Alzheimer's disease

This trial tests whether an experimental drug called RO7568282 can slow the progression of early Alzheimer's disease. About 450 people with mild cognitive impairment or mild dementia due to Alzheimer's will receive either the drug or a placebo for 72 weeks. Researchers will measu…

This pilot study tests whether electroconvulsive therapy (ECT) can improve thinking and memory in people with Alzheimer's disease. ECT is a procedure that uses electrical stimulation to trigger a controlled seizure under anesthesia, and it is already used for severe depression. R…

This phase 2 trial tests whether terazosin, a drug already used for high blood pressure, can increase energy production in the brains of people with Alzheimer's disease. Researchers will give 100 participants either terazosin or a placebo for 78 weeks and measure ATP, the body's …

This trial tests whether a combination of two antiretroviral drugs, emtricitabine and tenofovir, is safe and tolerable in older adults with early Alzheimer's disease. Participants take the drug or a placebo daily for 28 days, then undergo blood tests, cognitive checks, and brain …

This trial tests whether a specific acupressure routine, performed by trained caregivers three times a week for a year, can slow cognitive decline in older adults with early or mild Alzheimer's disease. Participants will be randomly assigned to receive either the full acupressure…

This early-stage trial evaluates an investigational drug called BMS-986446 (moponetug) in healthy adults and in people with early Alzheimer's disease. The study aims to understand how the drug moves through the body, its safety, and how well it is tolerated when given as a single…

This study tests an experimental pill called RP902 in 360 people with mild cognitive impairment caused by Alzheimer's disease. Participants will take the drug or a placebo for 48 weeks to see if it slows memory decline. The trial is conducted at about 50 sites in China and may ex…

This trial investigates whether a surgical procedure that connects lymph vessels in the neck to veins, combined with the standard drug donepezil, can slow cognitive decline in people with moderate Alzheimer's disease. The surgery aims to improve drainage of waste from the brain, …

This study tests whether a daily 240 mg dose of Ginkgo biloba extract can change certain blood markers linked to Alzheimer's disease in people with mild cognitive impairment. Over 6 months, 120 participants will be randomly assigned to receive either Ginkgo biloba or a placebo. T…

This study tests a one-time microsurgery that connects lymphatic vessels in the neck to veins, aiming to improve drainage of waste proteins from the brain. Fifty-nine people with severe Alzheimer's will receive the surgery plus standard medication. Researchers will measure change…

This study tests a surgical procedure called deep cervical lymphovenous anastomosis (LVA) for people with moderate Alzheimer's disease. The surgery aims to improve the brain's ability to clear waste proteins, like amyloid-beta, which are linked to Alzheimer's. Researchers will co…

This study tests an oral medication called Gut-X-001 in 120 people with Alzheimer's disease. The goal is to see if it can improve thinking, daily living skills, and brain health. Participants will receive the drug or a placebo for 6 months, with an option to continue for another …

This early-stage trial tests whether lithium orotate, a form of the mineral lithium, is safe and reaches the brain in people with early Alzheimer's. Forty adults with confirmed Alzheimer's will take either the supplement or a placebo for 9 weeks. Researchers will measure lithium …

This pilot study tests whether a noninvasive ultrasound device can safely help clear waste from the brain in people at risk for Alzheimer's. Fifteen adults with signs of amyloid buildup will receive either real or sham ultrasound sessions over four weeks. The main goal is to chec…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of Alzheimer's disease by regulating the 'gut-brain axis'—the link between gut bacteria and the brain. Researchers will treat 200 Alzheimer's patients with either real or sham rTM…

This Phase 1 trial tests a new drug called AK152 in healthy volunteers and people with Alzheimer's disease. The main goal is to check if it is safe and tolerable, and to see how the body processes it. The study is small and early-stage, so it will not prove whether the drug works…

This study tests a French questionnaire designed to identify spatial orientation problems in people with Alzheimer's disease. Researchers will ask 330 participants—including Alzheimer's patients, their caregivers, and healthy older adults—to fill out the questionnaire. The goal i…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This study will test a wearable headband called Somfit that measures brain activity during sleep in people with early or no Alzheimer's symptoms. Researchers want to see if it works as well as a full lab sleep test. If it does, it could make it easier to track sleep changes linke…

This Phase 2 trial tests whether combining psilocybin—a compound from certain mushrooms—with daily cognitive training can enhance brain plasticity in adults aged 65 and older. Participants include healthy older adults and those with mild cognitive impairment or early-stage Alzhei…

This study investigates whether playing 3D motion-sensing games (using Kinect and Google Cardboard) can improve motor control, thinking skills, and quality of life in people with mild to moderate Alzheimer's disease. Participants play specially designed games for 30 minutes a day…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests whether dronabinol, a synthetic form of THC (the active ingredient in cannabis), can safely reduce agitation in people with Alzheimer's disease. About 140 adults aged 50 to 90 with Alzheimer's-related agitation will receive either dronabinol or a placebo for 12 w…

This study explores whether drinking beetroot juice twice a day is practical and acceptable for people with mild-to-moderate Alzheimer's disease. Thirty participants will take the juice for one week, with help from a caregiver, to see if they can stick with it and if it causes an…

Researchers at Tufts Medical Center are testing an advance care planning program for people 65 and older who have Alzheimer's disease or related dementias, or who face a higher risk of dying within a year. The program pairs participants with counselors and videos that explain car…

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

This study uses a special full-body PET scan to look for activated T cells (a type of immune cell) in the brain and body of people with Alzheimer's disease. Ten participants with Alzheimer's and some healthy volunteers will get the scan to compare results. The goal is to better u…

This study aims to find out how many hospitalized patients in Iraq are malnourished, a problem that can lead to more complications and longer stays. Researchers will screen 300 adults in two hospitals using standard tools to identify those at risk. The goal is to gather data to i…

This study will test if wearable devices like smartwatches and rings can detect early signs of mild cognitive impairment and Alzheimer's disease in 150 adults aged 65 and older. Participants will wear the devices for 30 days while researchers collect data on activity, sleep, and …