Fixing sleep may calm Alzheimer's-Related mood swings, study hints

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males and females of any racial or ethnic group, aged 50-90 (inclusive) * Subjective complaint of insomnia associated with daytime impairment or distress (ISI ≥ 10) * Subjective complaint of sleep disturbance ≥ 3 months in duration * Subjective complaint of Neuropsychiatric symptoms (Self-Report NPI distress total score ≥ 4 on any measure other than the sleep domain OR current symptoms from Study Partner NPI ≥ 1 * Able to verbalize understanding of involvement in the research and provide written informed consent or provide assent co-signed by a LAR * Fluent and literate in English * Written, informed consent * Medications (including any dementia-related meds) stable for at least 4 weeks prior to study baseline * Research diagnosis of memory impairment based on the following: i) Global Clinical Dementia Rating (CDR) of 0.5 or 1.0. OR a diagnosis of memory impairment from the Stanford/VA AD Center * MRI safety screen passed , as assessed by the attached MRI safety screening form from the Stanford CNI, excluding mild claustrophobia that will be further screened at the in-person screening session per the screening protocol * Have a caregiver or study partner willing to aid in facilitating the protocol and ratings * Reside within approximately 60 miles of Stanford University Exclusion Criteria: * less than 20 on the Mini-Mental State Examination (MMSE) * Acute or unstable chronic illness: including but not limited to: uncontrolled thyroid disease, kidney, prostate or bladder conditions causing excessively frequent urination (\> 3 times per night); medically unstable congestive heart failure, angina, other severe cardiac illness as defined by treatment regimen changes in the prior 3 months; stroke with serious sequelae; cancer if \< 1 year since end of treatment; asthma, emphysema, or other severe respiratory diseases uncontrolled with medications; and neurological disorders (with the exception of mild AD) such as Parkinson's disease and unstable epilepsy as defined by treatment regimen changes in the prior 3 months; unstable adult onset diabetes as defined by treatment regimen changes in the prior 3 months. * Use of medication specifically prescribed for sleep disturbance or nighttime-only, low dose anti-depressants (e.g., doxepin, amitriptyline, trazodone used only at sub-therapeutic anti-depressant doses and taken only at bedtime) specifically prescribed for sleep disturbance and unwilling or unable to discontinue \> two weeks (anti-depressants) or \>1 week (sleep medications) prior to baseline data collection. * Current or lifetime history of bipolar disorder * History of psychosis preceding onset of memory impairments * Substance abuse or dependence * Excessive alcohol consumption (\>14 drinks per week or \> 4 drinks per occasion) * Current exposure to trauma, or exposure to trauma within the past 3 months * Presence of suicidal ideations representing high risk as measured by the Columbia-Suicide Severity Rating Scale (C-SSRS). Individuals are considered high risk if they have endorsement of either of the following: 1. A score of 4 or more for the past month on the C-SSRS 2. ) A positive endorsement, relative to the past 90 days, in the "Suicide Behavior" section of item #6 (Have you ever done anything, started to do anything, or prepared to do anything to end your life?) * History of significant head trauma followed by persistent neurologic deficits or known structural brain abnormalities OR traumatic brain injury in the past two months * Severe impediment to vision, hearing and/or hand movement, likely to interfere with the ability to complete the assessments, or are unable and/or unlikely to follow the study protocols * Current or expected cognitive behavior therapy or other evidence based psychotherapies; therapy for another condition (e.g. Depression) * History of falling and/or severe mobility impairment * Individuals who are not CPAP adherent or have untreated severe OSA (AHI \>= 30).CPAP adherence being defined as using the CPAP machine 70% of nights for a minimum of 4 hours per night. * Received Cognitive Behavior Therapy for Insomnia (CBT-I) or Desensitization Therapy for Insomnia (DTI) within the past year * Are not fully vaccinated for COVID-19 (e.g. 2 doses of Moderna or BioNTech, Pfizer vaccines; or 1 for Johnson and Johnson) and unwilling, if asked, to provide proof (e.g., CDC COVID-19 Vaccination Card, e-Health record, etc.)