Disease by developmental or physiological process

This study follows people with Fabry disease who have already received FLT190, an experimental gene therapy that delivers a working copy of the GLA gene. The goal is to see how safe the treatment is over the long term and whether its effects last. Researchers will track participa…

This trial is testing a gene therapy called FLT190 in adult men with classic Fabry disease, a genetic condition that causes harmful fat buildup in cells. The therapy uses a modified virus to deliver a working copy of the faulty gene, potentially enabling the body to produce the m…

Researchers are testing an experimental oral drug called MBX-102 in adults with type 2 diabetes whose blood sugar remains too high on metformin alone. The trial compares two doses of MBX-102 with a placebo and with Actos, an approved diabetes drug. About 242 participants take the…

This study tested a new medicine, GSK3915393, in 158 people with idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring and breathing difficulty. The goal was to see if the drug could slow lung function decline compared to a placebo. The trial was termin…

Researchers are testing an experimental drug called JMT103 in adults with cancer whose blood calcium levels are dangerously high and who have not responded to standard intravenous bisphosphonate treatment. Participants receive JMT103 as an injection under the skin every four week…

This study follows 170 people with chronic hepatitis D who are taking bulevirtide to see how well it works over time and what side effects may occur. Researchers will track serious liver problems like liver failure, cancer, or need for transplant. The goal is to understand the dr…

This study tested a combination of an immunotherapy drug (nivolumab) and low-dose chemotherapy in children and teenagers whose solid tumors had not responded to standard treatments. The goal was to see if the combination was safe and could help control the cancer. The trial was s…

This study tests an experimental drug called GSK4527226 in 367 people with early Alzheimer's (mild memory problems or mild dementia). Participants receive either a low dose, high dose, or placebo through an IV. The goal is to see if the drug can slow down declines in memory and d…

Researchers are testing whether combining two chemotherapy drugs, pralatrexate and romidepsin, is safe and effective for people with lymphoid cancers that have returned or stopped responding to treatment. The trial first finds the highest dose people can tolerate, then gives that…

This phase II trial is testing whether a combination of two drugs, rigosertib and pembrolizumab, can help people with advanced melanoma that no longer responds to standard immunotherapy. The study involves 7 participants with unresectable or metastatic melanoma. The goal is to se…

This study looked at whether using antibiotic ear drops during and after ear tube surgery reduces the chance of tube blockage or ear drainage in children. Only 9 children took part, and each child received drops in one ear but not the other. The study was stopped early, so the fi…

This phase 2 trial tests a new drug called HB-1, which combines two blood pressure medicines (telmisartan and verapamil), to see if it can reduce unexpected panic attacks in people with panic disorder. The study plans to enroll 240 adults aged 18 to 65 and compare HB-1 against pl…

Researchers are testing an experimental drug called LY2140023 in people with schizophrenia who have already completed a short-term trial of the same drug. The study compares LY2140023 to standard antipsychotic medications like olanzapine, aripiprazole, risperidone, and quetiapine…

This study tests an inhaled medicine called SNG001 in patients with severe viral pneumonia who need a breathing machine. The goal is to see if it safely helps clear the virus faster and lowers the risk of death. About 550 adults, mostly over 50 or with weakened immune systems, wi…

Researchers are studying the long-term safety of pomaglumetad methionil, an experimental drug taken by mouth, in adults with schizophrenia. About 129 participants receive the drug and are monitored for up to five years. The study tracks movement side effects, weight, blood sugar,…

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and change…

Critically ill patients often have low magnesium, which can lead to heart rhythm problems and other complications. When magnesium is given through an IV, the body keeps only about half of it. Researchers are testing whether giving the same dose over 8 hours instead of 4 hours hel…

Researchers are testing an experimental immunotherapy called ALT-801 alongside the chemotherapy drug cisplatin in people with metastatic melanoma that cannot be cured with surgery. The trial enrolls about 22 participants who have not received prior chemotherapy for their melanoma…

This study tested whether adding vibostolimab to the standard immunotherapy pembrolizumab can better prevent melanoma from returning after surgery. About 1,600 people with high-risk stage II to IV melanoma took part. The goal was to see if the combination keeps cancer away longer…

Researchers are testing repeated doses of an experimental drug called WVE-004 in adults who have ALS, frontotemporal dementia, or both, linked to a mutation in the C9orf72 gene. Participants receive the drug by spinal injection every 12 weeks for up to 96 weeks. The study tracks …

This small Phase 2 trial tested an experimental drug called Auxora in 10 patients with critical COVID-19 pneumonia who were on ventilators. The goal was to see how the drug affected immune cells in the lungs and to check its safety. The study was terminated early, so results are …

This registry study follows people who receive the NUsurface meniscus implant, a device designed to replace a damaged meniscus in the knee. Researchers track pain and knee function over time using standard scores like KOOS and WOMET. The goal is to see how well the implant works …

Researchers are testing an experimental oral drug called enpatoran in adults with dermatomyositis and polymyositis, two rare muscle-weakening diseases. Participants receive enpatoran or a placebo twice daily for up to 24 weeks while continuing their standard care. The trial measu…

Researchers are testing whether piromelatine 20 mg, a tablet that acts on melatonin and serotonin receptors, can slow cognitive decline in people aged 60 to 85 with mild dementia from Alzheimer's disease. The study enrolls 216 participants who do not carry a specific genetic vari…

This trial tests whether an AI-driven texting tool, combined with support from peer recovery coaches, can help Black and Latinx people who use opioids start buprenorphine treatment in primary care. Participants are enrolled from emergency departments and receive text messages wit…

This study tests a new drug (ADI-PEG 20) combined with chemotherapy and radiation before surgery for soft tissue sarcoma. The goal is to find the safest dose and see how well it shrinks tumors. Only 6 patients with intermediate or high-grade sarcoma of the trunk or limbs are taki…

This study tests whether a daily kava drink can help active smokers who don't plan to quit reduce their smoking and lower their risk of lung cancer. Twenty adult smokers will take kava daily for several months. Researchers will check how well participants stick with the regimen, …

This early-phase trial is testing a new treatment called KYV-101, which uses a patient's own modified immune cells (CAR-T cells) to target and destroy faulty B cells that drive lupus kidney inflammation. The study involves 6 adults with lupus nephritis that hasn't responded to st…

This phase 2 trial tests whether LY3549492, an oral tablet, helps adults who are overweight or obese and have type 2 diabetes lose weight. Participants receive either LY3549492 or a placebo for about 11 months. Researchers measure changes in body weight and the percentage of peop…

This study compares continuing oral diabetes medications (like metformin) versus switching to insulin in hospitalized adults with type 2 diabetes. About 255 participants will be randomly assigned to either stay on their usual pills or receive insulin injections. The goal is to se…

This early-stage trial tests a radioactive drug called [225Ac]Ac-A9-3408 in 50 adults with melanoma that has spread or can't be removed by surgery. The main goals are to find a safe dose and check for side effects. Participants receive the drug every 6 weeks for up to 6 doses, an…

This Phase 2 trial tested an oral drug called ladarixin in 141 people aged 14-45 recently diagnosed with type 1 diabetes. The goal was to see if ladarixin could preserve the body's ability to produce insulin by protecting beta cells. The study was terminated early, so while it ma…

This early-phase trial is testing a personalized cell therapy called KYV-101 for people with lupus nephritis that hasn't responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and destroy faulty B cells that drive the disease. Only 2 p…

This trial compares two approved eczema drugs, upadacitinib and dupilumab, in people with moderate-to-severe atopic dermatitis. Researchers will measure how well each drug clears the skin and improves quality of life, including itch and sleep. The study aims to confirm earlier fi…

This trial tests whether the antiviral drug valganciclovir can improve hearing and language outcomes in infants who have hearing loss due to congenital cytomegalovirus (CMV) infection. Infants aged 1 to 12 months with confirmed sensorineural hearing loss will receive either valga…

This early-stage trial tested a gene therapy called SBT101 for adrenomyeloneuropathy (AMN), a rare nerve disease that causes walking difficulties. Eight adults received either the therapy or a sham procedure. The study was terminated early, so we have limited data on safety and e…

This study tested three different antibiotic regimens for people with recurrent Clostridium difficile infection (C. diff), a serious gut infection that keeps coming back. The goal was to see if newer drugs like fidaxomicin or a tapered/pulsed course of vancomycin work better than…

This study is a patient registry that collects information on people with severe aortic stenosis or aortic regurgitation who are treated with the Trilogy heart valve system, a device implanted via a catheter (TAVI) to replace the aortic valve without open-heart surgery. The goal …

This trial tests whether valproate, a medication used for epilepsy, can help prevent or ease alcohol withdrawal symptoms in heavy drinkers admitted to trauma care. Participants receive standard treatment with lorazepam (a benzodiazepine) as needed, and some also get valproate. Th…

This study tests an experimental drug called REGN7041 in 72 people with active noninfectious uveitis, a condition causing inflammation inside the eye. The drug is an antibody designed to calm the immune system. Since this is the first time it's tested in humans, the main goal is …

This study looked at how well the drug iptacopan works for people with paroxysmal nocturnal hemoglobinuria (PNH) when used in everyday medical practice in Russia. Only 6 adults took part, and the study was terminated early. Researchers measured whether patients' hemoglobin levels…

This trial tests whether an experimental oral medication, deucrictibant, can reduce the number of swelling attacks in people with hereditary angioedema (HAE) types I and II. Participants take either a low or high dose of the drug or a placebo for 12 weeks, and then may continue o…

This study tests whether inhaling alpha-1 antitrypsin (AAT) daily can slow lung function loss in people with Alpha-1 deficiency and moderate-to-severe lung disease. 220 adults will receive either the drug or a placebo for two years, then all will receive the drug for two more yea…

This trial tests whether a combination of plasma exchange, rituximab, and intravenous immunoglobulins can improve survival in people hospitalized in intensive care with a severe acute exacerbation of idiopathic pulmonary fibrosis (IPF). IPF is a progressive lung disease, and thes…

This study tests whether a single injection of Axolotl Ambient, a fluid rich in growth factors derived from human amniotic cells, can reduce pain and improve function in people with ankle osteoarthritis. Participants will be randomly assigned to receive either the investigational…

This trial explores whether adding counseling, cognitive behavioural therapy, or hypnotherapy to nicotine replacement therapy can help cancer patients quit smoking before their surgery. The study includes adults with breast, digestive, gynecologic cancer, or melanoma who smoke da…

This pilot study tests whether simvastatin (a cholesterol-lowering drug) and ursodeoxycholic acid (a bile acid medication), taken alone or together for six months, can improve markers of liver fibrosis in adults with advanced liver scarring after viral hepatitis has been controll…

This phase 3 trial tests whether an inhaled combination of budesonide (a corticosteroid) and formoterol (a bronchodilator) can prevent acute respiratory failure in hospitalized adults with pneumonia and low blood oxygen levels. Participants receive either the active treatment or …

This study tested the drug alemtuzumab in children aged 10 to 18 with relapsing-remitting multiple sclerosis (MS) whose disease was still active despite other treatments. The goal was to see if the drug could reduce new brain lesions and improve quality of life. However, the tria…

This study tested a new antibody called ICT01 combined with low-dose interleukin-2 (IL-2) in 56 people with advanced solid tumors like colorectal, ovarian, and pancreatic cancer. The goal was to see if the combo is safe and can shrink tumors. Early results suggest it may help con…

This trial tests whether a short vocational advice program helps people on sick leave return to work sooner. Adults who have been off work for at least two weeks due to health issues receive support from a trained worker to identify barriers and plan their return. The study compa…

This phase 3 trial tests whether metformin, a standard diabetes medication, can prevent or reverse metabolic syndrome in men with prostate cancer who are starting androgen deprivation therapy (ADT). Metabolic syndrome—a cluster of conditions like high blood sugar, high blood pres…

This study investigates how effectively two opioid antidotes—naloxone (given as a nasal spray or injection) and nalmefene (given as an injection)—can reverse dangerous breathing problems caused by strong opioids like fentanyl. The trial includes both healthy volunteers and people…

This pilot trial investigates whether potassium citrate can improve bone quality and strength in adults and children with chronic kidney disease. Participants take either potassium citrate or a placebo for six months, along with blood and urine tests and advanced bone scans. The …

This early-stage trial tested four different doses of siplizumab in 8 people aged 8–45 who were diagnosed with type 1 diabetes within the past 18 months. The goal was to find a safe dose that changes certain immune cell patterns linked to better insulin production. Participants r…

This study watches 200 adults with moderate to severe psoriasis who switch from ustekinumab to guselkumab in everyday medical practice. Researchers track how well the new drug clears skin symptoms and check for side effects over 52 weeks. The goal is to see if guselkumab works sa…

This trial tests whether a weekly IV antibiotic called oritavancin, given alongside medication for opioid use disorder, can help people finish treatment for serious infections like bloodstream or bone infections without needing to stay in a nursing facility. The study enrolls adu…

This study is testing a new thumb implant called the InDx CMC Implant for people with thumb arthritis. The implant replaces part of the thumb joint to improve hand function and reduce pain. Researchers will track safety and how well the implant works in 73 adults over time.

This early-stage trial tested whether adding an experimental drug called VIB4920 to standard TNF-inhibitor therapy could improve disease control in people with rheumatoid arthritis. Only 2 participants were enrolled before the study was terminated, so no meaningful conclusions ca…

This study investigates whether a 10-week behavioral intervention called JASPER can improve early communication skills and alter brain activity in toddlers and preschoolers with autism. Participants aged 18 to 59 months receive twice-weekly sessions focused on joint attention and…

This study looks at the long-term safety and tolerability of a drug called rocatinlimab for people with moderate-to-severe atopic dermatitis (eczema). It involves over 2,600 adults and teenagers who have already completed a previous rocatinlimab study. Researchers will monitor si…

This trial tests whether a telehealth-based family navigation program helps Black toddlers under age 4 start autism-specific intervention faster after diagnosis. Families in the program receive up to four virtual sessions with a trained navigator who helps them find and enroll in…

This trial investigates whether screening for gestational diabetes earlier in pregnancy (at 18-20 weeks instead of the usual 24-28 weeks) and providing prompt lifestyle advice and medication if needed can reduce complications such as large babies, C-sections, and high blood press…

This trial compares two approaches to antibiotic use after appendix removal surgery: a restrictive course (none or up to 24 hours) versus a liberal course (24 hours to 4 days). The goal is to see if the shorter course is just as safe and effective, while reducing side effects and…

This study tests whether brensocatib can reduce painful lumps and abscesses in people with moderate to severe hidradenitis suppurativa (HS). About 214 adults will receive either brensocatib or a placebo for 16 weeks. The goal is to see if the drug improves skin lesions and overal…

This early-phase trial tested a new therapy called CYNK-001, which uses natural killer cells from the placenta to fight COVID-19. It enrolled only 7 adults with moderate COVID-19. The study was terminated early, so we have limited information on safety and effectiveness.

This study looks at the long-term safety of brazikumab, a drug given as a shot every 4 weeks, for people with moderate to severe ulcerative colitis. Participants had already taken part in an earlier study of brazikumab. The goal is to see if the drug remains safe over a longer pe…

This study tested an experimental drug called SAR442501 in children with achondroplasia, a common form of dwarfism. The goal was to see if the drug was safe and could improve growth. However, the trial was stopped early after enrolling only 16 children, so we have very little inf…

This study looked at the long-term safety and effects of ALZ-801, a tablet taken twice daily, in 163 people with early Alzheimer's disease who have the APOE4/4 gene. Participants had already completed a previous phase 3 study. The goal was to see if the drug could slow cognitive …

This phase 2 trial tested brazikumab in 242 adults with moderate-to-severe ulcerative colitis. Participants received either brazikumab or a placebo intravenously and then as injections over 54 weeks. The goal was to see if the drug could improve symptoms and heal the colon lining…

This study compared two antiplatelet drug regimens after transcatheter aortic valve implantation (TAVI) for aortic stenosis. One group received ticagrelor alone, the other received aspirin plus clopidogrel. The goal was to see which caused fewer serious complications like bleedin…

This study looks at people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are in deep remission. It compares two methods for gradually increasing the time between infliximab infusions: one based on symptoms and one based on drug levels in the blood. T…

This phase 2 trial investigates whether a personalized course of peginterferon alfa-2a can control membranous nephropathy, an autoimmune kidney disease. The treatment targets the Th17 inflammatory pathway, which is linked to a higher risk of relapse. Participants receive injectio…

This study tested a special bone graft material (MatriBONE mixed with the patient's own bone marrow) for spinal fusion surgery in people with painful degenerative back problems. The goal was to see how well the bones fused together after 12 months. However, the trial was stopped …

This study tested whether using a Freestyle Libre 2 continuous glucose monitor for 28 days, along with standard therapeutic education, helps people recently diagnosed with type 2 diabetes improve their blood sugar control. The trial enrolled 27 adults diagnosed within the past ye…

This study was designed to check the long-term safety of an experimental drug called GSK1070806 for people with moderate to severe eczema (atopic dermatitis). It enrolled 79 adults who had already completed an earlier study of the same drug. The study was terminated early, so res…

This study looked at whether treating the dental cause of chronic maxillary sinusitis with dental procedures and medication could resolve symptoms. Only 16 patients were enrolled before the study was terminated. The main goal was to see if symptoms disappeared and pus cleared fro…

This trial tests whether performing balloon aortic valvuloplasty without the blood thinner heparin reduces serious bleeding and blood vessel complications. About 94 adults with severe, symptomatic aortic stenosis will be randomly assigned to receive either heparin or a placebo du…

This phase 2 trial tested whether cannabidiol (CBD), a non-psychoactive compound from cannabis, could help people with alcohol use disorder reduce their drinking. The study also looked at whether CBD could protect the brain and liver from alcohol's harmful effects. Only 10 people…

This study tested two different proton therapy schedules for people with large choroidal melanomas (eye cancer) that would normally require removal of the eye. The goal was to see if a gentler radiation schedule could control the tumor and avoid severe side effects, allowing pati…

This study tested an experimental drug called ARO-ANG3 in 18 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. Participants received injections of the drug and were monitored for safety and cholesterol change…

This study tested whether adding the drug aticaprant to standard antidepressants could prevent depression from returning in people with major depressive disorder who also experience a loss of interest or pleasure (anhedonia). The study enrolled 47 adults who had responded well to…

This study tested whether giving the heart medication metoprolol through a vein could help people with severe lung failure (ARDS) in the ICU. The goal was to see if it helped them breathe without a machine for more days. However, the trial was stopped early and only 14 people too…

This study tested an injectable drug called GSK1070806 in 161 adults with moderate to severe atopic dermatitis (eczema) who had already tried other treatments. The goal was to see if the drug could reduce eczema severity and itching compared to a placebo. However, the trial was t…

This study tested an early speech therapy program for children born very prematurely or with severe growth restriction. The program involved 10 to 20 sessions with a trained speech therapist from 6 to 24 months of age. The goal was to see if it could reduce language and communica…

This study tested an experimental drug called CRD-4730 in people with a rare inherited heart rhythm disorder (CPVT) that can cause dangerous fast heartbeats. Seven adults received two different doses of the drug and a placebo to check safety and how the body processes it. The stu…

This study tested giving hepatitis C treatment to people who inject drugs while they were already in the hospital for other infections. The goal was to cure their hepatitis C and make sure they stayed connected to care afterward. The study was stopped early, but it included 21 pa…

This study tested an experimental drug called GS-0272 in adults with rheumatoid arthritis to see if it is safe and how the body processes it. The trial was stopped early, so results are limited. About 55 people were planned to take part, receiving either the drug or a placebo.

This study looked at whether taking probiotic tablets (Lactobacillus reuteri) twice a day, along with regular tooth brushing, could reduce gum inflammation in teenagers with braces. Only 3 participants were enrolled before the study was terminated early, so no meaningful results …

This study tested an experimental drug called TOL-3021 in people with type 1 diabetes to see if it could help preserve the body's ability to produce insulin. The trial enrolled 78 participants aged 12 to 41 who had been diagnosed within the last 5 years. The study was terminated …

This study looked at whether giving antibiotics for a shorter time after appendix removal works as well as a longer course. It included adults with simple or complex appendicitis. The goal was to see if shorter treatment could reduce side effects and still cure the infection.

This study tested a low dose of a drug called ATG to see if it could delay or prevent type 1 diabetes in people at high risk. Only 2 people enrolled, so the study was stopped early. The goal was to measure how long it took for participants to develop full-blown diabetes.

