New drug duo aims to slow Alzheimer's by targeting brain tangles
NCT ID NCT06602258
First seen Nov 14, 2025 · Last updated May 22, 2026 · Updated 23 times
Summary
This study tests whether adding an experimental drug called E2814 to the approved Alzheimer's drug lecanemab can reduce harmful tau protein in the brain. It involves 105 people with early-stage Alzheimer's (mild memory problems or mild dementia). Participants receive either E2814 or a placebo along with lecanemab, and researchers measure changes in spinal fluid and brain scans over 6 to 24 months. The goal is to find the right dose that safely slows disease progression.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Abington Neurological Associates LTD
Abington, Pennsylvania, 19001, United States
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Advanced Clinical Research Network
Miami, Florida, 33165, United States
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Alzheimer's Research and Treatment Center
Wellington, Florida, 33467, United States
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Alzheimer's Research and Treatment Center-Stuart
Stuart, Florida, 34997, United States
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Axiom Brain Health
Tampa, Florida, 33609, United States
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Banner Sun Health Research
Phoenix, Arizona, 85006, United States
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Bradenton Research Center
Bradenton, Florida, 34205, United States
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Charter Research
The Villages, Florida, 32162, United States
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Columbus Memory Center, PC
Columbus, Georgia, 31909, United States
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Hattiesburg Clinic
Hattiesburg, Mississippi, 39401, United States
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K2 Medical Research
Clermont, Florida, 34711, United States
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Keimei Memorial Hospital
Honjō, Miyazaki, 880-1111, Japan
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Keio University Hospital
Shinjuku, Tokyo, 160-8582, Japan
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Kerwin Memory Center
Dallas, Texas, 75231, United States
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National Center for Geriatrics and Gerontology
Ōbu, Aichi-ken, 474-8511, Japan
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National Clinical Research-Richmond, Inc
Richmond, Virginia, 23294, United States
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National Hospital Organization Hiroshima-Nishi Medical Center
Ōtake, Hiroshima, 739-0696, Japan
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Neurology Clinic, P.C.
Cordova, Tennessee, 38018, United States
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Osaka Metropolitan University Hospital
Osaka, 545-8586, Japan
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Progressive Medical Research
Port Orange, Florida, 32124, United States
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Renstar Medical Research
Ocala, Florida, 34470, United States
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Rijikai Medical Corporation Katayama Medical Clinic
Kurashiki, Okayama-ken, 710-0813, Japan
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Tokyo Medical University Hospital
Shinjuku, Tokyo, 160-0023, Japan
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale University School of Medicine
New Haven, Connecticut, 06510, United States
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Yamagata Tokushukai Hospital
Yamagata, 990-0834, Japan
Conditions
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