Disease by molecular mechanism

This trial tests an experimental gene therapy called OCU400 in people with retinitis pigmentosa or Leber congenital amaurosis, which are inherited conditions that cause progressive vision loss and can lead to blindness. The therapy is given as a single injection into the eye, wit…

This early-stage study tests a vaccine called AV-1959D in 48 people with early Alzheimer's disease. The vaccine aims to train the immune system to target harmful amyloid plaques in the brain. The main goal is to check if the vaccine is safe and tolerable.

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study tests an experimental drug called ALN-APP in 200 adults with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. The drug is given via spinal injection and aims to slow disease progression and reduce new brain bleeds. Participants will be …

This study tests whether benfotiamine, a form of vitamin B1, can safely slow memory and thinking decline in people with early Alzheimer's. About 406 adults aged 50-89 with mild symptoms will take the drug or a placebo for up to 72 weeks. Researchers will measure changes in cognit…

This study tests a drug called selumetinib in children and young adults (ages 3-18) with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be removed by surgery. The goal is to see if the drug can shrink or slow the growth of these tumors. Participants take the dru…

This study tests a drug called selumetinib in adults with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be removed by surgery. The goal is to see if the drug can shrink these tumors or slow their growth. Participants take the drug twice daily and are monitored …

This study tests an experimental drug called RO7126209 (Trontinemab) in people with early to moderate Alzheimer's disease. The drug is given by IV infusion and aims to reduce amyloid plaques in the brain, a hallmark of Alzheimer's. About 241 participants will receive either the d…

This trial is testing whether adding hydroxychloroquine to two targeted cancer drugs (dabrafenib and trametinib) can help children and young adults with certain brain tumors that have come back or not responded to treatment. The study includes patients with specific genetic chang…

This early-stage study tests a new drug called RO7812653 in 50 people with early Alzheimer's disease. The main goal is to check if the drug is safe and how the body handles it. Participants receive a single dose injected into the spine and are closely monitored for side effects.

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This study tests whether deep brain stimulation (DBS) can improve thinking and memory in people with early Alzheimer's disease. Two participants will have electrodes implanted in a brain area that produces a key chemical for memory. The goal is to see if daily, one-hour stimulati…

This trial tests whether a dietary supplement called NVP-NK4146 can improve memory and thinking in older adults with mild cognitive impairment due to Alzheimer's disease. Participants aged 60 and older will take the supplement or a placebo twice daily for 36 weeks. Researchers wi…

This trial tests a device called Lixelle, which attaches to a standard dialysis machine to filter out beta-2 microglobulin, a protein that builds up in the blood of people on long-term dialysis and can cause painful joint and bone deposits. The study includes 40 adults on thrice-…

This study tests a new medicine called ONO-2020 in 240 people with mild to moderate Alzheimer's disease. The goal is to see if it can safely improve memory and thinking skills. Participants will receive either the drug or a placebo for 26 weeks, and researchers will track side ef…

This phase 2 trial tests a drug combination including daratumumab for people with AL amyloidosis, a rare disease where abnormal proteins damage organs, especially the heart. The study has two groups: one gets the full combo right away, the other starts some drugs later. Researche…

This phase 2 study tests a vaccine called JNJ-64042056 in 55 people with very early signs of Alzheimer's (no symptoms yet but tau buildup in the brain). The vaccine is designed to train the immune system to attack tau protein, which forms tangles in Alzheimer's. Participants rece…

This study follows 165 children who previously took dabrafenib and/or trametinib for certain brain tumors. Researchers want to see if these drugs are safe over the long term and how they affect growth. The children continue their treatment and are monitored for side effects and d…

This trial tests whether an experimental drug called donanemab can slow the mental and functional decline seen in early Alzheimer's disease. Participants with mild symptoms receive either donanemab or a placebo via IV infusion, and researchers track changes in cognition and daily…

This study looks at whether taking selumetinib with a low-fat meal reduces stomach problems in teenagers with neurofibromatosis type 1 (NF1) who have tumors that cannot be removed by surgery. About 24 teens will take the drug under both fed and fasted conditions to compare drug l…

This trial tests whether delivering interdisciplinary care via video telehealth can improve access and satisfaction for people with Lewy body dementia (LBD) and their caregivers. Participants receive remote consultations with a team of specialists, including a neurologist, therap…

This study tests whether a daily soy-based supplement called Equol can slow down stiffening of the arteries, small blood vessel damage in the brain, and memory decline. About 369 older adults (ages 65-85) will take Equol or a placebo for two years. Researchers will measure artery…

This Phase 2 trial tests the safety and effectiveness of YA-101, an oral drug, in 75 people with multiple system atrophy (MSA), a rare and progressive brain disorder. Participants will receive either YA-101 or a placebo twice daily for several weeks. The study will monitor side e…

This study tests a drug called selumetinib in 32 Chinese children and adults with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be surgically removed. The goal is to check the drug's safety and how well it works at shrinking these tumors. Participants take the …

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This study compares a targeted drug called selumetinib to standard chemotherapy (carboplatin/vincristine) in children aged 2 to 21 with neurofibromatosis type 1 (NF1) and low-grade glioma, a type of brain tumor. The goal is to see if selumetinib works as well or better at control…

This study tests a granule (sprinkle) form of the drug selumetinib in children aged 1 to under 7 years who have neurofibromatosis type 1 (NF1) with painful, inoperable tumors. The goal is to find the right dose, check safety, and see if it shrinks tumors. About 36 children will t…

This study tests an experimental daily pill (RO7269162) in 256 people who either have brain plaques but no symptoms, or have mild memory problems due to Alzheimer's. Participants take the pill or a placebo for about 1.5 years, with regular check-ups to monitor safety and brain ch…

This Phase 3 trial tests an experimental drug called ALXN2220 in about 1,180 adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal protein builds up in the heart, causing heart failure. The drug is designed to remove those protein deposits. Partic…

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow disease progression by blocking a process linked to Alzheimer's. A…

This Phase 2 trial tests an experimental drug called CT1812 in 540 people with early Alzheimer's disease. Participants receive either the drug or a placebo for 18 months. The goal is to see if CT1812 can slow declines in memory, thinking, and daily function. The study is active b…

This phase 2 trial tests whether daratumumab, an antibody that targets cancer cells, can improve outcomes for people with multiple myeloma after they receive a stem cell transplant. The study involves 31 participants and is currently active but not recruiting. The main goal is to…

This trial tests an experimental drug called NPI-001 in people aged 50 to 85 with mild cognitive impairment or mild Alzheimer's disease. Participants take either the drug or a placebo as tablets twice daily for 12 months, with doses increasing over time. The study measures safety…

This early-stage trial tests a combination of three drugs—venetoclax, ixazomib, and dexamethasone—in 24 patients with light chain amyloidosis that has returned or not responded to prior treatment. The study focuses on finding the safest dose and checking side effects. All partici…

This Phase 1 study tests the safety of OLX-07010, a drug designed to stop tau proteins from clumping in the brain—a hallmark of Alzheimer's disease. Researchers will give single or multiple doses to 88 healthy adults and elderly volunteers to see how the body handles the drug and…

This phase 2 trial is testing whether combining daratumumab, venetoclax, and dexamethasone can produce a deep and rapid response in people newly diagnosed with light-chain (AL) amyloidosis who carry a specific genetic marker called t(11;14). The study enrolls 36 participants and …

This study tests lecanemab, an antibody that targets amyloid plaques in the brain, in 40 people who carry a gene mutation that causes early-onset Alzheimer's. Participants previously received another anti-amyloid drug and will now receive lecanemab to see if it can fully clear am…

This study tests whether two drugs, E2814 and lecanemab, can slow the progression of Alzheimer's in people who carry a gene mutation that causes the disease. About 197 participants will receive either the drugs or a placebo over 2 to 4 years. Researchers will measure changes in t…

This study tests whether experimental drugs can slow down memory and thinking problems in people who have a gene mutation that causes Alzheimer's disease. About 490 adults aged 18-80 with this genetic risk are taking either a study drug or a placebo. The goal is to see if the dru…

This study tests a drug called ACP-204 for treating psychosis (hallucinations or delusions) in people with Lewy body dementia. It is a 52-week open-label extension, meaning all 126 participants will receive the drug. The main goal is to check for side effects over the long term. …

This phase 2 trial tests whether low-dose interleukin-2 (IL-2), an immune-modulating drug, can slow cognitive decline in people with early Alzheimer's disease. Forty participants will receive either IL-2 injections or a placebo for several months, and their cognitive function wil…

