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New drug peresolimab tested for rheumatoid arthritis – study ends early

NCT ID NCT05516758

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested peresolimab, an experimental drug, in 491 adults with moderately-to-severely active rheumatoid arthritis who had not responded well to other treatments. The goal was to see if peresolimab could reduce joint pain and swelling better than a placebo. However, the study was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
peresolimab
What this could lead to
If successful, peresolimab could offer a new treatment option for people with rheumatoid arthritis who haven't responded well to other therapies.
What could go wrong
This trial was terminated early, so results are limited. It's a phase 2 study, meaning it's still early and may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

491 people

The number who actually took part.

Started

Aug 2022

Finished

Jan 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of adult onset rheumatoid arthritis (RA) for at least 3 months prior to screening, as defined by the 2010 ACR/European League Against Rheumatism (EULAR) classification criteria * Have moderately-to-severely active RA, at screening and baseline, defined by the presence of * ≥6 swollen joints based on 66 joint count, and * ≥6 tender joints based on 68 joint count. * Have had an inadequate response to, or loss of response or intolerance to at least 1 conventional synthetic DMARD (csDMARD), biologic DMARD ( bDMARD), or targeted synthetic DMARD (tsDMARD) treatment. Exclusion Criteria: * Have Class IV RA according to ACR revised criteria. * Have presence of 1 or more significant concurrent medical conditions per investigator judgment, including but not limited to * poorly controlled diabetes or hypertension * chronic kidney disease stage IIIb, IV, or V * symptomatic heart failure according to New York Heart Association Class II, III, or IV * myocardial infarction, unstable angina pectoris, stroke or transient ischemic attack, within the past 12 months before randomization * severe chronic pulmonary disease, for example, requiring oxygen therapy * major chronic inflammatory disease or connective tissue disease other than RA, including but not limited to, * systemic lupus erythematosus * psoriatic arthritis * axial spondyloarthritis including ankylosing spondylitis and non-radiographic axial spondyloarthritis * reactive arthritis * gout * scleroderma * polymyositis * dermatomyositis * active fibromyalgia, or * multiple sclerosis

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Conditions

The condition(s) this trial relates to.

arthritic joint disease arthropathy autoimmune disease connective tissue disorder immune system disorder musculoskeletal system disorder rheumatic disorder rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthritis Autoimmune diseases Connective tissue diseases Immune system diseases Joint diseases Musculoskeletal diseases Rheumatic diseases Rheumatoid arthritis

Contacts and locations

Locations

  • AA Medical Research Center

    Grand Blanc, Michigan, 48439, United States

  • APRILLUS Asistencia E Investigacion

    CABA, Buenos Aires F.D., 1406, Argentina

  • Accel Research Sites - Birmingham Clinical Research Unit

    Birmingham, Alabama, 35216, United States

  • Accurate Clinical Management

    Baytown, Texas, 77521, United States

  • Accurate Clinical Management - Houston

    Houston, Texas, 77084, United States

  • Accurate Clinical Research

    Lake Charles, Louisiana, 70605, United States

  • Accurate Clinical Research

    Houston, Texas, 77089, United States

  • Afflilated Hospital of Bengbu Medical College

    Bengbu, Anhui, 233004, China

  • Aggarwal and Associates Limited

    Brampton, Ontario, L6T 0G1, Canada

  • Ai Centrum Medyczne Sp. Z O.O. Sp.K.

    Poznan, Greater Poland Voivodeship, 61-113, Poland

  • Albuquerque Center for Rheumatology

    Albuquerque, New Mexico, 87102, United States

  • Albuquerque Clinical Trials, Inc.

    Albuquerque, New Mexico, 87102, United States

  • Altoona Center For Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Ambulatorium Sp. z o.o.

    Elblag, Warmian-Masurian Voivodeship, 82-300, Poland

  • Arizona Arthritis & Rheumatology Associates, PLLC

    Phoenix, Arizona, 85037, United States

  • Arizona Arthritis & Rheumatology Research PLLC

    Gilbert, Arizona, 85297, United States

  • Arizona Arthritis & Rheumatology Research, PLLC

    Glendale, Arizona, 85306, United States

  • Arizona Arthritis & Rheumatology Research, PLLC

    Mesa, Arizona, 85210, United States

  • Arthritis & Osteoporosis Associates - Freehold

    Freehold, New Jersey, 07728, United States

  • Arthritis Northwest, PLLC

    Spokane, Washington, 99204, United States

  • Arthritis and Rheumatology Center of MI - Rochester Hills

    Rochester Hills, Michigan, 48307, United States

  • Attikon General University Hospital

    Chaïdári, Attikí, 12462, Greece

  • Baycare Medical Group

    St. Petersburg, Florida, 33705, United States

  • Baycare Medical Group

    Tampa, Florida, 33614, United States

  • Bayside Misato Medical Center

    Kochi, 781-0112, Japan

  • Biopharma Informatic, LLC

    Houston, Texas, 77043, United States

  • Biopharma Informatic, LLC

    Houston, Texas, 77084, United States

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, A Coruña [La Coruña], 15006, Spain

