APLASTIC ANEMIA

This study tests whether giving emapalumab early can help children with aplastic anemia recover their blood cell counts within six weeks. About 35 children with newly diagnosed severe aplastic anemia will receive the drug before standard treatments. The goal is to see if this app…

This study tests a combination of drugs to help people with aplastic anemia or low-risk myelodysplastic syndrome (MDS) who have dangerously low blood counts. The treatment includes horse anti-thymocyte globulin (hATG) and cyclosporine to calm the immune system, plus steroids and …

This study tests a new stem cell transplant method for adults aged 40 to 60 with severe aplastic anemia that did not improve or came back after standard drug therapy. The approach uses a drug called cyclophosphamide after transplant to lower the risk of graft-versus-host disease,…

This study looks at how well umbilical cord blood stem cells from unrelated donors help patients with serious blood cancers, immune problems, or genetic disorders. About 30 people will receive a transplant to see how quickly their blood cells recover and how often the transplant …

This study tests a two-step method using lower doses of radiation and chemotherapy before a stem cell transplant for people with various blood cancers or bone marrow failure. The goal is to see if this gentler approach reduces the chance of dying from the transplant itself. About…

This study tests whether a tailored exercise program combined with a vitamin-like supplement (NAD+ precursor) can improve muscle mass, strength, and fitness in teens and young adults who had a bone marrow transplant for leukemia or other blood disorders. Participants will be rand…

This study looks at the safety and effectiveness of Revolade (eltrombopag) in children aged 6 to 17 with aplastic anemia, a condition where the bone marrow doesn't make enough blood cells. The children in this study have not been treated with anti-thymocyte globulin (ATG) before.…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study tests whether adding ruxolitinib to standard medications can prevent graft-versus-host disease (GVHD) in older adults with aplastic anemia who receive a stem cell transplant. GVHD occurs when donor cells attack the patient's body. The trial enrolls about 20 people aged…

This study is a long-term observation of 1,000 patients receiving stem cell transplants for blood diseases at a hospital on the Qinghai-Tibet Plateau. Researchers will collect information on patient health, treatment results, and costs to understand how high altitude affects reco…

This study is creating a large database of people with various blood diseases in China, such as leukemia, multiple myeloma, and hemophilia. Researchers will collect information from medical records and follow participants over time to learn about disease patterns, treatments, out…

This study aims to create a prediction tool for pregnant women with aplastic anemia, a rare blood condition that raises risks for both mother and baby. Researchers will follow 300 women to identify factors that lead to complications like bleeding, preterm birth, or low birth weig…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. About 60 youth and their parents will try the tool and report how easy and helpfu…

This study uses a non-invasive brain imaging technique called fNIRS to see how anemia affects brain networks involved in thinking and memory. Researchers will monitor brain activity in 323 adults with anemia to identify which brain regions are impacted. The goal is to detect cogn…