This study tests whether a daily 10 mg pill called Xanamem can safely slow memory and function loss in people with mild or moderate Alzheimer's dementia. About 247 participants will receive either Xanamem or a placebo for 36 weeks, with an option to continue the drug for up to 10…

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This study tests a drug called teclistamab in 30 people with AL amyloidosis, a rare disease where abnormal proteins damage organs. Participants have already had other treatments. The goal is to see if teclistamab can reduce or eliminate the harmful proteins in the blood. The stud…

This study tests a drug called trametinib in children with a rare blood cancer (juvenile myelomonocytic leukemia) that has returned or not responded to treatment. The drug works by blocking certain enzymes that help cancer cells grow. The goal is to see if it can shrink or contro…

This phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…

This early-phase trial tests whether adding the drug isatuximab to standard chemotherapy can safely treat people with high-risk AL amyloidosis, a rare disease where abnormal proteins damage organs. Eleven participants will receive the combination to see if it reduces toxicity and…

This study tests a new treatment called NXC-201 CAR-T for people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The therapy uses a patient's own immune cells, modified to target and destroy the cells producing these proteins. The trial is open to …

This Phase 3 trial tests an experimental drug called amlenetug in 401 people with multiple system atrophy (MSA), a rare and serious brain disorder. The goal is to see if the drug can slow the worsening of symptoms and improve survival. Participants receive either the drug or a pl…

This phase 2b trial tests whether adding ALXN2220 to eplontersen works better than eplontersen alone for adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart. About 326 participants will receive either the combinati…

This study tests a new drug called PMN310 in people with early Alzheimer's disease. The goal is to see if it is safe and if it can reduce signs of the disease in the brain. About 144 participants will receive multiple doses of the drug or a placebo. This is an early-phase trial, …

This early study tests a gene therapy that delivers a protein called BDNF directly into the brain. The goal is to see if it is safe and can slow or prevent brain cell loss in people with early Alzheimer's or mild cognitive impairment. Only 12 participants will be enrolled in this…

This study tests a drug called mirdametinib in 114 adults and children with a genetic condition called NF1 that causes nerve tumors (plexiform neurofibromas) that cannot be removed by surgery and cause serious problems. The drug works by blocking a protein that helps tumors grow.…

This registry follows 735 people with mild Alzheimer's or mild cognitive impairment who are receiving an FDA-approved anti-amyloid drug (lecanemab) as part of their regular care. Researchers will track changes in memory, daily function, and caregiver needs over time to see how th…

This study tests a combination of two drugs, venetoclax and dexamethasone, in people with a rare blood disorder called AL amyloidosis that has come back or not improved after treatment. The trial includes 53 adults with a specific genetic marker (t(11;14)). The goal is to find th…

This study tests an experimental drug called THN391 in 15 people with early Alzheimer's disease who also have small vessel disease in the brain. Participants receive three monthly IV infusions of either THN391 or a placebo. The main goal is to check safety and how the drug behave…

This study tests an experimental drug called CAEL-101 in 125 people with a rare disease called AL amyloidosis, where abnormal proteins build up in organs like the heart and kidneys. The drug is designed to remove those protein deposits. The goal is to see if it helps people live …

This study investigates whether combining the medication lovastatin with intensive reading tutoring can improve reading abilities in children and young adults (ages 8-20) with Neurofibromatosis Type 1 (NF1) who have reading disabilities. Participants first receive either lovastat…

This phase 2 trial tests whether allopregnanolone, a natural hormone, can safely help repair the brain in people with early Alzheimer's disease. About 100 volunteers aged 55 to 80 will receive weekly infusions of the drug or a placebo for several months. Researchers will measure …

This Phase 2 study tests an experimental drug called BIIB080 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The drug is injected into the fluid around the spinal cord every 12 or 24 weeks. Researchers want to see if it can slow the worsening…

This study tests an experimental drug called ONO-2808 in people with multiple system atrophy (MSA), a rare and serious brain disease. About 92 participants will receive either the drug or a placebo daily for up to 80 weeks. The goal is to see if the drug is safe and might help co…

This phase 3 study tests Coagadex, a human clotting factor X, in 15 adults with acquired factor X deficiency caused by AL amyloidosis. The goal is to see if it safely stops active bleeding and helps manage bleeding during surgery. Participants receive the drug on demand for bleed…

This phase 3 trial tests whether CAEL-101, an antibody that removes abnormal protein deposits from organs, can help people with AL amyloidosis live longer and avoid heart-related hospital stays. About 281 participants who have not yet received treatment for their plasma cell diso…

This study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injection…

This early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…

This study tests if a new growth hormone medicine (somapacitan) given once a week works as well as the standard daily growth hormone (Norditropin) for children who are very short due to being born small, or having Turner syndrome, Noonan syndrome, or unknown causes. About 412 chi…

This Phase 2 trial tests whether a patient's own stem cells, injected into the spinal fluid, can slow the progression of multiple system atrophy (MSA), a rare and fatal brain disease. The study involves 71 adults aged 30-70 with early-stage MSA. Researchers will measure changes i…

This study tests whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 participants will take rapamycin for 12 months while researchers monitor side effects and changes in memory and thinking. The goal i…

This study tests a drug called eplontersen in Chinese adults with a heart condition caused by abnormal protein buildup. The goal is to see if the drug lowers that protein and is safe over time. Participants will be randomly assigned to receive the drug or a placebo for 24 weeks, …

This study tests an investigational drug called lecanemab in people aged 55-80 who have early signs of Alzheimer's-related brain changes but no memory problems yet. The goal is to see if the drug can slow cognitive decline and reduce amyloid buildup over about 4 years. Around 140…

This study tests whether the drug tafamidis can safely stop the progression of ATTR amyloidosis in people who have already received a heart transplant. About 25 stable patients will take tafamidis daily for 12 months. Researchers will measure changes in blood protein levels, nerv…

This expanded access program offers the experimental drug zervimesine (CT1812) to people aged 50 to 86 with mild-to-moderate dementia with Lewy bodies. Participants take one 100 mg pill daily for up to a year. The goal is to provide access to the drug and collect long-term safety…

This study aimed to test a drug called BAC in people with Alzheimer's disease or vascular dementia. The goal was to see if it could improve thinking and memory, and to check for side effects. However, the trial was withdrawn before any participants were enrolled, so no results ar…

This study tests whether a daily pill called buntanetap can help people with early Alzheimer's disease think more clearly and handle daily tasks better. About 760 adults aged 55-85 will take either the drug or a placebo for 18 months. Researchers will check memory, thinking, and …

This study tests a new drug called DAY101 (tovorafenib) against standard chemotherapy for children and young adults with a type of brain tumor called low-grade glioma that has a specific gene change (RAF alteration). The goal is to see if the new drug works better at shrinking tu…

This study tests a drug called selumetinib in children and young adults with low grade glioma that has come back or not responded to other treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose and see if it can shrink…

This study is for people with systemic amyloidosis, a disease where abnormal proteins build up in organs. It tests the long-term safety of an experimental drug called AT-02. About 120 adults will receive the drug and be monitored for side effects and how the drug behaves in the b…

This trial aimed to test an experimental drug called CM-336 for people with AL amyloidosis that has returned, not responded to treatment, or only partially responded after initial therapy. The drug works by helping the immune system attack and destroy harmful cells. However, the …

This phase 2 trial tests the drug trametinib in 45 people aged 2 months to 30 years with vascular anomalies caused by changes in the Ras/MAPK pathway. Participants take trametinib daily for up to 3 years. The study measures whether the drug shrinks lesions, improves quality of li…

This phase 2 trial tests the drug trametinib in children and young adults (ages 1 month to 25 years) with low-grade glioma or plexiform neurofibroma that has not responded to prior treatment. Participants take a daily oral dose for up to 18 cycles. The study aims to see if the dr…

This study tests whether regular warm-water baths can improve blood sugar control and brain energy use in healthy adults aged 65 and older who are at risk for Alzheimer's disease. Over 10 weeks, 60 participants will soak in warm water three times a week. Researchers will measure …

This study is checking the long-term safety of a drug called eplontersen in people with ATTR-CM, a heart condition caused by abnormal protein buildup. About 1400 adults who completed earlier studies will receive eplontersen injections. Researchers will monitor side effects, kidne…

