LOW GRADE GLIOMA

This study is testing whether a pill called selumetinib works as well as or better than standard intravenous chemotherapy (carboplatin/vincristine) for children and young adults with low-grade brain tumors linked to Neurofibromatosis Type 1 (NF1). The main goals are to see which …

This study tested a drug called selumetinib for children and young adults whose low-grade brain tumors have returned or stopped responding to treatment. The goal was to find a safe dose and see if the drug could shrink or control the tumors. Participants took the drug orally in r…

This study is testing a more precise type of radiation called proton therapy for adults with certain slow-growing brain tumors. The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by limiting radiation exposure to healt…

This study is testing whether the immunotherapy drug nivolumab can help control the growth of certain brain tumors (gliomas) that have specific genetic changes. It is enrolling 62 adults whose tumors have either a very high number of mutations or a normal number. The main goal is…

This early-stage study is testing a new two-drug combination (BGB-290 and temozolomide) for adolescents and young adults with specific types of brain tumors that have returned or are newly diagnosed. The main goal is to find the safest dose and understand the side effects. Resear…

This study is testing an online meditation and breathing program designed for couples where one person has a brain tumor. The goal is to see if the program is practical and helps improve spiritual well-being, sleep, mood, and overall quality of life for both the patient and their…

This study aims to understand if changes in seizure frequency can serve as an early warning sign for brain tumor progression in patients with low-grade gliomas. Researchers will track 100 adult patients who have seizures related to their brain tumors and are receiving treatment. …

This study aims to understand how a specific type of brain tumor (glioma) changes and becomes more aggressive over time. Researchers will use special brain scans to track chemical levels in the tumors of about 42 adults who have this condition. The goal is to learn if these chemi…

This early study aims to understand if an experimental drug called niraparib reaches brain tumor tissue effectively. It involves 16 adults with recurrent, slow-growing brain tumors (gliomas) who are already scheduled for surgery. Researchers will measure how much of the drug gets…