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Alzheimer's Tau-Targeting antibody trial halted midway

NCT ID NCT04619420

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental antibody called JNJ-63733657 in 523 people with early Alzheimer's disease. The antibody aims to clear tau protein clumps in the brain, which are linked to cognitive decline. Participants received either the antibody or a placebo by IV infusion. The trial was terminated early, so we have less data than planned, but results may still help researchers understand if targeting tau can slow Alzheimer's.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
JNJ-63733657 (an antibody designed to target tau protein in the brain)
What this could lead to
If successful, this could point toward a treatment that slows cognitive decline in early Alzheimer's disease.
What could go wrong
The trial was terminated early, so results are limited. It is still unclear whether targeting tau protein will meaningfully help patients, and antibody therapies can have side effects like infusion reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

523 people

The number who actually took part.

Started

Jan 2021

Finished

Mar 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Early Alzheimer's disease (AD): Gradual and progressive subjective decline in the participant's cognition over at least the past 6 months, as reported by the participant and informant (study partner) and Clinical Dementia Rating-Global Score (CDR-GS) of 0.5 and memory box score greater than or equal to (\>=) 0.5 at screening * Participants must have positive tau PET results * Able to read and write and with a minimum 5 years of formal education as reported by participant and study partner at screening * Have a designated study partner who has adequate literacy to participate and be judged to have high likelihood of completing the study with the participant * Male participants must agree not to donate sperm for the purpose of reproduction during the study and up to 16 weeks after receiving the last dose of study intervention Exclusion Criteria: * Participants with CDR GS \>=2 at predose baseline Clinical Dementia Rating (CDR) administration * Participants who fulfill diagnostic criteria for Mild Cognitive Impairment (MCI) or dementia/mild or major neurocognitive disorder suspected to be due to any etiology other than AD (example, Parkinson's disease, cerebrovascular disease, normal pressure hydrocephalus, head injury, drug or alcohol abuse/dependence, anoxic brain injury, (Et cetera\[etc\]) * Geriatric Depression Scale (GDS) 30 score greater than (\>) 12 * Hachinski Ischemic Scale (HIS) \>4 * Has received medications that affect the central nervous system (CNS), except treatments for AD, for less than 2 months; that is, doses of chronic medications that effect the CNS should be stable for at least 2 months before the start of screening. If a participant has recently stopped a chronic medication that effects the CNS, he or she must have discontinued treatment at least 2 months before the start of screening. Chronic use of benzodiazepines is not permitted

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Conditions

The condition(s) this trial relates to.

Alzheimer disease cognitive disorder Cognitive Dysfunction dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Cognitive dysfunction Dementia

