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New strategy aims to tame common virus after stem cell transplants

NCT ID NCT01199562

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Feb 01, 2026 · Last updated Jun 10, 2026 · Updated 23 times

Summary

This study tests a modified plan to prevent and treat cytomegalovirus (CMV) infection in people with blood cancers who have had a donor stem cell transplant. CMV is a common virus that can cause serious problems after transplant. The study involves 153 participants and looks at whether delaying or adjusting anti-CMV treatment can still keep patients safe while reducing unnecessary medication.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

Conditions

The condition(s) this trial relates to.

acquired polycythemia vera acute biphenotypic leukemia acute myeloid leukemia anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma aplastic anemia B-cell chronic lymphocytic leukemia blast phase chronic myelogenous leukemia, BCR-ABL1 positive Burkitt lymphoma chronic eosinophilic leukemia chronic myelogenous leukemia, BCR-ABL1 positive chronic myelomonocytic leukemia chronic neutrophilic leukemia Congenital Abnormalities cytomegalovirus infection diffuse large B-cell lymphoma essential thrombocythemia extranodal nasal NK/T cell lymphoma follicular lymphoma hairy cell leukemia hematopoietic and lymphoid system neoplasm Hodgkins lymphoma Immunoglobulin Light-chain Amyloidosis intraocular lymphoma large-cell immunoblastic lymphoma Leukemia, Large Granular Lymphocytic leukemia, myeloid, accelerated-phase Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Leukemia, Myeloid, Chronic-Phase Lymphoma, B-Cell, Marginal Zone Lymphoma, Extranodal NK-T-Cell mantle cell lymphoma mast cell leukemia mycosis fungoides Myeloproliferative Disorders non-Hodgkin lymphoma plasma cell myeloma Precursor Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma primary cutaneous T-cell non-Hodgkin lymphoma primary myelofibrosis prolymphocytic leukemia Sezary syndrome Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACCELERATED PHASE CHRONIC MYELOGENOUS LEUKEMIA ACCELERATED PHASE CHRONIC MYELOGENOUS LEUKEMIA ACUTE UNDIFFERENTIATED LEUKEMIA ADULT ACUTE LYMPHOBLASTIC LEUKEMIA IN REMISSION ADULT ACUTE MYELOID LEUKEMIA IN REMISSION ADULT ACUTE MYELOID LEUKEMIA WITH 11Q23 (MLL) ABNORMALITIES ADULT ACUTE MYELOID LEUKEMIA WITH DEL(5Q) ADULT ACUTE MYELOID LEUKEMIA WITH INV(16)(P13;Q22) ADULT ACUTE MYELOID LEUKEMIA WITH T(15;17)(Q22;Q12) ADULT ACUTE MYELOID LEUKEMIA WITH T(16;16)(P13;Q22) ADULT ACUTE MYELOID LEUKEMIA WITH T(16;16)(P13;Q22) ADULT ACUTE MYELOID LEUKEMIA WITH T(8;21)(Q22;Q22) ADULT ACUTE MYELOID LEUKEMIA WITH T(8;21)(Q22;Q22) ADULT GRADE III LYMPHOMATOID GRANULOMATOSIS ADULT NASAL TYPE EXTRANODAL NK/T-CELL LYMPHOMA ANAPLASTIC LARGE CELL LYMPHOMA ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA APLASTIC ANEMIA ATYPICAL CHRONIC MYELOID LEUKEMIA, BCR-ABL NEGATIVE ATYPICAL CHRONIC MYELOID LEUKEMIA, BCR-ABL NEGATIVE BLASTIC PHASE CHRONIC MYELOGENOUS LEUKEMIA BLASTIC PHASE CHRONIC MYELOGENOUS LEUKEMIA CHRONIC EOSINOPHILIC LEUKEMIA CHRONIC MYELOMONOCYTIC LEUKEMIA CHRONIC NEUTROPHILIC LEUKEMIA CHRONIC PHASE CHRONIC MYELOGENOUS LEUKEMIA CONTIGUOUS STAGE II ADULT BURKITT LYMPHOMA CONTIGUOUS STAGE II ADULT DIFFUSE LARGE CELL LYMPHOMA CONTIGUOUS STAGE II ADULT DIFFUSE MIXED CELL LYMPHOMA CONTIGUOUS STAGE II ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA CONTIGUOUS STAGE II ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA CONTIGUOUS STAGE II ADULT LYMPHOBLASTIC LYMPHOMA CONTIGUOUS STAGE II GRADE 1 FOLLICULAR LYMPHOMA CONTIGUOUS STAGE II GRADE 2 FOLLICULAR LYMPHOMA CONTIGUOUS STAGE II GRADE 3 FOLLICULAR LYMPHOMA CONTIGUOUS STAGE II MANTLE CELL LYMPHOMA CONTIGUOUS STAGE II MARGINAL ZONE LYMPHOMA CONTIGUOUS STAGE II SMALL LYMPHOCYTIC LYMPHOMA CUTANEOUS B-CELL NON-HODGKIN LYMPHOMA CUTANEOUS B-CELL NON-HODGKIN LYMPHOMA CYTOMEGALOVIRUS INFECTION DE NOVO MYELODYSPLASTIC SYNDROMES DE NOVO MYELODYSPLASTIC SYNDROMES ESSENTIAL THROMBOCYTHEMIA EXTRAMEDULLARY PLASMACYTOMA EXTRANODAL MARGINAL ZONE B-CELL LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE HEMATOPOIETIC/LYMPHOID CANCER INTRAOCULAR LYMPHOMA ISOLATED PLASMACYTOMA OF BONE MAST CELL LEUKEMIA MENINGEAL CHRONIC MYELOGENOUS LEUKEMIA MENINGEAL CHRONIC MYELOGENOUS LEUKEMIA MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM, UNCLASSIFIABLE NODAL MARGINAL ZONE B-CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT BURKITT LYMPHOMA NONCONTIGUOUS STAGE II ADULT BURKITT LYMPHOMA NONCONTIGUOUS STAGE II ADULT DIFFUSE LARGE CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT DIFFUSE LARGE CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT DIFFUSE MIXED CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT DIFFUSE MIXED CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA NONCONTIGUOUS STAGE II ADULT LYMPHOBLASTIC LYMPHOMA NONCONTIGUOUS STAGE II ADULT LYMPHOBLASTIC LYMPHOMA NONCONTIGUOUS STAGE II GRADE 1 FOLLICULAR LYMPHOMA NONCONTIGUOUS STAGE II GRADE 1 FOLLICULAR LYMPHOMA NONCONTIGUOUS STAGE II GRADE 2 FOLLICULAR LYMPHOMA NONCONTIGUOUS STAGE II GRADE 2 FOLLICULAR LYMPHOMA NONCONTIGUOUS STAGE II GRADE 3 FOLLICULAR LYMPHOMA NONCONTIGUOUS STAGE II GRADE 3 FOLLICULAR LYMPHOMA NONCONTIGUOUS STAGE II MANTLE CELL LYMPHOMA NONCONTIGUOUS STAGE II MANTLE CELL LYMPHOMA NONCONTIGUOUS STAGE II MARGINAL ZONE LYMPHOMA NONCONTIGUOUS STAGE II MARGINAL ZONE LYMPHOMA NONCONTIGUOUS STAGE II SMALL LYMPHOCYTIC LYMPHOMA NONCONTIGUOUS STAGE II SMALL LYMPHOCYTIC LYMPHOMA POLYCYTHEMIA VERA POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER PREVIOUSLY TREATED MYELODYSPLASTIC SYNDROMES PREVIOUSLY TREATED MYELODYSPLASTIC SYNDROMES PRIMARY MYELOFIBROSIS PRIMARY SYSTEMIC AMYLOIDOSIS