This study tests whether blood plasma from young, healthy, and very fit donors is safe and can help people with early Alzheimer's disease. Sixty patients aged 50-75 will receive monthly transfusions of either this 'exercise plasma' or a saltwater placebo over a year. Researchers …

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This study tests an experimental drug called Lu AF82422 in 64 people with multiple system atrophy (MSA), a rare and serious brain disease. The goal is to see if the drug can slow down the worsening of symptoms like movement problems and daily living difficulties. Participants rec…

This study tests whether a person's own stem cells can be safely injected into the spinal fluid to treat multiple system atrophy (MSA), a rare and serious brain disease. About 30 adults aged 30-80 with MSA will receive the treatment. The main goal is to check for side effects, an…

This study tests whether lecanemab can slow memory and thinking decline in people with early Alzheimer's disease. About 1,900 participants received either the drug or a placebo for 18 months, followed by an open-label extension where everyone can get lecanemab. The main goal is t…

This Phase II trial tests whether high-dose vitamin D (4,000 IU daily) can correct deficiency and slow cognitive decline better than standard doses in 180 older adults aged 65-90. Participants include those with normal thinking, mild impairment, or early Alzheimer's. The study la…

This phase 2 trial is testing whether a combination of two drugs, dasatinib and quercetin, is safe and feasible for people with early-stage Alzheimer's or mild cognitive impairment. The drugs aim to clear aging 'senescent' cells that may contribute to brain damage. 48 participant…

This study tests whether ATI-045 can safely reduce eczema symptoms like redness, itching, and skin patches in people with moderate-to-severe disease. About 110 adults who haven't had success with topical treatments will receive either the drug or a placebo. The main goal is to se…

This study tests the drug selumetinib in adults with neurofibromatosis type 1 (NF1) who have painful, inoperable nerve tumors called plexiform neurofibromas. About 145 participants will receive either selumetinib or a placebo to see if the drug can shrink the tumors and reduce pa…

This study tests whether adding sodium benzoate (a common food preservative) to brain stimulation therapy can improve thinking and memory in people with early Alzheimer's or mild cognitive impairment. 140 participants will receive two weeks of brain stimulation and then 24 weeks …

This study looks at how often older adults (62+) who are worried about memory loss should take dance or music classes to boost brain health and physical fitness. Over 6 months, 165 participants will attend 1, 2, or 3 group classes per week. Researchers will measure changes in mem…

This study tests a drug called vosoritide in 56 children with short stature caused by certain genetic conditions. The drug targets the growth plate to help children grow faster. Participants are observed for 6 months, then treated with daily injections for 12 months to check safe…

This study tests whether adding daratumumab back to pomalidomide and dexamethasone can improve complete remission rates in 15 adults with relapsed or refractory AL amyloidosis who have already received daratumumab. Participants receive the three-drug combination to control the di…

This Phase 2 trial tests whether a sleep-deepening drug (lower-sodium oxybate) or a nerve-stimulating device (non-invasive vagus nerve stimulation), or both, can help clear amyloid-beta protein from the brain in people with cerebral amyloid angiopathy (CAA). Sixty participants wi…

This study is for people with a rare heart condition called ATTR amyloidosis with cardiomyopathy, where abnormal protein builds up in the heart. It tests the long-term safety and effectiveness of a drug called vutrisiran, given as an injection every three months. About 700 adults…

This study aimed to test a monthly injection called ION-682884 in people with TTR amyloid cardiomyopathy, a condition where abnormal protein deposits damage the heart. Only patients who had already completed a 2-year study of a similar drug (inotersen) were eligible. The goal was…

This study tests whether a smartphone app that coaches older adults to eat more protein can help them maintain muscle mass and strength. Researchers will enroll 140 participants who are open to changing their diet and using an app. The app provides personalized nutritional coachi…

This study tests a surgical procedure that aims to improve the brain's waste-clearing system in people with Alzheimer's disease. The surgery involves relieving pressure on lymphatic vessels in the neck and connecting a lymph node to a vein to help drain harmful proteins. Research…

This study tests whether olive pomace oil, a type of olive oil, can lower brain inflammation in people with early-stage Alzheimer's. Researchers will give 40 Alzheimer's patients and 40 healthy adults meals containing either pomace oil or a different oil, then measure blood marke…

This phase 2 trial is testing whether adding a new drug called E2814 to the existing Alzheimer's drug lecanemab can better slow the disease in people with early Alzheimer's. The study involves 105 participants and will measure changes in tau protein levels in spinal fluid and bra…

This early-stage trial tests a gene therapy called AAV2-GDNF for multiple system atrophy (MSA), a rare and serious brain disorder. Nine adults with MSA will receive either the gene therapy or a sham surgery. The main goal is to check safety, but researchers will also look for any…

This study tests a modified plan to prevent and treat cytomegalovirus (CMV) infection in people with blood cancers who have had a donor stem cell transplant. CMV is a common virus that can cause serious problems after transplant. The study involves 153 participants and looks at w…

This study tests a program that uses a smartphone app, an activity tracker, phone coaching, and rewards to help adults in rural Kentucky eat more fruits and vegetables, cut down on fat, get more exercise, and spend less time on screens. About 279 participants will use the app and…

This study tests whether using focused ultrasound to temporarily open the blood-brain barrier can safely help standard antibody therapy reach the brain in people with mild Alzheimer's or mild cognitive impairment. About 15 participants will receive the combined treatment. The goa…

This study tests a drug called vutrisiran in 655 adults with a rare heart condition caused by abnormal protein buildup (ATTR amyloidosis with cardiomyopathy). The drug is given as a shot every 3 months and aims to reduce deaths and heart-related hospital stays. The goal is to see…

This study tests whether a second round of treatment with ALXN2220 is safe and can improve heart function in people with transthyretin amyloid cardiomyopathy, a condition where abnormal proteins build up in the heart. About 35 adults who previously received the drug will get it a…

This study tests whether a drug made from Ginkgo Biloba extract (Egb761) can lower a key Alzheimer's protein in the blood and improve thinking skills. Fifty adults with mild memory problems will take the drug twice daily for 6 months. The goal is to see if it can reduce brain dis…

This study looks at the long-term safety and effects of a drug called eplontersen in people with a rare inherited nerve disease called hATTR-PN. About 151 participants who completed earlier studies will receive regular injections of eplontersen. The goal is to see if the drug rem…

This pilot study tests whether lamivudine, an antiviral drug used for HIV, can lower levels of brain-damage-related proteins in the blood of people with mild cognitive impairment (MCI) who also have early signs of Alzheimer's disease. Twenty-three participants will take lamivudin…

This phase 2 trial is testing whether the oral chemotherapy drug ixazomib can help control AL amyloidosis after initial treatment. Seventeen adults with the disease will take ixazomib along with low-dose dexamethasone to see if it delays organ progression or the need for more the…

This study tests whether the drug idebenone can slow or prevent the progression of a sleep disorder called iRBD into Parkinson's disease or similar brain conditions. About 142 adults aged 40-75 with iRBD will receive either idebenone or a placebo for 5 years. Researchers will tra…

This study tests the long-term safety of an experimental drug called NNC6019-0001 in people with transthyretin amyloid cardiomyopathy, a rare heart disease that can lead to heart failure. All 80 participants have already completed an earlier study and will receive the drug every …

This Phase 3 study tests an injected drug called remternetug against a placebo in 1,400 people with early Alzheimer's who are at risk for worsening memory and thinking. The goal is to see if the drug can delay or prevent meaningful decline in daily function. Participants may be i…

This study tests whether treating severe gum disease can slow down Alzheimer's disease. Researchers will give 26 people with both conditions deep dental cleaning, extractions if needed, and oral hygiene training. Over 24 months, they will track memory, thinking skills, and brain …

This study is testing a new medicine called VY7523 in 52 people with early Alzheimer's disease. The goal is to see if the drug is safe and how it works in the brain. Some participants will get the drug, others a placebo, and the study lasts up to 12 months for the highest dose gr…

This Phase 2 trial tests whether sabirnetug, given as an IV infusion every four weeks, can slow cognitive and functional decline in people with early Alzheimer's disease. About 542 participants will receive either sabirnetug or a placebo. The main outcome is change in a combined …

This study is checking the long-term safety of a drug called acoramidis in people with a rare heart condition called transthyretin amyloid cardiomyopathy. About 389 participants who finished a previous 30-month trial will take acoramidis twice daily for up to 5 years. Researchers…

