LOW GRADE GLIOMA

This early-stage study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in adolescents and young adults with IDH1/2-mutant gliomas, a type of brain tumor. The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnose…

This early-stage trial tests the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose brain tumors (low- or high-grade gliomas) have returned after prior treatment. The drugs work by blocking different growth signals in t…

This study compares a targeted drug called selumetinib to standard chemotherapy (carboplatin/vincristine) in children aged 2 to 21 with NF1-related low-grade glioma. The goal is to see if selumetinib works as well or better at controlling the tumor and improving vision. About 165…

This study tests a new drug called DAY101 (tovorafenib) against standard chemotherapy for children and young adults with a slow-growing brain tumor (low-grade glioma) that has a specific genetic change (RAF alteration). The goal is to see if DAY101 can shrink tumors or stop them …

This study tests a drug called selumetinib in children and young adults with low grade glioma, a type of brain tumor that has returned or not responded to standard treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose…

This study tests whether the immunotherapy drug nivolumab can help control brain tumors called gliomas that have specific genetic changes (IDH mutations). About 62 adults with these tumors will receive nivolumab through an IV every few weeks. The main goal is to see if the drug c…

This study tests a precise type of radiation called proton therapy for people with low-grade or certain grade 3 brain tumors (gliomas). The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by sparing healthy brain tissue…

This study tests an online mind-body program for people with brain tumors (glioma or cancer spread to the brain) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life. About 74 couples will participate to see if the program…

This study looks at how seizures change over time in people with low grade glioma (a type of brain tumor) and whether those changes relate to how well the tumor is controlled. Researchers will track 100 adults with brain tumors and a history of seizures who are receiving tumor tr…

This early-stage trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug reaches the tumor and how it affects cancer cells. The goal is to ga…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …