ALZHEIMER'S DISEASE

This early-stage study tested an experimental drug called SHR-1707 in 33 people with mild memory problems or mild Alzheimer's disease. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked at whether it could reduce sticky plaques in …

This study tested whether a low dose of nilotinib, a drug used for leukemia, is safe for people with mild to moderate Alzheimer's disease. Researchers wanted to see if it could reach the brain and affect proteins linked to Alzheimer's, like tau and amyloid. 37 participants took e…

This study tested a drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease (mild cognitive impairment or mild dementia). Participants received different doses of the drug or a placebo every 2 or 4 weeks for 18 months. The goal was to see if the drug could sl…

This study tested three non-drug therapies—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild to moderate Alzheimer's. The goal was to see if these approaches could slow the progression to severe dementia. Participants were over 50 and no…

This study tested an experimental drug called 50561 in 68 people with mild to moderate Alzheimer's disease. Participants were randomly assigned to receive either the drug or a placebo, and neither they nor the doctors knew who got which. The main goal was to see if the drug could…

This study tested a new imaging agent called [18F]APN-1607 to see if it can help diagnose Alzheimer's disease by detecting specific brain changes. About 230 people took part, including those with Alzheimer's, mild cognitive impairment, and healthy volunteers. The goal was to comp…

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict if someone with mild memory problems will develop Alzheimer's. Over 1,000 older adults with either mild cognitive impairment or Alzheimer's dis…

This early-stage study tested the safety and tolerability of a new drug called BMS-984923 in 51 healthy older adults and people with Alzheimer's disease. Researchers gave increasing doses to see if it caused side effects or lab changes. The goal was not to treat the disease but t…

This study tested whether different amounts of light exposure could help people with Alzheimer's disease sleep better and feel calmer. 135 participants were randomly assigned to get 2 hours, 4 hours, or all-day morning light. The goal was to see which length worked best for impro…

This early-stage study tested a new drug called IBC-Ab002 in 40 people with early Alzheimer's disease. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo through an IV. The study focused on side effects…

This study looked at whether music therapy singing sessions can improve memory, language, and quality of life in 100 people with Alzheimer's disease or mild cognitive impairment. Over 12 months, participants worked with a licensed music therapist and were compared to a control gr…

This study tested an experimental drug called SAGE-718 in 174 people with mild memory problems or mild dementia caused by Alzheimer's disease. The main goal was to see if the drug could improve thinking skills, especially processing speed, compared to a placebo. The trial has bee…

This study tested a personalized care plan for people with Alzheimer's who have agitation and live at home. A nurse worked with doctors and caregivers to find the causes of agitation and provide targeted support, using telehealth and caregiver training. The goal was to reduce hos…

This study tested an experimental drug called NMRA-323511 in two groups: healthy older adults and people with Alzheimer's who experience agitation. The goal was to see if the drug is safe and if it can reduce agitated behaviors like pacing or yelling. The study was small and earl…

This study tested whether long-term exposure to a special light can improve sleep and memory in 73 people with mild cognitive impairment or early Alzheimer's disease living at home. Participants used the light at home, and researchers measured changes in thinking skills and sleep…

This study tested a dietary supplement made from medium-chain triglycerides (MCTs), a type of fat found in coconut oil, in 43 people with mild-to-moderate Alzheimer's disease or a related language disorder. The main goal was to see if the supplement was safe and tolerable, and to…

This early-stage study tested a new medicine called MK-1167 in 28 people with Alzheimer's disease who were already taking donepezil. The main goal was to check if MK-1167 is safe and how the body processes it. Researchers measured side effects and drug levels in the blood to guid…

This early-stage study tested the safety of a drug called MK-8189 in 29 people with Alzheimer's disease, some of whom also had symptoms of agitation or psychosis. The main goal was to see if the drug was safe and tolerable. This is a first step toward finding new treatments for t…

This study looked at whether a specially designed light therapy can improve sleep, thinking, mood, and behavior in people with Alzheimer's disease or mild cognitive impairment. About 100 participants received either the active light or a placebo for 6 months. The goal was to see …

This study used special brain scans to measure amyloid protein buildup in 60 people with Alzheimer's disease or related conditions like posterior cortical atrophy and logopenic progressive aphasia. Researchers compared early-onset and late-onset Alzheimer's to see how age influen…

This study looked at whether certain hormone levels in the blood are different in people with Alzheimer's disease, mild memory problems, or normal aging. Researchers measured IGF-I and IGFBP-3 in 693 older adults to see if these levels are linked to thinking and memory. The goal …

This study looked at whether changes in the back of the eye (the retina) can be an early sign of Alzheimer's disease. Researchers measured the thickness of the retinal nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye measur…

This study looked at whether text message reminders help people over 55 with normal thinking or mild memory issues follow a daily morning light routine. The light therapy is meant to adjust the body's internal clock. Twenty healthy adults took part, and researchers measured their…

This study tested whether a virtual reality headset that flashes lights and plays sounds is safe and comfortable for people with early Alzheimer's and for healthy older adults. 27 volunteers tried the headset while researchers measured brain activity and asked about side effects.…

This study collected blood samples from over 2,200 people with dementia (like Alzheimer's) and healthy volunteers to find genes linked to these brain diseases. Researchers compared DNA from patients and their families to discover new genetic causes and risk factors. The goal is t…

This study looked at how people with Alzheimer's disease search for objects in realistic scenes and real-life settings. Researchers tracked eye movements to understand which parts of attention and memory are impaired. The goal was to link these visual difficulties to problems wit…

This study followed 404 older adults who had surgery for a broken hip to see how long they lived over the next 10 years. Researchers checked whether early signs of Alzheimer's disease in the brain (measured in spinal fluid) or memory problems before the fracture were linked to hi…

This study involved over 6,000 Medicare patients with mild cognitive impairment or dementia. Researchers wanted to see if a special brain scan (amyloid PET) helps doctors make better treatment decisions and improves patient outcomes. The study focused on including people from div…

This study looked at 242 volunteers to find early markers of Alzheimer's disease using brain imaging. Researchers tracked changes in brain structure, activity, and proteins over time. The goal was to understand how Alzheimer's develops and to help with earlier diagnosis. Particip…