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New antibody could clear toxic proteins from organs in rare disease

NCT ID NCT04512235

Ongoing Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 20 times

Summary

This study tests a drug called CAEL-101 in people with AL amyloidosis, a rare disease where abnormal proteins build up in organs like the heart and kidneys. The drug is designed to remove these protein deposits. The trial includes 281 participants who have not had prior treatment for their plasma cell disorder. Researchers are checking if CAEL-101 helps people live longer and reduces heart-related hospital stays.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Scottsdale, Arizona, 85259, United States

  • Research Site

    Duarte, California, 91010, United States

  • Research Site

    Palo Alto, California, 94304, United States

  • Research Site

    San Francisco, California, 94143, United States

  • Research Site

    Jacksonville, Florida, 32224, United States

  • Research Site

    Weston, Florida, 33331, United States

  • Research Site

    Indianapolis, Indiana, 46202, United States

  • Research Site

    New Orleans, Louisiana, 70112, United States

  • Research Site

    Baltimore, Maryland, 21201, United States

  • Research Site

    Boston, Massachusetts, 02111, United States

  • Research Site

    Boston, Massachusetts, 02118, United States

  • Research Site

    Boston, Massachusetts, 02215, United States

  • Research Site

    Detroit, Michigan, 48201, United States

  • Research Site

    Rochester, Minnesota, 55905, United States

  • Research Site

    St Louis, Missouri, 63110, United States

  • Research Site

    New York, New York, 10032, United States

  • Research Site

    New York, New York, 10065, United States

  • Research Site

    Rochester, New York, 14642, United States

  • Research Site

    Chapel Hill, North Carolina, 27599, United States

  • Research Site

    Durham, North Carolina, 27705, United States

  • Research Site

    Winston-Salem, North Carolina, 27157, United States

  • Research Site

    Cleveland, Ohio, 44195, United States

  • Research Site

    Columbus, Ohio, 43210, United States

  • Research Site

    Portland, Oregon, 97239, United States

  • Research Site

    Philadelphia, Pennsylvania, 19104, United States

  • Research Site

    Nashville, Tennessee, 37232, United States

  • Research Site

    Dallas, Texas, 75390, United States

  • Research Site

    Houston, Texas, 77030, United States

  • Research Site

    Salt Lake City, Utah, 84112, United States

  • Research Site

    Seattle, Washington, 98109, United States

  • Research Site

    Madison, Wisconsin, 53792, United States

  • Research Site

    Milwaukee, Wisconsin, 53226, United States

  • Research Site

    Box Hill, 3128, Australia

  • Research Site

    Murdoch, WA6150, Australia

  • Research Site

    Westmead, 2145, Australia

  • Research Site

    Woolloongabba, 4102, Australia

  • Research Site

    Linz, 4020, Austria

  • Research Site

    Vienna, 1090, Austria

  • Research Site

    Anderlecht, 1070, Belgium

  • Research Site

    Leuven, 3000, Belgium

  • Research Site

    Porto Alegre, 90110-270, Brazil

  • Research Site

    Ribeirão Preto, 14051-140, Brazil

  • Research Site

    Salvador, 41253-190, Brazil

  • Research Site

    Calgary, Alberta, T2N 4N2, Canada

  • Research Site

    Toronto, Ontario, M5G 2M9, Canada

  • Research Site

    Beijing, 100034, China

  • Research Site

    Beijing, 100730, China

  • Research Site

    Guangzhou, 510180, China

  • Research Site

    Hangzhou, 310009, China

  • Research Site

    Shanghai, 200032, China

  • Research Site

    Suzhou, 215006, China

  • Research Site

    Wenzhou, 325000, China

  • Research Site

    Wuhan, 430022, China

  • Research Site

    Ostrava Poruba, 708 52, Czechia

  • Research Site

    Prague, 12808, Czechia

  • Research Site

    Caen, 14033, France

  • Research Site

    Créteil, 94000, France

  • Research Site

    Dijon, 21079, France

  • Research Site

    Lille, 59037, France

  • Research Site

    Limoges, 87042, France

  • Research Site

    Marseille, 13009, France

  • Research Site

    Paris, 75010, France

  • Research Site

    Pessac, 33604, France

  • Research Site

    Pierre-Bénite, 69310, France

  • Research Site

    Poitiers, 86021, France

  • Research Site

    Rennes, 35033, France

  • Research Site

    Toulouse, 31100, France

  • Research Site

    Tours, 37044, France

  • Research Site

    Berlin, 12203, Germany

  • Research Site

    Düsseldorf, 40225, Germany

  • Research Site

    Essen, 45147, Germany

  • Research Site

    Hamburg, 22767, Germany

  • Research Site

    Heidelberg, 69120, Germany

  • Research Site

    Würzburg, 97080, Germany

  • Research Site

    Athens, 11528, Greece

  • Research Site

    Rio, 26504, Greece

  • Research Site

    Thessaloniki, 54636, Greece

  • Research Site

    Haifa, 31096, Israel

  • Research Site

    Jerusalem, 91120, Israel

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    Petah Tikva, 49100, Israel

  • Research Site

    Tel Aviv, 64239, Israel

  • Research Site

    Tel Litwinsky, 52621, Israel

  • Research Site

    Brescia, 25123, Italy

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    Fukushima, 960-1295, Japan

  • Research Site

    Kanazawa, 920-8641, Japan

  • Research Site

    Kashiwa-shi, 277-8567, Japan

  • Research Site

    Kita-ku, 603-8151, Japan

  • Research Site

    Kumamoto, 860-8556, Japan

  • Research Site

    Matsumoto-shi, 390-8621, Japan

  • Research Site

    Nagoya, 467-8602, Japan

  • Research Site

    Shibuya-ku, 150-8935, Japan

  • Research Site

    Gdansk, 80-214, Poland

  • Research Site

    Warsaw, 01-748, Poland

  • Research Site

    Saint Petersburg, 197022, Russia

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Seoul, 06591, South Korea

  • Research Site

    Barcelona, 08036, Spain

  • Research Site

    Barcelona, 8035, Spain

  • Research Site

    Gijón, 33394, Spain

  • Research Site

    Granada, 18014, Spain

  • Research Site

    Madrid, 28003, Spain

  • Research Site

    Madrid, 28040, Spain

  • Research Site

    Majadahonda, 28222, Spain

  • Research Site

    Pamplona, 31008, Spain

  • Research Site

    Salamanca, 37007, Spain

  • Research Site

    Seville, 41013, Spain

  • Research Site

    Valencia, 46009, Spain

  • Research Site

    Glasgow, G12 0YN, United Kingdom

  • Research Site

    London, NW1 2PG, United Kingdom

Conditions

Explore the condition pages connected to this study.

AL AMYLOIDOSIS AL AMYLOIDOSIS