New pill could replace chemo for kids with brain tumor
NCT ID NCT05566795
First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 31 times
Summary
This study tests a new drug called DAY101 (tovorafenib) against standard chemotherapy for children and young adults with a slow-growing brain tumor (low-grade glioma) that has a specific genetic change (RAF alteration). The goal is to see if DAY101 can shrink tumors or stop them from growing better than chemo. About 418 participants will be randomly assigned to receive either DAY101 pills or standard chemo.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aarhus Universitetshospital
Aarhus, Central Jutland, 8200, Denmark
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Aghia Sofia General Children's Hospital
Athens, 11527, Greece
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Albany Medical Center
Albany, New York, 12208, United States
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Alberta Children's Hospital
Calgary, Alberta, T3B 6A8, Canada
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Alder Hey Children's NHS Foundation Trust
Liverpool, England, L12 2AP, United Kingdom
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Arnold Palmer Hospital for Children
Orlando, Florida, 32806, United States
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Astrid Lindgrens Barnsjukhus Solna
Stockholm, 171 77, Sweden
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Athens General Children's Hospital
Athens, 11527, Greece
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Azienda Ospedale Università di Padova
Padova, 35128, Italy
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Azienda Ospedaliera U. Meyer
Florence, 50139, Italy
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Azienda Ospedaliera di Rilievo Nazional Santobono Pausilipon
Naples, 80131, Italy
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Azienda Sanitaria Universitaria Friuli Centrale - P.O. Santa Maria della Misericordia
Udine, 33100, Italy
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Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari
Bari, 70124, Italy
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Birmingham Women's and Children's NHS Foundation Trust
Birmingham, England, B4 6NH, United Kingdom
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British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3N1, Canada
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CCHE
Cairo, Cairo Governorate, 11441, Egypt
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CHU Sainte-Justine
Montreal, Quebec, H3T IC5, Canada
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Cambridge University Hospitals NHS Foundation Trust
Cambridge, CB2 0QQ, United Kingdom
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Centre Hospitalier Universitaire Vaudois Lausanne
Lausanne, 1011, Switzerland
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Centre Hospitalier de l'Université Laval et Centre Mère-Enfant Soleil
Québec, G1V 4G2, Canada
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Centre Léon Bérard
Lyon, 69008, France
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Centre de Lutte contre le Cancer - Centre Oscar Lambret
Lille, 59020, France
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Chang Gung Memorial Hospital - Linkou Branch
Taoyuan, 333, Taiwan
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Charité Universitätsmedizin Berlin
Berlin, 13353, Germany
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Children's Health Ireland at Crumlin
Crumlin, Dublin, D12 N512, Ireland
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Children's Health Queensland Hospital and Health Service
South Brisbane, Queensland, 4101, Australia
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital London Health Sciences Centre
London, Ontario, N6A 5W9, Canada
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital at Westmead
Westmead, 2145, Australia
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Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1, Canada
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Children's Hospital of Orange County Main Campus - Orange
Orange, California, 92868, United States
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Children's Minnesota
Minneapolis, Minnesota, 55404, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Children's of Alabama
Birmingham, Alabama, 35233, United States
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Childrens MS Cncr Ctr Bld Dsr
Jackson, Mississippi, 39216, United States
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Cleveland Clinic Main Campus
Cleveland, Ohio, 44195, United States
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Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
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Columbia University
New York, New York, 10032, United States
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Connecticut Children's Medical Center
Hartford, Connecticut, 06106-3322, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dell Children's Medical Center of Central Texas
Austin, Texas, 78723, United States
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Drottning Silvias barn- och ungdomssjukhus
Gothenburg, 416 85, Sweden
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Duke Cancer Institute
Durham, North Carolina, 27705, United States
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Evangelische Klinikum Bethel (EvKB)
Bielefeld, 33617, Germany
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Fakultní Nemocnice Brno - D?tská Nemocnice
Brno, 625 00, Czechia
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Fondazione IRCCS - Istituto Nazionale dei Tumori
Milan, Milan, 20133, Italy
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Great Ormond Street Hospital for Children
Oxford, England, WC1N 3JH, United Kingdom
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Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC)
São Paulo, 04039-001, Brazil
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Gustave Roussy
Villejuif, 94805, France
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Helsingin yliopistollinen sairaala (HUS)
Helsinki, FI-00290, Finland
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Hospital Infantil Universitario Niño Jesús
Madrid, 28009, Spain
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Hospital Sant Joan de Déu Barcelona
Barcelona, 08950, Spain
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Hospital Universitari Vall d'Hebrón
Barcelona, 08035, Spain
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Hospital Universitari i Politècnic La Fe
Valencia, 46026, Spain
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Hospital Universitario Cruces
Barakaldo, 48903, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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Hôpital de la Timone
Marseille, 13005, France
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Institut Curie
Paris, 75248, France
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Istituto Giannina Gaslini
Genova, 16147, Italy
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Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701, United States
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King Hussein Cancer Foundation - King Hussein Cancer Center
Amman, Muhafazat al-Asima, 11941, Jordan
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Leeds Teaching Hospital NHS Trust