PROGRESSIVE HAIRY CELL LEUKEMIA, INITIAL TREATMENT PROLYMPHOCYTIC LEUKEMIA RECURRENT ADULT ACUTE LYMPHOBLASTIC LEUKEMIA RECURRENT ADULT ACUTE MYELOID LEUKEMIA RECURRENT ADULT BURKITT LYMPHOMA RECURRENT ADULT DIFFUSE LARGE CELL LYMPHOMA RECURRENT ADULT DIFFUSE MIXED CELL LYMPHOMA RECURRENT ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA RECURRENT ADULT GRADE III LYMPHOMATOID GRANULOMATOSIS RECURRENT ADULT HODGKIN LYMPHOMA RECURRENT ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA RECURRENT ADULT LYMPHOBLASTIC LYMPHOMA RECURRENT ADULT T-CELL LEUKEMIA/LYMPHOMA RECURRENT CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA RECURRENT GRADE 1 FOLLICULAR LYMPHOMA RECURRENT GRADE 2 FOLLICULAR LYMPHOMA RECURRENT GRADE 3 FOLLICULAR LYMPHOMA RECURRENT GRADE 3 FOLLICULAR LYMPHOMA RECURRENT MANTLE CELL LYMPHOMA RECURRENT MARGINAL ZONE LYMPHOMA RECURRENT MYCOSIS FUNGOIDES/SEZARY SYNDROME RECURRENT SMALL LYMPHOCYTIC LYMPHOMA REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA REFRACTORY HAIRY CELL LEUKEMIA REFRACTORY MULTIPLE MYELOMA RELAPSING CHRONIC MYELOGENOUS LEUKEMIA SECONDARY ACUTE MYELOID LEUKEMIA SECONDARY ACUTE MYELOID LEUKEMIA SECONDARY MYELODYSPLASTIC SYNDROMES SECONDARY MYELOFIBROSIS SPLENIC MARGINAL ZONE LYMPHOMA STAGE 0 CHRONIC LYMPHOCYTIC LEUKEMIA STAGE 0 CHRONIC LYMPHOCYTIC LEUKEMIA STAGE I ADULT BURKITT LYMPHOMA STAGE I ADULT DIFFUSE LARGE CELL LYMPHOMA STAGE I ADULT DIFFUSE MIXED CELL LYMPHOMA STAGE I ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA STAGE I ADULT HODGKIN LYMPHOMA STAGE I ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA STAGE I ADULT LYMPHOBLASTIC LYMPHOMA STAGE I ADULT T-CELL LEUKEMIA/LYMPHOMA STAGE I CHRONIC LYMPHOCYTIC LEUKEMIA STAGE I CHRONIC LYMPHOCYTIC LEUKEMIA STAGE I CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE I CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE I GRADE 1 FOLLICULAR LYMPHOMA STAGE I GRADE 1 FOLLICULAR LYMPHOMA STAGE I GRADE 2 FOLLICULAR LYMPHOMA STAGE I GRADE 2 FOLLICULAR LYMPHOMA STAGE I GRADE 3 FOLLICULAR LYMPHOMA STAGE I GRADE 3 FOLLICULAR LYMPHOMA STAGE I MANTLE CELL LYMPHOMA STAGE I MANTLE CELL LYMPHOMA STAGE I MARGINAL ZONE LYMPHOMA STAGE I MARGINAL ZONE LYMPHOMA STAGE I MULTIPLE MYELOMA STAGE I MULTIPLE MYELOMA STAGE I MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE I MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE I SMALL LYMPHOCYTIC LYMPHOMA STAGE I SMALL LYMPHOCYTIC LYMPHOMA STAGE II ADULT HODGKIN LYMPHOMA STAGE II ADULT T-CELL LEUKEMIA/LYMPHOMA STAGE II CHRONIC LYMPHOCYTIC LEUKEMIA STAGE II CHRONIC LYMPHOCYTIC LEUKEMIA STAGE II CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE II CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE II MULTIPLE MYELOMA STAGE II MULTIPLE MYELOMA STAGE II MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE II MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE III ADULT BURKITT LYMPHOMA STAGE III ADULT BURKITT LYMPHOMA STAGE III ADULT DIFFUSE LARGE CELL LYMPHOMA STAGE III ADULT DIFFUSE LARGE CELL LYMPHOMA STAGE III ADULT DIFFUSE MIXED CELL LYMPHOMA STAGE III ADULT DIFFUSE MIXED CELL LYMPHOMA STAGE III ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA STAGE III ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA STAGE III ADULT HODGKIN LYMPHOMA STAGE III ADULT HODGKIN LYMPHOMA STAGE III ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA STAGE III ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA STAGE III ADULT LYMPHOBLASTIC LYMPHOMA STAGE III ADULT LYMPHOBLASTIC LYMPHOMA STAGE III ADULT T-CELL LEUKEMIA/LYMPHOMA STAGE III ADULT T-CELL LEUKEMIA/LYMPHOMA STAGE III CHRONIC LYMPHOCYTIC LEUKEMIA STAGE III CHRONIC LYMPHOCYTIC LEUKEMIA STAGE III CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE III CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE III GRADE 1 FOLLICULAR LYMPHOMA STAGE III GRADE 1 FOLLICULAR LYMPHOMA STAGE III GRADE 2 FOLLICULAR LYMPHOMA STAGE III GRADE 2 FOLLICULAR LYMPHOMA STAGE III GRADE 3 FOLLICULAR LYMPHOMA STAGE III GRADE 3 FOLLICULAR LYMPHOMA STAGE III MANTLE CELL LYMPHOMA STAGE III MANTLE CELL LYMPHOMA STAGE III MANTLE CELL LYMPHOMA STAGE III MARGINAL ZONE LYMPHOMA STAGE III MARGINAL ZONE LYMPHOMA STAGE III MARGINAL ZONE LYMPHOMA STAGE III MULTIPLE MYELOMA STAGE III MULTIPLE MYELOMA STAGE III MULTIPLE MYELOMA STAGE III MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE III MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE III MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE III SMALL LYMPHOCYTIC LYMPHOMA STAGE III SMALL LYMPHOCYTIC LYMPHOMA STAGE III SMALL LYMPHOCYTIC LYMPHOMA STAGE IV ADULT BURKITT LYMPHOMA STAGE IV ADULT DIFFUSE LARGE CELL LYMPHOMA STAGE IV ADULT DIFFUSE MIXED CELL LYMPHOMA STAGE IV ADULT DIFFUSE SMALL CLEAVED CELL LYMPHOMA STAGE IV ADULT HODGKIN LYMPHOMA STAGE IV ADULT IMMUNOBLASTIC LARGE CELL LYMPHOMA STAGE IV ADULT LYMPHOBLASTIC LYMPHOMA STAGE IV ADULT T-CELL LEUKEMIA/LYMPHOMA STAGE IV CHRONIC LYMPHOCYTIC LEUKEMIA STAGE IV CHRONIC LYMPHOCYTIC LEUKEMIA STAGE IV CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE IV CUTANEOUS T-CELL NON-HODGKIN LYMPHOMA STAGE IV GRADE 1 FOLLICULAR LYMPHOMA STAGE IV GRADE 1 FOLLICULAR LYMPHOMA STAGE IV GRADE 2 FOLLICULAR LYMPHOMA STAGE IV GRADE 2 FOLLICULAR LYMPHOMA STAGE IV GRADE 3 FOLLICULAR LYMPHOMA STAGE IV GRADE 3 FOLLICULAR LYMPHOMA STAGE IV MANTLE CELL LYMPHOMA STAGE IV MANTLE CELL LYMPHOMA STAGE IV MARGINAL ZONE LYMPHOMA STAGE IV MARGINAL ZONE LYMPHOMA STAGE IV MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE IV MYCOSIS FUNGOIDES/SEZARY SYNDROME STAGE IV SMALL LYMPHOCYTIC LYMPHOMA STAGE IV SMALL LYMPHOCYTIC LYMPHOMA T-CELL LARGE GRANULAR LYMPHOCYTE LEUKEMIA T-CELL LARGE GRANULAR LYMPHOCYTE LEUKEMIA WALDENSTROM MACROGLOBULINEMIA WALDENSTROM MACROGLOBULINEMIA