This study tests a new, more stable version of the chemotherapy drug melphalan in people with multiple myeloma or AL amyloidosis who are getting a stem cell transplant. The goal is to find the best dose that reaches a target level in the body, while possibly causing fewer side ef…

This study tests a new medicine called AR1001 in people with early Alzheimer's disease. About 1,535 participants will take either the drug or a placebo for 52 weeks to see if it slows memory and thinking decline. The goal is to control the disease, not cure it, and researchers wi…

This phase 2 trial tests whether an experimental drug called XBD173 can improve blood flow in the brains of people with Alzheimer's disease. About 51 participants will take the drug or a placebo for 28 days. Researchers will use MRI scans and blood tests to measure changes in bra…

This trial aimed to test the safety of giving four infusions of a patient's own fat-derived stem cells to people with early Alzheimer's disease. It was designed for adults aged 50-85 with mild cognitive impairment or early-stage Alzheimer's. However, the study was withdrawn befor…

This early-phase trial tests a personalized vaccine (ALZN002) made from a patient's own immune cells, designed to train the body to attack amyloid plaques in the brain. Thirty people with mild-to-moderate Alzheimer's will receive either the vaccine or a placebo. The main goal is …

Researchers at Beijing Anzhen Hospital are studying whether a computer model that combines two types of heart scans can predict 12-month survival in people with light-chain cardiac amyloidosis, a condition where abnormal proteins stiffen the heart. The study enrolls 49 patients w…

This trial tests an experimental imaging tracer called [11C]-CS1P1, which is designed to attach to a protein involved in brain inflammation. The study will first check the tracer's safety and how it moves through the body in healthy volunteers, then compare its signals in people …

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study investigates whether a combination of skin biopsies, speech analysis, and ultra-high field 7T MRI can detect early signs of Parkinson's disease and dementia with Lewy bodies. It focuses on people with a specific type of REM sleep behavior disorder triggered by serotone…

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that stiffens the heart. Doctors receive special training on how to spot and diagnose the condition using standard tests. The goal is to see if thi…

This study tests an AI tool called AIDP that analyzes MRI scans to help diagnose Parkinson's disease and two similar conditions (MSA and PSP). Researchers at 21 sites will compare the AI's diagnosis to that of movement disorder specialists. The goal is to see if the tool can impr…

This study tests whether a special heart scan using a radioactive drug called 123I-MIBG can help identify Lewy body disease, a type of dementia that also affects movement and sleep. Researchers will compare scan results with clinical diagnoses in 50 people who have conditions lik…

This study is testing whether artificial intelligence can detect transthyretin amyloid cardiomyopathy (ATTR-CM), a serious and often underdiagnosed heart condition, earlier than usual. Researchers will use AI algorithms to analyze routine ECGs and heart ultrasounds from up to 1.5…

This study tests whether smartphone usage data can help tell the difference between normal memory complaints, mild cognitive decline, and Alzheimer's disease. Researchers will collect data from 90 participants' phones over three months. If it works, it could offer a simple, low-c…

This trial tests whether an artificial intelligence tool called EchoNet-LVH can help screen for cardiac amyloidosis, a rare but serious heart condition that is often misdiagnosed. The AI analyzes routine echocardiograms to flag suspicious patterns that might indicate the disease.…

This study tests whether a radioactive tracer called 124I-evuzamitide can detect amyloid deposits in the heart and elsewhere in people aged 60 and older who have lumbar spinal stenosis or carpal tunnel syndrome. Participants will receive a single dose of the tracer and undergo a …

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This large study tests whether a simple iPad-based cognitive test, called MyCog, can help primary care doctors detect early dementia and cognitive impairment in underserved communities. Over 57,000 older adults from 24 clinics will take the test during routine visits. The goal is…

This study explores whether a self-administered digital test called eSAGE, combined with information from electronic health records and machine learning, can help detect early signs of cognitive impairment, including dementia and Alzheimer's disease. Researchers will analyze data…

This study tests a new radioactive tracer called Fluselenamyl for PET scans to detect beta-amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will check its safety and how well it works in 60 healthy volunteers and people with mild cognitive impairment o…

This study aimed to see if a special fMRI scan (fMRI-SAM) could help detect Alzheimer's disease early. Researchers planned to compare brain activity in 25 people with Alzheimer's, 25 with mild memory problems (MCI), and 60 healthy adults. The goal was to find differences that mig…

This early-phase study tests whether a single injection of pramlintide, a diabetes drug, can temporarily increase levels of Alzheimer's-related proteins in the blood, potentially revealing early signs of the disease. Researchers will measure changes in beta-amyloid and tau protei…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study is developing a web-based app that analyzes how you speak and remember things to quickly detect early cognitive problems like dementia or Alzheimer's. Researchers will enroll 500 people (healthy adults over 45 and those already diagnosed with mild cognitive impairment …

Stanford University is developing a mobile app that uses video of a simple physical test (the Short Physical Performance Battery) to assess physical and cognitive function in older adults. The study will collect video data from 30 healthy volunteers to train the app's AI. The goa…

This study is looking for better ways to diagnose Parkinson's disease using samples that are easy to collect, like blood, skin, and nasal swabs. Researchers will compare these samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. The goal…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study is testing whether a blood test can identify people who have Alzheimer's-related brain changes, even if they have no memory problems. Researchers will enroll 2000 adults aged 50-80, some with risk factors like family history. The goal is to see if the blood test can ac…

This study is testing a way to find cardiac amyloidosis—a rare but serious heart condition—earlier in people aged 65 and older. Researchers in Turkey will screen 800 patients at family medicine clinics using simple blood tests and medical history. The goal is to see if this appro…

Researchers at Mayo Clinic are testing whether measuring brain stiffness with a special MRI scan (magnetic resonance elastography) can serve as a new biomarker for Alzheimer's disease. The study will enroll 450 adults, including healthy volunteers, people with mild cognitive impa…

This study aimed to test a computer algorithm that uses insurance claims data to identify people with ATTR amyloidosis, a rare disease that affects the heart and nerves. Researchers planned to check how well the algorithm worked by reviewing medical records. However, the study wa…

This study tests whether combining aerobic exercise with cognitive training, delivered via interactive 'exergames' at home, can help prevent Alzheimer's in older adults who have memory concerns but no diagnosed dementia. Participants will be randomly assigned to either an exergam…

This trial tests whether a specific type of computerized cognitive training, called speed-of-processing training, can delay the onset of mild cognitive impairment or dementia in adults aged 65 and older. Participants will complete 45 sessions of either the training or a general c…

This study looks at whether long-term, high-intensity indoor cycling can slow or delay Alzheimer's-related brain changes in healthy older adults (ages 65-80) who carry the APOE ε4 gene, a known risk factor. Participants, who are currently inactive, will use a Peloton bike at home…

This study tests whether metformin, a drug used for diabetes, can prevent Alzheimer's dementia in people with mild cognitive impairment (MCI). Over 18 months, 326 overweight adults aged 55-90 with MCI will receive either metformin or a placebo. Researchers will track memory, brai…

This study tests an 8-week group program called My Healthy Brain for adults aged 50 and older who have memory concerns but not dementia. The program teaches about lifestyle factors like exercise, sleep, and diet that may help prevent dementia. Researchers want to see if the progr…

This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy gre…

This 7-year study tests whether a combination of mild electrical brain stimulation (tDCS) and computer-based memory exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression (both risk factors for…

This study tests whether donanemab, a monthly infusion, can delay or prevent memory and thinking problems in people who have early signs of Alzheimer's disease but no symptoms yet. About 3000 participants with a positive blood test for Alzheimer's-related proteins are being follo…

This study looks at whether memantine, a drug already used for Alzheimer's symptoms, might help prevent the disease in people at high risk. Researchers are testing it in 32 adults aged 50 to 65 who have a family history of dementia and carry the ApoE4 gene. The main goal is to se…

This study tests a website called 'Small Steps' that helps people aged 65 and older make small changes to their daily routines—like sitting less, moving more, and sleeping better—to reduce dementia risk. 88 participants will be split into two groups and followed for 36 weeks. The…

This study tests whether masupirdine, a daily tablet, can safely reduce agitation in people with Alzheimer's dementia. About 375 participants will receive either masupirdine or a placebo. The main goal is to see if the drug improves agitation symptoms, which can include aggressio…

