ALZHEIMER'S DISEASE

This study aimed to test a drug called BAC in people with Alzheimer's disease or vascular dementia. The goal was to see if BAC could improve thinking and memory, and to check for side effects. However, the trial was withdrawn before any participants were enrolled, so no results a…

This study tests an experimental pill (RO7269162) in 256 adults who are at risk for or in early stages of Alzheimer's disease. Participants take the pill or a placebo daily for about 1.5 years. Researchers check for side effects and measure changes in brain plaques and other mark…

This study tests whether adding an experimental drug called E2814 to the approved Alzheimer's drug lecanemab can reduce harmful tau protein in the brain. It involves 105 people with early-stage Alzheimer's (mild memory problems or mild dementia). Participants receive either E2814…

This study tests an experimental drug called GSK4527226 in 367 people with early Alzheimer's (mild memory problems or mild dementia). Participants receive either a low dose, high dose, or placebo as an IV infusion. The goal is to see if the drug can slow down worsening of memory …

This study tests an experimental drug called remternetug against a placebo in about 1400 people with early Alzheimer's who are at risk for worsening memory and thinking problems. The goal is to see if the drug can delay or prevent significant decline in daily function and cogniti…

This study tests the drug lecanemab in 40 people who have a gene mutation that causes early-onset Alzheimer's. The goal is to see if removing amyloid plaques from the brain can delay or slow memory loss and other symptoms. Participants previously received another experimental dru…

This study tests whether changing the dose schedule of donanemab can lower the risk of a brain swelling side effect called ARIA-E while still clearing amyloid plaques. About 1,175 adults with early symptomatic Alzheimer's will receive different dosing regimens over 91 weeks. The …

This study tests a structured care plan for treating agitation and aggression in people with Alzheimer's disease. The plan combines medications and non-drug approaches based on regular assessments. Researchers will compare this approach to usual care in 187 participants living in…

This study aims to see if a blood test can identify people who may have amyloid buildup in the brain, a hallmark of Alzheimer's disease. Researchers will test 2,000 adults aged 50-80, with or without memory symptoms, to sort them into low, medium, or high risk groups. The goal is…

This study develops and tests personalized treatments for older adults with memory loss due to Alzheimer's disease. It uses computer algorithms to tailor cognitive training and brain stimulation (tACS) based on individual brain scans. About 460 participants will join to see if th…

This study tests a new website tool called WeCareToFeedDysphagia to see if it reduces feelings of burden in caregivers of people with Alzheimer's or related dementias who also have trouble swallowing. About 802 caregivers will either get access to the tool or not, and all will ha…

This study tests whether a special oil from olive pomace can lower inflammation in people with early-stage Alzheimer's. Researchers will give 40 Alzheimer's patients and 40 healthy adults meals containing either pomace oil or a standard sunflower oil, then measure blood markers o…

This study tests a 4-week occupational therapy program using a multisensory environment (lights, sounds, textures) for people with moderate Alzheimer's. The goal is to see if it improves thinking, behavior, and daily function, while also reducing stress for their caregivers. 24 p…

This study tests whether learning memory tricks (like mnemonics) can improve thinking and memory in adults over 50 who have mild memory worries. About 80 participants will be split into two groups: one gets structured memory training with daily practice, the other just receives g…

This study tests whether a drug called XBD173 can improve blood flow in the brains of people with Alzheimer's disease. About 51 participants will take the drug or a placebo for 28 days and have MRI scans and blood tests. The goal is to see if the drug helps the brain's blood vess…

This study is testing whether smartphones and wearable devices can detect early signs of Alzheimer's disease better than standard questionnaires. Researchers will follow 3,500 adults, including healthy volunteers and those with mild cognitive impairment or Alzheimer's, to see if …

This study tests a new, highly detailed PET/CT scanner (NeuroEXPLORER) against standard scanners for people with conditions like dementia, Parkinson's, epilepsy, brain tumors, and head/neck cancers. About 1,600 participants will get both scans in one visit to see if the new scann…

This study looks at brain tissue from people who donated their brains after death, and at nerve cells grown in a lab from patients. The goal is to find out how synapses (the connections between brain cells) are different in people with schizophrenia, depression, bipolar disorder,…