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Breathing machine showdown: which mode helps obese patients best?

NCT ID NCT04131660

Symptom relief Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two types of non-invasive breathing support for people with sudden breathing failure who are obese or have sleep apnea. One machine automatically adjusts pressure and volume, while the other uses a fixed pressure setting. The goal was to see which method clears carbon dioxide from the blood faster and reduces breathing pauses during sleep. Only 14 people participated before the study was stopped early.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Dec 2019

Finished

Jun 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient of age * Patient benefitting of social security * Informed patient who signed the information note and the research enlighted consent form * Admission in respiratory intensive care unit for an acid-hypercapnic exacerbation (defined by pH≤ 7,35) * BMI ≥ 30kg/m2 * PaCO2 \> 6.5 kPa on blood gases at ICU admission Exclusion Criteria: * Confirmed COPD with a spirometry (VEMS/CVF \< 70%) * Pregnant women, or breast-feeding women * Patient with a judiciary or administrative liberty deprivation * Patients under guardianship * Contraindication to NIV

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Conditions

The condition(s) this trial relates to.

Acidosis Acidosis, Respiratory acute respiratory failure Apnea Hypercapnia Obesity obesity disorder obesity-hypoventilation syndrome obstructive sleep apnea syndrome respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory failure Apnea, obstructive Hypercapnic respiratory failure Hypoventilation syndrome Obesity Respiratory acidosis

Contacts and locations

Locations

  • CHU Rouen

    Rouen, 76031, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.