About 60 adults with advanced prostate cancer that has spread and is no longer respondin…

This early-stage trial tests a new drug called TB511, alone or with pembrolizumab, in people with advanced solid tumors (lung, prostate, colorectal, or liver cancer) that stopped responding to standard treatments. The study has two parts: first, finding the safest dose of TB511 a…

This study tests a new approach called Bioblation, where doctors perform a prostate biopsy and laser treatment in a single session. It is for men with severe urinary symptoms who are likely to have low- or intermediate-risk prostate cancer. The goal is to relieve symptoms quickly…

This study tests whether adding two extra drugs to standard hormone therapy can more thoroughly clear high-risk prostate cancer before surgery. About 94 men will receive the combination, then have their prostate removed to check for remaining cancer cells. The goal is to see if t…

This study tests whether adding darolutamide to standard hormone therapy after prostate removal can delay or prevent cancer recurrence in high-risk patients. About 40 men will receive the drug combination for 2 years, with regular PSA tests and scans to monitor outcomes. The goal…

This study tests a new navigation system that combines PSMA-PET, MRI, and ultrasound images to guide surgeons during robot-assisted prostate removal. About 98 men with prostate cancer that has spread just outside the gland will take part. The goal is to remove all cancer while pr…

This early-stage study tests a new radioactive drug called 177Lu-FC516 in 13 men with advanced prostate cancer that no longer responds to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also look at whether the drug can…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests if tamoxifen, a common breast cancer drug, can help men recover normal testosterone levels faster after finishing hormone therapy for prostate cancer. About 96 men who completed hormone therapy will take tamoxifen or a placebo to see if it speeds up recovery and …

This study tests a new way to detect prostate cancer early by looking at how suspicious spots on MRI scans change over time, instead of relying on a single scan. The goal is to reduce unnecessary biopsies and avoid treating cancers that are not dangerous. The study will include 3…

This study tests a special fluorescent dye (DGPR1008) that makes prostate cancer cells glow during robot-assisted surgery. About 18 men with prostate cancer will receive the dye before surgery. The goal is to see if the dye helps surgeons find and remove more cancer tissue, poten…

This early-phase study tests a new radioactive imaging agent called 68Ga-OncoACP3 in 20 men with prostate cancer. The goal is to check its safety and measure how much radiation the body receives during imaging. It may help doctors see where cancer has spread or returned.

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (point-of-care) and standard lab tests. Researchers will measure how long each method takes to give results. About 210 adults having high-risk surgeries (like heart or joint replacemen…

This study will follow 1000 men with suspected prostate cancer to see if repeated MRI scans can better detect dangerous cancers and reduce the need for biopsies. Participants will have MRI scans over time, and doctors will track how the images change. The goal is to make prostate…

This study looks at whether a high-resolution ultrasound technique, called micro-ultrasound, can find aggressive prostate cancers that standard MRI scans might miss. About 90 men with low-risk prostate cancer or those on active surveillance will get a micro-ultrasound exam. If su…

This study tests a new biopsy approach for men with suspected prostate cancer. Instead of taking many random samples, doctors will focus on the MRI-visible lesion and the area right around it. The goal is to find dangerous cancers while reducing the detection of slow-growing canc…

This study is testing a new blood test called PROSTest to see if it can accurately detect prostate cancer in men with high PSA levels or abnormal exams. About 1,500 men scheduled for a prostate biopsy will give a blood sample before the procedure. The test results will be compare…

This study tests whether adding a special PET scan (18F-PSMA) to an MRI can better detect serious prostate cancer in men whose MRI results are not clear. About 250 men will be randomly assigned to get either an MRI-guided biopsy or a combined MRI+PET-guided biopsy. The goal is to…

This study looks at a new way to diagnose serious prostate cancer in men aged 50 to 75 with high PSA levels. Instead of always doing a biopsy, men first get an MRI. Only those with suspicious MRI results get a biopsy, and researchers compare two biopsy methods to see which finds …

This study tests three new radioactive imaging agents against the standard one to see which best highlights prostate cancer tumors on PET/CT scans. Nine men with advanced prostate cancer will receive both the standard and new agents so doctors can compare how clearly tumors appea…

This study tests a new, high-resolution PET-CT scan done during prostate cancer surgery. The goal is to see if it can accurately find any cancer left behind or spread to nearby lymph nodes, helping surgeons remove it all. Ten men with high-risk prostate cancer will get the scan r…

This study tests a new PET scanner designed specifically for the prostate. Researchers want to see if it can find prostate cancer more clearly than standard whole-body scans. About 25 men with known or suspected prostate cancer will get both a standard scan and the new scan, and …

