LOW GRADE GLIOMA

This study tests a drug called mirdametinib in children, adolescents, and young adults with low-grade glioma, a type of brain tumor. The drug is designed to reach the brain and block signals that help tumors grow. The goal is to find the best dose, check safety, and see if it can…

This study is testing a new drug called tovorafenib in Japanese children, adolescents, and young adults (ages 6 months to 25 years) with a specific type of brain tumor (low-grade glioma) that has come back or is growing. The drug is taken once a week by mouth. The main goals are …

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor cells. The goal is to see if this approach can st…

This study tests whether a targeted drug called selumetinib works as well as or better than standard chemotherapy (carboplatin and vincristine) for children and young adults (ages 2-21) with a slow-growing brain tumor called low-grade glioma that does not have certain genetic cha…

This early-stage study is testing a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with solid tumors that have returned or not responded to treatment. The main goal is to find a safe dose and check for side effects. The study is…

This study tests a vaccine made from proteins found on glioma cells, combined with an immune booster, in children with low-grade gliomas that cannot be removed by surgery and have come back after other treatments. The goal is to see if the vaccine can shrink the tumors or keep th…

This study looks at whether people with a slow-growing brain tumor (low-grade glioma) that has a specific gene change (BRAF V600) can safely stop or lower their dose of two targeted drugs (dabrafenib and trametinib) after taking them for 12-24 months. About 96 participants will e…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and high blood pressure, while still preventing brain swelling. About 200 adults with certain brain tumors will be enrolled. T…

This study looks at whether special brain exercises can help adults with low-grade glioma improve memory, attention, and thinking skills that often get worse after surgery, radiation, or chemo. About 97 participants will try one of three rehab methods (in-person, app-based, or te…

This study collects tumor tissue from 50 adults with low- or high-grade glioma to create living organoids in the lab. Researchers will study these organoids to learn why gliomas are so hard to treat. The goal is to find new ways to predict and improve treatment outcomes. No direc…

This study is testing whether a special PET-MRI scan using a tracer called 18F-Fluciclovine can better monitor low-grade gliomas (a type of brain tumor) in children and young adults. About 30 participants will get the scan before starting treatment, then again at 3 months and 1 y…