Researchers at Baylor College of Medicine are testing whether a supplement combination called GlyNAC can improve brain energy use and reduce inflammation in people with Alzheimer's disease. The trial enrolls 52 adults aged 55 to 85 who have progressive memory loss and amyloid pla…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This study tests a new drug called CST-3056 in 12 adults with neurogenic orthostatic hypotension (a sharp drop in blood pressure when standing) caused by Parkinson's disease or pure autonomic failure. The goal is to see if the drug can improve blood pressure and reduce symptoms l…

This study tests a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can safely increase brain activity and improve memory in people with mild cognitive impairment or mild Alzheimer's disease. Participants will receive ultrasound to a k…

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study tests a mobile telehealth app called Brain CareNotes designed to help unpaid Hispanic caregivers manage challenging behaviors in people with Alzheimer's or related dementias. The app offers coaching and tools to handle symptoms like agitation or wandering. Researchers …

This study explores whether a type of improvised music, designed with calming sound parameters, can reduce anxiety in people with Alzheimer's disease and in healthy adults. Researchers will measure changes in anxiety scores, blood pressure, and heart rate before and after listeni…

This study is testing the long-term safety of a drug called ML007C-MA for people with Alzheimer's disease who also have hallucinations and delusions. About 210 adults who completed a previous study will take the drug twice daily for up to 52 weeks. The goal is to see if the drug …

This study tests an 8-week program that helps people with mild dementia and their caregivers identify and use their strengths. The program includes workshops and a biography activity led by trained volunteers. Researchers will measure changes in thinking skills and caregiver conf…

This study tests a program called FPCI-AL that helps staff in assisted living communities interact more positively with residents who have dementia. Researchers will work with staff for several months to improve care interactions. The goal is to reduce residents' behavioral sympt…

This study tests a non-invasive technique called temporal interference stimulation (TIS) that uses weak electrical fields to target deep brain areas involved in memory and emotion. Researchers will give two weeks of TIS to people with Alzheimer's disease who also have depression,…

This study tests a rideshare service where drivers are specially trained to assist older adults, including those with Alzheimer's or memory problems. The drivers help riders from door to door, even handing them off to clinic staff. The goal is to see if this service reduces misse…

This study looked at whether sunlight exposure therapy could improve sleep problems in people with Alzheimer's disease. Sixty participants with mild Alzheimer's and sleep issues received a health education plan on sun exposure and were followed for 14 days. The goal was to see if…

This early-stage study tests whether two drugs, dasatinib and quercetin, are safe and practical for people with mild cognitive impairment or Alzheimer's disease. The drugs aim to clear aging cells that may contribute to brain decline. Twenty participants aged 55 and older will be…

This study tests whether a safe, painless brain stimulation technique called tDCS can improve verbal learning in people with Alzheimer's disease. Researchers will compare active stimulation to a sham (fake) version in 90 participants with typical or language-based Alzheimer's. Th…

This study tests a website tool called WeCareToFeedDysphagia to see if it reduces stress and burden for people caring for older adults with Alzheimer's disease or related dementias who also have trouble swallowing. About 800 caregivers will be split into two groups: one gets acce…

This study tests whether a device that plays brief, soft sounds during deep sleep can enhance brain wave activity in people with mild cognitive impairment due to Alzheimer's disease. Participants use the device at home each night for three months, with an optional three-month ext…

This study tests a web-based support program called Hospital GamePlan4Care for caregivers of veterans with dementia who are discharged from skilled nursing facilities to home. Fifty-five caregivers will receive either the program (website, emails, and phone coaching) or basic hea…

This study tests whether a wearable light device can help improve sleep and daily rhythms in people with Alzheimer's who have sleep problems. Researchers will also use activity trackers and blood tests to better understand the disease. About 162 participants will try the light th…

This study planned to test whether automated music therapy could help manage agitation and sleep problems in people with severe Alzheimer's living in nursing homes. An actigraph would detect sleep issues and trigger music sessions automatically. The trial was withdrawn before any…

This study looks at whether special video games (serious games) that combine physical and mental exercises are a good value for managing Alzheimer's disease. About 136 people with mild to moderate Alzheimer's will either play these games with a therapist or receive usual care. Re…

This study tests whether monthly alexandrite laser treatments can safely shrink or improve the look of skin tumors in adults with neurofibromatosis type 1 (NF1). Ten participants will receive up to six monthly laser sessions, with some areas treated with cooling and others withou…

This study tests whether taking a special olive oil (high in a compound called oleocanthal) along with curcumin (the active part of turmeric) is safe and might help shrink skin tumors in adults with neurofibromatosis type 1 (NF1). About 23 participants take the supplements twice …

This study tests a new way to match dementia caregivers with each other for emotional support using a computer algorithm. Researchers want to see if matching based on personal preferences leads to better satisfaction and less stress than random matching. About 355 caregivers of p…

This study tests whether using a device that delivers light and sound stimulation for 60 minutes each day is safe and practical for people with mild Alzheimer's. Fifteen participants will use the device at home for 6 to 9 months. The main goals are to see if people can stick with…

This study tests a headset that delivers flashing lights and clicking sounds at 40 times per second (40 Hz) for one hour daily. Researchers want to see if this stimulation improves visual processing and thinking in 20 people aged 60+ with Alzheimer's disease. Participants will ha…

This study tests a biodegradable tube that is placed over a cut nerve during a leg biopsy. The goal is to see if it is safe and reduces common side effects like pain, redness, and swelling. Twenty adults with various nerve conditions are taking part, and half will get the tube wh…

This pilot study tested whether a non-invasive brain stimulation technique called tDCS could improve cognitive and motor functions in older adults with mild Alzheimer's disease living in supportive housing. Eleven participants received either real or sham stimulation over 10 sess…

This study tests a 6-week online program called Learning Skills Together for family caregivers of people with Alzheimer's or related dementias. The program includes weekly group discussions and a workbook covering topics like communication, medication management, and home safety.…

This study tests a new, non-invasive brain stimulation technique called Temporal Interference Stimulation (TIS) in 40 people with early-stage Alzheimer's. Participants receive either real or sham stimulation for 2 weeks. Researchers will check if it improves thinking and memory r…

This study tests whether a non-invasive brain stimulation technique called paired associative stimulation (PAS) can improve memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Participants receive daily sessio…

This study tests whether special lights placed over doorways can help reduce nighttime falls in assisted living residents with Alzheimer's or related dementias. The lights are low-intensity and outline the bathroom or entry door, providing visual cues to improve balance. Research…

This early-stage trial tests whether monthly injections of Kybella (a drug that dissolves fat) can safely shrink skin tumors in people with Neurofibromatosis Type 1. Up to 15 adults will receive up to 6 monthly treatments, and researchers will compare treated and untreated tumors…

This study tests a structured care pathway for treating agitation and aggression in people with Alzheimer's disease. The pathway combines personalized activities with medication guidelines to reduce symptoms and avoid using too many drugs. Researchers will compare this approach t…

This study tests whether shining near-infrared light on the head (a device called NirsCure) can safely help people with mild-to-moderate Alzheimer's disease. 38 participants will either get real light or a sham treatment for 16 weeks, then everyone can get the real light for up t…

This study tests a tablet-based app called the Digital Memory Notebook (DMN) to help older adults with mild memory problems or early Alzheimer's manage everyday tasks like appointments and medications. Twenty participants will learn to use the app over six weekly sessions, then c…

This small, early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who also had significant anxiety or agitation. The goal was to see if the treatment could reduce these behavioral sy…

This study tests whether a home-based telenursing program, led by a specialist nurse, can improve quality of life and reduce complications like falls for people with atypical parkinsonism (MSA or PSP). About 164 participants will receive proactive and reactive remote monitoring a…

This study tests whether a non-invasive brain stimulation technique called theta-burst stimulation (TBS) can improve cognitive function in people diagnosed with young-onset Alzheimer's disease (before age 65). Seventy participants will receive TBS to a specific brain area, and re…

This study tests a 12-week program called PERSEVERE for 502 family caregivers of people with Lewy body dementia (LBD). Caregivers are matched with a trained peer mentor who guides them through lessons on LBD and provides support. The goal is to see if this reduces caregiver strai…

This study tests if learning memory techniques (like mnemonics) can improve thinking and memory in adults over 50 who have mild memory concerns. 80 participants will either take memory training or just get information. The goal is to see if training helps and if benefits last up …

This study looks at whether online community support and telemedicine can improve quality of life for people with Parkinson's disease, Lewy body dementia, and related conditions, as well as their caregivers. About 632 participants will receive palliative care training for their d…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study tests whether coaching for people with dementia and their caregivers can improve care and reduce future emergency room visits. About 19,200 participants aged 66 and older with Alzheimer's or related dementias will receive different combinations of support after an ER v…