This study tests whether an artificial intelligence (AI) algorithm can help doctors find more aggressive prostate cancers during biopsies. About 50 men with uncertain or low-risk MRI results will be randomly assigned to either an AI-guided biopsy or a standard biopsy. The goal is…

This study will compare two imaging methods—18F-PSMA PET/CT and standard CT—in men with prostate cancer. The goal is to see if the newer scan is better at finding cancer initially, tracking how well treatment works, and detecting cancer that has come back. About 59 participants w…

This early-stage trial tests a fluorescent dye called AS1986NS that may help doctors see prostate cancer cells during a biopsy. Ten men with suspected prostate cancer will receive a tiny dose of the dye before their standard biopsy. The main goal is to check if the dye is safe an…

This study tests whether a gentle magnetic brain stimulation (TMS) given during surgery can prevent postoperative delirium—sudden confusion—in older adults (60+) having urological procedures. Researchers will compare delirium rates in 220 participants who receive TMS or a sham tr…

This study tests whether listening to music during a prostate biopsy can lower pain and anxiety. About 78 men over age 50 with suspected prostate cancer will take part. Half will listen to music during the procedure, the other half will not. The goal is to see if music helps make…

This study tests a program for men having robot-assisted prostate removal for prostate cancer. The program includes a daily low-dose erectile medication, pelvic floor exercises, aerobic exercise, nutrition advice, and mental health support, all done at home. Researchers want to s…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study compares how two treatments for early-stage prostate cancer affect quality of life. 102 sexually active men will either have their whole prostate removed or a targeted ultrasound treatment (HIFU). They will answer questionnaires about urinary, bowel, and sexual functio…

This study tests whether early electroacupuncture can help men recover urinary control after prostate removal for cancer. 216 participants will receive either real or sham electroacupuncture for 6 weeks starting 1 week after surgery. The main goal is to see if more people achieve…

This study compares two radiation schedules for men whose prostate cancer has returned after surgery. The standard treatment involves 25 sessions over 5 weeks, while the shorter option uses 20 sessions over 4 weeks. The goal is to see if the shorter schedule causes fewer urinary …

This study tests whether a 16-week remote exercise program can improve physical function and quality of life in 40 World Trade Center responders who have had prostate cancer. Participants will do supervised group workouts via video call. The goal is to see if the program is pract…

This study tests whether starting acupuncture before the urinary catheter is removed can help men control their bladder better right after prostate cancer surgery. 144 men will get either real or fake acupuncture, and their urine leakage will be measured. The goal is to see if ea…

This study tests a web-based program called SCIPI that gives men with early-stage prostate cancer easy-to-understand information, tools for talking with doctors, and social support. The goal is to see if using SCIPI helps men feel more confident in their treatment choices and imp…

This study tests whether a more targeted (focal) radiation boost to the main tumor, combined with standard external beam radiation, can better preserve urinary quality of life compared to treating the entire prostate gland. The trial enrolls 58 men with intermediate- or high-risk…

This study tests whether adding electroacupuncture to standard local anesthesia can lower pain and anxiety for men undergoing a prostate biopsy. About 190 men will receive either real or sham electroacupuncture during the procedure. The goal is to see if this safe, needle-based t…

This study looks at whether acupuncture can ease hot flashes in men receiving hormone therapy for prostate cancer. Hot flashes are a common side effect that can disrupt sleep, mood, and daily life. About 40 men will receive real or sham acupuncture to see if it reduces hot flash …

This study tests whether fezolinetant can reduce hot flashes in men with prostate cancer who are on hormone therapy (ADT). About 54 men will be randomly assigned to receive the drug or a placebo. The main goal is to see if the drug lowers the frequency and severity of hot flashes…

This study tests a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) to see if it helps reduce anxiety and depression and improve quality of life in 300 Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. Participants will be randomly a…

This study tests a new type of radiation therapy for early-stage prostate cancer that delivers treatment in fewer, stronger doses. The machine adjusts the radiation beam daily to match the patient's anatomy, which may reduce side effects. Researchers will track quality of life an…

This study explores whether analyzing tumor DNA in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to find the best methods for collecting and analyzing the DNA. …

This study looks at whether a simple blood test can predict which prostate cancer patients will have late side effects from a precise type of radiation therapy called SBRT. About 220 men aged 60 or older with low- or intermediate-risk prostate cancer will give a blood sample befo…