Contacts and locations

Locations

  • AZ St.-Jan Brugge-Oostende AV

    Bruges, 8000, Belgium

  • Advanced Memory Research Institute of NJ

    Toms River, New Jersey, 08755, United States

  • Alexian Brothers Medical Center - Neuroscience Research Institute

    Elk Grove Village, Illinois, 60007, United States

  • Algemeen Ziekenhuis Delta

    Roeselare, 8800, Belgium

  • Alphab Global Research

    Jupiter, Florida, 33458, United States

  • Alzheimers Research and Treatment Center

    Wellington, Florida, 33414, United States

  • Anil Nair dba Alzheimer's Disease Center

    Braintree, Massachusetts, 02184, United States

  • Aqualane Clinical Research

    Naples, Florida, 34105, United States

  • Austin Health

    Ivanhoe, 3079, Australia

  • Australian Alzheimer's Research Foundation Incorporated

    Nedlands, 6009, Australia

  • Axiom Clinical Research of Florida

    Tampa, Florida, 33609, United States

  • BRC - Amsterdam

    Amsterdam, 1081 GN, Netherlands

  • BRC - Den Bosch

    's-Hertogenbosch, 5223 LA, Netherlands

  • BRC Zwolle

    Zwolle, 8052 AZ, Netherlands

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Box Hill Hospital

    Box Hill, 3128, Australia

  • Brain Matters Research

    Delray Beach, Florida, 33445, United States

  • Brown University School of Medicine

    Providence, Rhode Island, 02906, United States

  • CHU Nantes - Hopital Nord Laënnec

    Nantes, 44093, France

  • CHU Toulouse - Hôpital La Grave

    Toulouse, 31059, France

  • Centro At. Esp. Oroitu

    Algorta - Getxo, 48993, Spain

  • Charing Cross Hospital

    London, W6 8RF, United Kingdom

  • Charter Research

    The Villages, Florida, 32162, United States

  • Chu Rennes Hopital Pontchaillou

    Rennes, 35009, France

  • Cleveland Clinic Lou Revo Center for Brain Health

    Cleveland, Ohio, 44195, United States

  • ClinCloud Clinical Research

    Viera, Florida, 32904, United States

  • Clinical NeuroScience Solutions Inc

    Jacksonville, Florida, 32256, United States

  • Clinical Research Hospital Tokyo

    Shinjuku-ku, 162-0053, Japan

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • Dignity Health

    Phoenix, Arizona, 85013, United States

  • Fukuoka University Hospital

    Fukuoka, 814-0180, Japan

  • Fund. Ace-Inst. Cat. Neuroc. Aplicades

    Barcelona, 08028, Spain

  • Georgetown University Clinical Research Unit CRU

    Washington D.C., District of Columbia, 20007, United States

  • Great Lakes Clinical Trials

    Chicago, Illinois, 60640, United States

  • HammondCare Neurodegenerative Clinical Trials - VIC

    Malvern, 3144, Australia

  • Hattiesburg Clinic

    Hattiesburg, Mississippi, 39401, United States

  • Himeji Central Hospital Clinic

    Himeji, 672-8043, Japan

  • Hopital Charles Nicolle

    Rouen, 76031, France

  • Hopital Lariboisiere-Fernand Widal

    Paris, 75010, France

  • Hopital Pellegrin CHU Bordeaux

    Bordeaux, 33076, France

  • Hopital Pitie Salpetriere

    Paris, 75013, France

  • Hopital Roger Salengro - CHU Lille

    Lille, 59037, France

  • Hosp. Clinico San Carlos

    Madrid, 28040, Spain

  • Hosp. Del Mar

    Barcelona, 08003, Spain

  • Hosp. Mutua Terrassa

    Terrassa, 08221, Spain

  • Hosp. Univ. I Politecni La Fe

    Valencia, 46026, Spain

  • Hosp. Univ. Santa Maria

    Lleida, 25198, Spain

  • Hosp. de La Santa Creu I Sant Pau

    Barcelona, 08025, Spain

  • Hôpital Bretonneau

    Tours, 37000, France

  • Idc Salud Hosp. Gral. de Catalunya

    Barcelona, 08195, Spain

  • Inage Neurology and Memory Clinic

    Chiba, 263-0043, Japan

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Irvine Clinical Research

    Irvine, California, 92614, United States

  • JEM Research LLC

    Atlantis, Florida, 33462, United States

  • Jessa Ziekenhuis

    Hasselt, 3500, Belgium

  • Jinsenkai MI Clinic

    Toyonaka-shi, 5600004, Japan

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • Karolinska Universitetssjukhuset