  • CHUS - Hospital Clinico Universitario

    Santiago de Compostela, Galicia [Galicia], 15706, Spain

  • CIPREC

    Buenos Aires, Buenos Aires F.D., C1061AAS, Argentina

  • Cape Fear Arthritis Care

    Leland, North Carolina, 28451, United States

  • Centre de Recherche Musculo-Squelettique

    Trois-Rivières, Quebec, G9A 3Y2, Canada

  • Centro Medico del Angel

    Mexicali, Estado de Baja California, 21100, Mexico

  • Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan

    San Juan, 5400, Argentina

  • Centro Privado de Medicina Familiar / Mindout Research

    Ciudad Autónoma de Buenos Aire, Buenos Aires, 1417, Argentina

  • Centro Reumatologico Caguas

    Caguas, 00725, Puerto Rico

  • Centro de Investigaciones Médicas Tucuman

    San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina

  • Centro de Investigaciones Reumatológicas

    San Miguel de Tucumán, Tucumán Province, 4000, Argentina

  • Centrum Medyczne Reuma Park

    Warsaw, Masovian Voivodeship, 02-665, Poland

  • Chubu Rosai Hospital

    Nagoya, Aichi-ken, 455-8530, Japan

  • Clinica Adventista Belgrano

    CABA, Ciudad Autónoma de Buenos Aire, C1430EGF, Argentina

  • Clinica de Investigacion en Reumatologia y Obesidad S. C.

    Guadalajara, Jalisco, 44650, Mexico

  • Clinical Research of West Florida

    Tampa, Florida, 33606, United States

  • Clinical Research of West Florida, Inc. (Clearwater)

    Clearwater, Florida, 33765, United States

  • Clinstile, S.A. de C.V.

    Mexico City, Mexico City, 06700, Mexico

  • Clinvest Research LLC

    Springfield, Missouri, 65807, United States

  • Clínica Gaias - Santiago

    Santiago de Compostela, A Coruña [La Coruña], 15702, Spain

  • DJL Clinical Research, PLLC

    Charlotte, North Carolina, 28211, United States

  • DM Clinical Research - Tomball

    Tomball, Texas, 77375, United States

  • DM Clinical Research/Rheumatology Clinic of Houston

    Tomball, Texas, 77377, United States

  • Dan La, MD Inc

    Tujunga, California, 91042, United States

  • Denver Arthritis Clinic

    Denver, Colorado, 80230, United States

  • Desert Medical Advances

    Rancho Mirage, California, 92270, United States

  • Encore Medical Research of Boynton Beach

    Boynton Beach, Florida, 33436, United States

  • ForCare Clinical Research

    Tampa, Florida, 33613, United States

  • Fundación Respirar

    Buenos Aires, C1426ABP, Argentina

  • G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.

    Québec, G1V 3M7, Canada

  • GCM Medical Group, PSC - Hato Rey Site

    San Juan, 00917, Puerto Rico

  • General Hospital of Athens Hippokratio

    Athens, Attikí, 115 27, Greece

  • General Hospital of Athens Laiko

    Athens, Attikí, 11527, Greece

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, Illinois, 60640, United States

  • Great Lakes Research Group, Inc.

    Bay City, Michigan, 48706, United States

  • HARAC Research Corp

    Avon Park, Florida, 33825, United States

  • Health Research of Oklahoma

    Oklahoma City, Oklahoma, 73103, United States

  • Hinsdale Orthopaedics - llinois Bone & Joint Institute

    Hinsdale, Illinois, 60521, United States

  • Hirose Clinic - Tokorozawa

    Tokorozawa, Saitama, 359-1111, Japan

  • Hiroshima Clinic

    Hiroshima, 733-0032, Japan

  • Hiroshima University Hospital

    Hiroshima, 734-8551, Japan

  • Hospital Córdoba

    Córdoba, 5004, Argentina

  • Hospital Quiron Infanta Luisa

    Seville, 41010, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Huashan Hospital Affiliated Fudan University

    Shanghai, Shanghai Municipality, 200040, China

  • Instituto Medico Strusberg

    Córdoba, X5000EDC, Argentina

  • Investigacion y Biomedicina de Chihuahua

    Chihuahua City, 31000, Mexico

  • Jiangxi Pingxiang People's Hospital

    Pingxiang, Jiangxi, 337055, China

  • Joseph S. and Diane H. Steinberg Ambulatory Care Center

    Brooklyn, New York, 11201, United States

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Juntendo University Urayasu Hospital

    Urayasu, Chiba, 279-0021, Japan

  • Kohler and Milstein Research S.A. de C.V.

    Mérida, Yucatán, 97070, Mexico

  • Koujunkai Daido Clinic

    Nagoya, Aichi-ken, 457-8511, Japan

  • Laila A Hassan, MD, PA

    Houston, Texas, 77089, United States

  • Latin Clinical Trial Center

    San Juan, 00909, Puerto Rico

  • MICS Centrum Medyczne Warszawa

    Warsaw, Masovian Voivodeship, 00-874, Poland

  • Machida Municipal Hospital

    Tokyo, 194-0023, Japan

  • Medvin Clinical Research - Metyas

    Covina, California, 91722, United States

  • Medvin Clinical Research - Su

    Whittier, California, 90602, United States

  • Metroplex Clinical Research Center

    Dallas, Texas, 75231, United States

  • Mindful Medical Research

    San Juan, 00918, Puerto Rico

  • Nagaoka Red Cross Hospital

    Nagaoka, Niigata, 940-2108, Japan

  • Nagasaki Internal Medicine- Rheumatology Hospital

    Nagasaki, 850-0832, Japan

  • National Hospital Organization Chibahigashi National Hospital

    Chiba, 260-8712, Japan

  • Newport Huntington Medical Group

    Huntington Beach, California, 92648, United States

  • Nova Reuma Społka Partnerska

    Bialystok, Podlaskie Voivodeship, 15-707, Poland

  • Nzoz Bif-Med

    Bytom, Silesian Voivodeship, 41-902, Poland

  • Okayama City General Medical Center Okayama City Hospital

    Okayama, 700-8557, Japan

  • Organizacion Medica de Investigacion

    CABA, Buenos Aires, C1015, Argentina

  • Osi Bilbao-Basurto

    Bilbao, Basque Country, 48013, Spain

  • Paramount Medical Research & Consulting, LLC

    Middleburg Heights, Ohio, 44130, United States

  • Piedmont Arthritis Clinic

    Greenville, South Carolina, 29601, United States

  • Qualiclinic

    Budapest, 1036, Hungary

  • Revita Clinic

    Budapest, Pest County, 1027, Hungary

  • Rheuma Medicus- Zak��ad Opieki Zdrowotnej

    Warsaw, Masovian Voivodeship, 02-118, Poland

  • Rheumatology & Pulmonary Clinic

    Beckley, West Virginia, 25801, United States

  • Sagawa Akira Rheumatology Clinic

    Sapporo, Hokkaido, 060-0001, Japan

  • Saint Louis Rheumatology

    St Louis, Missouri, 63119, United States

  • Sasebo Chuo Hospital

    Sasebo, Nagasaki, 857-1195, Japan

  • ShenZhen People's Hospital

    Shenzhen, Guangdong, 518020, China

  • Shinkokura Hospital

    Kitakyushu, Fukuoka, 803-0816, Japan

  • Shinonoi General Hospital

    Nagano, 388-8004, Japan

  • Sound Clinical Research, LLC

    Bothell, Washington, 98021, United States

  • St Joseph Heritage Healthcare

    Fullerton, California, 92835, United States

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida, 34652, United States

  • Szpital Uniwersytecki Nr 2 w Bydgoszczy

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland

  • Tekton Research - Fort Collins - East Harmony Road

    Fort Collins, Colorado, 80528, United States

  • Tekton Research, Inc

    Austin, Texas, 78745, United States

  • The First Affiliated Hospital of Shantou University Medical College

    Shantou, Guangdong, 515041, China

  • The First Affiliated Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, 510080, China

  • Tobata General Hospital

    Kitakyushu, Fukuoka, 804-0025, Japan

  • Tonan Hospital

    Sapporo, Hokkaido, 060-0004, Japan

  • Tongji Hospital Tongji Medical,Science & Technology

    Wuhan, Hubei, 430030, China

  • Twoja Przychodnia NCM

    Nowa Sól, Lubusz Voivodeship, 67-100, Poland

  • Twoja Przychodnia Poznanskie Centrum Medyczne

    Poznan, Greater Poland Voivodeship, 61-293, Poland

  • University General Hospital of Heraklion

    Heraklion, Krítí, 711 10, Greece

  • University Hospital of Alexandroupolis

    Alexandroupoli, Évros, 68100, Greece

  • University of Occupational and Enviromental Health

    Kitakyushu, Fukuoka, 807-8556, Japan

  • Vital Medical Center

    Veszprém, Veszprém City, 8200, Hungary

  • West Broward Rheumatology Associates

    Tamarac, Florida, 33321, United States

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

  • Wolverine Clinical Trials

    Tustin, California, 92780, United States

  • Xiangya Hospital Central South University

    Changsha, Hunan, 410008, China

  • Yoshida Internal Medicine Clinic

    Sakaki, Nagano, 389-0606, Japan

More trials for these conditions

Other studies related to the condition(s) this trial covers.