This study tests whether monthly nurse-led coaching sessions over a year can help people with mild cognitive impairment or dementia and their caregivers. Researchers will track symptoms, quality of life, and how well care plans are documented. The goal is to improve supportive ca…

This Mayo Clinic study tests a new device designed to clear fluid and debris from surgical drain tubes more effectively than the current method of using fingers. The trial will enroll 500 adults who have abdominal surgery with Jackson-Pratt drains. Nurses will rate how easy the d…

This study is testing whether using HEPA air purifiers at home can reduce respiratory symptoms and improve lung function in children and adults with Cystic Fibrosis (CF) or Primary Ciliary Dyskinesia (PCD). Participants will have two purifiers installed in their home and will und…

This study tests whether wearing a special helmet that shines near-infrared light on the head can help brain cells work better and protect themselves. About 100 people with early to mid-stage dementia will wear the helmet regularly for 8 weeks. Researchers will check memory, thin…

This study tests whether virtual reality (VR) reminiscence therapy can reduce behavioral problems and improve quality of life in 50 nursing home residents with mild to moderate Alzheimer's disease. Participants will use VR to explore familiar heritage sites, aiming to trigger pos…

This study is testing a device called MemorEM, which is a cap that sends low-level electromagnetic waves to the head. The goal is to get feedback from 1,000 patients with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, on how easy the device is to use…

This study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …

This study tests a new device called the Catheter Caps Case (C3) for dialysis patients. The goal is to see if it is more comfortable and easier to use than the usual gauze and tape. Ten adults with a dialysis catheter will try the device for 15 minutes, and researchers will measu…

This study is testing whether a daily supplement made from baker's yeast can improve digestion and reduce gut symptoms in healthy adults aged 50 to 99. Participants take 15 grams of the supplement each day and report any changes in how their stomach feels. The goal is to see if t…

This study tests whether taking melatonin for 4 weeks before egg retrieval can improve egg quality and pregnancy rates in women with diminished ovarian reserve (low egg supply). The trial involves 64 women undergoing ICSI (a type of IVF). Half receive melatonin, half a placebo, a…

This small study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can improve thinking and memory in people with early-stage Alzheimer's disease. Six participants will receive either real TBS or a sham (fake) treatment to see if the re…

This study tests a new, non-invasive treatment using low-intensity ultrasound to stimulate a deep brain area (the hippocampus) in older adults with mild memory and sleep problems. The goal is to see if it safely improves sleep quality and thinking skills. Twenty participants aged…

This study tests a new, non-invasive treatment called transcranial photobiomodulation (t-PBM) for people with mild cognitive impairment or early Alzheimer's disease. 196 participants aged 65-85 will receive either real or fake light therapy to the forehead for 8 weeks. The goal i…

This study explores whether a simple music activity—tapping along to rhythms together—can improve social attention and feelings of closeness in people with frontotemporal dementia or Alzheimer's disease, and their caregivers. Eighty patient-caregiver pairs will participate in a c…

This study tests whether a drug called siltuximab can reduce symptoms like weakness, fatigue, nausea, and pain after a stem cell transplant in patients aged 60-75 with multiple myeloma or AL amyloidosis. The drug blocks a protein linked to inflammation, which may help patients re…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

This study tests whether combining speech therapy with a gentle brain stimulation technique (tDCS) can help people with primary progressive aphasia (PPA) communicate better. Ten participants will receive treatment at home via video calls. The goal is to see if this approach is fe…

This study tests a personalized brain stimulation device (tACS) for older adults with mild cognitive impairment or mild Alzheimer's. The device uses AI to tailor the stimulation based on each person's brain scans. About 460 participants will join to see if it safely improves memo…

This study tests a specially designed garment for elderly dementia patients who have incontinence and often remove their protective pads. The goal is to see if a more dignified, comfortable garment can improve satisfaction for patients and caregivers. Forty participants will be r…

This phase 3 study tests a drug called ampreloxetine for people with multiple system atrophy (MSA) who experience dizziness and fainting due to low blood pressure when standing. About 102 adults with MSA will take the drug for 20 weeks, then some will switch to placebo to see if …

This natural history study follows 259 children, adolescents, and adults with Neurofibromatosis Type 1 (NF1) for up to 10 years. Researchers will track tumor growth, monitor quality of life, and perform genetic testing to better understand how the disease changes over time. The g…

This study develops and tests a decision-making program designed specifically for African American adult daughters who make healthcare choices for their parents with dementia. The program focuses on communication, problem-solving, and understanding the healthcare system, all whil…

Researchers in Argentina are developing and testing a self-administered questionnaire to measure how hereditary transthyretin amyloidosis affects patients' physical, emotional, and social quality of life. The study includes input from neurologists, a cardiologist, a psychologist,…

Researchers are checking whether tests of muscle strength, walking, balance, and fine motor skills give consistent results in people with polyneuropathy. About 520 adults with various forms of nerve damage, plus healthy volunteers, take part. Participants complete physical tests,…

This study follows 285 older adults with Alzheimer's or mild cognitive impairment to learn how they make decisions about aging in place or moving to long-term care. Researchers will track planning and preferences over time. No treatment or intervention is being tested.

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

This study aims to find blood-based biomarkers that signal the presence and size of plexiform neurofibromas in people with Neurofibromatosis type 1 (NF1). Researchers will collect blood samples and use whole-body MRI to compare biomarker levels in 200 participants with different …

This study compares two different radioactive tracers used in PET scans to measure tau tangles in the brain, a hallmark of Alzheimer's disease. Researchers will scan over 800 participants with either Flortaucipir or MK-6240 to see how well they work over time. The goal is to harm…

This pilot study tests a program that screens older dialysis patients for common age-related problems like falls, memory trouble, and medication issues. A geriatrics team then gives personalized recommendations to the dialysis clinic. The goal is to see if this approach is practi…

Researchers are testing whether combining genetic data, blood or brain biomarkers, and detailed thinking and memory tests can better predict who might develop Alzheimer's disease. The study follows 200 adults with either mild memory complaints or early cognitive decline over two …

This study is testing whether a blood test (liquid biopsy) can detect a rare but serious nerve tumor called MPNST earlier than current methods in adults with Neurofibromatosis Type 1 (NF1). Researchers will compare the timing of tumor detection by the blood test versus standard i…

This study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's over several years. Researchers use brain scans, memory tests, and blood samples to track how the disease progresses. The goal is to find better ways to diagnose and treat Alzheimer'…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study is a disease registry that collects information from routine medical care of about 350 adults diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM) in Taiwan, Hong Kong, and Malaysia. Researchers will look at patient characteristics, treatments received, and ho…

This study follows 20,000 healthy Chinese adults aged 40-75 living at various altitudes to see if chronic low oxygen levels increase the risk of multiple system atrophy (MSA), a rare and fatal brain disease. Participants undergo checkups and overnight oxygen monitoring, then are …

This study monitors the safety of selumetinib in children aged 3 to 18 with neurofibromatosis type 1 and symptomatic, inoperable plexiform neurofibromas. Researchers will track potential side effects on the heart, bones, muscles, liver, eyes, and puberty. The goal is to better un…

This study uses anonymous health insurance records from Germany to learn more about a rare heart condition called ATTR-CM, where abnormal protein builds up in the heart. Researchers will look at survival rates, hospital visits, and how common the disease is. No new treatments are…

This observational study follows up to 3,000 people who were previously screened for anti-amyloid Alzheimer's prevention trials but did not qualify based on amyloid levels. Over about 6 years, researchers will track changes in blood biomarkers, brain amyloid (via PET imaging), an…

This study follows 1,000 adults aged 50 and older to see how the health of their heart and blood vessels relates to early signs of Alzheimer's disease and brain aging. Researchers will use brain scans, memory tests, and blood or spinal fluid samples to look for connections betwee…

This program collects brain and other tissue samples from adults, including healthy individuals and those with memory disorders, to support research on Alzheimer's disease. Participants are typically enrolled in affiliated studies or approved on a case-by-case basis. The goal is …

This observational study is looking at a protein called neurofilament light chain (NfL) in the blood of people who carry a gene variant for hereditary ATTR amyloidosis, both those without symptoms and those with nerve damage. Researchers want to see if NfL levels can help detect …