This study looked at whether people who had heart surgery for endocarditis (a serious heart infection) related to IV drug use could safely switch from IV antibiotics to oral pills after just two weeks. The goal was to see if this shorter hospital stay was safe and effective. The …

This study tested whether clemastine fumarate, an allergy medication, could improve eye movement problems in people with multiple sclerosis (MS). The trial planned to enroll 80 MS patients with a specific eye condition called internuclear ophthalmoparesis, but was terminated earl…

This phase 2 trial tested KVD824, an oral pill, to prevent swelling attacks in people with hereditary angioedema types I and II. The study planned to compare three doses against a placebo over several months. However, the trial was terminated early with only 33 participants, so t…

This study tested a drug called INT-787 in 67 people with severe alcohol-associated hepatitis, a serious liver condition. The trial was a phase 2a proof-of-concept study, but it was terminated early. Researchers were looking at safety, how well the drug works, and how the body pr…

This study tested whether hydroxychloroquine, a drug used for lupus and arthritis, could help control ANCA vasculitis—a group of autoimmune diseases that cause blood vessel inflammation. Adults with mild disease activity were randomly assigned to receive hydroxychloroquine or a p…

This study tested whether regular phone calls after a first hospital stay for anorexia nervosa could help patients maintain a healthy weight and avoid relapse. Researchers planned to compare phone-based support to standard follow-up care in people over 15. The study was terminate…

This phase 2 trial tested two doses of an oral drug called fidrisertib (IPN60130) in children and adults with fibrodysplasia ossificans progressiva (FOP), a rare condition where soft tissues turn into bone. The goal was to see if the drug could reduce new abnormal bone growth com…

This study aimed to see if following the exact dosing instructions for oral semaglutide helps control blood sugar in people with type 2 diabetes who are already on metformin. Only one person enrolled before the study was stopped early. The main focus was on changes in blood sugar…

This phase II trial tested whether adding radiotherapy to the immunotherapy drug pembrolizumab could better control advanced melanoma than pembrolizumab alone. Only 17 people took part before the study was stopped early. The goal was to see if radiation could trigger an 'abscopal…

This small Phase 2 study tested two doses of vonafexor, an oral drug, in 10 people with mild-to-moderate chronic kidney disease and suspected MASH (a type of fatty liver disease). The goal was to see if vonafexor could improve kidney function. However, the trial was terminated ea…

This study tested an experimental drug called KRRO-110 in healthy volunteers and people with Alpha-1 Antitrypsin Deficiency (AATD), a genetic condition that can cause lung and liver damage. The goal was to check safety and how the drug moves through the body. However, the trial w…

This early-stage study tested whether injecting donor stem cells (remestemcel-L) into the colon could help people with severe ulcerative colitis that hadn't responded to other treatments. Only 7 adults took part before the trial was stopped early. The main goal was to check safet…

This early-stage study tested whether injecting donor stem cells directly into fistulas (abnormal tunnels) could help people with Crohn's disease. The trial planned to enroll 25 adults but was terminated early. The goal was to check safety and see if the treatment could lead to c…

This study tested the long-term safety of a drug called aticaprant when added to a standard antidepressant for adults with major depression. The trial planned to enroll 871 people but was terminated early, so the full safety and effectiveness data are not available. Researchers w…

This study tested whether the statin drug rosuvastatin, taken daily with supplements, could improve bone density and reduce heart disease risk in adults with long-term spinal cord injury. Only 8 people enrolled before the trial was stopped early. Participants received either rosu…

This trial tested a gene therapy for X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder that leaves boys unable to fight off infections. The treatment involved taking the patient's own blood stem cells, adding a working copy of the faulty gene, and returning …

This phase 2 study tested a drug called TMP-301 in 110 adults with alcohol use disorder to see if it is safe and helps reduce drinking. Participants took TMP-301 or a placebo daily for 14 weeks. The trial was terminated early, so we don't have clear results on whether the drug wo…

This study tested a drug called PrimeC in people with mild to moderate Alzheimer's disease. The goal was to see if it is safe and if it helps with thinking and daily activities. The study was stopped early and only 8 people took part, so results are very limited.

This study tested a new drug called belcesiran in people with a genetic condition called alpha-1 antitrypsin deficiency that causes liver damage. The goal was to see if the drug is safe and can lower harmful protein levels in the liver. The trial was stopped early, so results are…

This study looked at whether different medications for opioid use disorder (methadone, buprenorphine/naloxone, or naltrexone) could reduce immune system inflammation in people with HIV. Researchers measured changes in blood markers of immune activation over 24 weeks. The trial wa…

This study tested whether switching to a two-drug HIV treatment (raltegravir plus maraviroc) could reduce belly fat (lipohypertrophy) in people whose HIV was already well-controlled. It included 48 adults on stable HIV therapy for at least 5 years. The study was stopped early, so…

This study tested an experimental drug called LNA043, given as injections into the knee, to see if it could slow cartilage loss and reduce pain in people with knee osteoarthritis. The trial planned to follow 576 participants for up to 5 years, but it was terminated early. The mai…

This study looked at two ways of giving growth hormone to short children who were born small for their age. The goal was to see which dosing method works better for growth and has fewer side effects on metabolism. Only 10 children took part before the study was stopped early.

This study tested an experimental antibody called JNJ-63733657 in 523 people with early Alzheimer's disease. The antibody aims to clear tau protein clumps in the brain, which are linked to cognitive decline. Participants received either the antibody or a placebo by IV infusion. T…

This study tested whether adding anakinra, an anti-inflammatory drug, to standard steroid treatment could lower relapse rates in people with giant cell arteritis, a blood vessel disease. The trial planned to include 70 adults over 50 but was stopped early with only 30 participant…

This study tested a drug called vatiquinone in 68 people with mitochondrial disease and epilepsy that doesn't respond to standard treatments. Participants were randomly assigned to receive either vatiquinone or a placebo for 24 weeks to see if the drug could reduce the number of …

This study tested a combination pill called IHL-675A, which contains cannabidiol (CBD) and hydroxychloroquine, in people with rheumatoid arthritis. The goal was to see if it safely reduces pain and improves daily function. The trial planned to enroll 128 volunteers but was termin…

This study tested a drug called imsidolimab for adults with generalized pustular psoriasis (GPP), a rare and painful skin condition. The trial aimed to see if the drug is safe and works over the long term. However, the study was terminated early, so we have less information than …

This study tested whether breathing in nitric oxide gas could keep mild-to-moderate COVID-19 from becoming severe. Researchers enrolled 62 hospitalized adults who were breathing on their own. The goal was to see if the gas reduced the need for a breathing tube. The trial was stop…

This small, early-stage trial tested a combination of a steroid spray (triamcinolone) and a decongestant spray (oxymetazoline) to help people who were dependent on decongestants stop using them. The study planned to slowly reduce the decongestant dose while keeping the steroid st…

This study tested a new way to manage blood pressure in new mothers with severe postpartum preeclampsia. Participants received standard blood pressure medications, but one group had personalized blood pressure targets based on real-time brain monitoring. The goal was to keep bloo…

This study looked at whether a plant-based diet and lifestyle changes could help people with type 2 diabetes, prediabetes, or obesity improve their health. Researchers aimed for diabetes remission (normal blood sugar without medication for at least 3 months) or significant weight…

This study looked at whether using a combination of weight-loss medications could help people with obesity lose weight and improve the health of their blood vessels. It involved 128 adults aged 40-75 who were obese and had at least one heart risk factor. The study was stopped ear…

This early study tested a weekly injection of allopregnanolone, a natural brain steroid, in 6 people with early Alzheimer's or mild cognitive impairment. The goal was to find a safe dose and check for side effects. The trial was terminated early, so we have limited information on…

This phase II trial tested the drug imatinib in 13 adults with metastatic ocular melanoma, a rare eye cancer that has spread. The goal was to see if imatinib could stop tumor growth for at least 3 months. The trial was terminated early, so the results are limited and it is unclea…

This study tested whether high-dose fish oil supplements could improve nerve function in people with prediabetes and early diabetic neuropathy. Researchers planned to enroll 40 adults aged 55–80, but the trial was terminated early with only 31 participants. Participants took eith…

This study tested whether a three-drug combination (encorafenib, binimetinib, and pembrolizumab) works better than a two-drug combo (ipilimumab and nivolumab) for people with advanced melanoma that has a BRAF mutation and has already been treated with anti-PD-1 therapy. The trial…

This trial tested a personalized approach for children with relapsed or hard-to-treat neuroblastoma. Doctors used a tumor biopsy to find genetic changes and then assigned a combination of targeted drugs (ceritinib and ribociclib) to match those changes. The study was terminated e…

This phase 2 study tested a treatment called brexucabtagene autoleucel, a CAR T-cell therapy made from a patient's own immune cells, for four rare B-cell cancers: Waldenstrom macroglobulinemia, Richter transformation, Burkitt lymphoma, and hairy cell leukemia. The trial enrolled …

This study compared two antiviral medicines (oral valganciclovir and topical ganciclovir 2%) against a placebo for treating CMV-related inflammation in the front of the eye. The goal was to see which approach better controls the infection and reduces complications like pain, glau…

This study tested the drug empagliflozin (a diabetes medicine) in 20 people who had a kidney transplant, some with type 2 diabetes and some without. The goal was to see if the drug could help protect their heart and kidney function. The trial was stopped early, so the findings ar…

This study looks at the long-term safety of a drug called efgartigimod for adults with moderate-to-severe bullous pemphigoid, a condition that causes painful blisters. Participants who finished the main study can continue treatment for up to 48 weeks, with the option to pause and…

This study tested whether a team-based approach using continuous glucose monitors could help adults with type 1 diabetes better control their blood sugar and avoid another hospital stay after a diabetic ketoacidosis (DKA) episode. Only 2 people enrolled before the study was stopp…

This study tested a gel made from hyaluronic acid and amino acids (Gumblast) to see if it helps surgical wounds in the mouth heal better. It involved 28 adults who needed at least two teeth extracted, with one socket treated with the gel and the other left to heal normally. The t…

This study tested a completely virtual early intervention program for toddlers with autism, using telehealth coaching to help parents embed learning into daily activities. Researchers planned to enroll 240 children from eight US regions, but the trial was terminated early with on…

This study tested an experimental drug called vobramitamab duocarmazine in people with advanced prostate cancer and other solid tumors that stopped responding to standard treatments. The goal was to see if the drug could shrink tumors or slow cancer growth. The trial was terminat…

This study tested a drug called voclosporin in teenagers with lupus nephritis, a kidney disease caused by lupus. The goal was to see if it could improve kidney function better than a placebo. Only 9 teens took part before the study was stopped early, so we don't have clear answer…

This study looked at the long-term safety of the drug voclosporin in adolescents and children with lupus nephritis, a kidney disease caused by lupus. Participants took voclosporin capsules twice daily along with standard medications. The trial was terminated early and only enroll…

This study tested a dental health education program for people with schizophrenia to see if it could improve their oral hygiene and quality of life. Participants were randomly assigned to either the education program or standard monitoring. The study lasted 12 months and included…

This early-phase study tested a radioactive drug called 225Ac-SSO110 combined with standard immune checkpoint inhibitors for people with advanced small cell lung cancer or Merkel cell carcinoma. The goal was to check safety and find the right dose. However, the trial was terminat…

This study tested a mobile app that uses rewards to encourage people with opioid use disorder to start and stick with medication-assisted treatment after an emergency room visit. 41 adults from two hospitals were given access to the app for 12 weeks. The goal was to see if the ap…

This study looked at whether liraglutide, a diabetes drug, can reduce liver fat and improve cholesterol in people with type 2 diabetes. It involved 127 patients who took liraglutide for 6 months, with liver fat measured by MRI. However, the trial was terminated early, so the full…

This study tested two doses of an inhaled drug called CHF6001 (Tanimilast) added to standard triple therapy in people with severe COPD and chronic bronchitis. The goal was to see if it could reduce the number of moderate or severe flare-ups over a year. The trial was terminated e…

This early-phase study tested whether a fecal transplant from a healthy donor could be safe and affect the immune system in people with relapsing-remitting multiple sclerosis. Only 5 participants were enrolled before the study was stopped. The goal was to see if changing gut bact…