    Stockholm, 14186, Sweden

  • Kawartha Centre - Redefining Healthy Aging

    Peterborough, Ontario, K9H 2P4, Canada

  • Kawashima Neurology Clinic

    Fujisawa-shi, 251-0038, Japan

  • Keikokai P-One Clinic

    Hachiōji, 192-0071, Japan

  • Keystone Clinical Studies LLC

    Plymouth Meeting, Pennsylvania, 19462, United States

  • Kobe City Medical Center General Hospital

    Kobe, 650-0047, Japan

  • Koukan Clinic

    Kawasaki, 210-0852, Japan

  • Kurume University Hospital

    Kurume, 830-0011, Japan

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • McGill University

    Montreal, Quebec, H3A 2B4, Canada

  • Memory Clinic Inc

    Bennington, Vermont, 05201, United States

  • Merritt Island Medical Research, LLC

    Merritt Island, Florida, 32952, United States

  • Miami Jewish Health System

    Miami, Florida, 33137, United States

  • Nagomi Clinic

    Toyonaka-shi, 560-0004, Japan

  • National Center For Geriatrics And Gerontology

    Obu-shi, 474-8511, Japan

  • National Hospital Organization Hizen Psychiatric Center

    Kanzaki-gun, 842-0192, Japan

  • Neuro Trials Victoria

    Carlton, 3053, Australia

  • NeuroCognitive Institute

    Mount Arlington, New Jersey, 07856, United States

  • Neurological Associates of Albany, PC

    Albany, New York, 12208, United States

  • Neuropsychiatric Research Center of SWFL

    Fort Myers, Florida, 33912, United States

  • New York University Medical Center

    New York, New York, 10016, United States

  • Pacific Research Network Prn

    San Diego, California, 92103, United States

  • Palm Beach Neurology and Premier Research Institute

    West Palm Beach, Florida, 33407, United States

  • Parkwood Institute

    London, Ontario, N6C 0A7, Canada

  • Princeton Medical Institute

    Princeton, New Jersey, 08540, United States

  • QPS Netherlands

    Leeuwarden, 8934AD, Netherlands

  • Rakuwakai Otowa Hospital

    Kyoto, 607-8062, Japan

  • Rakuwakai Otowa Rehabilitation Hospital

    Kyoto, 607-8113, Japan

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • Rijikai Medical Corporation Katayama Medical Clinic

    Kurashiki-shi, 7100813, Japan

  • Royal Adelaide Hospital

    Adelaide, 5000, Australia

  • Royal Melbourne Hospital

    Parkville, 3050, Australia

  • Royal United Hospital

    Bath, BA1 3NG, United Kingdom

  • Saiseikai Narashino Hospital

    Narashino, 275-0006, Japan

  • Sandhill Research

    Decatur, Georgia, 30030, United States

  • Sensible Healthcare

    Ocoee, Florida, 34761, United States

  • Shonan Kamakura General Hospital

    Kamakura-shi, 247-8533, Japan

  • Stanford University Medical Center

    Palo Alto, California, 94304, United States

  • Stedman Clinical Trials

    Tampa, Florida, 33613, United States

  • Syrentis Clinical Research

    Santa Ana, California, 92705, United States

  • Takeda General Hospital

    Aizu-Wakamatsu, 965-8585, Japan

  • Tandem Intermediate LLC

    Maitland, Florida, 32751, United States

  • The Emory Clinic

    Atlanta, Georgia, 30329, United States

  • The University of Texas Health Science Center at Houston

    Houston, Texas, 77054, United States

  • Tokyo Medical University Hospital

    Tokyo, 160-0023, Japan

  • Tokyo Metropolitan Geriatric Hospital

    Tokyo, 173-0015, Japan

  • Toronto Memory Program (Neurology Research Inc.)

    Toronto, Ontario, M3B 257, Canada

  • UCL Hopital Saint-Luc

    Brussels, 1200, Belgium

  • UHN-Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

  • UZ Antwerpen

    Edegem, 2650, Belgium

  • UZ Brussel

    Jette, 1090, Belgium

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • University of Alabama Birmingham

    Birmingham, Alabama, 35233, United States

  • University of California - Los Angeles

    Los Angeles, California, 90095, United States

  • University of California San Diego Medical Center

    La Jolla, California, 92037, United States

  • University of Miami Miller School of Medicine

    Miami, Florida, 33136, United States

  • University of South Florida - Health Byrd Alzheimer Institute

    Tampa, Florida, 33613, United States

  • University of Virginia

    Charlottesville, Virginia, 22903, United States

  • Velocity Clinical Research

    East Syracuse, New York, 13057, United States

  • Wake Forest Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School Of Medicine

    St Louis, Missouri, 63110, United States

  • Wexner Medical Center at the Ohio State University

    Columbus, Ohio, 43221, United States

  • Yale University School Of Medicine

    New Haven, Connecticut, 06510, United States

  • Yokohama Brain and Spine Center

    Yokohama, 235-0012, Japan

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