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Blood test for dementia put to the test in 3,000-Patient study

NCT ID NCT07238049

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether simple blood tests can accurately diagnose dementia in everyday clinic settings. Over 3,000 people aged 45 and older with memory problems will give blood samples and answer questionnaires. Researchers will check how reliable and acceptable these blood tests are compared to standard methods like spinal taps or brain scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test to help diagnose dementia earlier and more accurately in routine clinics.
What could go wrong
This is an observational study, not a treatment trial. It only measures accuracy and feasibility; it may not change care directly. Results may vary across diverse populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,165 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Oct 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

People referred to, eligible for referral or already under review at primary and/or secondary memory assessment services (including memory clinics, brain health clinics) with some form of cognitive symptoms and/or cognitive disorders of any severity will be eligible for recruitment. Also, we recruit a subset of individuals who are not under a secondary care memory clinic but who have a clinical picture that would be suitable for secondary care assessment in memory clinic services.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: The participant may enter the study if ALL of the following apply: * Willing and able to give informed consent for participation in the study (translation needs for study information and forms for non-English speakers will be defined locally) OR Adults who otherwise lack the capacity to consent but for whom advice regarding participation has been obtained via a consultee using the personal or nominated consultee process * Male or Female, aged 45 years and above * Referred or referable with cognitive or behavioural symptoms and/or diagnosed with a cognition related disorder; including those with subjective cognitive impairment and functional disorders. Exclusion Criteria: The participant may not enter the study if ANY of the following apply: * Lack of venous access * Unwilling to consent to NHS data linkage or in Northern Ireland, unwilling to allow long term follow up by access to electronic NHS records.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease (AD) Dementia Mild cognitive impairment (MCI)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    27 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aneurin Bevan University Health Board

    Newport, United Kingdom

  • Barts Health NHS Trust

    London, United Kingdom

  • Belfast Health & Social Care Trust

    Belfast, United Kingdom

  • Berkshire Healthcare NHS Foundation Trust

    Bracknell, United Kingdom

  • Betsi Cadwaladr University Health Board

    Bangor, United Kingdom

  • Bradford District Care NHS Foundation Trust

    Bradford, United Kingdom

  • Cambridgeshire and Peterborough NHS Foundation Trust

    Cambridge, United Kingdom

  • Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust

    Newcastle upon Tyne, United Kingdom

  • Devon Partnership NHS Trust

    Exeter, United Kingdom

  • Dorset HealthCare University NHS Foundation Trust

    Bournemouth, United Kingdom

  • East London NHS Foundation Trust

    London, United Kingdom

  • Greater Manchester Mental Health Foundation Trust

    Manchester, United Kingdom

  • Hampshire and Isle of Wight NHS Foundation Trust

    Southampton, United Kingdom

  • Lancashire & South Cumbria NHS Foundation Trust

    Preston, United Kingdom

  • Midlands Partnership University NHS Foundation Trust

    Stafford, United Kingdom

  • North Bristol NHS Trust

    Bristol, United Kingdom

  • Nottingham University Hospitals NHS Trust

    Nottingham, United Kingdom

  • Oxford Health NHS Trust

    Oxford, United Kingdom

  • ReMind UK

    Bath, United Kingdom

  • Sheffield Health and Social Care NHS Foundation Trust

    Sheffield, United Kingdom

  • Sheffield Teaching Hospital

    Sheffield, United Kingdom

  • South London and Maudsley (SLaM)

    London, United Kingdom

  • St George's Hospital

    London, United Kingdom

  • Surrey and Borders Partnership NHS Foundation Trust

    Redhill, United Kingdom

  • Sussex Partnership NHS Foundation Trust

    Worthing, United Kingdom

  • University Hospital Southampton

    Southampton, United Kingdom

  • West London NHS Trust

    London, United Kingdom

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