ALZHEIMER'S DISEASE

This study tests a special light device that people with mild to moderate Alzheimer's use at home. The goal is to see if the near-infrared light can help slow down memory and thinking problems. About 320 people aged 50 to 85 will take part, and half will use a fake device for com…

This study will follow 3,000 South Korean Alzheimer's patients taking LEQEMBI for up to 6 years to monitor safety, especially brain swelling, small bleeds, and larger hemorrhages. Researchers will use real-world data from a national registry. The goal is to understand risks in ev…

This study is testing the drug lecanemab in 200 people with early-to-moderate Alzheimer's disease. Participants will receive either lecanemab or standard treatment for 24 months. Researchers will use brain scans, eye imaging, and memory tests to see if the drug slows the disease …

This study tests whether a drug called leronlimab is safe for people with Alzheimer's disease or mild cognitive impairment due to Alzheimer's. It also looks at whether the drug can reduce inflammation in the brain. Twenty volunteers aged 50 and older will receive weekly injection…

This study tests an experimental treatment called ACI-24.060, designed to train the immune system to attack harmful amyloid plaques in the brain. It involves 176 adults with early-stage Alzheimer's or Down syndrome (who are at high risk for Alzheimer's). The goal is to see if it …

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild Alzheimer's disease or related memory problems. The drug is given via a spinal injection and aims to reduce a harmful protein called tau in the brain. The main goals are to check safety and how the dru…

This study tests whether a surgical procedure on neck lymph vessels can help drain fluid from the brain better in people with Alzheimer's disease. About 114 participants will either receive the surgery plus standard medication or medication alone. Researchers will track thinking …

This early-stage trial tests a gene therapy that delivers a protein called BDNF directly into the brain. The goal is to slow or prevent brain cell loss in people with early Alzheimer's or mild cognitive impairment. The study involves 12 participants and focuses on safety and memo…

This study tests whether a special light and sound device used at home for 6 months can help people with mild Alzheimer's. The device uses a 40Hz frequency to boost brain waves, which in animal studies reduced harmful protein buildup and improved memory. Researchers will measure …

This study is the first time the drug Leucettinib-21 is being tested in humans. It will check the drug's safety in healthy volunteers and in people with Down syndrome or Alzheimer's disease. The goal is to see if the drug is safe and how the body processes it, which is a step tow…

This early-stage study tests a new drug called RO7812653 in about 50 people with early Alzheimer's disease. The main goal is to check if the drug is safe and how the body handles it. Participants receive a single dose injected into the spine and are closely monitored for side eff…

This study looks at the long-term safety and effects of the experimental drug GSK4527226 in people with early Alzheimer's disease. All 220 participants will receive the drug and must have completed a previous related study. The main focus is on side effects, including brain swell…

This study tests an experimental drug called VHB937 in people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. About 407 participants will receive either the drug or a placebo for 72 weeks, and researchers will track changes in …

This study is testing whether a blood test measuring a protein called p-Tau217 can accurately diagnose Alzheimer's disease. Currently, diagnosis requires a spinal tap to analyze spinal fluid. Researchers will compare the blood test results with the standard spinal fluid tests in …

This study is looking for the best cutoff values for key Alzheimer's markers in spinal fluid and blood. Researchers will test 3,200 people, including those with Alzheimer's, mild memory problems, other dementias, and healthy adults. The goal is to improve how doctors diagnose Alz…

This study aims to see if a new blood test can accurately diagnose Alzheimer's disease by detecting specific proteins (Aβ and Tau seeds) in the blood. Researchers will test 1,500 people aged 55-75, including those with Alzheimer's, other dementias, and healthy individuals. The go…

This study tests a new imaging tracer called [18F]NIDF that binds to tau tangles in the brain, which are linked to Alzheimer's and other neurodegenerative diseases. About 20 healthy volunteers and patients will receive the tracer and undergo PET scans to see how well it works and…

This study is testing whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can improve symptoms in people with mild to moderate Alzheimer's disease. Researchers will use brain scans and thinking tests to measure changes in memory, daily func…

This study tests whether giving insulin once a week for up to 2 hours can improve how the body uses sugar and help thinking and memory in people with Alzheimer's disease. Eight adults with mild to moderate Alzheimer's will receive the treatment for 6 months and complete memory te…

This study tests if shining a special light on the forehead (called photobiomodulation) can improve thinking skills in people with mild memory loss or early Alzheimer's. Researchers will give the light treatment and then check memory, attention, and blood markers. The goal is to …

This study tests whether a special light that flickers 40 times per second can help people with mild to moderate Alzheimer's disease. Over 6 months, 62 participants will use the light device for 1 hour each day. Researchers will measure changes in brain activity, memory, and thin…