This study aims to understand how migration history and social factors affect the quality of life of Black immigrant men who have had prostate cancer. Researchers will interview 40 men from Sub-Saharan Africa and the Caribbean to learn about their experiences. The goal is to iden…

This study looks at whether a test called minimal residual disease (MRD) can help predict how well treatment works in men with metastatic hormone-sensitive prostate cancer. Researchers will follow 50 newly diagnosed patients to see how different gene patterns affect treatment res…

This study looks at how a short, home-based high-intensity workout changes steroid hormone levels in men with low-grade prostate cancer who are on active surveillance. About 49 men will do one supervised bodyweight HIIT session and provide saliva samples. The goal is to understan…

This study looks at pain in two common ways to take a prostate sample to check for cancer. About 200 men having their first biopsy will rate their expected and actual pain. The goal is to help doctors pick the method that causes less discomfort.

This study tests whether ChatGPT, an AI chatbot, can help men with localized prostate cancer better understand their pathology results. Fifty participants who recently had a prostate biopsy will use the chatbot to explain their diagnosis and then meet with their doctor. The goal …

This study looks at whether a blood test can find tiny bits of cancer DNA left after surgery in people with breast, lung, prostate, ovarian, or stomach cancer. About 840 adults who had surgery to remove their cancer will give blood samples over 9 months. The goal is to see how of…

This study will test new educational tools and resources to help people better understand prostate cancer prevention and care. About 3,100 adults, including patients, caregivers, and healthcare workers, will take part across six European countries. The goal is to see if these too…

This study tests a new device that monitors radiation in real time during brachytherapy, a type of internal cancer treatment for prostate and gynecologic cancers. The goal is to catch any errors in radiation delivery immediately, making treatment safer. About 20 patients will hel…

This study works with 100 people from groups often left out of prostate cancer care—Black African and Caribbean men, transgender and non-binary people with a prostate, and those with limited healthcare access. Researchers will interview participants to find out what makes genetic…

This study tests a special microscope that lets surgeons check for leftover cancer cells right during prostate removal surgery. About 20 men with prostate cancer will take part. The goal is to see if this technique works well in real time, helping surgeons remove all cancer while…

This study tests whether the Stockholm3 blood test can accurately detect when low-risk prostate cancer becomes more aggressive in men who are closely monitored instead of treated immediately. Researchers will compare the test results with follow-up biopsies in 350 men. If success…

This study looks at two different gas flow rates (low vs. minimal) for anesthesia during robot-assisted prostate removal. The goal is to see which one keeps breathing and oxygen levels more stable during surgery. About 70 men having this procedure will take part, and their blood …

This study looks at 100,000 men in the UK who had surgery or radiation to cure their prostate cancer. It compares four ways of doing follow-up check-ups: hospital visits, GP visits, shared care, or self-care. The goal is to find which method works best for catching cancer return …

This study looks at whether taking a short course of the drug bicalutamide can make PSMA PET/CT scans better at finding small amounts of prostate cancer that standard scans miss. It involves 20 adults with recurrent prostate cancer and very low PSA levels. Participants are random…

This study tests an artificial intelligence tool that helps doctors and physicists review radiation treatment plans for prostate cancer before patients start therapy. The AI highlights differences in how providers plan treatments and points out warning signs to look for, aiming t…

This study is for men with intermediate- or high-risk prostate cancer who will receive hormone therapy and radiation. Researchers want to see if a special type of scan, done during hormone therapy, can help doctors better target the remaining cancer with radiation while avoiding …

This study tests a new type of scan (low-count SPECT) to see how the drug Radium-223 spreads in the body of men with advanced prostate cancer that has spread to the bones. About 38 men who are already eligible for Radium-223 will get the scan. The goal is to see if the scan can a…

This study looks at whether analyzing tumor cells found in the blood can help predict how well certain cancer drugs (PARP inhibitors and chemotherapy) will work. Researchers will collect blood samples from 300 adults with advanced breast, prostate, pancreatic, or ovarian cancer. …

This study tests whether trained veteran peer navigators can help other veterans make informed choices about PSA screening for prostate cancer. About 228 male veterans aged 40-69 will receive decision coaching from a peer before their primary care visit. The goal is to reduce con…

This study asks 800 Black and mixed-ancestry men with prostate cancer to share their quality of life and mental health through questionnaires. The goal is to understand how treatments affect them differently, so doctors can provide better, fairer care. No new treatments are teste…

This study looks at whether a special PET scan using fluciclovine can help doctors decide on treatment for men whose prostate cancer has returned after initial therapy. It is for men whose standard PSMA PET scan was negative or unclear. The goal is to see if this additional scan …