This early-phase trial tested taselisib, a drug that blocks a faulty protein causing excessive growth in people with PIK3CA-related overgrowth. Nineteen participants took the drug daily for four weeks to see if it was safe and tolerable. The study was stopped early, so we have li…

This early-phase trial tested a new therapeutic vaccine (EO2401) combined with the immunotherapy drug nivolumab in 70 people with advanced adrenocortical carcinoma or malignant pheochromocytoma/paraganglioma. The goal was to see if the combination is safe and can shrink tumors or…

This Phase 3 trial tested an oral drug called venglustat in 75 adults and children with late-onset Tay-Sachs or Sandhoff disease, rare genetic disorders that cause progressive nerve damage. The drug aimed to lower toxic fat buildup in the brain and slow disease worsening. However…

This study tested leflunomide, a drug used for rheumatoid arthritis, in 3 adults with MEN1 syndrome—a genetic condition that raises the risk of multiple tumors. The goal was to see if 6 months of daily leflunomide could shrink or stabilize tumors. However, the trial was terminate…

This Phase 2 study tested the drug ravulizumab (Ultomiris) in 123 adults with lupus nephritis or IgA nephropathy, two conditions that cause kidney inflammation. Participants received either ravulizumab or a placebo alongside standard care. The study aimed to see if the drug could…

This study tested a new drug called ARC-520 in 79 people with chronic hepatitis B. Some participants received ARC-520 alone, while others got it combined with standard treatments like entecavir or tenofovir. The goal was to see if ARC-520 could lower hepatitis B surface antigen l…

This study tested whether combining two immunotherapy drugs (nivolumab and relatlimab) works better than nivolumab alone to keep melanoma from returning after surgical removal. It involved over 1,000 adults and teens with stage III or IV melanoma that had been completely removed.…

This early-phase trial tested whether nicotinamide riboside (a form of vitamin B3 sold as Niagen) could help repair nerve damage in people with type 2 diabetes or prediabetes. Only 10 participants were enrolled before the study was terminated. The main goal was to measure changes…

This study looked at how well the drug tofacitinib (Xeljanz) works for people with moderate to severe ulcerative colitis in everyday medical practice in Switzerland. It measured symptom improvement and gut inflammation using stool samples. The study was small with 18 participants…

This phase 3 study tested an experimental drug called birtamimab in 208 people with advanced AL amyloidosis, a rare disease where abnormal proteins damage organs like the heart. Participants received either birtamimab or a placebo, plus standard chemotherapy. The goal was to see …

This study tested an inhaled drug called CHF6001 (Tanimilast) in people with COPD and chronic bronchitis who were already on triple therapy. The goal was to see if adding this drug could reduce flare-ups. The trial was stopped early and involved about 4,700 participants.

This study tested a drug called varoglutamstat (PQ912) in people with early Alzheimer's disease. The goal was to see if it is safe and if it could slow memory and thinking problems. The trial was stopped early, so we have less information than planned. About 112 people took part,…

This study tested a medicine called Hizentra (IgPro20) in 134 adults with dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if weekly shots under the skin could improve symptoms better than a placebo. The study was stopped early, but res…

This study tested an oral medication called SAR444656 in 70 adults with moderate to severe atopic dermatitis (eczema) that was not well controlled with topical treatments. Participants received one of three doses of the drug or a placebo for 16 weeks. The goal was to see if the d…

This study tested a blood product called immune globulin (Flebogamma) in 191 people with post-polio syndrome, a condition causing new muscle weakness years after polio. The goal was to see if it could improve walking distance and reduce pain. The trial was terminated early, so we…

This trial tested a special dialysis device (MEX-CD1) designed to remove extra copper from the blood of people with Wilson's disease, a genetic condition that causes copper buildup. The study planned to give 5 to 10 treatments over consecutive days and check if the device worked …

This study tested peresolimab, an experimental drug, in 491 adults with moderately-to-severely active rheumatoid arthritis who had not responded well to other treatments. The goal was to see if peresolimab could reduce joint pain and swelling better than a placebo. However, the s…

This early study tested whether a single infusion of zoledronic acid, a drug used for osteoporosis, could improve bone health and slow joint damage after an ACL tear. Only 4 people were enrolled before the trial was terminated, so the results are very limited. The study aimed to …

This study tested whether statins, a common cholesterol drug, could change the gut bacteria in people with ulcerative colitis or Crohn's disease to a healthier type. The goal was to see if this change could reduce disease activity. The study was terminated early, so results are l…

This study followed one person with microtia (a small or missing outer ear) who had already received an AUR-201 implant — a 3D-printed ear made from their own cartilage cells. Researchers checked how well the implant kept its shape and whether any side effects appeared up to 96 w…

This trial tested a new ear implant called AUR-201 for people with a rare birth defect called microtia, where one ear is small or missing. The implant was custom-made using the patient's own cartilage cells and a 3D-printed scaffold. Only 3 people were enrolled before the study w…

This study tested whether adding low-dose methotrexate to standard anti-TNF therapy could improve and extend the response in adults with moderate to severe psoriasis. The trial planned to enroll 78 participants but was terminated early. The main goal was to see how long patients …

This study tested whether doing an early endoscopic ultrasound and removing any gallstones from the bile duct could help people with severe pancreatitis caused by gallstones. The trial planned to enroll many patients but was stopped early after only 27 participants. The main goal…

This study tested an experimental implant called AUR-201 to rebuild the outer ear in people with unilateral microtia (one ear that is small or missing). Only 2 people enrolled before the study was stopped early. The goal was to check safety and see if the implant improved ear app…

This study tested a new drug called REC-3964 to see if it could prevent repeat Clostridioides difficile (C. diff) infections in adults. Only 3 people were enrolled before the trial was stopped early. The goal was to check safety and whether the drug helped people stay infection-f…

This study tested a drug called niraparib in 22 adults with advanced solid tumors (like breast, lung, or pancreatic cancer) that have a specific genetic change called a PALB2 mutation. The goal was to see if the drug could shrink tumors or slow cancer growth. The study was stoppe…

This early-phase trial tested a new immunotherapy approach for children with DIPG, a rare and aggressive brain stem tumor. After standard radiation and chemotherapy, patients received special vaccines and immune cells designed to attack the tumor. The study was small (11 particip…

This study tested cariprazine (VRAYLAR), an approved schizophrenia drug in the U.S., for people with acute schizophrenia in Japan and Taiwan. Participants received either cariprazine or a placebo for 6 weeks, then could continue on cariprazine for 18 more weeks. The trial was ter…

This phase 2 trial tested a drug called REGN4461 (mibavademab) in 20 people with familial partial lipodystrophy, a rare condition causing abnormal fat distribution and metabolic problems. The study aimed to see if the drug could lower high triglycerides and improve blood sugar co…

This study tested whether using a smartphone app and a hand grip device could help people with rheumatoid arthritis manage their condition with fewer in-person doctor visits. About 94 adults with active rheumatoid arthritis were randomly assigned to use the app or continue standa…

This study tested whether pemafibrate, a drug that lowers triglycerides, could reduce heart attacks, strokes, and heart-related deaths in over 10,000 people with type 2 diabetes and high triglycerides. Participants took either pemafibrate or a placebo twice daily. The trial was t…

This study tested a drug called simufilam in over 1,000 people with mild-to-moderate Alzheimer's disease. Participants took either 50 mg, 100 mg, or a placebo twice daily for 76 weeks. The goal was to see if simufilam could slow memory loss and help with daily activities. However…

This phase 3 study tested whether adding an immunotherapy drug (spartalizumab) to two targeted therapy drugs (dabrafenib and trametinib) works better than the targeted drugs alone for people with advanced BRAF V600 mutant melanoma. The trial enrolled 568 participants but was term…

This study looked at whether using a positive airway pressure (PAP) machine at night can reduce the return of atrial fibrillation (an irregular heartbeat) in people who also have obstructive sleep apnea. About 129 participants with both conditions were assigned to receive either …

This phase 3 trial tested the drug miglustat (Zavesca) in 30 infants with Sandhoff or Tay-Sachs diseases, rare genetic disorders that destroy nerve cells. The goal was to see if the drug could reduce hospitalizations, seizures, and feeding problems while improving motor function.…

This phase 2 trial tested a weekly injection of lademirsen in 43 adults with Alport syndrome, a genetic condition that damages kidneys. The goal was to see if the drug could slow the decline in kidney function. The study was terminated early, so the results are limited and it's u…

This study compared two long-acting insulins, Toujeo and Tresiba, in people with type 2 diabetes who also have kidney problems and had never used insulin before. The goal was to see which one controls blood sugar better and causes fewer low blood sugar events. The trial was stopp…

This small phase 2 trial tested whether giving hepatitis B antibodies (HBIG) could clear the hepatitis B surface antigen in people with chronic hepatitis B. Only 13 patients were enrolled before the study was terminated. The goal was to see if a 12-week course of injections could…

This phase 2 trial tested two stronger treatment plans for children with very high risk neuroblastoma whose cancer did not respond well to initial chemotherapy. The treatments combined radioactive therapy (mIBG), chemotherapy drugs (topotecan and thiotepa), and a stem cell transp…

This study tested a system that automatically adjusts insulin delivery using a continuous glucose monitor, a smartphone app, and an insulin pump. It aimed to see if the system could help adults with type 1 diabetes spend more time with their blood sugar in a healthy range. Only o…

Researchers at a French hospital are testing whether offering hepatitis C screening to all adult inpatients is practical and useful. The study enrolls adults admitted to the hospital who agree to a blood test. The team measures how many patients get screened, how many test positi…

This study is testing a new medical device called MagIA IBC that uses a single drop of blood from a finger prick to screen for HIV, hepatitis B, and hepatitis C at the same time. Researchers will enroll 252 adults who are known or suspected to have one of these infections. The go…

Researchers are testing a CT scan that uses less contrast dye and lower radiation to diagnose appendicitis in young adults. The study compares this low-dose approach against standard dosing to see if it still gives accurate results. Participants are emergency patients with suspec…

This study tests whether a 10-minute video of a sleeping child, recorded by parents on a smartphone, can help identify obstructive sleep apnea. The video analysis will be compared with standard sleep monitoring and a clinical questionnaire in children aged 3 to 10 who snore. If t…

This study tests whether an artificial intelligence program called NeoRetina can accurately detect diabetic retinopathy and diabetic macular edema from simple eye photographs. Researchers will compare the AI's analysis to standard exams by eye doctors. The goal is to see if this …

This trial investigates whether a new, ultra-high-frequency ultrasound device can accurately measure the depth of skin melanomas before surgery. Currently, doctors must remove the tumor, measure its depth under a microscope, and then often perform a second surgery to remove more …

This study tests whether a tear sample can diagnose primary progressive multiple sclerosis (MS) as accurately as a spinal tap. Currently, doctors need to collect spinal fluid to confirm this type of MS, which is invasive and uncomfortable. Researchers will compare proteins in tea…