This study uses PET imaging to measure two key proteins in the brain—amyloid and tau—that are hallmarks of Alzheimer's disease. Researchers will follow 120 participants over five years, including people with normal aging, mild cognitive impairment, and dementia, to see how these …

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study follows people who previously received NTLA-2001, an experimental gene-editing therapy, for a type of amyloidosis that can affect nerves or the heart. The goal is to monitor long-term safety and see if the therapy's effects on disease markers persist over time. Partici…

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis, but no experimental treatment is given. The goal is to gather data that could …

This study follows 240 patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) to monitor the long-term safety of the drug TEGSEDI. Researchers will compare patients who have taken TEGSEDI with those who have not, focusing on side effects like low platel…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This study uses advanced PET scans to investigate how brain inflammation and tau protein buildup affect synaptic density in people with Alzheimer's disease. Researchers will compare Alzheimer's patients to healthy controls over two years, tracking changes in these brain markers. …

This study tests a program called Disaster PrepWise for caregivers of people with dementia. The program uses trained volunteers to help caregivers create emergency plans and build support networks. Researchers will measure whether the program improves caregivers' resilience and r…

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study is testing a web-based platform called LEAD that helps people in the early stages of Alzheimer's or dementia talk about and document their end-of-life care preferences. The goal is to make it easier for them and their care partners to feel confident in making future me…

This study investigates how a single high-fat meal (heavy cream) changes blood flow in the brain, and whether this effect differs based on a person's APOE gene variant — a known risk factor for Alzheimer's disease. Researchers will measure brain blood flow using MRI before and tw…

This study examines walking patterns in people with Parkinson's disease and similar neurological conditions, as well as healthy volunteers. Researchers aim to identify unique 'gait signatures'—speed-dependent measures of walking—that could help distinguish between different disor…

This study is testing a tiny camera called micro OCT that can take detailed pictures of cells inside the lungs and nose. Researchers want to see if it works well in people with cystic fibrosis and other lung conditions. The goal is to eventually use this imaging to detect early d…

This study tested whether a special PET imaging probe called [68Ga]CBP8 can measure scarring (fibrosis) in the hearts of people with cardiac amyloidosis, a rare condition where abnormal proteins build up in the heart. Researchers compared 18 participants with cardiac amyloidosis …

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study looks at how adults at risk for Alzheimer's disease react after learning their amyloid and tau biomarker test results. Researchers will track changes in distress, stigma, quality of life, and future planning over time. The goal is to understand the psychological and be…

This study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This study uses a special PET scan to look at tau protein buildup in the brains of African Americans who are either cognitively normal or have dementia. Researchers hope to learn how these brain changes differ across racial groups. The study involves 240 participants and uses a t…

This study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…

This study uses a radioactive tracer called [18F]MK-6240 to take detailed pictures of tau protein clumps in the brain, a hallmark of Alzheimer's disease. Researchers will scan 200 people from families with a rare genetic form of Alzheimer's to see how tau buildup changes over tim…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study follows 640 adults with normal cognition, mild cognitive impairment, or Alzheimer's disease to track brain changes over time. Researchers use advanced brain scans and genetic tests to understand how Alzheimer's develops. The goal is to find better ways to diagnose and …

This study uses special PET/CT scans to measure inflammation in the brains of people with Alzheimer's disease or Lewy body dementia. Researchers want to see if brain inflammation is linked to memory decline and other dementia symptoms. The study also tests a new radioactive trace…

This study looks at whether diabetes or blood sugar problems can worsen thinking and memory issues in people with myotonic dystrophy type 1. Researchers will use MRI brain scans and thinking tests over 4 years to track changes. The goal is to understand why some patients have mor…

This study looks at whether improving sleep through cognitive behavioral therapy (CBT-I) can reduce neuropsychiatric symptoms like anxiety, depression, and agitation in 150 older adults with mild cognitive impairment or early Alzheimer's. Participants are randomly assigned to CBT…

This study looks at whether adults aged 65 and older with memory concerns can collect a small blood sample at home to check for Alzheimer's disease risk. Participants will use a simple device to draw blood, mail it to a lab, and get results from a doctor over video. The goal is t…

This Stanford study is testing whether non-intrusive sensors placed in the home can automatically track neuropsychiatric symptoms like mood changes and agitation in older adults. Researchers will enroll 25 participants with or at risk of mild cognitive impairment or dementia, alo…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study looks at how thinking, memory, and movement change in older adults with conditions like dementia or Parkinson's disease. Researchers will use tests, brain scans, and lab samples to find clues for earlier diagnosis and better care. About 260 people, including healthy vo…

This study looks at how certain genes influence the activity of immune cells in the brain, called microglia, in people with Alzheimer's disease. Researchers will use a special PET scan to measure these cells in about 107 older adults, some with mild memory problems or Alzheimer's…

This study follows 96 people with end-stage kidney disease who need a brachiocephalic fistula for dialysis. Researchers collect data from exams, blood tests, and imaging to track changes in the vein over time. The goal is to learn what causes cephalic arch stenosis, a common narr…

This study is testing a new way to analyze MRI brain scans, called Cortical Disarray Measurement (CDM), to see if it can help diagnose Alzheimer's disease more accurately. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results wi…

This study tests three new imaging agents (18F-RO948, 18F-MK6240, and 18F-GTP1) to see how well they detect tau protein buildup in the brains of people with Alzheimer's disease compared to healthy older adults. About 38 participants aged 50-100 will receive PET scans to compare t…

This study looks at whether advanced monitoring devices can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients with acute kidney injury or end-stage kidney failure. About 30 adults in the intensive care unit wil…

This study looks at a small part of the brain called the locus coeruleus, which may be one of the first areas damaged in Alzheimer's disease. Researchers will use brain scans, eye tracking, and a mild nerve stimulation device to measure how this area affects attention and memory …

This study looks at whether high-intensity cycling during hemodialysis can protect the heart from damage that dialysis sometimes causes. Fifteen adults on dialysis will exercise at different intensities during their sessions. Researchers will use echocardiograms to measure heart …

This study looks at how things like social support, income, and health habits are linked to mental health and brain diseases such as depression, Alzheimer's, and Parkinson's. Researchers will collect surveys, blood samples, and optional brain scans from over 1,300 adults in Europ…

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which se…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study is creating a simple test to check if people with Alzheimer's or similar conditions can understand and agree to medical decisions. Researchers will work with 100-150 participants to compare the new test with existing methods and look at brain scans and blood markers. T…

This study uses special PET scans to look for signs of inflammation in the brains of people with Alzheimer's disease or mild cognitive impairment, compared to healthy volunteers. Nine participants will receive an investigational radioactive tracer called [18F]NOS, and some may al…

This study explores how non-invasive brain stimulation can help understand and treat agitation in people with Alzheimer's and mixed dementia. Researchers will use transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to study brain activity, and test whether tr…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study is creating a registry of 452 adults with a family history of Alzheimer's or early memory problems. Researchers will track their health, blood markers, and thinking skills over time to see if personalized care plans can help prevent or treat the disease. The goal is to…

This study looks at how age-related sleep changes and sleep apnea might increase the risk of Alzheimer's disease. Researchers will use brain scans and overnight sleep tests in 158 healthy adults aged 55-75 to measure amyloid buildup and sleep patterns over two years. The goal is …

This study looks at data from 1 million adults worldwide to see if eating nuts is linked to a lower risk of diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine information from many past studies to get clearer answers. The goal is to understand i…

This study follows 135 people with Lewy body dementia over up to 5 years, using special PET scans to measure brain changes linked to memory and thinking decline. Researchers hope to find imaging markers that show how the disease progresses. Participants will have regular tests an…

This study looks at how older adults (65+) with cancer understand their illness and what they value in life before and after a major operation. Researchers will interview 100 patients to learn about their awareness, expectations, and decision-making. No new drug or treatment is b…

This study looks at how the body's automatic nervous system controls blood flow in abdominal veins and how that might lead to high blood pressure in people with Multiple System Atrophy (MSA). Researchers will measure vein responses in about 16 participants aged 40-80 who have MSA…

The ALOHA study is a community-based research project for adults aged 50 and older in the Washington, D.C., Maryland, and Virginia area. Over five years, participants receive annual health assessments—including physical and cognitive tests—and get a personalized 'Health Passport'…

This study looks at what happens when healthy older adults learn their personal five-year risk of developing Alzheimer's dementia. Researchers are giving 450 participants their risk estimates at different times and tracking changes in mood, thinking, and distress. The goal is to …

