ARTHRITIS

This study is testing a new artificial joint (prosthesis) for people with painful, unstable elbows caused by arthritis or injury. About 84 adults under 85 years old will receive the implant and be followed for 24 months. The goal is to see if the device safely improves elbow func…

This study tests whether a device that emits 'biophotons' (a type of light energy) can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use the device or a placebo during sleep for 12 weeks. Researchers will measure pain levels, quality of…

This study compares two types of wrist fusion surgery for people with wrist arthritis caused by past injuries. 170 adults with stage II or III SLAC or SNAC wrist will be randomly assigned to have either a four-corner fusion or a three-corner fusion (which also removes a small bon…

This study looks at how 45, 90, or 150 minutes of physical activity each week affects arthritis symptoms like pain and mobility. Researchers will track changes in walking distance and other physical functions. The goal is to find the most effective amount of exercise for people w…

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking speed, step length, and safety in 150 participa…

This study is testing whether herbal medicines and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. About 25 adults will receive natural treatments aimed at improving health and quality of life. The goal is to see …

This study tests whether a group exercise program done over video calls is practical and well-liked by Veterans with knee or hip arthritis. Fifty Veterans will take part in a 3-month exercise program, then a 6-month follow-up with either text messages or extra group sessions. Res…

This study tests whether a tablet called dapansutrile can safely reduce joint pain during an acute gout flare. About 300 adults with gout will receive either the study drug or a placebo. The main goal is to measure pain relief 72 hours after the first dose.

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study aims to understand how spondyloarthritis (a group of bone and joint disorders causing pain and stiffness) progresses over time. Researchers will observe 2000 participants, including patients and their healthy relatives, using physical exams, blood tests, and imaging li…

This study aims to understand the natural history, genetics, and causes of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD). Researchers will follow up to 2,000 people with these conditions over time, collecting medical history, blood samples, …

This study aims to understand how severe and life-altering rheumatic side effects (like arthritis) can be for people receiving immune checkpoint inhibitor therapy for cancer. Researchers will interview 20 English-speaking adults who have been diagnosed with these side effects by …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect bone issues like cancer, infection, and arthritis. About 200 adults will get a tiny amount of radioactive tracer and be scanned for up to 3 hours. The goal is to see if…

This study collects joint fluid and blood samples from 500 people with different types of arthritis. Researchers will use these samples to test new ways to diagnose arthritis and track how well treatments work. Participants must have a swollen joint that can provide enough fluid.…

This study aims to better understand why people with inflammatory arthritis (like rheumatoid or psoriatic arthritis) experience chronic pain. Researchers will follow 350 patients starting new medications to identify different pain types and risk factors. The goal is to pave the w…

This study aims to learn more about the causes of rheumatic diseases, such as arthritis, and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing standard medical care and tests. No e…