AI-Powered brain zaps aim to boost memory in Alzheimer's
NCT ID NCT07208734
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a personalized brain stimulation device (tACS) for older adults with mild cognitive impairment or mild Alzheimer's. The device uses AI to tailor the stimulation based on each person's brain scans. About 460 participants will join to see if it safely improves memory and thinking.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial alternating current stimulation (tACS) device
- What this could lead to
- If it works, this could offer a personalized, non-drug way to ease memory and thinking problems in older adults with Alzheimer's.
- What could go wrong
- This is an early-stage study testing safety and effectiveness. The approach is complex and may not work for everyone. Results are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 460 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2024
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Inpatients or outpatients aged 50-90 years; 2. Patients diagnosed with amnestic mild cognitive impairment (aMCI) due to AD or mild dementia due to AD, based on the 2018 NIA-AA clinical diagnostic criteria established by the National Institute on Aging and the Alzheimer's Association; 3. Neuropsychological assessment showing MMSE scores between 18 and 26, and a CDR score of 0.5 or 1; 4. Able to communicate fluently in Chinese (non-illiterate); 5. For those currently receiving cholinesterase inhibitor therapy (e.g., donepezil or rivastigmine), the treatment dose must be stable, defined as a fixed dosage administered continuously for at least six weeks, with no adjustment of the medication regimen during the study period; 6. Provision of written informed consent. Exclusion Criteria: 1. Documented history of cerebrovascular stroke, with clear neurological deficits at onset and corresponding responsible lesions on neuroimaging; 2. Moderate to severe white matter lesions (Fazekas score 3-6); 3. Presence of any cause of consciousness disorder; 4. Severe aphasia or motor disability that prevents completion of neuropsychological assessments; 5. Current psychiatric disorders; 6. History of alcohol dependence, drug addiction, traumatic brain injury, epilepsy, encephalitis, normal-pressure hydrocephalus, or other neurological disorders that may cause cognitive impairment; 7. Systemic diseases that may contribute to mild cognitive impairment (e.g., hepatic or renal insufficiency, endocrine disorders, vitamin deficiencies); 8. Considered unsuitable for participation by the investigators.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Xuanwu Hospital, Capital Medical University, Beijing, Beijing 100053
Beijing, Beijing Municipality, 100053, China
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