This study tests a new drug combination, KarXT + KarX-EC, to see if it can improve memory and thinking in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug or a placebo. The goal is to measure changes in cognitive function and d…

This study looks at whether eating only during a 10-hour daytime window (and fasting for 14 hours at night) can improve sleep, thinking, and brain health in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Researchers will compare two fasting schedu…

This study is testing whether a fecal microbiota transplant (FMT) is safe and doable for people with mild-to-moderate Alzheimer's disease. Ten participants will receive the transplant via colonoscopy. The main goal is to check for side effects and see if the procedure is practica…

This study tests a device called ATNC MDD-V1 that combines magnetic brain stimulation with cognitive training to help people with mild Alzheimer's disease. Researchers want to see if it improves thinking and memory over 24 weeks. The study involves 180 adults aged 60-85 who are a…

This study tests if combining a medication (methylphenidate) with a type of non-invasive brain stimulation can reduce apathy in people with Alzheimer's disease or mixed dementia. Apathy, or lack of motivation, is a common and troubling symptom. The study will involve 12 participa…

This early study is testing whether a natural supplement called fisetin is safe for older adults with mild Alzheimer's disease or mild cognitive impairment. Only 5 participants will take the supplement, and researchers will closely watch for any side effects. This is a very small…

This study tests whether a new drug combination, KarXT + KarX-EC, can improve memory and thinking in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug or a placebo, and researchers will measure changes in thinking skills and dai…

This study uses special PET scans to measure inflammation in the brains of people with diseases like Alzheimer's, Parkinson's, and ALS, compared to healthy volunteers. Researchers want to see if certain proteins called COX-1 and COX-2 are higher in diseased brains. About 184 adul…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study is looking for new ways to detect Parkinson's disease, Alzheimer's disease, and type 2 diabetes earlier and track them better. Researchers will study blood samples and brain scans from 500 participants to find unique markers. The goal is to improve diagnosis and monito…

This study uses a special PET scan to measure brain inflammation in people with multiple sclerosis or Alzheimer's disease, compared to healthy volunteers. Researchers aim to see if the pattern of inflammation differs between these diseases and relates to symptom severity. Up to 2…

This study watches 5,000 people with early Alzheimer's who are taking lecanemab in regular medical care. The goal is to learn about brain changes called ARIA that can happen with this drug, and how doctors manage treatment when these changes occur. No new treatments are being tes…

This registry collects contact info from people interested in Alzheimer's prevention research. Enrollees receive news and emails about studies in their area, such as surveys, lifestyle programs, memory tests, brain scans, or drug trials. Anyone can join online with no obligation …

This study looks at how Alzheimer's patients naturally speak and compares it to how dementia is shown in novels. Researchers want to see if fiction matches real-life memory loss patterns. The goal is to create a tool that helps doctors spot dementia earlier and helps caregivers b…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood of healthy adults aged 35 to 65. These particles help cells talk to each other and may affect heart and brain health. Researchers will compare blood samples …

This study looks at how social thinking skills (like understanding others' emotions) relate to real-life social behaviors in people with Alzheimer's or frontotemporal degeneration. Researchers will test 120 adults aged 40-85 using questionnaires and brain scans. The goal is to be…

This study looks at the help that family members and friends give to people with Alzheimer's disease. Researchers want to understand how this care changes as the disease gets worse and what it costs. About 312 people aged 60 and older with Alzheimer's, along with their caregivers…

This study is gathering data from 1,200 older adults (ages 60-90) who are either cognitively normal, have mild memory problems, or have mild-to-moderate Alzheimer's. Researchers will collect blood samples, digital measurements (like from apps or devices), and brain scans to see i…

This study looks at whether certain blood markers and brain scans can help predict which older adults with memory loss or frailty will need to visit the emergency room within six months. Researchers will follow 110 participants aged 65 and older who have lost some independence. T…

This study looks for early signs of Alzheimer's disease in people who carry a genetic mutation that causes it. Researchers will use blood tests, brain scans, and memory tests to find biomarkers that predict when symptoms might start. The goal is to better understand the disease a…

This study tests a new imaging tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers aged 50 and older, including healthy individuals. The goal is to better understand …

This study follows 1,000 adults who have early memory concerns but no dementia. Researchers will use blood tests and yearly check-ups over 5 years to learn who may be at risk for Alzheimer's disease. The goal is to better understand early signs and improve future prevention strat…

This study aims to identify early risk factors for Alzheimer's disease by following 850 adults with normal memory or mild cognitive issues. Researchers will track changes in thinking skills, brain scans, and spinal fluid markers over time, with a special focus on how blood sugar …

This study uses special brain scans (Tau PET/CT) to look at tau protein buildup in older adults with mild cognitive impairment or Alzheimer's disease. Researchers aim to understand why Alzheimer's affects people differently by linking scan patterns with memory, thinking, and othe…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…