Leeds, England, LS1 3EX, United Kingdom
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Maine Children's Cancer Program
Scarborough, Maine, 04074, United States
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Manchester University NHS Foundation Trust
Manchester, England, M13 PWL, United Kingdom
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McMaster Children's Hospital
Hamilton, Ontario, L8S 4L8, Canada
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Medizinische Universität Innsbruck
Innsbruck, Tyrol, 6020, Austria
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Medizinische Universität Wien
Vienna, 1090, Austria
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Motol University Hospital
Prague, 5 150 06, Czechia
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NHS Greater Glasgow and Clyde
Glasgow, Scotland, G51 4TF, United Kingdom
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New York University Langone Health
New York, New York, 10016, United States
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Nicklaus Children's Hospital
Miami, Florida, 33155, United States
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Norton Children's Hospital
Louisville, Kentucky, 40202, United States
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Oregon Health Science University
Portland, Oregon, 97239, United States
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Oslo Universitetssykehus
Oslo, 372, Norway
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Ospedale Infantile Regina Margherita
Torino, Turin, 10126, Italy
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Ospedale Pediatrico Bambino Gesù
Roma, Rome, 00165, Italy
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Packard Children's Hospital Stanford
Palo Alto, California, 94304, United States
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Perth Children's Hospital
Nedlands, 6009, Australia
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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Prinses Maxima Centrum Kinderoncologie
Utrecht, 3584 CS, Netherlands
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Rigshospitalet
Copenhagen, 2100, Denmark
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Riley Hospital for Children at Indiana University Health
Indianapolis, Indiana, 46202, United States
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Royal Belfast Hospital for Sick Children
Belfast, Northern Ireland, BT9 7AB, United Kingdom
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Schneider Children's Medical Center of Israel
Petah Tikva, 49202, Israel
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Semmelweis Egyetem Tűzoltó utcai II. Sz. Gyermekgyógyászati Kliniká
Budapest, 1094, Hungary
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital
Seoul, 03722, South Korea
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Sheffield Children's Hospital
Sheffield, South Yorkshire, S10 2TH, United Kingdom
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SickKids - The Hospital for Sick Children
Toronto, M5G 1X8, Canada
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Sidra Medicine
Doha, 26999, Qatar
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SingHealth Group - KK Women's and Children's Hospital
Singapore, 229899, Singapore
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Skånes Universitetssjukhus - Lund
Lund, 221 85, Sweden
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St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
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Starship Paediatric Blood & Cancer Center
Grafton, 1023, New Zealand
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Stollery Children's Hospital
Edmonton, Alberta, T6G 2B7, Canada
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Sydney Children's Hospital - Randwick
Randwick, 2031, Australia
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Taipei Medical University Hospital
Taipei, 110, Taiwan
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Tampereen Yliopistollinen Sairaala
Tampere, 33520, Finland
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Texas Children's Hospital
Houston, Texas, 77030, United States
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The Christie Hospital
Manchester, M20 4BX, United Kingdom
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The Edmond and Lily Safra Children's Hospital
Ramat Gan, 5265601, Israel
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The Montreal Children's Hospital
Montreal, Quebec, H4A 3J1, Canada
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, England, NE1 4LP, United Kingdom
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The Royal Children's Hospital - Children's Cancer Centre
Parkville, 3052, Australia
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The Royal Marsden NHS Foundation Trust
Sutton, Surrey, SM2 5PT, United Kingdom
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UCSF Benioff Children's Hospital
San Francisco, California, 94158, United States
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Universitaets - Kinderspital Zürich
Zurich, 8032, Switzerland
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Universitaetsklinikum Essen
Essen, North Rhine-Westphalia, 45147, Germany
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, 3000, Belgium
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Universitetssykehuset Nord-Norge - Tromsø
Tromsø, Troms, 9038, Norway
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University Hospital Southampton NHS Foundation Trust
Southampton, Hampshire, SO16 6YD, United Kingdom
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University Hospitals Bristol and Weston NHS Foundation Trust
Bristol, BS2 8HW, United Kingdom
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Florida Health
Gainesville, Florida, 32610, United States
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University of Iowa Hospitals Clinics
Iowa City, Iowa, 52242, United States
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University of Michigan - - C.S. Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198-6878, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Wisconsin - Madison
Madison, Wisconsin, 53792, United States
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Universitätsklinikum Augsburg
Augsburg, Bavaria, 86156, Germany
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Universitätsklinikum Erlangen
Erlangen, Bavaria, 91054, Germany
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Universitätsklinikum Frankfurt
Frankfurt am Main, Hesse, 60590, Germany
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Universitätsklinikum Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Universitätsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
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Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitätsklinikum Leipzig
Leipzig, Saxony, 4103, Germany
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Universitätsklinikum Tübingen
Tübingen, 72076, Germany
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Universitätsklinikum Würzburg
Würzburg, Bavaria, 97080, Germany
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Univerzitetni Klinini Center Ljubljana
Ljubljana, 1000, Slovenia
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Women's and Children's Health Network
North Adelaide, 5006, Australia
Conditions
Explore the condition pages connected to this study.