RHEUMATIC DISEASES

This study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo to see if it reduces joint pain, swelling, and inflamm…

This study tests a new treatment using specially engineered immune cells (CAR-NK cells) in children aged 5 and older with severe rheumatic diseases like lupus that have not responded to standard therapies. The cells are designed to target and destroy faulty immune cells that caus…

This study is testing a new blood test that may help doctors choose the most effective medicine for people with rheumatic diseases like rheumatoid arthritis, lupus, and vasculitis. Researchers will take a blood sample and use it to see how a person's immune cells react to differe…

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study looks at whether a computer program for doctors and easy-to-read brochures for patients can help adults aged 60 and older with rheumatic conditions stop or reduce medications that may be risky. Researchers will follow 100 participants for about 18 months to track medic…

This study involves about 70 children and young people (ages 0-18) with rheumatic conditions like juvenile arthritis or lupus who have taken steroids in the last two years. Researchers will hold focus groups and interviews to understand how steroids affect their daily life and we…

This study aims to learn more about the causes of rheumatic diseases, such as arthritis, and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing standard medical care and tests. No e…