This study tested a new imaging tool called multispectral optoacoustic tomography (MSOT) to see if it could safely detect inflammation in people with graft-versus-host disease, Crohn's disease, or colitis. The device uses light and sound to create images of inflamed areas. The tr…

This study looked at whether a third-trimester ultrasound can accurately find bowel rotation issues in fetuses that raise the risk of a life-threatening twist (volvulus). Researchers compared ultrasound results with fetal MRI, the current best method. The study included 77 pregna…

This study tested a wearable device that sits on the neck to detect swallowing problems in people with conditions like stroke, Parkinson's, multiple sclerosis, Alzheimer's, or dementia. The device was compared to a standard X-ray test. Unfortunately, the device did not meet the a…

This study tests whether a vaginal testosterone cream can prevent repeat urinary tract infections (UTIs) in postmenopausal women aged 60-90 who have had at least three UTIs. Participants will apply the cream or a placebo for 9 months and be monitored for infections. The goal is t…

Researchers are testing whether a plant-based diet can improve heart health in police officers who are overweight or have type 2 diabetes. The trial enrolls 20 officers from the Washington, D.C. police department and randomly assigns them to either follow a vegan diet with weekly…

This study tests a fully online program called Yes and Know for teens aged 14-19. The program includes group sessions and digital tools to teach about sexual health, relationships, and life skills. About 1,200 teens will take part, with half receiving the program and half receivi…

This trial tests whether giving mothers a DHA-rich omega-3 supplement after delivering very preterm (before 29 weeks) could improve their babies' chances of surviving without bronchopulmonary dysplasia, a chronic lung condition. Half the mothers receive DHA capsules, and half rec…

This study tested a drug called belapectin to see if it could prevent the formation of esophageal varices (enlarged veins in the esophagus) in people with NASH cirrhosis and signs of high blood pressure in the liver. The trial enrolled 357 adults and compared belapectin to a plac…

This study tested whether using stitches coated with an antibacterial agent (triclosan) could reduce infections after cesarean delivery. Over 1,100 women were planned to take part, but the trial was stopped early. Because it was terminated, we cannot draw firm conclusions about w…

This study tested a special program called ADAPT for families who adopted children from foster care. The program includes sessions on trust, behavior management, and dealing with loss. Researchers wanted to see if it could improve children's mental health and prevent family disru…

This study tested whether eating yoghurt daily for 24 weeks could improve blood sugar control in adults with prediabetes (high risk for type 2 diabetes). Only 8 people enrolled, and the study was stopped early, so no firm conclusions can be drawn. The goal was to see if a simple …

This study tested whether the cholesterol-lowering drug pravastatin could prevent preeclampsia in women who had a previous early preterm delivery due to the condition. The trial planned to enroll 1,550 women but was terminated early with only 102 participants. Because it stopped …

This phase 3 trial tested a vaccine called POL-103A (Seviprotimut-L) in 504 people with high-risk melanoma who had just had surgery. The goal was to see if the vaccine could prevent the cancer from coming back. However, the study was terminated early, so it is not known whether t…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

Researchers are testing whether a 12-week exercise program can improve thinking skills, physical fitness, and quality of life for adults in opioid substitution therapy. Participants are randomly assigned to start exercise right away or after a 12-week wait. The study measures cha…

Researchers at Ohio State University are running a double-blind, randomized trial to compare three single-dose injections for knee osteoarthritis: Zilretta, Synvisc-One, and Monovisc. The study enrolls adults aged 25 to 85 with painful knee osteoarthritis that continues despite p…

Researchers at the University of Florida are testing whether computerized cognitive training can help people with alcohol use disorder improve their memory, self-control, and thinking skills during inpatient treatment. Participants complete up to 12 sessions of adaptive brain-tra…

Paramedics in the Netherlands often treat severe pain after trauma with either fentanyl or esketamine, but no one knows if one works as well as the other or if a nasal spray works as well as an IV. The FORE-PAIN trial randomly assigns adults with acute traumatic pain to one of fo…

This study looks at whether a ketogenic diet (high-fat, low-carb) is practical and safe for people with early-stage Alzheimer's disease over one year. The diet may provide an alternative energy source for the brain and reduce inflammation. Researchers will track diet adherence, b…

Transgender and gender diverse adults smoke at higher rates than the general population, and stigma, discrimination, anxiety, and depression may make quitting harder. Researchers at Massachusetts General Hospital are adapting an existing smoking cessation program called QUIT, whi…

Researchers at Stanford University are comparing two types of night splints for people with plantar fasciitis, a common cause of heel pain. The trial tests whether a dynamic splint, which allows some foot movement, works as well as a static splint that holds the foot in one posit…

This study tested a WaterPik-like device to massage and clean the scalp in people with dandruff, seborrheic dermatitis, or hair loss. Only 2 people took part before the study was stopped early. The goal was to see if the device could reduce flaking and redness.

This study tests whether a biofeedback breathing system called Freespira can reduce anxiety and panic symptoms in young people aged 9 to 17. Over 8 weeks, one group uses the device while a control group waits. The goal is to see if the device helps lower anxiety scores on a stand…

This study tests two experimental drugs (REGN5713 and REGN5715) given alone or together to reduce eye allergy symptoms caused by birch pollen. About 350 adults with birch pollen allergy will receive the drugs or a placebo and then be exposed to pollen in a controlled setting. The…

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study tested whether a 4-month exercise program done at home could help Hispanic/Latino adults with multiple sclerosis (MS) improve their physical function, manage symptoms, and feel better overall. Participants worked with coaches via video calls and compared results to a c…

This study aimed to see if a smartphone app called IONA Mind could help treat depression in people who have had head and neck cancer. Participants would use the app for 6 weeks and fill out surveys. However, the trial was terminated early after enrolling only 1 person, so no mean…

This trial tests whether a combination of virtual reality and psychotherapy can help people undergoing colonoscopy without sedation feel less anxious and experience less pain. Participants will be randomly assigned to receive the VR-enhanced psychotherapy, a sham VR distraction, …

This study tested whether a simple internet-based self-help program could help people with long-term insomnia stop using sleeping pills like benzodiazepines or Z-drugs. The program used sleep restriction and stimulus control techniques. 62 adults who had been taking sleep medicat…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This study tests whether placebo pills taken knowingly — called open-label placebo — can reduce depression symptoms in unmedicated teens aged 13–18 with mild to moderate depression. Participants take placebo pills for two weeks while researchers use brain scans to see if the trea…

This phase 2 trial tests whether nabilone, a synthetic cannabinoid, can reduce agitation in people with frontotemporal dementia (FTD). Participants receive both nabilone and a placebo in random order to compare effects. The study includes adults with behavioral variant FTD or pri…

This pilot study tests whether a short-term group therapy called Emotional Awareness and Expression Therapy (EAET) can help people with persistent physical symptoms like pain or fatigue that have no clear medical cause. The therapy focuses on helping participants identify and exp…

This study tests whether a mindful walking program can help people with knee osteoarthritis walk better and more often. Participants are randomly assigned to either a mindful walking group or a self-care education group, both meeting over 11 sessions in 6 months. The study focuse…

This study tests whether virtual reality (VR) can help young adults with public speaking anxiety. Participants receive either one or three sessions of VR exposure therapy, followed by a 4-week online program. The goal is to see if a single VR session works as well as multiple ses…

This trial tests whether adding lidocaine ear drops to standard painkillers provides better ear pain relief for children aged 1–6 with acute otitis media. Half the children receive the ear drops plus usual care (oral painkillers, with or without antibiotics), while the other half…

This study tested a new drug called REL-1017 as an extra treatment for adults with major depression who didn't get enough help from standard antidepressants. The trial was stopped early and included only 27 participants. The main goal was to see if the drug could reduce depressio…

This study tested a new drug called REL-1017 (esmethadone) as an add-on treatment for people with major depression who weren't helped enough by their current antidepressant. The trial was a Phase 3, double-blind, placebo-controlled study with 236 participants. However, the study …

This phase 3 trial tests whether ARD-101 can reduce the intense, constant hunger (hyperphagia) seen in Prader-Willi syndrome. About 90 participants will take either ARD-101 or a placebo daily for 12 weeks. Caregivers will track changes in hunger-related behaviors using a standard…

This study tested whether a single 200 mg dose of American Ginseng (Cereboost) could improve attention and brain function in healthy young adults aged 18-40. Participants completed cognitive tests and gave blood samples over 6 hours. However, the trial was terminated early and on…

This study compared a newer, less invasive procedure called balloon sinuplasty to standard surgery for people with frontal sinusitis that did not improve with medication. The balloon procedure uses a small catheter to open blocked sinus passages, aiming to reduce pain, bleeding, …

This study tested whether propranolol, a beta-blocker usually used for heart conditions, can reduce nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder that causes abnormal blood vessels. Fifteen adults with HHT took either propranolol or a p…

This study tested whether N-acetylcysteine (NAC), an antioxidant, could help reduce impulse control disorders caused by Parkinson's medications. Only 14 people with mild-to-moderate symptoms were enrolled before the trial was stopped early. The goal was to see if 10 weeks of NAC …

This study tested whether closing a small hole in the heart (called a PFO) with a device could reduce migraine headaches. It planned to compare the real procedure to a sham (fake) procedure in adults aged 18-55 with frequent migraines. However, the study was stopped early after e…

This study looked at whether adding high-dose steroid pulses to the usual oral steroid course could help people with moderate ulcerative colitis flares achieve remission without needing other treatments. The trial was terminated early and enrolled 75 adults with left-sided or ext…

This study tested a small device worn on the ear that uses mild electrical pulses to help control pain after a liver transplant. The goal was to see if it could reduce the need for strong painkillers like opioids. The study was stopped early and included 27 adults waiting for a l…

This study looked at whether giving vitamin C to elderly patients hospitalized with pneumonia could improve their breathing and daily function. Only 9 people took part before the study was stopped early. Because it was so small, we can't say if vitamin C helps or not.

