New radiation method aims to cut side effects in prostate cancer treatment

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male patients aged 18 years and older 4. In good general health as evidenced by medical history to be a candidate for curative-intent prostate cancer treatment 5. Ability to receive pelvic radiotherapy and be willing to adhere to the SUPR-SABR regimen 6. Previously untreated prostate cancer (with cytotoxic chemotherapy, surgical or radiation therapy) 7. Localized adenocarcinoma of the prostate with the following features: 1. cT1-T2c 2. PSA\<20 * Patients receiving a 5-alpha reductase inhibitor must have a PSA \<10 3. Grade Group 1-3 8. Patient willing and able to complete the EPIC questionnaire at time of registration and 1-, 12-, and 24- months post treatment 9. Prostate volume \<120 cc 10. History and physical including a digital rectal exam 90 days prior to registration 11. ECOG performance status 0-2 12. Be eligible and willing to undergo MRI prostate and pelvis as a component of RT planning 13. Bone and soft tissue imaging as clinically indicated (for unfavorable intermediate risk or symptomatic patients only) within 120 days prior to registration 14. IPSS score ≤20 at time of initial history and physical with treating radiation oncologist Exclusion Criteria: 1. Female patients (due to lack of prostate gland) 2. Concurrent use of testosterone supplementation 3. Known homozygous for ATM pathogenic mutation 4. Prior pelvic RT 5. Treatment with another investigational drug for prostate cancer 6. Pre-existing conditions or overall health status which disqualifies the patient from curative-intent RT 7. Prior or concurrent invasive pelvic malignancy (except non-melanomatous skin cancer) or lymphomatous or hematogenous malignancy, unless disease free for a minimum of 5 years 8. Patients with distant metastases from prostate cancer 9. Patients with lymph node involvement by prostate cancer 10. Prior prostatectomy, cryotherapy, high-intensity focused ultrasound, pelvic irradiation overlapping with fields needed for prostate cancer treatment, prostate brachytherapy, or previous cytotoxic chemotherapy for prostate cancer 11. Unwilling or unable to provide informed consent