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Can't smell or hear? study links sensory loss to brain decline over 5 years

NCT ID NCT06991816

Knowledge-focused Sponsor: University of Campania Luigi Vanvitelli Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which sensory losses matter most for brain health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify which sensory losses most strongly predict cognitive decline, guiding future prevention or monitoring strategies.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to everyone. The small size (100 people) limits reliability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients affected by mild cognitive impairment (MCI), Alzheimer Disease in Early stage, Parkison Disease in early stage

Ages

60 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients between 60 and 85 years of age * in general good health * the absence of known severe psychiatric disorders * available to be included in the study and * to follow the 5-year follow-up. Exclusion Criteria: * Obstructive nasal problems * Previous endoscopic nose + paranasal sinus surgery * Chronic use of cortisone spray and/or systemic * Subjects with previous stroke and outcomes * Subjects with history of stroke in the last 3 years without outcomes * Head trauma in the last 24 months * Previous ear surgery * Patients who have been exposed to chemical agents without protection for work, e.g. carpenters * previous Covid with outcomes (olfactory, vestibular, auditory and cognitive "brain fog")

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Anosmia Cognitive Dysfunction hearing loss disorder Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Mild cognitive impairment Parkinson

Contacts and locations

Locations

  • Vanvitelli ENT department

    Naples, Campania, 80138, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.