This study compared two drugs, prednisolone and colchicine, to see if they work equally well for treating sudden gout attacks in everyday doctor visits. About 186 adults with acute gout pain in their hands or feet took part. The goal was to measure pain relief after three days of…

This study tested a smartphone app that teaches mindfulness meditation to help Black and Latino adults with anxiety during the COVID-19 pandemic. About 400 participants were assigned to one of two mindfulness programs or a waitlist. The trial was terminated early, so we don't hav…

This study tested a new method for starting buprenorphine (a medication for opioid use disorder) in hospitalized adults who also have chronic pain. Instead of requiring patients to stop all other opioids and go through withdrawal first, the new method starts with very low doses o…

This pilot study aimed to compare trazodone and quetiapine for treating delirium in ICU patients. It enrolled only 10 adults in the surgical ICU who had delirium with symptoms like agitation or hallucinations. The study was terminated early, so the results are very limited and ca…

This pilot study tested whether MitoQ, an antioxidant supplement, could improve bladder symptoms like urgency and frequency in women aged 50 and older with metabolic syndrome. Twenty participants took either MitoQ or a placebo for 4 months, tracking their symptoms through questio…

This study tested whether a daily serum and cream could improve skin hydration and reduce redness in people with dry skin. Twenty-one adults applied the products for 14 days. The researchers measured skin moisture and redness before and after treatment to see if the products help…

This study tested whether a mindfulness program (including meditation, body scans, and gentle yoga) could help people with implanted heart devices like ICDs or pacemakers feel less anxious, stressed, and depressed. The study planned to enroll 34 adults who had recently received s…

This study compared two types of non-invasive breathing support for people with sudden breathing failure who are obese or have sleep apnea. One machine automatically adjusts pressure and volume, while the other uses a fixed pressure setting. The goal was to see which method clear…

This study tested whether adding sophrology (a relaxation method using breathing, visualization, and gentle movement) to speech therapy could reduce anxiety in people with aggressive brain tumors. Only 13 patients were enrolled before the trial was stopped early. The goal was to …

This study tested a device that delivers high-flow oxygen through the nose during throat surgery. The goal was to keep patients' oxygen levels safe without using a breathing tube. The trial included 29 adults in two French hospitals. The device was considered safe if blood oxygen…

This study looked at whether adding cognitive remediation therapy (a type of brain training) to supported education (help returning to school) improves academic functioning in young adults with psychotic disorders. Only 9 people enrolled before the study was stopped early. The go…

This study tested a morphine gel applied directly to painful mouth sores caused by chemotherapy. The goal was to see if the gel could relieve pain better than morphine given through an IV. The study included children and young adults aged 5 to 25. The gel was applied four times a…

This study tested alivis, a smartphone app that teaches coping skills for borderline personality disorder (BPD). It was designed for people aged 18-65 with BPD, who used the app alongside their usual treatment. The goal was to see if the app reduces BPD symptoms, depression, and …

This study looked at whether a special protocol used by community pharmacists in France can help women with simple bladder infections (cystitis) get relief more quickly. The goal was to reduce symptoms and avoid unnecessary trips to the doctor or emergency room. The study include…

This Phase 2 trial tested a neuroscience-based technique combining memory structuring and deep vagal breathing to reduce PTSD symptoms in people with advanced, incurable cancer and their partners. The study enrolled 19 patients who had just received a terminal diagnosis. The appr…

This pilot study tested whether combining repetitive transcranial magnetic stimulation (rTMS) with computerized cognitive training could help adults with schizophrenia who have thinking and memory problems. Twelve participants received either active or sham rTMS followed by cogni…

This study tested whether teaching teens and young adults (ages 14-29) the correct way to use nasal sprays for hay fever would improve their symptoms compared to standard care. The trial was terminated early and enrolled only 18 participants. The goal was to see if repeat educati…

This study tested whether adding aticaprant to standard antidepressants could help people with major depression who still feel no pleasure (anhedonia). The trial was stopped early after enrolling only 101 participants. No results are available, so it is unknown if aticaprant work…

This study tested whether EEG neurofeedback—a type of brain training that uses real-time brainwave readings—can help people with aphasia (trouble speaking or understanding language) improve their communication, sleep, and anxiety. Seven adults with aphasia from stroke or primary …

This small study tested whether flibanserin (Addyi), a drug approved for low sexual desire in women, could also help men with low libido. Eight men aged 18–69 with low desire but normal mood and erectile function took either the drug or a placebo for three months. The trial was t…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study tested whether hospitalized adults with type 2 diabetes or prediabetes could safely do 30 minutes of resistance training each day. The goal was to see if this exercise routine is feasible and if it helps control blood sugar and prevent muscle loss during a hospital sta…

This study was designed to track side effects and quality of life in people aged 70 and older with advanced melanoma or non-small cell lung cancer who are starting immunotherapy. Researchers planned to monitor 40 participants for serious side effects and changes in daily well-bei…

This study tested a new medicine called NRCT-101SR for teenagers aged 13 to 17 with ADHD. The goal was to see if it safely reduces ADHD symptoms compared to a placebo. The trial was stopped early, so results are limited. It involved 95 participants and used standard ADHD rating s…

This study tested whether using less opioids for initial pain relief in children with acute pancreatitis is as effective and safer than the usual opioid-first approach. It involved 23 children at Boston Children's Hospital. The goal was to gather data for a larger future trial.

This study looked at how well Petit Drill syrup works and how safe it is for calming throat irritation and dry cough in children from 6 months to 6 years old. The syrup is a soothing substance recommended by the World Health Organization for this age group. The study planned to t…

This Phase 2 trial tested an experimental drug called EP262 in 113 people with chronic spontaneous urticaria (long-lasting hives with no clear cause). Participants took either EP262 or a placebo daily for 6 weeks, while continuing their usual antihistamines. The study aimed to se…

This study tested a prescription cream called ruxolitinib on adults with mild-to-moderate eczema who had trouble sleeping because of their condition. The goal was to see if the cream could help them sleep longer and better. The study was stopped early, but it involved 47 particip…

This study tested whether adding physical rehabilitation and personalized nutrition to standard care helps patients with infective endocarditis (a serious heart infection) feel better during their hospital stay. The goal was to improve mental health and quality of life. The study…

This study compared three different injections—platelet-rich plasma, botulinum toxin, and steroids—for treating tennis elbow pain. It aimed to see which worked best for pain relief. Only 13 people took part before the study was stopped early.

This study tested a new drug, SAR444656, in 70 adults with moderate to severe hidradenitis suppurativa (HS), a painful skin condition causing boils and abscesses. Participants took the drug or a placebo for 16 weeks to see if it reduced the number of inflamed nodules and abscesse…

This study tested a rehabilitation program for hand sensitivity problems in people with multiple sclerosis. The program used TENS (a mild electrical stimulation device) and hand exercises to improve the ability to feel and recognize objects. The goal was to improve quality of lif…

This study tested a home system that uses aromatherapy, music, and brain-training games to help older adults with mild memory issues stay safe and independent. Only 4 people took part before the study was stopped early. The goal was to see if seniors would use and enjoy these non…

This study tested whether a small device that sends mild electrical pulses to the vagus nerve (through the ear) can reduce pain and inflammation in children with juvenile idiopathic arthritis. The trial planned to enroll children ages 5 to 18, but was terminated early after only …

This study tested a nasal spray called PH94B to see if it could quickly reduce anxiety in adults with social anxiety disorder during a public speaking task. About 228 participants were expected to take the spray or a placebo before speaking. The trial was terminated early, so res…

This study tested whether a virtual reality (VR) tour of the delivery room and neonatal unit could reduce anxiety in pregnant women hospitalized with a high risk of preterm birth. The 85 participants were between 24 and 34 weeks pregnant and had received steroids for fetal lung d…

This study tested an experimental drug called GSK3858279 in 147 adults with chronic nerve pain from diabetes. The goal was to see if it could reduce pain better than a placebo. However, the trial was terminated early, so we have less information than planned.

This study tested if tecar therapy (a type of electrical heat treatment) could reduce pain from cesarean section scars. About 19 women with painful scars received either real tecar therapy or a fake (sham) treatment over 3 weeks, in addition to standard scar massage. The goal was…

This study compares a new minimally invasive procedure called genicular artery embolization (GAE) to standard steroid injections for reducing knee pain from osteoarthritis. It was designed for adults over 40 whose knee pain hasn't improved with other treatments. The goal is to se…

This study tested an experimental drug called GSK3858279 in 314 adults with moderate to severe knee osteoarthritis pain. The goal was to find the best dose that reduces pain safely. However, the trial was stopped early, so we have less information than planned.

This study tested whether using a blood flow restriction (BFR) cuff during physical therapy could help people with shoulder injuries regain strength and return to activity faster. Only 3 people took part before the study was stopped early. The approach uses a special tourniquet t…

This pilot study tested whether the sleep drug tasimelteon (Hetlioz) could reduce dream-enactment events in people with REM behavior disorder. Twenty participants took a nightly 20 mg capsule and tracked their symptoms in a daily diary. The study was terminated early, so results …

This early-stage trial tested a single dose of a drug called briquilimab in 27 adults with chronic hives caused by cold or friction that did not improve with standard allergy pills. The main goal was to check safety and see if the drug could reduce symptoms. However, the trial wa…

This pilot study tested a digital training task called GAMBIT in 50 adults with PTSD. The goal was to see if playing this brain-training game could improve brain circuit flexibility and reduce PTSD symptoms. The study was terminated early, so the findings are limited.

This study tested a program where people with rheumatoid arthritis (RA) were paired with a trained peer supporter for up to 6 months. The goal was to see if sharing experiences and support could improve daily function, medication adherence, and symptoms like pain and fatigue. The…

This pilot study looked at whether an interactive storyteller called LUNII could lower anxiety in children aged 4 to 6 with cleft lip and palate before their bone graft surgery. The goal was to see if using the device before the operation would also reduce pain and shorten hospit…

This study tested a digital health app called medidux™ in 196 people with HER2-positive breast cancer. The app was used for up to 16 weeks during chemotherapy to help track and manage side effects. The goal was to see if using the app reduced the number of severe side effects. Ho…

This study tested whether teaching people recovering from ACL reconstruction to run with a forefoot strike and a faster step rate could reduce knee pain and improve function. Ten active-duty soldiers and cadets participated. The approach is non-invasive and focuses on retraining …

This study aimed to see if certain eye tests could predict which people with dry eye disease would get relief from over-the-counter artificial tears. Researchers planned to enroll 66 adults with dry eye, but the study was terminated early with only 36 participants. Participants u…

This study tested whether a robotic seal named PARO could help elderly people with moderate to severe memory problems feel calmer during daily care like bathing. The robot was used for a few minutes before and during care, twice a week for 16 weeks. The goal was to see if it redu…

This study tested whether combining a computer-based speed-of-processing training with a gentle electrical brain stimulation (alpha-tACS) could improve how quickly people with mild cognitive impairment process visual information. The trial planned to enroll 40 adults aged 65 and …

People who have a stroke face a much higher risk of heart problems in the following weeks, but researchers do not fully understand why. This study uses PET/MRI scans of the heart and blood tests for inflammatory markers to see whether inflammation develops in the heart after a st…

Researchers at the University of California, San Francisco are studying whether stimulating the vagus nerve through the ear during a nap can improve memory. The trial enrolls healthy adults aged 18 to 64 who nap regularly. Participants receive either active stimulation or a sham …

This study investigates why some people with Graves' disease continue to feel mentally fatigued even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid from 180 participants—60 with mental fatigue, 60 without, and 60 healthy controls—to f…

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cra…

This study looks at whether people with Fabry, Gaucher, or Hunter disease are more likely to continue their IV treatment when it's given at home versus at a hospital. Researchers will review existing data from 222 patients in Mexico. No new treatments are given; the goal is to un…

This study looks at brain activity in 100 adults with major depression who are receiving a treatment called accelerated TMS. Researchers use a special brain scanner (TD-fNIRS) to see if patterns of brain activity can predict who will respond well to the treatment. Healthy volunte…