This study uses a portable 48-hour EEG monitor to check for hidden seizures in people with early-onset Alzheimer's disease (ages 40-64). Researchers want to learn how common seizures and epilepsy are in this group. The study involves 20 participants and is purely observational, m…

This study aims to test a risk assessment screening and a caregiver coaching program to prevent elder abuse in people with dementia. Researchers will compare caregivers who receive the screening and coaching to those who do not, looking at stress, depression, and anxiety. The goa…

This long-term study uses yearly brain scans, genetic tests, and thinking/memory assessments to track changes in nearly 1,800 people with various dementias (like Alzheimer's and vascular dementia) and over 140 healthy older adults. The goal is to better diagnose, monitor, and eve…

This study is testing a new, low-cost eye scanner to see if it can take clear pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from this device with those from a standard, expensive scanner. They will also measure the thick…

This study was designed to see if a tracking system called Care Companion could help family caregivers of people with dementia who are at risk of wandering. The study was withdrawn before any participants were enrolled, so no results are available. It would have asked caregivers …

This study is analyzing blood samples from 1,799 people with Alzheimer's, dementia, depression, bipolar disorder, schizophrenia, or Parkinson's disease. Researchers want to see if certain substances in the blood can help doctors diagnose and manage these conditions more accuratel…

This study is a registry that collects information from about 2,000 people with mild cognitive impairment or Alzheimer's disease. Researchers will track how the disease progresses and how treatments work in real-world settings. The goal is to better understand Alzheimer's and imp…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study aimed to see if an online lesson could improve people's knowledge and healthy habits for preventing dementia. It planned to enroll Canadians aged 16 and older without dementia, giving some the prevention lesson and others a different topic. However, the study was withd…

This study will test whether it's possible to create a registry for people with Alzheimer's who are receiving lecanemab infusions, along with their care partners. Researchers want to see if they can collect information on quality of life and caregiver burden in a real-world clini…

This study follows 80 people with Neurofibromatosis type 1 (NF1) who are at high risk for developing malignant peripheral nerve sheath tumors (MPNST). Researchers will use yearly whole-body MRI scans, blood samples, and checkups to track changes in nerve lesions over time. The go…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study creates a database of 476 patients in the Bronx who were tested for transthyretin amyloid cardiomyopathy (ATTR-CM), a serious and often missed heart condition. Researchers collected health records, imaging results, and outcomes like hospitalizations and deaths. The goa…

This study follows 20 adults with hereditary transthyretin amyloidosis (ATTRv) who have both nerve and heart involvement. They are treated with patisiran or vutrisiran for two years. Researchers use MRI scans and questionnaires to see how the drugs affect heart structure and func…

This study will collect brain scans from over 10,000 healthy people in China to create standard brain charts. These charts will show what a normal brain looks like at different ages. Doctors can then compare a patient's brain scan to these charts to help diagnose diseases like mu…

This study uses a special brain scan to measure amyloid protein buildup in 800 people already enrolled in an Alzheimer's research center. The goal is to understand when amyloid starts accumulating and how fast it builds up, which could reveal a window for early treatment. Partici…

This study looks at 50 people with TTR amyloid cardiomyopathy, a condition where abnormal proteins build up in the heart. Researchers want to see if a special SPECT scan can measure blood flow in the heart's tiny vessels, which may be impaired even without blocked arteries. Parti…

This study monitors indoor air quality in 500 French schoolchildren's classrooms, measuring pollutants like chemicals, allergens, and microbes. Researchers will track asthma and allergy symptoms using questionnaires and lung function tests. The goal is to understand how combinati…

The PorchLight Project tests whether training senior volunteers can improve care for people with memory loss or Alzheimer's disease. Over 340 volunteers and clients in Minnesota are taking part. The training includes online modules, a course, and monthly check-ins. Researchers wi…

This study planned to see if using a special blood test (PrecivityAD2) could help doctors diagnose Alzheimer's disease or other dementias more quickly. It was designed for veterans and people in other closed healthcare systems who had memory problems. However, the study was withd…

This study looks at brain tissue and lab-grown nerve cells from people with schizophrenia, depression, bipolar disorder, frontotemporal dementia, and Alzheimer's. Researchers want to find out how problems with synapses—the connections between brain cells—differ in these condition…

This program aims to enroll up to 500,000 people aged 50-90 in the U.S. who are interested in Alzheimer's research. Participants provide basic health information and consent to genetic testing (APOE) without receiving their results. Their genetic profile is then used to match the…

This study follows 90 people with Multiple System Atrophy (MSA), a rare brain disease, for 12 months. Researchers measure changes in movement, thinking, brain scans, and blood markers to better understand how the disease progresses. The goal is to gather information, not to test …

This study looks at how weight-loss (bariatric) surgery might change memory and thinking skills in people with obesity who also have cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if los…

This study uses a safe, painless eye scan called OCT to look at support cells (glia) in the retina, which is part of the brain. Researchers want to see if these cells work differently in people with early signs of Alzheimer's compared to those without. If they find a difference, …

This study uses a special brain scan called Tau PET to look at a protein linked to Alzheimer's disease in healthy older African Americans. Researchers want to learn how this protein builds up and relates to memory changes over time. The goal is to better understand early signs of…

This study follows 130 older adults with mild to moderate Alzheimer's for up to 5 years to see if frailty (weakness, slow walking, exhaustion, weight loss, low activity) leads to faster loss of daily living skills. Participants are tested at the start and after one year, with lon…

This study collects medical information from 3400 people with primary ciliary dyskinesia (PCD) around the world. Researchers will look at symptoms, lung function, growth, and test results to better understand how the disease affects people over time. The goal is to learn more abo…

This study is testing whether simple blood tests can accurately diagnose dementia in everyday clinic settings. Over 3,000 people aged 45 and older with memory problems will give blood samples and answer questionnaires. Researchers will check how reliable and acceptable these bloo…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study uses special brain scans (tau PET) to see how anti-amyloid immunotherapy affects tau protein buildup in people with mild Alzheimer's disease. About 135 participants will get two tau PET scans—one before starting treatment and another 12-18 months after finishing it. Th…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study uses blood samples and health data from over 13,000 older adults to see if Alzheimer's-related blood markers differ between men and women. Researchers aim to create a sex-specific risk score that could help predict the disease earlier and personalize future treatments.…

This study involves 400 healthy adults aged 60-85 to test new computerized measures of thinking and daily function. Participants are randomly assigned to take either the new tests or standard tests over one year. The goal is to see if the new tests are better at detecting changes…

This study follows 1,400 people with early-stage Alzheimer's or mild cognitive impairment to understand how the disease affects healthcare costs and daily life over time. Participants are not given any experimental treatment. The goal is to gather information for research purpose…

This study follows 500 people with neurofibromatosis type 1 (NF1) to see how their skin tumors (called cutaneous neurofibromas) grow and change over time. Researchers use 3D whole-body photography to track tumor number and size each year. The goal is to better understand these tu…

This study is testing whether smartphones and wearable devices can detect early signs of Alzheimer's disease better than traditional questionnaires. Researchers will follow 3,500 people with and without memory problems to see if digital tools can spot subtle changes in daily acti…

This study follows 132 people with Parkinson's disease or multiple system atrophy who previously received the gene therapy AB-1005. Researchers will track safety and how well the treatment works over the long term. No new treatments are given; it's purely observational.

This study looks at the genes of 1000 people with severe early-onset obesity to find rare genetic causes. It focuses on conditions like Bardet-Biedl syndrome. The goal is to better understand these conditions and improve how they are diagnosed. Participants provide a blood or sal…

This study is a registry that will follow up to 221 children with Noonan Syndrome who are already taking or starting Norditropin® for short stature. Researchers will collect information on growth, side effects, and quality of life over time. No new treatment is being tested—the g…

This study looks at whether group visits in primary care can help adults aged 70 and older complete advance care planning documents, like living wills. About 516 participants will either join two 2-hour group discussions or receive mailed resources. The goal is to see if the grou…

This study uses MRI scans to track how blood vessels in the brain change over time in people with early Alzheimer's disease and healthy volunteers. Researchers aim to understand if reduced blood vessel reactivity is an early sign of dementia. The study involves 120 participants a…

This study uses monthly MRI scans to closely watch brain changes in 75 people with cerebral amyloid angiopathy (CAA), a condition common in older adults that can cause bleeding and strokes. Researchers aim to understand how small bleeds and silent strokes develop over time. Parti…