This study examines the medical records of 400 people diagnosed with various types of lymphoma at a French hospital between 1999 and 2018. Researchers want to see how long patients survived and whether the care they received matched what medical guidelines recommend. The goal is …

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goa…

This study explores whether tailoring when children with developmental language disorder (DLD) practice recalling new words can improve their learning. Researchers compare a standard fixed schedule to an adaptive one that adjusts to each child's progress. Four- and five-year-olds…

This study is looking at whether yearly ultrasound scans can detect blood vessel abnormalities throughout the body in women with Turner syndrome, not just in the heart area. Turner syndrome is a genetic condition that increases the risk of serious vascular problems, which can sho…

This study checks on people who previously received gene editing for hemophilia B or mucopolysaccharidosis (MPS) I or II. No new treatment is given; instead, participants are monitored for up to 10 years to see if any new health problems or worsening of existing conditions appear…

This pilot study tests a new approach to supporting people after a stay in the intensive care unit (ICU). Many ICU survivors face ongoing psychological and physical challenges, such as depression, anxiety, and disability. The intervention involves a case manager who coordinates a…

This study investigates whether MRI can detect early signs of pancreatic damage linked to obesity and metabolic syndrome, which are risk factors for pancreatic cancer. Researchers will compare MRI images with tissue samples from patients undergoing pancreatic surgery, as well as …

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide, which stops the pancreas from making insulin. Researchers will then measure their fasting blood su…

This study is looking at whether tumor biopsies can help predict which patients with melanoma, non-small cell lung cancer, or head and neck cancer will respond to immunotherapy drugs called PD-1 or PD-L1 inhibitors. Researchers will collect tissue samples from about 152 adults be…

This study watches 400 people with chronic spontaneous urticaria (long-lasting hives) who are prescribed dupilumab by their doctor. Researchers collect information from medical records and patient surveys to see how the drug works in real life, its safety, and how it affects qual…

This study looks at how caring for a child recently diagnosed with type 1 diabetes affects caregivers' work, daily life, and well-being. About 100 Canadian caregivers will fill out online questionnaires about their productivity, healthcare use, and quality of life. No treatment i…

This study aimed to better understand eczema by collecting data, blood, and skin samples from 69 participants across Canada. It also compared two types of light therapy (broadband vs narrowband UVB) to see which works better for treating eczema. The study was terminated early, so…

This study looks at whether heart cells that age rapidly after a heart attack release harmful proteins that make heart disease worse. Researchers will collect blood and heart tissue samples from people undergoing coronary artery bypass surgery after a recent heart attack or for s…

This study looks at children and teens in Russia who may have a rare genetic condition called lysosomal acid lipase deficiency (LAL-D). Researchers will check for the disease in up to 1,200 participants using blood tests and genetic testing. The goal is to understand how often LA…

This study used a special MRI technique to look at tiny brain changes in people who recently had a first episode of symptoms that could lead to multiple sclerosis (MS). Researchers compared 84 participants (patients and healthy controls) to see if early memory problems are linked…

This study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…

This study explores whether the community of bacteria living on the skin (the skin microbiome) plays a role in vitiligo—a condition that causes white patches—and in side effects from anti-PD-1 immunotherapy for advanced melanoma. Researchers will collect skin swabs from people wi…

This study aimed to see if certain substances in stool and blood can predict whether the gut lining has healed in people with moderate to severe ulcerative colitis. Researchers planned to measure these markers in 62 adults before and after treatment. The study was terminated earl…

This study tested whether real-time fMRI neurofeedback could help young adults with major depression reduce repetitive negative thinking. Participants received either real or fake feedback while their brain activity was monitored. The trial was terminated early, so the findings a…

This study aimed to see if a simple brain-wave test (LDAEP) could predict which veterans with PTSD or depression would improve with the SSRI medication sertraline (Zoloft). Participants took sertraline or a placebo for 14 weeks while researchers measured their brain activity and …

This study aimed to find out how common sperm problems are in men with Fabry disease. Researchers planned to check sperm samples from 22 men aged 18 to 65. The study was stopped early, so results are limited.

This study investigated whether polyomaviruses (a type of common virus) are found more often in people with autoimmune thyroiditis or goiters. Researchers compared virus presence in blood, urine, and thyroid tissue from 49 patients undergoing thyroid surgery. The goal was to see …

This study aimed to understand why people with autism or schizophrenia sometimes struggle to recognize emotions on faces. Researchers used brain wave recordings (EEG) and eye-tracking to see how participants processed facial expressions. The study included people with autism, sch…

This study looked at how noninvasive brain stimulation techniques like rTMS, tDCS, and ECT change BDNF levels in people with depression or schizophrenia. Researchers took blood samples before and after stimulation to measure BDNF, a protein linked to brain health. The study was t…

This study looks at the tiny hair-like structures (cilia) inside the fallopian tubes of women who have had surgery to remove a tube or uterus. Researchers want to see if differences in these cilia help explain why some women have ectopic pregnancies (when a fertilized egg grows o…

This study aimed to see how total hip replacement changes the way the pelvic bone moves during daily activities like sitting and standing. Researchers used an ultrasound device to measure pelvic tilt in 15 people with hip arthritis before and after surgery. The study was terminat…

This study collects small skin samples from children aged 2 to 17 with Costello syndrome or a related condition. Researchers will analyze the cells to understand how a mutation in the HRAS gene affects energy use and mitochondria. The goal is to learn more about the disease's und…

This study looked at whether a gentle, adapted physical activity program could help women with anorexia nervosa during refeeding. Researchers measured changes in a metabolic pathway linked to mood and energy. Only 9 people took part, and the study was stopped early, so the findin…

This study tested whether special insoles with pressure sensors (FEETME®) can accurately measure walking speed in people with CIDP, a nerve condition that causes walking difficulties. Researchers compared the insoles to a standard walkway system in 18 adults aged 18-75 with CIDP.…

This study aimed to see if a sedative called dexmedetomidine produces sleep more like natural sleep than another sedative, propofol. Researchers planned to measure brain activity in 3 healthy volunteers during drug-induced and natural sleep. The trial was terminated early, so onl…

This study looked at whether people with type 2 diabetes who have a chronic cough also have damage to small nerves in their skin. Researchers compared diabetic patients with and without chronic cough using nerve tests and skin biopsies. The study was terminated early with only 7 …

This early-stage study tested whether inhaling the cancer drug afatinib works as well as taking it by mouth. Four healthy adult smokers received both forms in separate sessions to compare drug levels in the blood and lungs. The study was terminated early, so the findings are limi…

This study aimed to understand why people with autism often feel overwhelmed by sensory input like bright lights or loud noises. Researchers planned to use virtual reality and brain scans to see how the brain reacts to unpleasant visual stimuli. The study was terminated early and…

This study tested a French version of a questionnaire that measures how much patients know about lithium, a drug used for bipolar and schizoaffective disorders. Researchers wanted to see if higher knowledge scores matched safe lithium levels in the blood. The study included 22 ho…

This pilot study measured brain activity (EEG) in 6 healthy volunteers while they performed computer tasks that test attention and memory. The goal was to develop better ways to measure thinking skills that could be used in future Alzheimer's drug trials. The study was terminated…

This study looks at adults with phenylketonuria (PKU) who were diagnosed as newborns and treated with a special diet. Researchers want to see if how long and how strictly they followed the diet as children affects their intelligence (IQ) as adults. The goal is to use this informa…

This study looked at whether sleep disorders like insomnia and nightmares are connected to suicide attempts. Researchers compared people who had just attempted suicide with those who had suicidal thoughts but no attempt. The goal was to see if sleep problems might be a trigger. T…

This study looked at how being exposed to alcohol before birth might affect adults' ability to read emotions and make decisions. Researchers planned to compare adults with prenatal alcohol exposure to those without, using computer tasks. The study was terminated early and only en…

This study aimed to see if orthognathic (jaw) surgery improves quality of life for people born with cleft lip and palate. Researchers planned to compare questionnaire scores before and 6 months after surgery in about 10 participants. The study was terminated early, so results are…

This study tested a serious game called Bipolife® for people with bipolar disorder who had already completed a psychoeducation program. The game encourages players to take their medication, keep a daily routine, and contact their doctor if symptoms return. The trial was terminate…

This study looked at whether a newer, low-dose X-ray system (EOSedge) produces images good enough for planning hip replacement or revision surgery, compared to standard digital X-rays. About 97 adults who needed hip surgery X-rays took part. The goal was to see if using just one …

This small, early-terminated study explored whether measuring certain receptors on immune cells could predict disease activity and rebound risk in multiple sclerosis patients taking or stopping ozanimod. Researchers analyzed blood samples from 23 adults with relapsing-remitting M…

This study aimed to find blood and tissue markers that could predict whether obese patients with type 2 diabetes would go into remission after bariatric surgery. Researchers planned to measure 9 specific molecules in blood samples and also collect fat and muscle tissue during sur…

This study looked at how early Alzheimer's disease affects a person's ability to make decisions. Researchers tested 100 people with Alzheimer's and healthy volunteers using memory and thinking tasks, plus a special decision-making test. The goal was to understand which brain func…

This early-stage study aimed to see if taking memantine, an Alzheimer's drug, for 15 days would change certain brain and cognitive markers in healthy young men aged 18-30. The goal was to validate a test battery for future Alzheimer's drug development. However, the study was term…

This study followed 83 people with advanced non-small cell lung cancer who were starting standard treatments. The goal was to collect information to help develop a digital tool that can spot early signs of pneumonitis/ILD, a serious lung inflammation that can occur as a side effe…

This study aimed to find biomarkers (measurable substances in the blood) that could help doctors diagnose bradykinin angioedema and predict how severe attacks might be. The condition causes sudden, unpredictable swelling, and current tests don't work well for all types. Researche…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study tested a virtual reality training program for maternity care providers, nurses, lactation consultants, and doulas. The goal was to improve teamwork and reduce pain disparities for birthing parents. The study enrolled 66 participants but was terminated early, so the res…

This study looked for new markers in blood and joint fluid to help doctors tell the difference between septic arthritis (a joint infection) and juvenile idiopathic arthritis (an inflammatory condition) in children. Researchers planned to analyze samples from 100 children under 15…

This study aimed to describe the features and natural history of idiopathic interstitial pneumopathy, a group of rare lung diseases, in both children and adults. Researchers planned to collect data from 1,600 participants, including medical history, imaging, and genetic tests, to…

This study aimed to see if a tiny camera on a thin tube (bronchoscopy) could help doctors diagnose diffuse lung diseases without needing a surgical lung biopsy. The camera takes live microscopic images of the air sacs. The study was stopped early, but it involved 38 adults with c…

This study aimed to compare the gut bacteria of children newly diagnosed with juvenile idiopathic arthritis, type 1 diabetes, or inflammatory bowel disease with those of their healthy siblings. Researchers wanted to see if differences in gut microbes and diet could explain why so…

This study was a large registry that planned to follow 180,000 patients in Germany with aortic valve problems (leaky or narrowed valves). The goal was to compare newer, less invasive treatments like TAVI with standard open-heart surgery to see which works best and for whom. Resea…

This small, early study tested a new approach called Auditory Control Enhancement (ACE) for people with schizophrenia who hear voices (auditory hallucinations) that don't respond to medication. ACE combines a mild brain stimulation technique called tDCS with cognitive training. T…

This study looked at how immunosuppressive medications used for rheumatoid arthritis and spondyloarthritis affect the body's ability to fight COVID-19. Researchers measured viral load and immune responses in 150 patients and their infected family members. The goal was to understa…

This study aimed to understand how withdrawal symptoms and drug-related cues influence decision-making in people with opioid use disorder. Participants completed choice tasks to see if they preferred high-probability rewards. The study was terminated early and only enrolled 2 par…

This study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) better recognize and describe their emotions. The goal was to see if improving emotion awareness could lower suicide risk. Only 11 veterans to…

This study looked at whether special MRI scans can detect early brain changes in people with multiple sclerosis who are starting treatment with Tysabri. Researchers planned to follow 70 patients for two years, comparing MRI images before and after treatment. The goal was to find …

This study looked at people with type 1 diabetes who use do-it-yourself automated insulin delivery (DIY-AID) systems. Researchers wanted to find the best blood glucose target to set 60 minutes before moderate aerobic exercise (like cycling) to keep blood sugar stable and avoid da…

This study aimed to understand why some people taking the cancer drug ibrutinib develop heart issues like atrial fibrillation (irregular heartbeat) and high blood pressure. Researchers planned to follow 8 patients with blood cancers, using heart tests and blood markers to try to …

This study looked at Latino adults with diabetes who attended free education classes. Researchers collected information about their health habits, blood sugar levels, and barriers to medical care. The goal was to better understand the needs of this community, not to test a new tr…

This study tested whether a 16-week program of yoga and lifestyle changes could affect gene activity (micro RNA) and heart disease risk factors in 16 adults with coronary artery disease. Participants had either undergone a heart procedure or had non-obstructive heart disease with…

This study aimed to see how dapagliflozin, a diabetes drug, affects blood vessel health in people with type 2 diabetes. Researchers planned to measure blood pressure and other markers of vascular function. However, the trial was terminated early and only enrolled 4 participants, …

This study looked at whether caregivers' negative beliefs about antipsychotic medications make it harder for people with schizophrenia to stick to their treatment. About 50 patients and their main caregivers answered questionnaires about medication beliefs and adherence. The goal…

This study gave healthy adults nose drops containing a harmless bacteria (N. lactamica) to see how the body's immune system responds. The goal is to learn if the immune response is the same whether the bacteria is cleared after 4 days or 14 days. This information will help design…

This study aimed to find brain and movement markers in people with a type of depression that doesn't respond to standard antidepressants, called anhedonic depression. Researchers measured brain waves (P300), walking speed, and hand movements in 36 participants. The goal was to id…

This study looked at whether people with type 1 or type 2 diabetes who have a 'Type A' (impatient, proactive) or 'Type B' (calm, slow) personality show different genetic markers linked to inflammation and stress. Researchers planned to collect blood samples and have participants …

This study looked at how the diabetes medication Liraglutide (Victoza) affects taste, food cravings, and eating habits in people with type 2 diabetes who are overweight. Researchers compared three groups: patients starting Liraglutide, diabetic patients not on the drug, and healt…

This study looked at how serotonin, a brain chemical, affects circuits involved in avoiding food in people with anorexia nervosa. Researchers used PET and fMRI scans to compare brain activity between 30 women with anorexia and 27 healthy women. The goal was to understand the brai…

This study looked at how the drug tralokinumab affects the skin of people with moderate to severe atopic dermatitis (eczema). Researchers measured drug levels and immune changes in skin samples after 16 weeks of treatment. The goal was to better understand how the drug works, whi…

This study looked at how mechanical ventilation (breathing machines) affects the energy centers (mitochondria) of immune cells in patients with severe lung infections and acute respiratory distress syndrome (ARDS). Researchers aimed to understand why some patients get worse despi…

This study looked at whether eating most calories before 2 PM could help control blood sugar in people with type 2 diabetes. It planned to enroll 10 participants but was terminated after only 2 joined. The goal was to compare early eating with a typical eating pattern over six da…

This study aimed to see if giving patients extra encouragement before and after esketamine treatment could improve their depression symptoms. Researchers planned to compare a group that received a positive presentation and follow-up session with a group that did not. However, the…

This study aimed to understand what happens in the mind during sleep by using sound cues in people who sleepwalk. Researchers wanted to see if they could trigger and measure mental processes in real time. The study was terminated early, so results are limited.

This study looked at whether people born with cytomegalovirus (CMV) infection who have hearing loss or balance problems also have a condition called endolymphatic hydrops (fluid buildup in the inner ear). Researchers used a special MRI scan with a contrast dye to check for this f…

This study aimed to find early signs of heart and blood vessel damage in people with obstructive sleep apnea, before serious symptoms appear. Researchers planned to follow 133 patients and check if CPAP treatment could reverse these early changes. The study was terminated early, …

This study aimed to see if using a CPAP machine (a device that helps breathing during sleep) reduces inflammation in fat tissue for people with sleep apnea, both obese and non-obese. Researchers planned to compare CPAP treatment to a placebo in 40 men. The study was stopped early…

This study aimed to find the best time (between 37 and 39 weeks of pregnancy) to deliver babies of women with poorly controlled gestational diabetes. Researchers planned to enroll up to 3,450 pregnant women but stopped early with 304 participants. The goal was to see which delive…

This pilot study tested whether continuous glucose monitors (CGMs) could be used in the days before and after surgery to track blood sugar in people with diabetes. Researchers placed a CGM sensor on 22 patients during a preoperative visit and compared its readings to standard fin…

This study contacted 321 people with sleep apnea who were part of earlier research to see what health problems they had over time. Researchers asked about heart issues, diabetes, cancer, and deaths. They also looked at whether using a CPAP machine affected these outcomes. The goa…

This study tested a wearable device called Syde® in 86 people with multiple sclerosis. Participants wore the device for one month every six months over two years. The goal was to see if the device's activity data matches standard clinic tests like walking speed and disability sco…

This study tracked 239 adults in France taking baclofen for alcohol use disorder. Researchers called participants monthly for a year to see how many stopped the drug due to side effects. The goal was to better understand which side effects are caused by baclofen versus other fact…

This study filmed consultations between dermatologists and infants under 6 months old with atopic dermatitis (eczema). Researchers analyzed the videos to identify specific behaviors that might indicate discomfort, since standard itch assessment scales don't work for babies this y…

This study involved 65 adults with obstructive sleep apnea who had been using CPAP therapy for at least 6 months. Participants stopped using CPAP for 2 weeks so researchers could measure changes in blood vessel function and nerve control of the heart. The goal was to see if a spe…

This study looked at how food intake relates to gut bacteria in women with anorexia nervosa compared to healthy volunteers. Researchers analyzed stool samples to measure immune-coated bacteria and dietary habits. The study was terminated early with only 14 participants, so findin…

This study looked at how certain immune cells, called non-conventional T cells, behave in patients with severe pneumonia and acute respiratory distress syndrome (ARDS). Researchers collected blood and airway samples from 258 intensive care unit patients to track these cells over …

This study aimed to understand how age influences serious health issues like infections, cancer, heart disease, and bone fractures in people with rheumatoid arthritis. Researchers compared patients over 65 with younger adults (18-50) who had the same disease. The study was stoppe…

This study aimed to find out how many people with Sjögren's dry eye have reduced feeling in their cornea (the clear front part of the eye). Researchers measured corneal sensitivity, tear production, and pain in 103 adults with confirmed Sjögren's syndrome and dry eye. The study w…

This study aimed to see if introducing formal home help (like a paid aide) improves the quality of life for people caring for elderly relatives with memory or thinking problems. Researchers planned to follow 12 caregivers for 90 days, measuring changes in their well-being, stress…

This study followed 65 adult men with a rare inherited nerve disease called AMN (a form of spastic paraplegia) to understand how their symptoms change over time. Researchers collected data on walking ability and quality of life. The goal was to fill gaps in knowledge about the di…

This study aimed to see if a wireless sensor could collect health information from babies with heart defects at home, replacing wired devices. Only 2 infants were enrolled before the study was stopped. The goal was to understand if the wireless device was easy to use and worked w…

This study followed 190 young women to learn how the body handles new HPV infections. Researchers measured virus levels, immune cells, and other factors over time. The goal was to understand why some infections clear quickly while others persist. No treatment was given; this was …

This study looked at why some people have more suicidal thoughts when they start or switch antidepressants. 38 adults with major depression used a smartphone app to rate their dark thoughts and mood daily for 30 days. The goal was to better understand and monitor this early risk …

This study looked at how JAK-STAT inhibitors, a type of drug used for rheumatoid arthritis, affect certain immune cells called regulatory B cells. Researchers analyzed blood samples from 27 patients to see if these drugs could boost anti-inflammatory functions. The study was term…

This pilot study analyzed special immune cells called regulatory T cells (Tregs) in the joint fluid of 19 people with rheumatoid arthritis during a flare-up. Researchers compared these cells to Tregs in the blood to understand how they behave in inflamed joints. No treatment was …

This study aimed to see if a mindfulness-based stress reduction program could lower stress and inflammation in people caring for someone with a severe psychiatric disorder. Researchers planned to compare a group taking mindfulness classes with a group receiving standard care, mea…

This study tested an online program called Teacher Help, designed to train teachers in evidence-based strategies for students with ADHD, autism spectrum disorder, or learning disabilities. Teachers worked through six online sessions with support from school psychologists. The goa…

This study aims to find out how common transthyretin amyloidosis cardiomyopathy (ATTR-CM) is in Russian patients with a certain type of heart failure. Researchers will review medical records and then invite some patients for extra heart tests to confirm or rule out ATTR-CM. The g…

This study looked at whether people with both rheumatoid arthritis and type 2 diabetes have a harder time controlling their diabetes than those with osteoarthritis and diabetes. Researchers planned to follow 176 adults to see how quickly they needed new diabetes treatments. Howev…

This study looked at how well the COVID-19 vaccine triggers an immune response in people with autoimmune or inflammatory diseases who take immunosuppressants or biologics. Researchers took blood samples before vaccination and at several points after to measure antibodies and T-ce…

This study tracked how the antibiotic ceftazidime-avibactam is used in real hospital settings in China for serious infections like pneumonia and abdominal infections. Researchers planned to enroll 450 patients but the study was terminated early. The goal was to see how often the …

This study looked at using point-of-care ultrasound (POCUS) to assess small bowel Crohn's disease. Researchers interviewed doctors, nurses, and patients to understand if POCUS could be useful in the NHS. They also compared how POCUS and MRI scans affected doctors' treatment decis…